Single high-dose dexamethasone improves the effect of ondansetron on acute chemotherapy-induced nausea and vomiting but impairs the control of delayed symptoms

Supportive Care in Cancer

Volumn 4, Issue 6, 1996, Pages 440-446

  Peterson, Curt ^a   Hursti, Timo J ^b   Börjeson, Sussanne ^a   Åvall Lundqvist, Elisabeth ^a   Fredrikson, Mats ^b   Fürst, Carl Johan ^a   Lomberg, Helena ^c   Steineck, Gunnar ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c GLAXOSMITHKLINE   (United States)

Author keywords

5 HT3 receptor antagonists; Cancer chemotherapy; Corticosteroids; Nausea and vomiting

Indexed keywords

ANTIEMETIC AGENT; ANTINEOPLASTIC AGENT; CISPLATIN; DEXAMETHASONE; DOXORUBICIN; HYDROCORTISONE; MELPHALAN; ONDANSETRON;

ARTICLE; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG COMBINATION; FEMALE; HUMAN; NAUSEA; OVARY TUMOR; RANDOMIZED CONTROLLED TRIAL; URINE; VOMITING;

ANTIEMETICS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CISPLATIN; DEXAMETHASONE; DOXORUBICIN; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; HYDROCORTISONE; MELPHALAN; NAUSEA; ONDANSETRON; OVARIAN NEOPLASMS; VOMITING;

EID: 0030278811     PISSN: 09414355     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01880642     Document Type: Article

References (22)

1. Aapro MS, Alberts DS (1981) Highdose dexamethasone for prevention of cisplatin-induced vomiting. Cancer Chemother Pharmacol 7:11-14
2. Andrews PL, Davis CJ (1993) The mechanism of emesis induced by anti-cancer therapies. In: Andrews PL. Sanger GJ (eds) Emesis in anti-cancer therapy. Mechanisms and management. Chapman & Hall, London, pp 113-161
3. Borcovec TD (1976) Physiological and cognitive processes in the regulation of anxiety. In: Schwartz GE, Shapiro S (eds) Consciousness and self-regulation. (Advances in research) Plenum Press, New York, pp 261-312
4. Carmichael J, Bessel EM, Harris AL, Hucheon AW, Dawes PJDK. Daniels S (1994) Comparison of granisetrone alone and granisetron plus dexamethasone in the prophylaxis of cytotoxic-induced emesis. Br J Cancer 70:1161-1164
5. Del Favero A, Roila F, Tonato M (1993) Reducing chemotherapy-induced nausea and vomiting. Current perspectives and future possibilities. Drug Safety 9:410-428
6. Eysenck HJ, Eysenck SBG (1975) Manual of the Eysenck Personality Questionnaire. Hodder and Stoughton, London
7. Fredrikson M, Hursti T, Fürst CJ, et al (1992) Nausea in cancer chemotherapy is inversely related to urinary cortisol excretion. Br J Cancer 65:779-780
8. Greenland S, Robins JM (1985) Estimation of a common effect parameter from sparse follow-up data. Biometrics 41:55-68
9. Haid M (1981) Steroid antiemetics may be harmful. N Engl J Med 304:1237
10. Hursti T, Fredrikson M, Steineck G, Börjeson S, Fürst CJ, Peterson C (1993) Endogenous cortisol exerts antiemetic effects similar to that of exogenous corticosteroids. Br J Cancer 68:112-114
11. Hursti T, Fredrikson M, Steineck G, Börjeson S, Fürst CJ, Peterson C (1994) Factors modifying the risk of acute and conditioned nausea and vomiting in ovarian cancer patients. Int J Oncol 41:695-701
12. Jones AL, Hill AS, Soukop M, et al (1991) Comparison of dexamethasone and ondansetron in the prophylaxis of emesis induced by moderately emetogenic chemotherapy. Lancet 338:483-487
13. Joss RA, Bacchi M, Buser K, et al (1994) Ondansetron plus dexamethasone is superior to ondansetron alone in the prevention of emesis in chemotherapy-naive and previously treated patients. Ann Oncol 5:253-258
14. Kris MG, Gralla RJ, Clarke RA, et al (1985) Incidence, course and severity of delayed emesis and vomiting following the administration of high dose cisplatin. J Clin Oncol 3:1379-1384
15. Kris MK, Tyson LB, Baltzer L, Pisters KMW (1991) Clinical trials in acute chemotherapy-induced vomiting. In: Bianchi AL, Grélot L, Miller AD, King GL (eds) Mechanisms and control of emesis. (Colloque INSERM, vol 223) Libbey Eurotext, Montrouge, pp 129-139
16. Kris MG, Tyson LB, Clarke RA, Gralla RJ (1992) Oral ondansetron for the control of delayed emesis after cisplatin. Cancer 70 [Suppl]:1012-1016
17. Markman M, Sheidler V, Ettinger DS, Quaskey SA, Mellits ED (1984) Antiemetic efficacy of dexamethasone: randomized double-Wind, crossover study with prochloperazine in patients receiving cancer chemotherapy. N Engl J Med 311:549-552
18. Powell, CB, Mutch DG, Kao M-S, et al (1990) Dexamethasone used as an antiemetic in chemotherapy protocols inhibits natural cytotoxic (NC) cell activity. Cancer 65:466-472
19. Roila F, Tonato M, Cognetti F, et al (1991) Prevention of cisplatin-induced emesis: a double-blind multicenter randomized crossover study comparing ondansetron and ondansetron plus dexamethasone. J Clin Oncol 9:675-678
20. Roila F, the Italian Group for Antiemetic Research (1995) Dexamethasone, granisetrone, or both for the prevention of nausea and vomiting during chemotherapy for cancer. N Engl J Med 332:1-5
21. Smith DB, Newland ES, Rustin GJS, et al (1991) Comparison of ondansetron and ondansetron plus dexamethasone as antiemetic prophylaxis during cisplatin-containing chemotherapy. Lancet 338:487-490
22. Spielberger CD, Gorsuch RL, Lushene R (1968) The State Anxiety Inventory (STAI). Consulting Psychologists Press, Palo Alto, Calif