Relaxant Effect of Tetrazepam on Rat Uterine Smooth Muscle: Role of Calcium Movement

Journal of Pharmacy and Pharmacology

Volumn 48, Issue 11, 1996, Pages 1169-1173

  Perez Guerrero, C ^a   Herrera, M D ^a   Marhuenda, E ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANXIOLYTIC AGENT; BENZODIAZEPINE DERIVATIVE; CALCIUM; CALCIUM CHANNEL; CENTRAL MUSCLE RELAXANT; ISOQUINOLINE DERIVATIVE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; POTASSIUM CHLORIDE; TETRAZEPAM; VANADIC ACID;

ANIMAL; ARTICLE; DOSE RESPONSE; DRUG EFFECT; FEMALE; METABOLISM; MUSCLE CONTRACTION; MUSCLE RELAXATION; RAT; SMOOTH MUSCLE; UTERUS; WISTAR RAT;

ANIMALS; ANTI-ANXIETY AGENTS; BENZODIAZEPINES; BENZODIAZEPINONES; CALCIUM; CALCIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; ISOQUINOLINES; MUSCLE CONTRACTION; MUSCLE RELAXANTS, CENTRAL; MUSCLE RELAXATION; MUSCLE, SMOOTH; POTASSIUM CHLORIDE; RATS; RATS, WISTAR; UTERUS; VANADATES;

EID: 0030278805     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1996.tb03915.x     Document Type: Article

References (30)

1. Anholt, R. R. H., Pedersen, P. L., De Souza, E. B., Snyder, S. M. (1986) The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane. J. Biol. Chem. 261: 576-583
2. 1 and oxytocin in Ca-free solution, Prostaglandins 34: 351-357
3. Bender, A.S., Hertz, L. (1985) Pharmacological evidence that the non-neuronal diazepam binding sites in primary cultures of glial cells is associated with a calcium channels. Eur. J. Pharmacol. 110: 278-288
4. Bolton, T. B. (1979) Mechanisms of action of transmitters and other substances on smooth muscle. Phisyol. Rev. 59: 606-718
5. D'Ocón, P., Anselmi, E., Villar, A. (1987) Role of stored Ca in contractions of rat uterus induced by acetylcholine: effects of preincubation with Mg-free solution. Arch. Int. Pharmacodyn. Ther. 286: 162-170
6. D'Ocón, P., Candenas, M. L., Anselmi, E., Zafra-Polo, M. C., Cortes, D, (1989) Antioquine: a new bisbenzylisoquinoleine alkaloid with calcium antagonist activity. Arch. Int. Pharmacodyn. Ther. 297: 205-215
7. Edwards, D., Good, D., Grager, S., Hollingsworth, M., Small, R. C., Weston, A. H. (1986) The spasmogenic action of oxytocin in rat uterus - comparison with other agonists. Br. J. Pharmacol. 88: 809-908
8. Erne, P., Chiesi, M., Longoni, S., Fulbright, J., Hermsmeyer, K. (1989) Relaxation of rat vascular muscle by peripheral benzodiazepine modulators. Clin. Invest. Inc. 84: 493-498
9. French, J. F., Rapoport, R. M., Matlib, M. A. (1989) Possible mechanism of benzodiazepine-induced relaxation of vascular smooth muscle. J. Cardiovasc. Pharmacol. 14: 405-412
10. Godfraind, T., Miller, R., Wibo, M. (1986) Calcium antagonisn and calcium entry blockade. Pharm. Rev. 38: 321-416
11. Groh, B., Muller, W. E. (1985) A comparison of the relative in vitro and in vivo binding affinities of various benzodiazepines and related compounds for the benzodiazepine receptor and for peripheral benzodiazepines binding sites. Res. Commun. Chem. Pathol. Pharmacol 49: 463-466
12. Grover, A. K., Kwan , C. N., Daniel, E. E. (1981) Na-Ca exchange in rat myometrium membrane vesicles highly enriched in plasma membranes. Am. J. Phisyol. 240: C175-C178
13. Haefely, W., Kyburz, E., Gereke, M., Möller. (1985) Recent advances in the molecular pharmacology of benzodiazepine receptors and in the structure-activity relationships of their agonist and antagonists. In: Testa, B. (ed.) Advances in Drug Research, Vol. XIV, Academic Press, London, pp 165-322
14. Hall, M. (1983) Prostaglandin synthesis inhibitors: effect on angiotensin II- and oxytocin-induced contractions in rat uterine smooth muscle. Br. J. Pharmacol. 79: 121-127
15. Hidalgo, A., Cantabrana, B., Andrés-Trelles, F. (1987) Efecto de inhibidores de la síntesis de eicosanoides (ISE) en útero aislado de rata. Rev. Farmacol. Clin. Exp. 4: 295-303
16. Kaplan, F. A. (1980) Pharmacokinetics of benzodiazepines. In: Priest, R. G., Vianna Filho, U., Amrein, R., Skreta, M. (eds) Benzodiazepines Today and Tomorrow, University Park Press, Baltimore pp 47-60
17. Keane, P. E., Bachy, A., Morre, M., Biziere, K. (1988a) Tetrazepam: a benzodiazepine which dissociates sedation from other benzodiazepine activities. I. Psychopharmacological profile in rodents. J Pharmacol. Exp. Ther. 245: 692-692
18. Keane, P. E., Bachy, A., Morre, M., Biziere, K.(1988b) Tetrazepam: a benzodiazepine which dissociates sedation from other benzodiazepine activities. II. In vitro and in vivo interactions whith benzodia-zepine binding sites. J Pharmacol. Exp. Ther. 245: 699-705
19. Le Fur, G., Perrier, N., Vaucher, N. (1983) Peripheral benzodiazepine binding sites: effect of PK 11195 1-(-2-chlorophenyl-N-methyl-NI-methylpropyl)-3-isoquinoline carboxamide. Life Sci. 32: 1839-1845
20. 3H]Ro 5-4864. Mol. Pharmacol. 22: 26-32
21. Mestre, M., Carriot, C., Belin, C., Uzan, A., Renault, C., Dubroeucq, M. C., Gueremy, C., Doble, A., Le Fur, G. (1985) Electrophysio-logical and pharmacological evidence that peripheral type benzodiazepine receptors are couple to calcium channels in the heart. Life Sci. 36: 391-400
22. Mironneau, C., Mironneau, J., Savineau, J. P. (1984) Maintained contractions of rat uterine smooth muscle incubated in a Ca-free solution. Br. J. Pharmacol. 82: 735-743
23. Müller, W. E., Ickstadt, T., Hopf, H. C. (1985) Peripheral benzodiazepine binding sites on striated muscles of the rat: properties and effects of denervation. J. Neural Transm. 61: 35-42
24. Nechay, B. R. (1984) Mechanisms of action of vanadium. Annu. Rev. Pharmacol. 24: 501-524
25. Parola, A. L., Stump, D. G., Pepperl, D. J., Krueger, K. E., Regan, J. W., Laird, H. E. (1991) Cloning and expression of pharmacologically unique bovine peripheral-type benzodiazepine receptor isoquinoline binding protein. J. Biol. Chem. 21: 14082-14087
26. Rampe, D., Triggle, D. J. (1986) Benzodiazepines and calcium channel function. Trends Pharmacol. Sci. 7: 461-463
27. Skerrit, J. H., Chow, S. C., Johnsons, G. A., Davis, D. L. (1982) Purines interact with 'central' but not 'peripheral' benzodiazepine binding sites. Neurosci. Lett. 34: 63
28. Savineau, J. P., Mironneau, J. (1990) Caffeine acting on pregnant rat myometrium: analysis of its relaxant action and its failure to release Ca from intracellular stores. Br. J. Pharmacol. 99: 261-266
29. Taft, W. C., De Lorenzo, R. J. (1984) Micromolar affinity benzodiazepine receptors regulate voltage-sensitive calcium channels in nerve terminal preparations. Proc. Natl Acad. Sci. USA. 81: 3118-3122
30. Villar, A., D'Ocón, P., Anselmi, E. (1986) Role of intracellular calcium stores in the contractile response of uterus to several agonists. J. Pharmacol. 17: 541-546