Pharmacological activity of the new calcium antagonist, lacidipine, on isolated preparations

General Pharmacology

Volumn 27, Issue 7, 1996, Pages 1255-1259

  Raddino, Riccardo ^a   Metra, Marco ^a   Nodari, Savina ^a   Pelá, Giovanna ^a   Fappani, Antonio ^a   Cas, Livio Dei ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

Author keywords

aortic strips; calcium channel blocking; lacidipine

Indexed keywords

ANGIOTENSIN; CALCIUM; CALCIUM ANTAGONIST; CALCIUM CHANNEL; LACIDIPINE; METHOXAMINE; NEW DRUG; NIFEDIPINE; NORADRENALIN; POTASSIUM CHLORIDE; VASOPRESSIN; VERAPAMIL;

ANIMAL TISSUE; AORTA; ARTICLE; CHRONOTROPISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY PRESSURE; CORONARY ARTERY SPASM; DRUG ANTAGONISM; FEMALE; INOTROPISM; ISOLATED ARTERY; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE CONTRACTION;

EID: 0030273266     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(95)02145-0     Document Type: Article

References (23)

1. Bayer R., Kalusche D., Kaufmann R. and Mannold R. (1975) Inotropic and electrophysiological actions of verapamil and D-600 in mammalian myocardium. III. Effects of optical isomers on transmembrane action potentials. Naunyn-Schmiedeberg Arch. Pharmac. 290, 81-97.
2. Bolton T. B. (1979) Mechanism of action of transmitter and other substances on smooth muscle. Physiol. Rev. 59, 606-718.
3. Bristow M. R. and Green R. D. (1977) Effect of diazoxide, verapamil and compound D-600 on isoproterenol and calcium-mediated dose-response relationships. Eur. J. Pharmac. 45, 267-279.
4. Broadley K. J. (1979) The Langendorff heart preparation: reappraisal of its role as a research and teaching model for coronary vasoactive drugs. J. Pharmac. Methods 2, 143-152.
5. Elliott H. L. (1993) Calcium antagonism: aldosterone and vascular responses to catecholamines and angiotensin II in man. J. Hypertens. 11 (Suppl 6P), S13-16.
6. Fleckenstein-Grun G., Frey M. and Fleckenstein A. (1984) Calcium antagonists: mechanism and therapeutic uses. TIPS 5, 283-286.
7. Furchgott R. F. and Bhadrakom S. (1953) Reaction of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs. J. Pharmac. Exp. Ther. 108, 129-143.
8. Glossman H., Ferry D. R., Lubbecke F., Mewes R. and Hofmann F. (1982) Calcium channels direct identification with radioligand binding studies. TIPS 3, 431-437.
9. Herbette L. G., Gaviraghi G., Tulenko T. and Mason R. P. (1993) Molecular interaction between lacidipine and biological membranes. J. Hypertens. 11 (Suppl.), S13-19.
10. Lee C. R. and Bryson H. M. (1994) Lacidipine: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of hypertension. Drugs 48, 274-276.
11. Mancia G., Ferrari A. U., Giannattasio C. and Trazzi S. (1993) Vascular effects of lacidipine: a review of animal and human data. J. Hypertens. 11 (Suppl.), S39-43.
12. Mattiazzi A. R. and Garay A. (1983) Negative inotropic effect of verapamil and phenylamine and its reserval by calcium or isoproterenol. Arch. Int. Physiol. Biochim. 91, 133-144.
13. Meredith P. A. and Reid J. L. (1993) Differences between calcium antagonists: duration of action and trough to peak ratio. J. Hypertens. 11 (Suppl.), S21-26.
14. Motomura S., Wu Z. J. and Hashimoto K. (1994) Lacidipine, a new long-acting dihydropyridine calcium antagonist, has high vascular selectivity against all intracardiac variables. Heart Vessels 8, 16-22.
15. Pfaffendorf M., Mathy M. J. and Van Zwieten P. A. (1993) In vitro effects of nifedipine, nisoldipine, and lacidipine on rat isolated coronary small arteries. J. Cardiovasc. Pharmac. 21, 496-502.
16. Pijl A. J., Pfaffendorf M. and Van Zwieten P. A. (1993) Hemodynamic and antiischemic effects of nifedipine, lacidipine, and nisoldipine in rat isolated working heart. J. Cardiovasc. Pharmac. 22, 381-387.
17. Raddino R., Manca E., Poli E., Bolognesi R. and Visioli O. (1986) Effects of 17 beta estradiol in the isolated rabbit heart. Arch. Int. Pharmacodyn. Ther. 281, 57-65.
18. Raddino R., Poli E., Ferrari R. and Visioli O. (1987) Effects of calcium entry blockers not connected with calcium channels inhibition. Gen. Pharmac. 18, 431-436.
19. Raddino R., Poli E., Pasini E. and Ferrari R. (1992) Effects of the novel calcium channel blocker anipamil, on the isolated rabbit heart. Naunyn-Schmiedeberg's Arch. Pharmac. 346, 339-344.
20. Spampinato S., Bachetti T., Carboni L., Ratti E., Van Amsterdam F. T. and Ferri S. (1993) Ca2+ channel blocking activity of lacidipine and amlodipine in A7r5 vascular smooth muscle cells. Eur. J. Pharmac. 244, 139-144.
21. Van Rossum J. M. (1963) Cumulative dose-response curves. Techniques for making the dose-response curves in isolated organs and the evaluation of drug parameters. Arch. Int. Pharmacodyn. Ther. 143, 299-330.
22. Van Zwieten P. A. and Pfaffendorf M. (1993a) Pharmacology of the dihydropyridine calcium antagonists: relationship between lipophilicity and pharmacodynamic responses. J. Hypertens. 11 (Suppl 6P), S3-8.
23. Van Zwieten P. A. and Pfaffendorf M. (1993b) Similarities and differences between calcium antagonists: pharmacological aspects. J. Hypertens. 11 (Suppl.) S3-11.