Potent peroxisome proliferators inhibit β-oxidation in the isolated perfused rat liver

Toxicology and Applied Pharmacology

Volumn 140, Issue 2, 1996, Pages 322-327

  Bojes, Heidi K ^a   Thurman, Ronald G ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMOOCTANOIC ACID; 2 ETHYLHEXANOL; 3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; ENZYME INHIBITOR; KETONE BODY; LONG CHAIN FATTY ACID COENZYME A LIGASE; NAFENOPIN; PEROXISOME PROLIFERATOR; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PIRINIXIC ACID; PROTEIN KINASE C; TUMOR PROMOTER; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL RESPIRATION; CONTROLLED STUDY; DOSE RESPONSE; FATTY ACID OXIDATION; KETOGENESIS; LIPID METABOLISM; LIVER PERFUSION; MALE; NONHUMAN; OXYGEN CONSUMPTION; RAT;

ANIMALIA;

EID: 0030273562     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0227     Document Type: Article

References (36)

1. Albro, P. (1975). The metabolism of 2-ethylhexanol in rats. Xenobiotica 5, 625-636.
2. Ballet, F., and Thurman, R. G. (1991). Why the perfused liver? In Research in Perfused Liver: Clinical and Basic Applications (F. Ballet and R. G. Thurman, Eds.), pp. 1-20. INSERM and John Libbey Eurotext, Paris and London.
3. Bergmeyer, H. U. (1988). Methods of Enzymatic Analysis, Academic Press, New York.
4. Blobe, G. C., Khan, W. A., and Hannun, Y. A. (1995). Protein kinase C: Cellular target of the second messenger arachidonic acid? Prostaglandins Leukotrienes Essent. Fatty Acids 52, 129-135.
5. Bojes, H. K., and Thurman, R. G. (1994). Peroxisomal proliferators inhibit acyl CoA synthetase and stimulate protein kinase C in vivo. Toxicol. Appl. Pharmacol. 126, 233-239.
6. Bronfman, M., Orellana, A., Morales, M. N., Morales, M. N., Bieri, F., Waechter, F., Staubli, W., and Bentley, P. (1989). Potentiation of diacyl-glycerol-activated protein kinase C by acyl-coenzyme A thioesters of hypolipidaemic drugs. Biochem. Biophys. Res. Commun. 159, 1026-1031.
7. Castagna, M., Takai, Y., Sano, K., Kikawa, U., and Nishizuka, Y. (1982). Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem. 257, 7847-7851.
8. Christiansen, R. Z. (1978). The effect of clofibrate feeding on hepatic fatty-acid metabolism. Biochim. Biophys. Acta 530, 314-324.
9. Eacho, P. I., Lanier, T. L., and Brodhecker, C. A. (1991). Hepatocellular DNA synthesis in rats given peroxisome proliferating agents: Comparison of Wy-14,643 to clofibric acid, nafenopin and LY171883. Carcinogenesis 12, 1557-1561.
10. Foxworthy, P. S., Perry, D. N., Hoover, D. M., and Eacho, P. I. (1990). Changes in hepatic lipid metabolism associated with lipid accumulation and its reversal in rats given peroxisome proliferator LY171883. Toxicol. Appl. Pharmacol. 106, 375-383.
11. George, M. E., and Andersen, M. E. (1986). Toxic effects of nonadecafluoro-n-decanoic acid in rats. Toxicol. Appl. Pharmacol. 85, 169-180.
12. Gottlicher, M., Widmark, E., Qiao, L., and Gustafsson, J. (1992). Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 89, 4653-4657.
13. Hawkins, J. M., Jones, W. E., Bonner, F. W., and Gibson, G. G. (1987). The effect of peroxisome proliferators on microsomal, peroxisomal, and mitochondrial enzyme activities in the liver and kidney. Drug. Metab. Dispos. 18, 441-515.
14. Keller, B. J., Marsman, D. S., Popp, J. A., and Thurman, R. G. (1992). Several nongenotoxic carcinogens uncouple mitochondrial oxidative phosphorylation. Biochim. Biophys. Acta 1102, 237-244.
15. Keller, B. J., Bradford, B. U., Marsman, D. S., Cattley, R. C., Popp, J. A., Bojes, H. K., and Thurman, R. G. (1993). The nongenotoxic hepatocarcinogen Wy-14,643 is an uncoupler of oxidative phosphorylation in vivo. Toxicol. Appl. Pharmacol. 119, 52-58.
16. Krisans, S. K., Mortensen, R. M., and Lazarow, P. B. (1980). Acyl-CoA synthetase in rat liver peroxisomes. J. Biol. Chem. 255, 9599-9607.
17. Lowry, O. H., Rosenbrough, N. J., Farr, A. L., and Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
18. Marsman, D. S., Cattley, R. C., Conway, J. G., and Popp, J. A. (1988). Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators Di(2-ethylhexyl)phthalate and [4-Chloro-6-(2,3-xylidino)-2-pyrimidinyl-thio]acetic acid (Wy-14,643) in rats. Cancer Res. 48, 6739-6744.
19. 2+-dependent protein kinase. Science 224, 622-624.
20. Merritt, J. E., Moores, K. E., Evans, A. T., Sharma, P., Evans, F. J., and MacPhee, C. H. (1993). Involvement of calcium in modulation of neutrophil function by phorbol esters that activate protein kinase C isotypes and related enzymes. Biochem. J. 289, 919-926.
21. Mitchell, F. E., Price, S. C., Hinton, R. C., Grasso, P., and Bridges, J. W. (1985). Time and dose-response study of the effects on rats of the plasticizer di(2-ethylhexyl) phthalate. Toxicol. Appl. Pharmacol. 81, 371-392.
22. Moser, G. J., and Smart, R. C. (1989). Hepatic tumor-promoting chlorinated hydrocarbons stimulate protein kinase C activity. Carcinogenesis 10, 851-856.
23. Nishizuka, Y. (1986). Studies and perspectives of protein kinase C. Science 233, 305-312.
24. Olson, C. T., and Andersen, M. E. (1983). The acute toxicity of perfluorooctanoic and perfluorodecanoic acids in male rats and effects on tissue fatty acids. Toxicol. Appl. Pharmacol. 70, 362-372.
25. Olson, M. J., and Thurman, R. G. (1987). Quantitation of ketogenesis in periportal and pericentral regions of the liver louble. Arch. Biochem. Biophys. 253, 26-37.
26. Price, S. C., Hinton, R. H., Mitchell, F. E., Hall, D. E., Grasso, P., Blane, G. F., and Bridges, J. W. (1986). Time and dose study on the response of rats to the hypolipidaemic drug fenofibrate. Toxicology 41, 169-191.
27. Raaka, B. M., and Lowenstein, J. M. (1979a). Inhibition of fatty acid oxidation by 2 bromooctanoate. Evidence for the enzymatic formation of 2-bromo-3-ketooctanoyl coenzyme A and the inhibition of 3-ketothiolase. J. Biol. Chem. 254, 6755-6762.
28. Raaka, B. M., and Lowenstein, J. M. (1979b). Inhibition of fatty acid oxidation by 2-bromooctanoate. Including effects of bromooctanoate on ketogenesis and gluconeogenesis. J. Biol. Chem. 254, 3303-3310.
29. Reddy, J. K., and Lalwani, N. D. (1983). Carcinogenesis by hepatic peroxisome proliferators: Evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. Crit. Rev. Toxicol. 12, 1-58.
30. Remmer, H., Schenkman, J., Estabrook, R. W., et al. (1966). Drug interaction with hepatic microsomal cytochrome. Mol. Pharmacol. 2, 187-190.
31. Renaud, G., Foliot, A., and Infante, R. (1978). Increased uptake of fatty acids by the isolated liver after raising the fatty acid binding protein concentration with clofibrate. Biochem. Biophys. Res. Commun. 161, 448-455.
32. Sirtori, C. R. (1985). Mechanisms of action of absorbable hypolipidemic drugs. Adv. Exp. Med. Biol. 183, 241-252.
33. Thurman, R. G., and Scholz, R. (1973). Interaction of mixed-function oxidation with biosynthetic processes. II. Inhibition of lipogenesis in perfused rat liver by aminopyrine. Eur. J. Biochem. 38, 73-78.
34. Van Rafelghem, M., Vanden Heuvel, J. P., Menahan, L. A., and Peterson, R. E. (1988). Perfluorodecanoic acid and lipid metabolism in the rat. Lipids 23, 671-678.
35. Vanden Heuvel, J. P., Kuslikis, B. I., Shrago, E., and Peterson, R. E. (1991). Inhibition of long-chain acyl-CoA synthetase by the peroxisome proliferator perfluorodecanoic acid in rat hepatocytes. Biochem. Pharmacol. 42, 295-302.
36. Wolf, M., Burgess, S., Misra, U. K., and Sahyoun, N. (1986). Postsynaptic densities contain a subtype of protein kinase C. Biochem. Biophys. Res. Commun. 140, 691-698.