SK&F 86002, a dual cytokine and eicosanoid inhibitor, attenuates endotoxin-induced cardiopulmonary dysfunction in the pig

Shock

Volumn 6, Issue 5, 1996, Pages 357-364

  Triplett, Elisabeth A ^a   Kruse Elliott, Kris T ^b   Hart, Arlene P ^a   Schram, Brian R ^a   MacWilliams, Peter S ^b   Cooley, A James ^b   Clayton, Murray K ^c   Darien, Benjamin J ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 PYRIDINYL)IMIDAZO(2,1 B)THIAZOLE; 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO(2,1-B)THIAZOLE; CYTOKINE; ICOSANOID; IMIDAZOLE DERIVATIVE; LIPOPOLYSACCHARIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PEROXIDASE; THIAZOLE DERIVATIVE; THROMBOXANE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; BIOSYNTHESIS; DRUG EFFECT; ENDOTOXEMIA; HEART; HEART STROKE VOLUME; LUNG; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SWINE; VASCULAR RESISTANCE; VASCULARIZATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYTOKINES; EICOSANOIDS; ENDOTOXEMIA; HEART; IMIDAZOLES; LIPOPOLYSACCHARIDES; LUNG; PEROXIDASE; STROKE VOLUME; SWINE; THIAZOLES; THROMBOXANES; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR RESISTANCE;

EID: 0030278176     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199611000-00010     Document Type: Article

References (35)

1. Dinarello CA: The proinflammatory cytokines interleukin-1 and tumor necrosis factor and treatment of the septic shock syndrome. J Infect Dis 163:1177-1184, 1991.
2. Beutler B: Cachectin/Tumor necrosis factor and lymphotoxin. Handbook of experimental pharmacology peptide growth factors and their receptor II. Sporn MB, Roberts AB (Eds), Heidelberg, Springer-Verlag. 39-70, 1990.
3. Filkins JP: Monokines and the metabolic pathophysiology of septic shock. Fed Proc 44:300-304, 1985.
4. Beutler B, Cerami A: Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature 320:584-588, 1986.
5. Tracey KJ, Beutler B, Lowry SK, Merryweather J, Wolpe S, Milsark IW, Hariri RJ, Fahey TJ, Zentella A, Albert JD, Shires GT, Cerami A: Shock and tissue injury induced by recombinant human cachectin. Science 234: 470-474, 1986.
6. Marks JD, Marks CB, Luce JM, Montgomery AB, Turner J, Metz CA, Murray JF: Plasma tumor necrosis factor in patients with septic shock: mortality rate, incidence of adult respiratory distress syndrome, and effects of methylprednisolone administration. Am Rev Respir Dis 141:94-97, 1990.
7. Michie HR, Manogue KR, Spriggs DR, Revhaug A, O'Dwyer S, Dinarello CA, Cerami A, Wolff SM, Wilmore DW: Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 318:1381-1386, 1988.
8. Damas P, Reuter A, Gysen P, Demonty J, Lamy M, Franchimont P: Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans. Crit Care Med 17:975-978, 1989.
9. Calandra T, Baumgarter J-D, Grau GE, Wu MM, Lambert PH, Schellekens J, Verhoef J, Glauser MP, the Swiss-Dutch J5 Immunoglobulin Study Group: Prognostic values of tumor necrosis factor/cachectin, interleukin-1, interferon-α, and interferon-γ in the serum of patients with septic shock. J Infect Dis 161:982-987, 1990.
10. Pinski MR, Vincent JL, Deviere J, Alegre M, Kahn RJ, Dupont E: Serum cytokine levels in human septic shock: relation to multiple-system organ failure and mortality. Chest 103:565-575, 1993.
11. Calandra T, Gerain J, Heumann D, Baumgartner JD, Glauser MP: High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines. Am J Med 91:23-29, 1991.
12. St John RC, Dorinsky PM: Immunologic therapy for ARDS, septic shock, and multiple-organ failure. Chest 103:932-943, 1993.
13. Prichett W, Hand A, Sheilds J, Dunnington D: Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor alpha. J Inflammation 45:97-105, 1995.
14. Olivera DL, Laydon JT, Hillegass L, Badger AM, Lee JC: Effects of pyridinyl imidazole compounds on murine TNFα production. Agents Actions 39:C55-C57, 1993.
15. Morris DD, Crowe N, Moore JN: Reduced endotoxin-induced production of tumor necrosis factor activity by equine peritoneal macrophages exposed to the dual inhibitor of arachidonic acid metabolism, SK&F 86002. Can J Vet Res 56:110-114, 1992.
16. Lee JC, Votta B, Dalton BJ, Griswold DE, Bender PE, Hanna N: Inhibition of human monocyte IL-1 production by SK&F 86002. Int J Immunotherapy VI 1:1-12, 1990.
17. Lee JC, Badger AM, Griswold DE, Dunnington D, Truneh A, Votta B, White JR, Young PR, Bender PE: Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors. Ann N Y Acad Sci 696:149-170, 1993.
18. Lee JC, Rebar L, Laydon JT: Effect of SK&F 86002 on cytokine production by human monocytes. Agents Actions 27:277-279, 1989.
19. Badger AM, Olivera D, Talmadge JE, Hanna N: Protective effect of SK&F 86002, a novel dual inhibitor of arachidonic acid metabolism, in murine models of endotoxin shock: inhibition of tumor necrosis factor as a possible mechanism of action. Circ Shock 27:51-61, 1989.
20. Smith EF, Slivjak MJ, Bartus JO, Esser KM: SK&F 86002 inhibits tumor necrosis factor formation and improves survival in endotoxemic rats. J Cardio Pharmacol 18:721-728, 1991.
21. DiMartino MJ, Griswold DE, Berkowitz BA, Poste G, Hanna N: Pharmacologic characterization of the antiinflammatory properties of a new dual inhibitor of lipoxygenase and cyclooxygenase. Agents Actions 20:113-123, 1987.
22. Griswold DE, Marshall PJ Webb EF, Godfrey R, Newton J, DiMartino MJ, Sarau HM, Gleason JG, Poste G, Hanna N: SK&F 86002: A structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem Pharmacol 36:3463-3470, 1987.
23. Olson NC, Brown TT, Anderson DL: Dexamethasone and indomethacin modify endotoxin-induced respiratory failure in pigs. J Appl Physiol 58:274-284, 1985.
24. 4 production during endotoxin-induced lung injury. J Appl Physiol 64:2100-2197, 1988.
25. Kruse-Elliott KT, Olson NC: CGS 8515 and indomethacin attenuate cytokine-induced cardiopulmonary dysfunction in pigs. Am J Physiol (Heart Circ Physiol 33) 263:H761-H770, 1992.
26. Espevik T, Nissen J: A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J Immunol Methods. 95:99-105, 1986.
27. Howard MO, Newton JF, Keohane DJ, Yodis LP, Saverino CM, Qualls CW Jr, Schwartz LW: In vitro metabolism of the novel antiinflammatory agent 6-(4′-fluorophenyl)-5-(4′-pyridyl)-2,3-dihydroimidazo-{2,1-b}- thiazole. Drug Metab Dispos 18:607-612, 1990.
28. Newton JF, Yodis LP, Keohane D, Eckardt R, Dewey R, Dent J, Mico B: Pharmacokinetics and metabolism of SK&F 86002 in male and female Sprague-Dawley rats. Drug Metab Dispos 17:174-179, 1989.
29. Olson NC, Joyce PB, Fleisher LN: Role of platelet-activating factor and eicosanoids during endotoxin-induced lung injury in pigs. Am J Physiol 258:H1674-H1686, 1990.
30. Olson NC, Joyce PB, Fleisher LN: Mono-hydroxyeicosatetraenoic acids during porcine endotoxemia. Lab Invest 63:221-232, 1990.
31. Olson NC, Kruse-Elliott KT, Dodam JR: Systemic and pulmonary reactions in swine with endotoxemia and gram-negative bacteremia. JAVMA 200:1870-1884, 1992.
32. Parrillo JE: The cardiovascular pathophysiology of sepsis. Ann Rev Med 40:469-485, 1989.
33. Rothlein R, Czajkowski M, Kishimoto TK: Intercellular adhesion molecule-1 in the inflammatory response. Chem Immunol 50:135-142, 1991.
34. Boschelli DH, Kramer JB, Khatana SS, Sorenson RJ, Connor DT, Ferin MA, Wright CD, Lesch ME, Imre K, Okonkwo GC, Schrier DJ, Conroy MC, Ferguson E, Woelle J, Saxena U: Inhibition of E-Selectin, ICAM-1, and VCAM-1-mediated cell adhesion by Benzo[b]thiophene-, Benzofuran-, Indole-, and Naphthalene-2-carboxamides: Identification of PD 144795 as an antiinflammatory agent. J Med Chem 38:4597-4614, 1995.
35. Modig J, Samuelsson T: Prevention by granulocyte depletion of endotoxin-induced adult respiratory distress syndrome: An experimental study in pigs. Resuscitation 15:187-199, 1987.