Pharmacokinetics, effects on renal function, and potentiation of atracurium-induced neuromuscular blockade after administration of a high dose of gentamicin in isoflurane-anesthetized dogs

American Journal of Veterinary Research

Volumn 57, Issue 11, 1996, Pages 1623-1626

  Martinez, Elizabeth A ^a   Mealey, Katrina L ^a   Wooldridge, Anne A ^a   Mercer, Dana E ^a   Cooper, Jonathan ^a   Slater, Margaret R ^a   Hartsfield, Sandee M ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ATRACURIUM; GENTAMICIN; INHALATION ANESTHETIC AGENT; ISOFLURANE; NEUROMUSCULAR BLOCKING AGENT;

ANESTHESIA; ANIMAL; ANIMAL DISEASE; ARTICLE; DOG; DRUG EFFECT; DRUG POTENTIATION; FEMALE; KIDNEY; MALE;

ANESTHESIA; ANESTHETICS, INHALATION; ANIMALS; ANTI-BACTERIAL AGENTS; ATRACURIUM; DOGS; DRUG SYNERGISM; FEMALE; GENTAMICINS; ISOFLURANE; KIDNEY; MALE; NEUROMUSCULAR NONDEPOLARIZING AGENTS;

EID: 0030278613     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Miller RD, Rupp SM, Fisher DM, et al. Clinical pharmacology of vecuronium and atracurium. Anesthesiology 1984;61:444-453.
2. Silverman DG, ed. Neuromuscular block in perioperative and intensive care. Philadelphia: JB Lippincott Co, 1994;184.
3. Basta SJ, Savarese JJ, Ali HH, et al. Histamine-releasing potencies of atracurium, dimethyl tubocurarine and tubocurarine. Br J Anaesth 1983;55:105S-106S.
4. Pittinger C, Adamson R. Antibiotic blockade of neuromuscular function. Annu Rev Pharmacol 1972;12:169-184.
5. Singh TN, Marshall IG, Harvey AC. Pre- and postjunctional blocking effects of aminoglycoside, polymixin, tetracycline, and lincosamide antibiotics. Br J Anaesth 1982;54:1295-1305.
6. Sulcoll MD, Gergis SD. Antibiotics and neuromuscular function. Anesthesiology 1981;55:148-159.
7. Potter JM, Eleson RG, Campbell RJ, et al. Potentiation by gentamicin of non-depolarizing neuromuscular block in the cat. Anaesth Intensive Care 1980;8:20-25.
8. Hildebrand SV, Hill T. Interaction of gentamycin and atracurium in anaesthetised horses. Equine Vet J 1994;26:209-211.
9. Forsyth SF, Ilkiw JE, Hildebrand SV. Effect of gentamicin administration on the neuromuscular blockade induced by atracurium in cats. Am J Vet Res 1990;51:1675-1678.
10. Gilbert DN. Once-daily aminoglycoside therapy. Antimicrob Agents Chemother 1991;35:399-405.
11. Nordstrom L, Ringberg H, Grunverg S, et al. Does administration of an aminoglycoside in a single daily dose affect its efficacy or toxicity? J Antimicrob Chemother 1990;25:159-173.
12. Smith CM, Steffey EP, Baggot JD, et al. Effects of halothane anesthesia on the clearance of gentamicin sulfate in horses. Am J Vet Res 1988;49:19-22.
13. Klein L. Neuromuscular blocking agents. In: Short CE, ed. Principles and practice of veterinary anesthesia. Baltimore: Williams & Wilkins Co, 1987;134-153.
14. Appel G. Aminoglycoside nephrotoxicity. Am J Med 1990; 88:16S-20S.
15. Frazier DL, Aucoin DP, Riviere JE. Gentamicin pharmacokinetics and nephrotoxicity in naturally acquired and experimentally induced disease in dogs. J Am Vet Med Assoc 1988;192:57-63.
16. Whelton A. Therapeutic initiatives for the avoidance of aminoglycoside toxicity. J Clin Pharmacol 1985;25:67-81.