The renin-angiotensin and fibrinolytic systems: Co-conspirators in the pathogenesis of ischemic cardiovascular disease

Trends in Cardiovascular Medicine

Volumn 6, Issue 7, 1996, Pages 239-243

  Brown, Nancy J ^a   Vaughan, Douglas E ^b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; ANGIOTENSIN; ANGIOTENSIN I; ANGIOTENSIN II [3-8]; ANGIOTENSIN III; BRADYKININ; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; METALLOPROTEINASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; QUINAPRIL; RENIN; TISSUE PLASMINOGEN ACTIVATOR;

ATHEROSCLEROSIS; CLINICAL TRIAL; FIBRINOLYSIS; GENETIC POLYMORPHISM; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SHORT SURVEY;

EID: 0030273406     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(96)00091-6     Document Type: Article

References (49)

1. Ahmad S, Ward PE: 1990. Role of aminopeptidase activity in the regulation of the pressor activity of circulating angiotensins. J Pharm Exp Ther 252:643-650.
2. Alderman MH, Madhavan S, Ooi WL, Cohen H, Sealey JE, Laragh JH: 1991. Association of renin-sodium profile with the risk of myocardial infarction in patients with hypertension. N Engl J Med 324:1098-1104.
3. Alexander CM, Werb Z: 1989. Proteinases and extracellular matrix remodeling. Curr Opin Cell Biol 1:974-982.
4. Arbustini E, Grasso M, Fasani R, et al.: 1995. Angiotensin converting enzyme gene deletion allele is independently and strongly associated with coronary atherosclerosis and myocardial infarction. Br Heart J 74:584-591.
5. Brown NJ, Gainer JV, Nadeau JH, Vaughan DE: 1995a. Plasminogen activator inhibitor antigen is increased in hypertensive African Americans with the ACE D allele. Circulation 92:I-552.
6. Brown NJ, Nadeau J, Vaughan DE: 1995b. Bradykinin increases tissue plasminogen activator in humans. Circulation 92:I-36.
7. Brunner HR, Laragh JH, Baer L: 1972. Essential hypertension: renin and aldosterone, heart attack and stroke. N Engl J Med 286: 441-445.
8. Cambien F, Poirier O, Lecerf L, et al.: 1992. Deletion polymorphism in the gene for angiotensin converting enzyme is a potent risk factor for myocardial infarction. Nature 359: 641-644.
9. Chobanian AV, Haudenschild CC, Nickerson C, Drago R: 1990. Anti-atherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit. Hypertension 15:327-331.
10. Davies MJ, Thomas A: 1984. Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death. N Engl J Med 310:1137-1140.
11. Dawson S, Hamsten A, Wiman B, Henney A, Humphries S: 1991. Genetic variation at the plasminogen activator inhibitor-1 locus is associated with altered levels of plasma plasminogen activator-1 activity. Arterioscler Thromb 11:183-190.
12. Emeis JJ, Tranquille N: 1992. On the role of bradykinin in secretion from vascular endothelial cells. Agents Actions 38:285-291.
13. Erdos E, Skidgel RA: 1987. The angiotensin I-converting enzyme. Lab Invest 56:345-348.
14. Eriksson P, Kallin B, van't Hooft FM, Bavenholm P, Hamsten A: 1995. Allele specific increase in basal transcription of the plasminogen activator inhibitor-1 gene is associated with myocardial infarction. Proc Natl Acad Sci USA 92:1851-1855.
15. Grainger DJ, Kirschenlohr HL, Metcalfe JC, Weissberg PL, Wade DP, Lawn RM: 1993. Proliferation of human smooth muscle cells promoted by lipoprotein (a). Science 260:1655-1658.
16. Hamdan AD, Quist WC, Gagne JB, Feener EP: 1996. Angiotensin-converting enzyme inhibition suppresses plasminogen activator inhibitor-1 expression in the neointima of balloon-injured rat aorta. Circulation 93:1073-1078.
17. Hamsten A, Wiman B, deFaire U: 1985. Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction. N Engl J Med 313:1557-1563.
18. Hamsten A, de Faire U, Walldins G, Szamosi A, et al.: 1987. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction. Lancet 2:3-9.
19. Hayek T, Keidar S, Mei-Yi, Oiknine J, Breslow J: 1995. Effect of angiotensin converting enzyme inhibitors on LDL lipid peroxidation and atherosclerosis progression in apo E deficient mice. Circulation 92:1-625.
20. Jansson JH, Boman K, Nilsson TK: 1993. Enalapril related changes in the fibrinolytic system in survivors of myocardial infarction. Eur J Clin Pharmacol 44:485-488.
21. Kerins DM, Hao Q, Vaughan DE: 1995. Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV. J Clin Invest 96:2515-2520.
22. Lachurie M-L, Azizi M, Guyene T-T, Alhenc-Gelas F, Menard J: 1995. Angiotensin-converting enzyme gene polymorphism has no influence on the circulating renin-angiotensin-aldosterone system or blood pressure in normotensive subjects. Circulation 91: 2933-2942.
23. Lindpaintner K, Pfeffer MA, Kreutz R, et al.: 1995. A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med 332:706-711.
24. Ludwig E, Corneli PS, Anderson JL, Marshall HW, Lalouel JM, Ward RH: 1995. Angiotensin-converting enzyme is associated with myocardial infarction but not with development of coronary stenosis. Circulation 91: 2120-2124.
25. Lupu F, Bergonzelli GE, Heim DA, et al.: 1993. Localization and production of plasminogen activator inhibitor 1 in healthy and atherosclerotic arteries. Arterioscler Thromb 13: 1090-1100.
26. Lyons RM, Gentry LE, Purchio AF, Moses HL: 1990. Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin. J Cell Biol 110:1361-1367.
27. Margaglione M, Grandone E, Celenano E, Mancini FP, Panico S, Di Minno G: 1995. Plasma PAI-1 levels in subjects attending a metabolic ward: relation to a common single base pair insertion (5G)/deletion (4G) polymorphism in the promoter of the gene. Circulation 92: I-623.
28. Mattu RK, Needham EWA, Galton DJ, Frangos E, Clark AJL, Caulfield M: 1995. A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study. Circulation 91:270-274.
29. Padro T, Emeis JJ, Steins M, Schmid KW, Kienast J: 1995. Quantification of plasminogen activators and their inhibitors in the aortic vessel wall in relation to the presence and severity of atherosclerotic disease. Arterioscler Thromb Vase Biol 15:893-902.
30. Pederson OD, Gram J, Bagger H, Keller N, Jespersen CT: 1994. Regulation of tissue-type plasminogen activator mediated fibrinolysis by plasminogen activator inhibitor type-1 in patients with ischemic heart disease: possible unfavorable effects of diuretics. Coronary Artery Dis 5:617-623.
31. Pfeffer M, Braunwald LA, Moye L, et al.: 1992. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 327:669-677.
32. Pfeffer MA, Hennekens CH: 1995. When a question has an answer: rationale for our early termination of the HEART trial [editorial]. Am J Cardiol 20:1173-1175.
33. Ridker PM, Gaboury CL, Conlin PR, Seely EW, Williams GH, Vaughan DE: 1993. Stimulation of plasminogen activator inhibitor in vivo by infusion of angiotensin II. Circulation 87:1969-1973.
34. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F: 1990. An insertion/deletion polymorphism in the angiotensin I converting enzyme gene accounting for half the variance of serum enzyme levels, J Clin Invest 86:1343-1346.
35. Ruiz J, Blanche H, Cohen N, et al.: 1994. Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 91:3662-3665.
36. Saksela O, Rifkin DB: 1988. Cell-associated plasminogen activation: regulation and physiologic functions. Am Rev Cell Biol 4:93-126.
37. Schneiderman J, Sawdey MS, Keeton MR: 1992, Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries. Proc Natl Acad Sci USA 89: 6998-7002.
38. Sealey JE, Laragh JH: 1990. The renin-angiotensin-aldosterone system for normal regulation of blood pressure and sodium and potassium homeostasis. In Laragh JH, Brenner BM, eds. Hypertension: Pathophysiology, Diagnosis, and Management. New York: Raven, pp 1287-1317.
39. Smith D, Gilbert M, Owen WG: 1985. Tissue plasminogen activator release in vivo in response to vasoactive agents. Blood 66:835-839.
40. Sprengers ED, Kluft C: 1987. Plasminogen activator inhibitors. Blood 69:381-387.
41. Timmermans PBMWM, Wong PC, Ghiu AT: 1993. Angiotensin II receptors and angiotensin II receptor antagonists. Pharm Rev 45: 205-251.
42. Tiret L, Rigat B, Visvikis S: 1992. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 51:197-205.
43. Ueda S, Elliott HL, Morton JJ, Connell JMC: 1995. Enhanced presser response to angiotensin I in normotensive men with the ACE deletion allele. Hypertension 25:1266-1269.
44. Vaughan DE, Lazos SA, Tong K: 1995a. Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. J Clin Invest 95:995-1001.
45. Vaughan DE, Rouleau J-L, Pfeffer MA: 1995b. Role of the fibrinolytic system in preventing myocardial infarction. Eur Heart J 16:31-36.
46. Walker ID, Davidson JF, Hutton I, Lawrie TDV: 1977. Disordered fibrinolytic potential in coronary artery disease. Thromb Res 10:509-520.
47. Wright RA, Flapan AD, Albert KGMM, Ludlam CA, Fox KAA: 1994. Effects of captopril therapy on endogenous fibrinolysis in men with recent uncomplicated myocardial infarction. J Am Coll Cardiol 24:67-73.
48. Yusef S, Pepine CJ, Garces C, Pouleur H, et al.: 1992. Effect of enalapril on myocardial infarction and unstable angina in patients with low ejection fractions. Lancet 340:1173-1178.
49. Zhao Y, Higashimori K, Higaki J, et al.: 1994. Significance of the deletion polymorphism of the angiotensin converting enzyme gene as a risk factor for myocardial infarction in Japanese. Hypertens Res 17:55-57.