Could schizophrenia be reasonably explained by Dohan's hypothesis on genetic interaction with a dietary peptide overload?

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 20, Issue 7, 1996, Pages 1083-1114

  Reichelt, Karl L ^a   Seim, Anders R ^a   Reichelt, Wenche H ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

aetiology; Dohan; exorphins; peptides; schizophrenia

Indexed keywords

PROTEIN;

DIET; DISEASE PREDISPOSITION; GENETICS; HUMAN; OVERNUTRITION; REVIEW; SCHIZOPHRENIA;

DIETARY PROTEINS; HUMANS; PEPTIDES; SCHIZOPHRENIA;

EID: 0030273233     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(96)00099-1     Document Type: Review

References (208)

1. ABASSI, Z.; GOLOMB, E.; and KEISER, H.R.(1992) Neutral endopeptidase inhibition increases the urinary excretion and plasma level of Endothelin. Metabolism 41:683-685.
2. ALPERS, D.H.(1986). Uptake and fate of absorbed amino acids and peptides in the mammalian intestine. Feder. Proceed. 452: 261-267.
3. ARREGUI, A., MACKAY, A.V.P., IVERSEN, L.L., and SYCHES, E.G.(1979). Reduction in angiotensin converting enzyme in substantia nigra in early onset schizophrenia. New Eng Jour Med. 300: 502-503.
4. ASANO, M., NIO, N. and ARAYOSHI, Y. (1991). Inhibition of prolyl-endopeptidase by synthetic peptide fragments of beta-casein. Agric Biol Chem. 55: 825-828.
5. ASHKENAZI, A., KRASILOWSKY, D., LEVIN, S., IDAR, D., KALIAN, M., HYALA, O., GINAT. Y. and HALPERIN, B.(1979). Immunological reaction of psychotic patients to fractions of gluten. Amer Journ Psychiat. 136:1306-1309.
6. ASPERGER, H.(1961). Der Psychopatholgie des Coeliaki Kranken Kindes. Annal der Paediat. 187:346-351.
7. ATCHINSON, J.A., GRIZZLE, W.E. and PILLON, D.S. (1989). Colonic absorption of insulin: An in vitro and in vivo evaluation. J of Pharmacol Exper Therap. 248: 567-572.
8. AXELSSON, I., JACOBSSON, I., LINDBERG, T. and BENEDIKTSSON, B. (1986) Bovine beta-lactoglobulin in human milk. Acta Paediat Scand. 75: 702-707.
9. BANKS, W.A. and KASTIN, A.J.(1989). Effects of neurotransmitters on the system that transports Tyr-Mif -1 and the enkephalins across the blood-brain barrier : A dominant role for serotonin. Psychopharmacol 98:380-385.
10. BANKS, W.A. and KASTIN, A.J. (1990). Peptide transport systems for opiates across the blood-brain barrier. Amer J Physiol. 259:E1-E10.
11. BARRERA, C., KASTIN, A.J. and BANKS, W.A.(1987). D-(Ala)-peptide T-amide is transported from blood to brain by a saturable system . Brain Res Bull. 19:629-633.
12. BECKMANN, H., SAAVEDRA, J.M. and GATTAZ, W.F.(1984). Low angiotensin-converting enzyme activity (kininase II) in cerebrospinal fluid of schizophrenics. Biol Psychiat. 19:679-684.
13. BENES, E., DAVIDSON, J., and BIRD, E.D.(1986). Quantitative cyto-architectural studies of the cerebral cortex of schizophrenics. Arch Gen Psychiat. 43:31-35.
14. BENES, E. and BIRD, E.D. (1987). An analysis of the arrangement of neurones in the singulatecortex of schizophrenics. Arch Gen Psychiat. 44: 608-616.
15. BERGEN, J.R., GRAY, F.W. and PUNNELL, R.B. (1965). Tarexein -like extracts: Effects on rat behavior. Arch Gen Psychiat. 22:80-82.
16. BERGER, D.A., WATSON, S.J., AKIL, H. and BARCHAS, J.D. (1981). The effects of naloxone on chronic schizophrenia. Amer J Psychiat. 138: 913-918.
17. BLASS, E.M. and FITZGERALD, E.(1988). Milk-induced analgesia and comforting in10-day-old rats: Opioid mediation. Pharmacol Biochem Behav. 29: 9-13.
18. BLAU, N., NIEDERWIESER, A. and SHMERLING, D.H. (1980). Peptiduria: presumably caused by aminopeptidase deficiency. A new inborn errror of metabolism. J Inherit Metab Dis.11(Suppl 2) :240-242.
19. BØHLEN, P. CASTILLO, F. LING, R. and GUILLEMIN, R. (1980). Purification of peptides: An efficient procedure for the separation of peptides from amino acids and salts. Int J Pept Prot Res.16: 306-310.
20. BOUCHARD, T.J., LYKKEN, D.T., MCGUE, M., SEGAL, N.L. and TELLEGEN, A. (1990). Sources of human physiological differences: The Minnesota study of Twins reared apart. Science. 250: 223-238.
21. BRANTL, V., TESCHEMACHER, H. BLÆSIG, J., HENSCHEN, A. and LOTTSPEICH, F. (1981) Opioid activities of beta-casomorphins. Life Sciences 28:1903-1909.
22. BROWN, R., COLTER, N., CORSELIS, J.A.N., CROW, T.J., FRITH, C.D., JAGOC, R. JOHNSTONE, W.C. and MARSH, L. ( 1986). Postmortem evidence of structural brain changes in schizophrenia: Difference in brain weight, temporal horn area and hippocampal gyrus compared with affective disorder. Arch. Gen. Psychiat. 43: 36-42.
23. BURHOL, K., JENSEN, T.G., FLORHOLEMN, T.G., JORDE, R., VONEN, B. and OLSEN, R.L.(1986). Protein-binding and aggregation of somatostatin in human plasma. Ital J Gastroent.18:1-6.
24. BURTON, P.B.J. and KNIGHT, D.E. (1992). Parathyroid hormone-related peptide can regulate the growth of human lung cancer cells, and may form part of an autocrine TGF-alpha loop. FEBS LETT. 305: 228-232.
25. CADE, R., WAGEMAKER, H., PRIVETTE, R.M., FREGLY, M.S., ROGERS, J. and ORLANDO, J. (1990). The effects of dialysis and diet in schizophrenia. Psychiatry :A world perspect. 3: 494-500.
26. CARLSSON, A. (1978). Does dopamine have a role in schizophrenia? Biol Psychiat.13: 3-21.
27. COLEMAN, M. (1976). Calcium studies and their relationship to coeliac disease in autistic patients. In: The Autistic Syndromes . M Coleman (Ed). pp 197-205. North Holland Publ Comp. Amsterdam.The Netherlands.
28. CORNELL, H.J. (1988). Amino acid composition of peptides remaining after in vitro digestion of a gliadin subfraction with duodenal mucosa for patients with coeliac disease. Clin Chim Acta. 176: 279-289.
29. CROW, T.J., COLTER, H. BROWN, R., BRUTON, C.J. and JOHNSTONE, E.C. (1983). Lateralized assymetry and temporal horn enlargement in schizophrenia. Schizo Res. 1: 155-156.
30. CROW, T.J. and JOHNSTONE, E.C. (1987). Schizophrenia: Nature of the disease process and its biological correlations. In Handbook of Physiology -The nervous system. F. Plum (Ed). pp. 843-869. American Physiol Soc. Baltimore.
31. CROW, T.J. (1994). Aetiology of schizophrenia. Curr Opin Psychiat. 7: 39-42.
32. DAHL-JØRGENSEN, K., JONER, G. and HANSSEN, K.F. (1991). Relationship between cow's milk consumption and incidence of IDDM in childhood. Diab Care. 14: 1081-1083.
33. DALGARD, O.S. (1967) Migrasjon og funksjonelle psykoser i Oslo. Thesis, pp.1-197, Univ of Oslo Press, Oslo, Norway.
34. DAVIS, T.P. SCHOEMAKER, H. COLLING, A. and YAMAMURA, H. (1983). Isolation and characterization in vitro central beta-endorphin metabolism in schizophrenia. Proceed West Pharmacol Soc. 26: 89-94.
35. DAVIS, P.D. and COLLING-BERGLUND, A. (1987). Neuroleptic drug treatment alters in vitro central neurotensin metabolism. Psychoneuroendocrinol. 12: 253-260.
36. DAVIS, M.H. and PIERRINGER, J. (1987). Regulation of dipeptidyl aminopeptidase 1 and angiotensin-converting enzyme activities in cultured murine brain cells by cortisol and thyroid hormone. J Neurochem. 48: 447-454.
37. DE GANDARIAS, J.M., IRAZUSTA, J., GIL, J., FERNANDEZ, D. and CASIS, L. (1994). Effect of Acute Lithium admininstration on pyroglutamyl-aminopeptidase-1 activity in several brain areas of the rat Arzneimittel-Forsch. 44: 119-121.
38. DEQUARDO, J.R., TANDON, R., GOLDMAN, R., MEADOR-WOODRUFF, J.H., MCGRATH-GIROUX, M. BRUNBERGr, J.A. and KIM, L. (1994). Ventricular enlargement, Neuropsychological status, and premorbid funtion in schizophrenia. Biol Psychiat. 35: 517-524.
39. DOHAN, F.C. (1966). Cereals and Schizophrenia. Data and hypothesis. Acta Psychiat Scand. 42: 125-152.
40. DOHAN, F.C., MARTIN, L., GRASBERGER, J.C., BOEHME, D., and COTRELL, J.C. (1972). Antibodies to wheat gliadin in blood of psychiatric patients: Possible role of emotional factors .Biol Psychiat. 5: 127-131.
41. DOHAN, F.C. and GRABERGER, J.C. (1973). Relapsed schizophrenics: Earlier discharge from the hospital after cereal-free, milk-free diet. Amer J Psychiat. 130: 685-686.
42. DOHAN, F.C. (1980). Hypothesis: Genes and neuroactive peptides from food as a cause of schizophrenia. In: Neural Peptides and Neuronal Communication. E. Costa and M. Trabucci (Eds). pp. 535-548, Raven press, New York. NY.
43. DOHAN, F.C. (1983). More on coeliac disease as a model for schizophrenia. Biol Psychiat. 18: 561-564.
44. DOHAN, F.C. HARPER, E.H. CLARK, M.H., RORDRIGUE, R.B. and ZIGAS, V. (1984). Is schizophrenia rare if grain is rare? Biol Psychiat. 19: 385-399.
45. DRYSDALE, A., DEACON, R., LEWIS, P., OLLY, S., ELECTRICWALA, A. and SHERWOOD, R. (1982). A peptide containing fraction of plasma of schizophrenic patients which binds to opiate receptors and induces hyperactivity in rats. Neurosci. 7: 1567-1574.
46. 3H)beta-casomorphin -5 uptake by eighteen brain regions in vivo J Neurochem. 41: 1229-1233.
47. ERMISCH, A., BRUST, P., KRETZSCHMAR, R. and BUHLE, H-J. (1993). Peptides and blood-brain barrier transport. Physiol Rev. 73: 489-527.
48. ERNST, M., DEVI, L., SILVA, R.R., GONZALES, N.M., SMALL, A.M., MAOLE, R.P. and CAMPBELL, M. (1993). Plasma beta-endorphin levels, naltrexone, and haloperidol in autistic children. Psychopharmacol Bull. 29: 221-227.
49. ESCOBAR, J.I. (1980). Hemodialysis as a treatment for schizophrenia. Psychosom. 21: 57-63.
50. FALKAI, P., BOGERTS, B., and ROZUMEK, M. (1988). Measurement of the alpha-cell migration in the entorhinal region: a marker for the developmental disturbance in schizophrenia? Schizo Res. 1: 157-158.
51. FINELLI, P.F., MCENTEES, W.J., AMBLER, M. and KESTENBAUM, D. (1980) Adult coeliac disease presenting as cerebellar syndrome. Neurol(NY) 30: 245-249.
52. FISH, N. (1986). Antecedents of an acute schizophrenic break. J Amer Acad Child Psychiat. 25: 595-600.
53. FLAUM, M., ARNDT, S. and ANDREASEN, N.C. (1990). The role of gender in studies of ventricular enlargement in schizophrenia: a predominantly male effect. Amer J Psychiat. 147: 1327-1332.
54. FOGELSON, D.L., MARDER SR. and VAN PUTTEN, T. (1980) Dialysis of schizophrenia: Revies of clinical trials and implications for further research. Amer J Psychiat. 137: 605-609.
55. FRENYO, V.L. (1987). Studies on the absorption of homologous and hetrologous IgG in artificially reared newborn pigs. Veter Res Comm. 11: 23-30.
56. FROHMAN, C.E., CZAJKOWSKI, N., LUBY, E.D., GOTTLIEB, J.S. and SENF, R. (1960). Further evidence of a plasma factor in schizophrenia. Arch Gen Psychiat. 2: 263-267.
57. FUKUDOME, S-I. and YOSHIKAWA, M. (1992). Opioid peptides derived from wheat gluten: their isolation and characterization. FEBS Lett. 296: 107-111.
58. GARDNER, M.L.G. (1994). Absorption of intact proteins and peptides.In: Physiology of the gastrointestinal tract.3rd ed. L.R. Johnson(Ed) pp.1795-1820. Raven Press, New York, N.Y.
59. GEDDES, J.R., BLACK, R.J., WHELLEY, L.J. and EAGLES, J.M. (1993). Persistance of the Decline in the Diagnosis of schizophrenia among first admissions to Scottish hospitals from 1969 to 1988. Brit J Psychiat. 163: 620-626.
60. GJESSING, R. (1976) .Contribution to the somatology of periodic catatonia. L. Gjessing and F.A. Jenner(Eds) Oxford, Pergamon press. New York.
61. GOBBI, G., BOUQUET, F., GICCO, L., LAMBERTINI, A., TASSINARI, C.A., VENTURA, L. and ZANIBONI, M.G. (1992). Coeliac disease, epilepsy and cerebral calcifications. The Lancet 340: 439-443.
62. GOODWIN, M.S., COWEN, M.A. and GOODWIN, T.C. (1971). Malabsorption and cerebral dysfunction: A multivariate and comparative study og autistic children. J Aut Childhood Schizo. 1: 48-62.
63. GOTTESEMAN, I.I. and BETELSEN, A. (1989). Confirming unexpressed genotypes for schizophrenia: Risks in the offspring of Fischer's Danish identical and fraternal discordant twins. Arch Gen Psychiat. 46: 867-872.
64. GRAFF, H. and HAMDFORD, A. (1961). Coeliac syndrome in the case histories of five schizophrenics. Psychiat Quat. 35: 306-313.
65. GRIFFITHS, E.C. (1975). Peptidase inactivation of hypothalamic releasing hormones. Horm Res. 7: 179-191.
66. GRIFFITHS, O.W. and MEISTER, A. (1979). Translocation of intracellular glutathione to membrane-bound -gamma glutamyl transpeptidase as a discrete step in the gamma-glutamyl cycle. Glutathionuria after inhibition of transpeptidase. Proc Nat Acad Sci. (USA) 76: 268-272.
67. GU, N-F., YAN, H-A., CAI, G-J., ZHANG, M.Y. XIA, Z-Y., WANG, W-L. ZHANG, Q-S. and WANG, Z-S. (1986). Hypothalamic dysfuntion related to third ventricular size. J Oslo City Hosp. 36: 117-121.
68. HADJIVASSILIOU, M., GIBSON, A., DAVIES-JONES, G.A.B., LOBO, A.J., STEPHENSON, T.J.and MILFORD-WARD, A.(1996) Does cryptic gluten sensitivity play a part in neurological illness? The Lancet. 347: 369-371.
69. HALLERT, C., ÅSTRØM, J. and SEDVALL, G.(1982). Psychic disturbances in adult coeliac disease III. Reduced central monoamine metabolism and signs of depression. Scand J Gastroenterol. 17:25-28.
70. HASLEWELL, J., LYNCH, S., WILLIAMSON, I., FOX, H. and MACKAY, M. (1992). Absorption of human calcitonin across the rat colon in vivo. Clin Sci. 82: 589-591.
71. HAUG, J.O. (1962). Pneumo-encephalographic studies in mental disease. Acta Psychiat Scand. Suppl 38:1-114.
72. HAUG, J.O. (1982). Pneumoencephalographic evidence of brain atrophy in acute and chronic schizophrenic patients. Acta Psychiat Scand. 46 :374-383.
73. HARRISON, G. and MASON, P. (1993). Schizophrenia. Falling incidence and better outcome. Brit J Psychiat.163: 535-541.
74. HEATH, R. and KRUPP, I. (1968). Schizophrenia as a specific biological disease. Amer J Psychiat. 124: 1019-1024.
75. HEKKENS, W. Th. J.M. (1991). The evolution in research in prolamin toxicity: From bread to peptide. In: Food Allergy and Food Intolerance , Nutritional Aspects and Developments. J.C Somoygi, H.R. Muller and Th. Ochthuizen (Eds). pp 90-104. Bibloteka Nutritional and Dietetica . No 48, Karger, Basel.
76. HILTON, C.W. PRASAD, C. VO. P. and MOUTON, C. (1992). Food contains the bioactive peptide cyclo (His-Pro) Clinic Endocrinol Metab. 75: 375-378.
77. HOLE, K. BERGSLIEN, H.A., JØRGHENSEN, H., BERGE, O-G., REICHELT, K.L. and TRYGSTAD, O.E. (1979). A peptide containing fraction in the urine of schizophrenic patients which stimulates opiate receptors and inhibits dopamine uptake. Neurosci. 4: 1883-1893.
78. HORI, R., SUITO, Y.S., YASUHARA, M. and OKUMURA, K. (1984). In vivo conversion of peptide drug into high molecular weight forms. J Pharmacol Dyn. 7: 910-916.
79. HUEBNER, K.F.R., LIBERMAN, R.P. RUBINO, R.P. and WALL, J.S. (1984). Demonstration of high opioid -like activity in isolated peptides from wheat gluten hydrolysates. Peptides 5: 1139-1147.
80. HUSBY, S. JENSENIUS, J.C. and SVEHAG, S.E. (1985). Passage of undegraded dietary antigen into the blood of healthy adults. Scand J Immunol. 22: 83-92.
81. IDET, M., GROF, J., MENYHART, J. and PAJOR, A. (1982). Elevated opioid activity in sera of chronic schizophrenics. Acta Physiol Hung. 60: 121-127.
82. JANSSON, B., KRISTJANSSON, E. and NILSSON, L. (1984). Schizofren psykosbild avklingade nær pasienten gavs glutenfri kost. Lækartidn. 81:148-149.
83. JOHNSTON, E.C. and LANG, F.H. (1994). Onset,course and outcome of schizophrenia . Curr Opin Psychiat. 7: 56-60.
84. JØRGENSEN, H.A. and CAPPELEN, C. ( 1982). Naloxone-induced reduction of schizophrenic symptoms: a case report. Acta Psychiat Scand. 65: 370-374.
85. KALLMAN, H. (1946). The genetic theory of schizophrenia-an analysis of 691 schizophrenic index families. Amer J Psychiat.103: 390-422.
86. KAHN, A., REBUFFAT, E., BLUM, D., CASIMIR, G. DUCHATEAU, J. MOZIN, M.J. and JOST, R. (1987). Difficulty of initiating sleep associated with cow's milk allergy in infants. Sleep. 10: 116-121.
87. KARJALAINEN, J. MARTIN, J.M. KNIP, M. ILONENI, J. ROBINSON, B.H., SAVILATHI, E. AKERBLOM, H.K. and DOSCH, H.M. (1992). Bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. New Eng J Med. 327: 302-307.
88. KASTIN, A.J. CASILLANOS, P.F. FISCHMAN, P.J. PROFITT, J.K. and GRAF, M.V. (1984). Evidence for peptide aggregates. Pharmacol Biochem Behav. 21: 969-974.
89. KENDLER, K.S. and DIEHL, S.R. (1993). The genetics of schizophrenia: A current, genetic-epidemiologic perspective. Schizo Bull. 19: 261-285.
90. KENDLER, K.S., MCGUIRE, M., GRUENBERG and WALSH, D. (1994). Clinical hetrogeneity in schizophrenia and the pattern of psychopathology in relatives: Results from an epidemiologically based family study. Acta Psychiat Scand. 89: 294-300.
91. KETY, S.S., ROSENTHAL, D., WENDER, P.H., SCHULSINGER, F. and JACOBSEN B. (1975). Mental illness in the biological and adoptive relatives of adopted individuals who became schizophrenic. In: Genetic Research in Psychiatry. R.P Fieve, D. Rosenthal and H. Boill (Eds). pp 199-220. Johns Hopkins University Press., Baltimore,Md.
92. KILSHAW, P.J. and CANT, A.J. (1984). The passage of maternal dietary protein into human breast milk. Internat Arch Allerg Appl Immunol. 75: 8-15.
93. KING, D.S. (1985). Statistical power and the controlled research on wheat gluten and schizophrenia .Biol Psychiat. 20: 785-787.
94. KINNEY, H.C. BURGER, P.C., HURWITZ, B.J., HUMANS, J.C. and GRANT, J.P.(1982). Degeneration of the central nervous system associated with celiac disease. J Neurol Sci. 53: 9-22.
95. KLOSSE, J.A, HUISTRA, D.Y., DEBREE, P.K. WADMAN ,S.K. and VLIEGENHART, J.F.G. (1972). An automated Chromatographic system for the combined analysis of urinary peptides and amino acids. Clin Chim Acta. 42: 409-422.
96. KOENIG, K. GOLDYSTONE, A.D.and LU, C.Y. (1989). Polyamines mediate the reversible opening of the blood-brain barrier by the intracarotid infusion of hyperosmolal mannitol. Brain Res. 483: 110-116.
97. KOHIMURA, M., NIO, N. and ARIYOSHI, Y. (1990). Inhibition of angiotensin-converting enzyme by synthetic peptide fragments of human K-casein. J Agric Biol Chem. 54: 835-836.
98. KOHIMURA, M., NIO, N. and ARIYOSHI, Y. (1990b). Inhibition of angiotensin -converting enzyme by synthetic peptide fragments of various Beta-caseins. J Agric Biol Chem. 54: 1101-1102.
99. KONING, P.A.L., COLLING-BERGLUND, A. and DAVIS, T.P. (1990). Chronic haloperidol and chloropromazine treatment alters in vitro beta-endorphin metabolism in rat brain. Eur J Pharmacol. 97: 15-28.
100. KONKOY, S.K., OAKES, M.G. and DAVIS, T.P. (1993). Chronic treatment with neuroleptics alters neutral endopeptidase 24.11 activity in rat brain regions. Peptides 14: 1017-1020.
101. KORANYI, L., WALENTIN, S., HEPP, J. and ENDROCZI, E. (1989). Changes in dipeptidyl peptidase (DPIV) activity in the T Lymphcytes of rats following administration of ACTH, dexamethasone and opiates. Exper Clin Endocrinol. 93: 61-68.
102. KRINGLEN, E. (1964). Schizophrenia in male monozygotic twins. Acta Psychiat Scand.178: 1-76.
103. KRINGLEN, E and CRAMER, G. (1989). Offspring of monozygotic twins discordant for schizophrenia . Arch Gen Psychiat. 46: 873-877.
104. KROLL, P., POTT, F.K. and SILK, K.R. (1978). Hemodialysis and schizophrenia: A negative report. J Nerv Ment Dis. 166: 291-293.
105. KUMAR, P.J., O'DONOGHUE, P.P., STENSON, K. and DAWSON, A.M. (1979). Reintroduction of gluten in adults and children with treated coeliac disease. Gut. 20: 743-749.
106. LABELLA, F.L., GEIGER, J.D. and GLAVIN, G.B. (1985). Administration of peptides inhibit the degradation of endogenous peptides .The dilemma of distinguishing direct from indirect effects. Peptides 6: 645-660.
107. LAERUM, O.D. and PAUKOVITS, W.P. (1989). Biological and chemical properties of the hemoregulatory peptide and possibilities for clinical applications. Pharmacol Therap. 44: 335-349.
108. LECRON, J-C., MINEAULT, M., ALLARD, M., DELAFOREST P.G., GOMBERT, J. and SIMONNET, G. (1992). Modulation of human lymphocyte proliferation by FLFQPQRFamide , a FMRF amide -like peptide with anti-opiate properties. J Neuroimmun 38: 1-8.
109. LEHTINEN, V. (1987). Schizophrenins epidemiologi. Nord Med. 19: 112-126.
110. LIFSHITZ, A., KUGELMASS, S. and KAROW, M. (1985). Perception-motor and memory performance of high-risk children. Schizo Bull. 11: 74-84.
111. LINDSTRØM, L.H., NYBERG, F., TERENIUS, L., BAUER, K., BESEV, G. GUNNE, L.M., LYRENÅS, S., WILLDECK-LUND, G. and LUNDBERG, B. (1984). CSF and Plasma beta-casomorphin like opioid peptides in postpartum psychosis. Amer J Psychiat. 141: 1059-1066.
112. LINDSTRØM, L.H., BESEV, G., GUNNE, L-M. and TERENIUS, L. (1986). CSF levels of receptor-active endorphins in schizophrenic patients :corrrelation with symptomatology and monoamine metabolites. Psychiat Res. 19: 93-100.
113. LORENZ, K. and LEE, V.A.(1977). The nutritional and psychological impact of cereal products in human nutrition. CRC Crit Rev Food Sci Nutr. 9: 383-457.
114. LORENZ, K. (1990). Cereals and schizophrenia. Adv Cereal Sci Technol. X: 435-469.
115. LOSONCZY, M.L., SONG, I.S., MOHS, R.C., MATHE, A.A., DAVIDSON, B.A., DAVIS, B.M. and DAVIS, K.L. (1986). Correlates of ventricular size in chronic schizophrenics .II. Biological Measures. Amer J Psychiat. 143: 1113-1118.
116. LOTHE, L., LINDBERG, T. and JAKOBSSON, I. (1982). Cow's milk formula as a cause of infantile colic :A double blind study. Pediatrics. 70: 7-10.
117. LOUKAS, S., VAROCUNA, D., ZIOUDROU, C., STREETY, R.A. and KLEE, W.A. (1983). Opioid activities and structure of alpha casein derived exorphins. Biochem. 22: 238-246.
118. LUNDE, H., SJAASTAD, Ø. and GJESSING ,L.R. (1982). Homocarnosinosis : Homocarnorsinuria. J Neurochem. 38: 238-246.
119. LYNCH, D.R. and SNYDER, S.H. (1986). Neuropeptides :Multiple molecular forms ,metabolic pathways and receptors. .Annual Rev Biochem. 55: 1081-1089.
120. MAES, M., SCHARPE, S., MELTZER, H.Y., SUY, E., COSYNS P. AND CALABRESE, J.(1992). Lower angiotensin 1 converting enzyme activity in melancholic subjects: A pilot study. Biol psychrat. 32: 621-624.
121. MAES, M., DEMEESTER, I., VANHOOF, G., SCHARPE, S. BOSMANS, E., VANDERVORST, C., VERKERK, R., MINNER, B. SUY, E. and RAUS, J. (1991). Decreased serum dipeptidyl peptidase IV activity in major Depression. Biol Psychrat. 30: 577-586.
122. MAES, M., GOOSSENS, F., SCHARPE, S., MELTZER, H.Y., D'HONDT, P. and COSYNS, P. (1994). Lower serum prolyl Endopeptidase enzyme activity in major depression :Further evidence that peptidases play a role in the pathophysiology of Depression. Biol Psychiat. 35: 545-552.
123. MAHE, S., TOME, D., DUMONTIER, A.M. and DESEUX, J.F.(1989). Absorption of intact morphiceptin by diisopropyl-flurorphosphate -treated rabbit ileum. Peptides. 10: 45-52.
124. MARCUS, J., HANS, S.L., AUERBACH, J.G. and AUERBACH, A.G. (1993). Children at risk for schizophrenia :The Jerusalem Infant development study. Arch Gen Psychiat 50: 797-809.
125. MAYERHOFF, D.I., LIEBERMAN, J.A., LEMUS, C.Z., POLLACK, S. and SCHNEIDER, B.S. (1990). Growth hormone response to growth hormone -releasing hormone in schizophrenic patients .Amer J Psychiat. 147: 1072-1077.
126. MENEZO, N.Y. and KHATCHATURIAN, C. 81986). Peptides bound to albumin .Life Sci. 39: 1751-1753.
127. MEDNICK, S.A., SCHULSINGER, F., HIGGINGS, J. and BELL, B. (1974). Genetics, Environment and psychopathology. pp 987-996. Elsevier North Holland press.
128. MIGLIORE-SAMOUR, D. and JOLLET, P. (1988). Casein ,a prohormone with immunostimulating role in the newborns? Experientia 44: 88-93.
129. MILLER, R. (1989). Schizophrenia as a progressive disorder: relations to EEG, CT, neuropathological and other evidence. Progr Neurobiol. 33: 17-44.
130. MURAHASHI, N., KATO, A., KOYAMA, N., WATANABE, S. YOZURIHA, T. and MAYAKE, Y. (1989). Rectal absorption of E-2078 (Dynorphin analogue peptide) in rats. J Pharmac. Pharmacol. 41: 770-774.
131. MURCH, S.H., MACDONALD, T.T., WALKER-SMITH, J.A., LEVIN, M., LIONETTI, P. and KLEIN, N.J. (1993). Disruption of sulphated glycosaminoglycans in intestinal inflammation. The Lancet. 341: 711-714.
132. MURUYAMA, S. and SUZUKI, H. (1982). A peptide inhibitor of angiotensin-1-converting enzyme in the tryptic hydrolysate of casein. J Agricul Biol. Chem. 46:1393-1394.
133. MYARA, I., CHARPENTIER, C. and LEMONNIER, A. (1984). Prolidase and prolidase deficiency. Life Sci. 34: 1985-1988.
134. NABER, D., RICKARD, D., POST, R.M., VANKAMMEN, D.P. WATERS, R.N. BALLINGER, J.O., GOODWIN, F.K. and BUNNEY, N.E. (1981). Endogenous opioid activity and beta-endorphin -immunoreactivity in CSF of psychiatric patients and normal volunteers. Amer J Psychiat. 138: 1451-1462.
135. NATTO, A. and SUZUKI, H. (1974). Further evidence for the formation in vivo of phosphopeptide in the intestinal lumen from dietary beta-casein. J Agric Biol Chem. 38: 1543-1545.
136. NEUCHTERLEIN, K.H. (1986). Childhood precursors of adult schizophrenia. J Child Psychol Psychiat. 27: 133-141.
137. NYBERG, F. LIBERMAN, H., LINDSTRØM, L.H., LYRENÆS , S., KOCH, G. and TERENIUS, L. (1989). Immunoreactive beta-casomorphin-8 in cerebrospinal fluid from pregnant and lactating women : correlation with plasma level. J Clin Endocrinol Metab. 68: 283-289.
138. ONSTAD, S., SKRE, I., TORGERSEN, S. and KRINGLEN, E. (1991). Twin concordance for DSM-III R schizophrenia. Acta Psychiat Scand. 83: 395-401.
139. PAGANELLI, R. and LEVINSKY, R.J. (1980). Solid phase radioimmunoassay for detection of circulating food protein antigen in human serum. J Immunol Method. 37: 333-340.
140. PAGANUZZI, A.S., ZUCCO, F., CARDELLI, M., DEANGELES, I., MATTEI, B., PINO, A., ROCCA, E. and ZAMPAGLIONI, F. (1985). Cytotoxic effects of wheat gliadin-derived peptides. Toxicol. 37: 225-232.
141. PAKKENBERG, B. (1987). Post-Mortem study of chronic schizophrenic brains. Brit J Psychiat. 151: 744-752.
142. PANDURANGI, A.K., DEWAN, M.J., BOUCHER, M., LEVY, M., RAMACHANDRAN, T., BARTELL, K., BICK, P.A., PHELPS, B.H. and MAJOR, L. (1986). A comprehensive study of chronic schizophrenic patients II. Acta Psychiat Scand. 73: 161-171.
143. PAUL, K-D., HENKER, J., TODT, A. and EYSOLD, R. (1985). EEG-Befunde Zoeliakikranken Kindern in Abhængigkeit von der Ernæhrung. Z Klin Med. 40: 707-709.
144. PINCUS, J.H. and BARRY, K. (1987). Influence of dietary proteins on motor function in Parkinsons Disease. Arch Neurol. 44: 270-272.
145. PLOMIN, R. (1995). Genetics and Children's experiences in the family. J Child Psychol Psychiat. 36: 33-68.
146. POTKIN, S.G., WEINBERGER, D., KLEIMAN, J., NASRALLAH, H., LUCHINS, D. and BIGELOW, L. (1981). Wheat gluten challange in schizophrenic patients.Am. J.Psychiat.138: 1208-1211.
147. REICHELT, K.L., HOLE, K., HAMBERGER, A., SÆLID, G., EDMINSON, P.D., BRÆSTRUP, C., LINGJÆRDE, O.L., LEDAAL, P. and ØRBECK, H. (1981). Biologically active peptide-containing fractions in schizophrenia and childhood autism. Adv Biochem Psychopharmacol. 28: 627-643.
148. REICHELT, K.L., EDMINSON, P.D. and TOFT, K.G. (1985). Urinary peptides in schizophrenia and depression. Stress Med. 1: 169-181.
149. REICHELT, K.L., PEDERSEN, O.S., KROGH, M.H., and GJERSTAD, B.T. (1987). Chemical diagnosis ,etiology and possible treatment of schizophrenia. In: Clinical Research in Psychiatry. C.B. Dahl, T. Haug, M. Svartberg, G. Linaker, and L. Eriksen, L.(Eds). pp 85-101. University of Trondheim Press. Trondheim,Norway.
150. REICHELT, K.L. SAGEDAL, E., LANDMARK, J., TSHUMI-SANDVIK, B., EGGEN, O. and SCOTT, H. (1990). The effect of gluten free diet on glycoprotein attached urinary peptide excretion and behaviour in schizophrenia. J Orthomol Med. 5: 223-239.
151. REICHELT, K.L., KNIVSBERG, A-M., LIND, G. and NØDLAND, M. (1991). Probable etiology and possible treatment of childhood autism. Brain Dysfunct. 4: 308-319.
152. REICHELT, K.L. and LANDMARK, J. (1995). Specific IgA antibody increases in schizophrenia. Biol Psychiat. 37: 410-413.
153. REICHELT ,K.L. AND TEIGLAND-GJERTSAD, B. (1995). Decreased urinary peptide excretion in schizophrenic patients after neuroleptic treatment. Psychiat Res. 58: 171-176.
154. RICE, J.R., HAM, C.H. and GORE, W.E. (1978). Another look at gluten in schizophrenia. Amer J Psychiat. 135: 1147-1148.
155. RIX, K.J.B., DICHTFIELD, J., FREED, D.L.J. GOLDBERG, D.P. and HILLIER, V.F. (1985). Food antibodies in acute Psychoses. Psychol Med. 15: 347-354.
156. ROBERTS, G.W. and BRUTON, C.J. (1990). Annotation. Notes from the graveyard: Neuropahology and schizophrenia. Neurophatol Appl Neurobiol. 16: 3-16.
157. ROCETTI, G., VENTURELLA, F. and RODA, I.G. (1988). Enkephalin binding system in human plasma III Comparative protection of different peptides. Neurochem Res. 13: 221-224.
158. ROOT, A.W., RETTER, E.D. and DUCKET, G.E. (1977). Urinary excretion of immunoreactive gonado-tropin releasing hormone like material in prepubertal and pubertal children. J Clin Endorinol Metab. 44: 909-914.
159. ROSENTHAL, D., WENDER, P. and KETY, S.S. (1971). The adopted -away offspring of schizophrenics. Amer J Psychiat. 128: 307-311.
160. ROTHMAN, R.B., DANKS, J.A. and IADROLA, M.J. (1987). Unexpectedly high levels of opioid peptides in rat brain membranes. Peptides 8: 645-649.
161. RYAN, C.M., YARMUSH, N.L., BURKS, J.F. and TOMPKINS, R.C. (1992). Increased gut permeability early after burns correlates with the extent of burn injury. Crit Care Med. 20: 1508-1512.
162. SCHOEMAKER, H. and DAVIS, T.P. (1984). Differential in vitro metabolism of beta-endorphin in schizophrenia. Peptides. 5: 1049-1054.
163. SCHOUTSEN, N. and DEJONG, J.W. (1984). Xanthine oxidase in rabbit plasma after application of a bovine milk preparation to small intestine. Arch Internat de Physiol Biochim. 92: 379-384.
164. SCHULSINGER, F. (1987). Skizofreniforskning i dag. Nord Med. 102: 114-117.
165. SIDEROWICZ, S., FIRKO, M., WASIK, A., SZEWCZYK, Z., SZEPTOWSKI, T. and WEYDE, W. (1980). Clinical trial of hemodialysis in chronic schizophrenics. Acta Psychiat Scand. 61: 223-227.
166. SINGH, M.M. and KAY, S.R. (1976). Wheat gluten as a pathogenic factor in schizophrenia. Science 191: 401-402.
167. SKRAASTAD, Ø. FOSSLI, T. EDMINSON, P.D. and REICHELT, K.L. (1987). Purification and characterization of a mitosis inhibitory tripeptide from mouse intestinal extracts. Epithelia 1: 107-119.
168. SOHLBERG, S.C. (1985). Personality and neuropsychological performance of high-risk children. Schizo Bull. 11: 107-111.
169. SOHLBERG, S.C. and YANIV, S. (1985). Social adjustment and cognitive performance of high -risk children. Schizo Bull. 11: 61-65.
170. STEVENS, JR. (1982). Neuropathology of schizophrenia. Arch Gen Psychiat. 39: 1131-1139.
171. STIENE-MARTIN, A. and HAUSER, K.E. (1991). Opioid dependent growth of glial cultures: suppression of astrocyte DNA synthesis by met-enkephalin. Life Sci. 46: 91-98.
172. STORMS, L.H. CLOPTON, J.M. and WRIGHT, C. (1982). Effects of gluten in schizophrenics. Arch Gen Psychiat. 39: 323-327.
173. STRANGER, E. (1987). Changes in the incidence of schizophrenia? Brit J Psychiat. 150: 1-7.
174. STUART, C.A. TWISELTON, R. NICHOLAS, M. and HIDE, D.W. (1984). Passage of cow's milk protein in breast milk. Clin Aller. 14: 533-535.
175. SUDDATH, R.I. CASANOVA, M.F., GOLDBERG, T.E., DANIEL, D.G. KELSOE, J.R. and WEINBERGER, D.R. (1989). Temporal lobe pathology in schizophrenia:a quantitative magnetic resonance imaging study. Amer J Psychiat. 146: 464-467.
176. SUGERMAN, A.A., SOUTHERN, D.L. and CURRAN, J.F.U. (1982). A study of antibody levels in alcoholic, depressive and schizophrenic patients. Annals Aller. 48:166-171.
177. SVEDBERG, J., DEHAAS, J., LEIMANSTOLL, G., PAUL, F. and TESCHE-MACHER, H. (1985). Demonstration of beta-casomorphin immunoreactive materials in vitro digests of bovine milk and in small intestinal contents after bovine milk ingestion in adult humans. Peptides. 6: 825-831.
178. SÆLID, G., HAUG, J.O., HEIBERG, T. and REICHELT, K.L. (1985). Peptide containing fractions in depression. Biol Psychiat. 20: 245-256.
179. TAIRA, T., HILAKIVI, L.A., AALTO, J. and HILAKIVI, I. (1990). Effects of Beta-casomorphin on neonatal sleep in rats. Peptides. 11: 1-4.
180. TAKAORI, K., BORTON, J. and DONOWITZ, M. (1986). The transfer of an intact oligopeptide across adult mammalian jejunum. Biochem Biophys Res Comm. 137: 602-607.
181. TANDON, R., MAZZARA, C., DEQUARDO, J., CRAIG, K.A., MEADOR-WOODRUFF, J.H. GOLDMAN, R. and GREDEN, J.F. (1991). Dexamethasone suppression test in schizophrenia: Relationship to symptomatolgy , ventricular enlargement , and outcome. Biol Psychiat. 29: 953-964.
182. THIBAULT, L., COULON, J-F. ROBERG, C., DONTIGNY, A., TREMBLAY, N. and ROBERG, A.G. (1988). Changes in serum amino acids content and dopamine -beta-hydroxylase activity and brain neurotransmitter interaction in cats fed casein with or without gluten. J Clin Biochem Nutr. 4: 209-221.
183. THOMPSON, S.E., CABITT ,J. and AUDUS, K.L. (1994). Leucine Enkephaline effects on paracellular and transcellular permeation pathways across brain microvessel endothelial cell monolayers. J Cardiovasc Pharmacol. 24: 818-825.
184. TRAFICANTE, L.S. and TURNBULL, B. (1982). Neuropeptide degrading enzyme(s) in plasma and brain:Effects of in vivo neuroleptic administration. Pharmacol Res Comm. 14: 341-348.
185. TRIGUEARA, D., BUCIAK, J. and PARDRIDGE, W.M. (1990). Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins. J Neurochem. 54: 1882-1888.
186. TRONCONE, R., SCARCELLA, A., DONATIELLO, A., CANNATARO, P., TARABUSCO, A. and AURICCHIO, S. (1987). Passage of gliadin into human breast milk. Acta Paediat Scand. 76: 453-456.
187. UNDRUM, T., LUNDE, H.A. and GJESSING, L.R. (1982). Determination of ophidine in human urine. J Chromat. 227: 53-59.
188. VLISSIDES, D.N., VENULET, A. and JENNER, F.A. (1986). A double blind gluten-free/gluten load controlled trial in a secure ward population. Brit J Psychiat. 148: 441-452.
189. WADA, J. and GIBSON, U.C. (1959). Behavioural and EEG changes induced by injectgion of schizophrenic urine extracts Amer Med Assoc Arch Neurol Psychiat. 104: 747-763.
190. WAGEMAKER, H. and CADE, R. (1977). The use of hemodialysis on chronic schizophrenic patients. Amer J Psychiat. 134: 684-685.
191. WAHLBECK, K., RIMON, R. and FYHRQUIST, F. (1993). Elevated angiotensin-converting enzyme (kininase II) in the cerebrospinal fluid of neuroleptic -treated schizophrenic patients. Schizo Res. 9: 77-82.
192. WALAAS, O., LINGJÆRDE, O., LØKEN, F. and HUNDEVEDT E. (1945). Effects of sera from schizophrenic patients on glucose utilization of isolated rat diaphragms. Scand J Clin Lab Invest. 6: 245-249.
193. WARD, M.E., MURPHY, J.T. and GREENBERG, G.R. (1985). Celiac disease and spinocerebellar degeneration with normal vitamin E status. Neurol. 35: 1191-1201.
194. WARING, R.H. and NGONG, J.M. (1993). Sulphate metabolism in allergy-induced autism: relevance to the disease aetiology. In: Biological perspectives in Autism. pp25-33. The autism Research Unit (Eds): Sunderland Univ. Sunderland. UK.
195. WAUTERS, E.A.K. and VANDER KAMER, J.H. (1978). Excretion of pyrrolidonyl peptides and amino acid conjugates in a patient with coeliac disease and cystic fibrosis. In: Perspectives in coeliac disease. pp473-477. B. McNicholl, C.F. McCarthy and P.F. Fotrell (Eds). University Park Press. Oxford.
196. WATANABE, Y., KOJIMA-KUMATSU, T. IWAKI-EGAWA, S. and FUJIMOTO, Y. (1993). Increased exretion of proline-containing peptides in dipeptidyl peptidase IV-deficient rats. Res Comm Chem Pathol Pharmacol. 81: 323-350.
197. WEBB, K.E. (1986). Amino acid and peptide absorption from the gastro-intestinal tract. Fed Proc. 45: 2268-2271.
198. WEINTRAUB, S.(1987). Risk factors in schizophrenia: The Stony Brook High-Risk project. Schizo Bull. 13: 439-450.
199. WIEGANT, V.M., VERHOEF, C.J., BURBACH, P.H. and DEWIED, D. (1988). Increased concentration of alpha and gamma-endorphin in post mortem hypothalamic tissue of schizophrenic patients. Life Sci. 42: 1733-1743.
200. WIESER, H., BELITZ, H-D, and ASHKENAZI, A. (1984). Amino-acid sequence of the coeliac active gliadin peptide B 3142. Z Lebensmittel-untersuch Forsch. 79: 3371-3376.
201. WOLCOWITZ, O.M., DURAN, A.R., BREIER, A., COHEN, M.R. and PICKAR, D. (1986). Endogenous opioid regulation of hypothalamo-pituitary axis activity in schizophrenia. Biol Psychiat. 21: 366-373.
202. WOLLINA, U., BONNEKOH, B. and MAHRLE, G. (1992). Vasoactive intestinal peptide(VIP) modulates the growth fraction of epithelial skin cells. Internat J Oncol. 1: 17-24.
203. WOODS, B.I., YURGULUM-TODD, D., BENES, F.M., FRANKENBURG, F.R., POPE, H.G. and MCSPORN, J. (1990). Progressive ventricular enlargement in schizophrenia: comparison to bipolar affective disorder and correlation with clinical course. Biol Psychiat. 27: 341-352.
204. WRIGHT, E.C., STERN, J., ERSSER, R. and PATRICK, A.D. (1979). Glutathionuria: Gamma-glutamyl transpeptidase deficiency. J Inherit Metab Dis. 2: 1-3.
205. YU, D., SEITZ, P.K., SELANAGAYAM, P., RAJARAMAN, S., TOWNSEND, C.M. and COOPER, C.W. (1992). Effects of vasoactive intestinal peptide on adenosine 3′-5′-monophosphate ornithine decaroxylase, and cell growth in a human colon cell line. Endocrinol. 131: 1188-1194.
206. ZAGON, I.S. and MCLAUGHLIN, P.J. (1987). Endogenous opioid systems regulate cell proliferation in the developing rat brain. Brain Res. 412: 68-72.
207. ZIOUDROU, C., STREATY, T.A. and KLEE, W.A. (1979). Opioids derived from food proteins. J Biol Chem. 254: 2446-2449.
208. ZIPURSKY, R.R., MARSH, L., LIM, K.O., DEMENT, S., SHEAR, P.K., SULLIVAN, E.V., MURPHY, G.M., CSERNANSKY, J.G. and PFEFFERBAUM, A. (1994) Volumetric MRI assessment of temporal lobe structures in schizophrenia. Biol Psychiat. 35: 501-516.