Quinolinic acid neurotoxicity: In vivo increased copper and manganese content in rat corpus striatum after quinolinate intrastriatal injection

Toxicology Letters

Volumn 87, Issue 2-3, 1996, Pages 113-119

  Santamaría, Abel ^a   Ríos, Camilo ^a,b   Pérez, Patricia ^a   Flores, Abigail ^a   Galván Arzate, Sonia ^a   Osorio Rico, Laura ^a   Solís, Fausto ^a  

^a Inst Natl de Neurol y N   (Mexico)

^b Department of Neurosurgery   (Mexico)

Author keywords

Copper; Corpus striatum; Excitotoxicity; Manganese; N methyl D aspartate receptors; Quinolinic acid

Indexed keywords

4 AMINOBUTYRIC ACID; COPPER; DIZOCILPINE; MANGANESE; QUINOLINIC ACID;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CONTROLLED STUDY; CORPUS STRIATUM; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0030273311     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-4274(96)03772-1     Document Type: Article

References (40)

1. [1] Beal, M.F., Kowall, N.W., Ellison, D.W., Mazurek, M.F., Swartz, K.J. and Martin, J.B. (1986) Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid. Nature 321, 168-171.
2. [2] Heyes, M.P., Saito, K., Crowley, J.S., Davis, L.E., Demitrack, M.A., Der, M., Dilling, L.A., Elia, J., Kruesi, M.J.P., Lackner, A., Larsen, S.A., Lee, K., Leonard, H.L., Markey, S.P., Martin, A., Milstein, S., Mouradian, M.M., Pranzatelli, M.R., Quearry, B.J., Salazar, A., Smith, M., Strauss, S.E., Sunderland, T., Swedo, S.W. and Tourtellotte, W.W. (1992) Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological diseases. Brain 115, 1249-1273.
3. [3] Stone, T.W. (1993) Neuropharmacology of quinolinic and kynurenic acids. Pharmacol. Rev. 45, 309-379.
4. [4] Ríos, C. and Santamaría, A. (1991) Quinolinic acid is a potent lipid peroxidant in rat brain homogenates. Neurochem. Res. 16, 1139-1141.
5. [5] Santamaría, A. and Ríos, C. (1993) MK-801, an N-methyl-D-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum. Neurosci. Lett. 159, 51-54.
6. [6] Kägi, J.H.R. and Schäffer, A. (1988) Biochemistry of metallothionein. Biochemistry 27, 8509-8515.
7. [7] Cohen, G. and Heikkila, R.E. (1974) The degeneration of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. J. Biol. Chem. 249, 2447-2452.
8. [8] Halliwell, B. (1984) Manganese ions, oxidation reactions and the superoxide radical. Neurotoxicology 5, 113-118.
9. [9] Halliwell, B. (1987) Oxidants and human disease. Some new concepts. FASEB J. 1, 358-364.
10. [10] Shoham, S., Wertman, E. and Ebstein, P. (1992) Iron accumulation in the rat basal ganglia after excitatory amino acid injections-dissociation from neuronal loss. Exp. Neurol. 118, 227-241.
11. [11] Dexter, D.T., Carayon, A., Javoy-Agid, F., Agid, Y., Wells, F.R., Daniel, S.E., Lees, A.J., Jenner, P. and Marsden, C.D. (1991) Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain 114, 1953-1975.
12. [12] Paxinos, G. and Watson, G. (1984) The rat brain in stereotaxic coordinates. Academic Press, New York. 13 Ríos, C., Alvarez-Vega, R. and Rojas, P. (1995) Depletion of copper and manganese in brain after MPTP treatment of mice. Pharmacol. Toxicol. 76, 348-352.
13. [12] Paxinos, G. and Watson, G. (1984) The rat brain in stereotaxic coordinates. Academic Press, New York. 13 Ríos, C., Alvarez-Vega, R. and Rojas, P. (1995) Depletion of copper and manganese in brain after MPTP treatment of mice. Pharmacol. Toxicol. 76, 348-352.
14. [14] Welz, B. (1976) Atomic absorption spectroscopy. Verlag-Chemie, New York.
15. [15] Van der Heyden, J.A.M. and Korf, J. (1978) Regional levels of GABA in the brain: rapid semiautomated assay and prevention of post mortem increase by 3-mercaptopropionic acid. J. Neurochem. 31, 197-203.
16. [16] Fleury, M.O. and Ashley, D.V. (1983) High-performance liquid chromatography analysis of amino acids in physiological fluids: on line precolumn derivatization with ophthaldialdehyde. Anal. Biochem. 133, 330-335.
17. [17] Smith, R.J. and Panico, K.A. (1985) Automated analysis of o-phthalaldehyde derivatives of amino acids in physiological fluids by reverse phase high performance liquid chromatography. J. Liq. Chromatogr. 8, 1783-1795.
18. [18] Santamaria, A., Ríos, C., Solís-Hernández, F., Ordaz-Moreno, J., González-Reynoso, L., Altagracia, M. and Kravzov, J. (1996) Systemic DL-kynurenine and probenecid pretreatments attenuate quinolinic acid-induced neurotoxicity in rats. Neuropharmacology, In press.
19. [19] Steel, R.G.D. and Torrie, J.H. (1980) Principles and procedures of statistics. McGraw-Hill Inc., U.S.A.
20. [20] Halliwell, B. and Gutteridge, J.M.C. (1985) The importance of free radicals and catalytic metals ions in human diseases. Mol. Aspects Med. 8, 89-193.
21. [21] Walshe, J.M. (1986) Wilson's disease. In: P.J. Vinken, G.W. Bruyn and H.L. Klawans. (Eds.), Handbook of clinical neurology. Elsevier Science Publishers, Amsterdam, pp. 223-238.
22. [22] Horoupian, D.S., Sternlieb, I. and Scheinberg, I.H. (1988) Neuropathological findings in penicillamine-treated patients with Wilson's disease. Clin. Neuropathol. 7, 62-67.
23. [23] Hartard, C., Weisner, B., Dieu, C. and Kunze, K. (1993) Wilson's disease with cerebral manifestation: monitoring therapy by CSF copper concentration. J. Neurol. 241, 101-107.
24. [24] Tanzi, R.E., Petrukhin, K., Chernov., l., Pellequer, J.L., Wasco, W., Ross, B., Romano, D.M., Parano, E., Pavone, L. and Brzustowicz, L.M. (1993) The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene, Nat. Genetics 5, 344-350.
25. [25] Bull, P.C., Thomas, G.R., Rommens, J.M., Forbes, J.R. and Cox, D.W. (1993) The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nat. Genetics 5, 327-337.
26. [26] Florence, T.M. (1991) The role of free radicals in cancer and aging. In: I.E. Dreosti, (Ed.), Trace elements, micronutrients, and free radicals. Humana Press, New Jersey, pp. 171-198.
27. [27] Rowley, D.A. and Halliwell, B. (1983) Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals in the presence of copper salts: a physiologically significant reaction? Arch. Biochem. Biophys. 225, 279-284.
28. [28] Aruoma, O.I., Halliwell, B., Gajewski, E. and Dizdaroglu, M. (1991) Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide. Biochem, J. 273, 601-604.
29. [29] Uchida, K. and Kawakishi, S. (1990) Site-specific oxidation of angiotensin I by copper (II) and L-ascorbate: conversion of histidine residues to 2-imidazolones. Arch. Biochem. Biophys. 283, 20-26.
30. [30] Yoshida, Y., Tsuchiya, J. and Niki, E. (1994) Interaction of alfa-tocopherol with copper and its effect on lipid peroxidation. Biochim. Biophys. Acta 1200, 85-92.
31. [31] Halliwell, B. (1987) Free radicals and metal ions in health and disease. Proc. Nutr. Soc. 46, 13-26.
32. [32] Halliwell, B. and Gutteridge, J.M.C. (1984) Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem. J. 219, 1-14.
33. [33] Donaldson, J. (1982) Manganese neurotoxicity: a model for free radical mediated neurodegeneration? Can. J. Physiol. Pharmacol. 60, 1398-1404.
34. [34] Gavin, C.E., Gunter, K.K. and Gunter, T.E. (1990) Manganese and calcium efflux kinetics in brain mitochondria: relevance to manganese toxicity. Biochem. J. 266, 329-334.
35. [35] Barbeau, A., Inoué, N. and Cloutier, T. (1976) Role of manganese in dystonia. Adv. Neurol. 14, 339-352.
36. [36] Graham, D.G., Tiffany, S.M., Bell, W.R. and Gutknecht, W.F. (1978) Autooxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine and related compounds towards C 1300 neuro-blastoma cells in vitro. Mol. Pharmacol. 14, 644-653.
37. [37] Graham, D.G. (1984) Catecholamine toxicity: a proposal for the molecular pathogenesis of manganese neurotoxicity and Parkinson's disease. Neurotoxicology 5, 83-96.
38. [38] Perry, T.L., Godin, D.V. and Hansen, S. (1982) Parkinson's disease: a disease due to nigral glutathione deficiency? Neurosci. Lett. 33, 305-310.
39. [39] Aschner, M. and Aschner, J.L. (1991) Manganese neurotoxicity: cellular effects and blood-brain barrier transport. Neurosci. Biobehav. Rev. 15, 333-340.
40. [40] Hartmann, H.A. and Evenson M.A. (1992) Deficiency of copper can cause neuronal degeneration. Med. Hyphotheses 38, 75-85.