Effects of carbamylcholine and pyridostigmine on cytoskeleton-bound and cytosolic phosphofructokinase and ATP levels in different rat tissues

General Pharmacology

Volumn 27, Issue 7, 1996, Pages 1241-1246

  Glass Marmor, Lea ^a   Chen Zion, Malca ^a   Beitner, Rivka ^a  

^a BAR ILAN UNIVERSITY   (Israel)

Author keywords

acetylcholine; brain; carbamylcholine; fructose 2,6 bisphosphate; gluco se 1,6 bisphosphate; glycolysis; heart; muscle; phosphofructokinase; pyridostigmine

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ADENOSINE TRIPHOSPHATE; CARBACHOL; CHOLINERGIC RECEPTOR STIMULATING AGENT; CHOLINESTERASE INHIBITOR; FRUCTOSE 2,6 BISPHOSPHATE; GLUCOSE 1,6 BISPHOSPHATE; GLYCOGEN; LACTIC ACID; PYRIDOSTIGMINE;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSKELETON; CYTOSOL; ELECTRON MICROSCOPY; ENZYME ACTIVITY; GLYCOGENOLYSIS; GLYCOLYSIS; HEART; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; SUBCUTANEOUS DRUG ADMINISTRATION; TISSUE INJURY; TISSUE LEVEL; TISSUE SPECIFICITY;

ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN; CARBACHOL; CYTOSKELETON; CYTOSOL; GLYCOGEN; GLYCOLYSIS; HEART; LACTIC ACID; MUSCLE, SKELETAL; MYOCARDIUM; PARASYMPATHOMIMETICS; PHOSPHOFRUCTOKINASE-1; PYRIDOSTIGMINE BROMIDE; RATS;

EID: 0030273191     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00048-1     Document Type: Article

References (47)

1. Adams V., Griffin L., Towbin J., Gelb B., Worley K. and McCabe E. R. B. (1991) Porin interaction with hexokinase and glycerol kinase: metabolic microcompartmentation at the outer mitochondrial membrane. Biochem. Med. Metab. Biol. 45, 271-291.
2. Akiyama N., Okumura K., Watanabe Y., Hashimoto H., Ito T., Ogawa K. and Satake T. (1989) Altered acetylcholine and norepinephrine concentrations in diabetic rat hearts. Role of parasympathetic nervous system in diabetic cardiomyopathy. Diabetes 38, 231-236.
3. Arnold H. and Pette D. (1968) Binding of glycolytic enzymes to structure proteins of the muscle. Eur. J. Biochem. 6, 163-171.
4. Beitner R. (1979) The role ot glucose-1,6-diphosphate in the regulation of carbohydrate metabolism in muscle. Trends Biochem. Sci. 4, 228-230.
5. Beitner R. (1984) Control of levels of glucose 1,6-bisphosphate. Int. J. Biochem. 16, 579-585.
6. Beitner R. (1985) Glucose 1,6-bisphosphate - the regulator of carbohydrate metabolism. In Regulation of Carbohydrate Metabolism (Edited by Beitner R.), Vol. 1, pp. 1-27. CRC Press, Boca Raton, FL.
7. Beitner R. (1990) Regulation of carbohydrate metabolism by glucose-1,6-bisphosphate in extrahepatic tissues; comparison with fructose-2,6-bisphosphate. Int. J. Biochem. 22, 553-557.
8. 2+ and calmodulin. Int. J. Biochem. 25, 297-305.
9. 2+ with calmodulin antagonists. Gen. Pharmac. 24, 847-855.
10. Beitner R. and Nordenberg J. (1979) The regulatory role of glucose-1,6-diphosphate in muscle of dystrophic mice. FEBS Lett. 98, 199-202.
11. Beitner R., Haberman S. and Nordenberg J. (1978a) The effect of epinephrine and dibutyryl cyclic AMP on glucose-1,6-bisphosphate levels and the activities of hexokinase, phosphofructokinase and phosphoglucomutase in the isolated rat diaphragm. Mol. Cell. Endocrinol. 10, 135-147.
12. Beitner R., Haberman S., Nordenberg J. and Cohen T. J. (1978b) The levels of cyclic GMP and glucose-1,6-diphosphate, and the activity of phosphofructokinase, in muscle from normal and dystrophic mice. Biochim. Biophys. Acta 542, 537-541.
13. Bessman S. P. (1966) A molecular basis for the mechanism of insulin action. Am. J. Med. 40, 740-749.
14. 2 levels in rat skeletal muscle. Biochem. Int. 17, 359-366.
15. Chen-Zion M., Livnat T. and Beitner R. (1992a) Insulin rapidly stimulates binding of phosphofructokinase and aldolase to muscle cytoskeleton. Int. J. Biochem. 24, 821-826.
16. Chen-Zion M., Bassukevitz Y. and Beitner R. (1992b) Sequence of insulin effects on cytoskeletal and cytosolic phosphofructokinase, mitochondrial hexokinase, glucose 1,6-bisphosphate and fructose 2,6-bisphosphate levels, and the antagonistic action of calmodulin inhibitors, in diaphragm muscle. Int. J. Biochem. 24, 1661-1667.
17. 2+ on binding of the glycolytic enzymes, phosphofructokinase and aldolase, to muscle cytoskeleton. Biochem. Med. Metab. Biol. 49, 173-181.
18. Chen-Zion M., Livnat T. and Beitner R. (1994) Effects of long-term streptozotocin diabetes on cytoskeletal and cytosolic phosphofructokinase and the levels of glucose 1,6-bisphosphate and fructose 2,6-bisphosphate in different rat muscles. Biochem. Med. Metab. Biol. 53, 137-144.
19. Clarke F., Stephan P., Morton D. and Weidemann J. (1985) Glycolytic enzyme organization via the cytoskeleton and its role in metabolic regulation. In Regulation of Carbohydrate Metabolism (Edited by Beitner R.), Vol. 2, pp. 1-31. CRC Press, Boca Raton, FL.
20. Gebbers J. -O., Lötscher M., Kobel W., Portmann R. and Laissue J. -A. (1986) Acute toxicity of pyridostigmine in rats: histological findings. Arch. Toxicol. 58, 271-275.
21. Hofer H. W. and Pette D. (1968) Wirkungen und Wechselwirkungen von Substraten und Effektoren an der Phosphofructokinase des Kaninchen-Skeletmuskels. Hoppe Seyler's Z. Physiol. Chem. 349, 1378-1392.
22. Ito T., Akiyama N., Ogawa T., Satake T., Kato T., Sugiyama S. and Ozawa T. (1989) Changes in myocardial mitochondrial electron transport activity in rats administered with acetylcholinesterase inhibitor. Biochem. Biophys. Res. Commun. 164, 997-1002.
23. Kato T., Sugiyama S., Hanaki Y., Fukushima A., Akiyama N., Ito T. and Ozawa T. (1989) Role of acetylcholine in pyridostigmine-induced myocardial injury: possible involvement of parasympathetic nervous system in the genesis of cardiomyopathy. Arch. Toxicol. 63, 137-143.
24. Kawabuchi M. (1982) Neostigmine myopathy is a calcium ion-mediated myopathy initially affecting the motor end-plate. J. Neuropathol. Exp. Neurol. 41, 298-314.
25. Koren-Schwartzer N., Chen-Zion M., Ben-Porat H. and Beitner R. (1994) Serotonin-induced decrease in brain ATP, stimulation of brain anaerobic glycolysis and elevation of plasma hemoglobin; the protective action of calmodulin antagonists. Gen. Pharmac. 25, 1257-1262.
26. 2 in vivo. Int. J. Biochem. 22, 857-863.
27. Lilling G. and Beitner R. (1991) Altered allosteric properties of cytoskeleton-bound phosphofructokinase in muscle irom mice with X chromosome-linked muscular dystrophy (mdx). Biochem. Med. Metab. Biol. 45, 319-325.
28. Lilling G., Bassukevitz Y. and Beitner R. (1991) Lithium-induced changes in cytoskeleton-bound phosphofructokinase and mitochondrially-bound hexokinase in rat brain and muscles. Lithium 2, 103-108.
29. Livnat T., Chen-Zion M. and Beitner R. (1993) Stimulatory effect of epidermal growth factor on binding of glycolytic enzymes to muscle cytoskeleton and the antagonistic action of calmodulin inhibitors. Biochem. Med. Metab. Biol. 50, 24-34.
30. Livnat T., Chen-Zion M., Brodie C. and Beitner R. (1995) Rapid stimulatory effect of insulin on binding of glycolytic enzymes to cytoskeleton of C-6 glial cells, and the antagonistic action of calmodulin inhibitors. Endocrine 3, 319-322.
31. Lowry O. H., Passonneau J. V., Hasselberger F. X. and Schulz D. W. (1964) Effect of ischemia on known substrates and cofactors of the glycolytic pathway in brain. J. Biol. Chem. 239, 18-30.
32. Lowry O. H., Rosenrough N. J., Farr A. L. and Randall R. J. (1951) Prorein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265-275.
33. Mansour T. E. (1972) Phosphofructokinase activity in skeletal muscle extracts following administration of epinephrine. J. Biol. Chem. 247, 6059-6066.
34. Mohan C., Geiger P. J. and Bessman S. P. (1989) The intracellular site of action of insulin: the mitochondrial Krebs cycle. In Current Topics in Cellular Regulation (Edited by Horecker B. L. and Stadtman E. R.), Vol. 30, pp. 105-142. Academic Press, New York.
35. Nicotera D., Bellono G. and Orrenius S. (1992) Calcium-mediated mechanisms in chemically induced cell death. Ann. Rev. Pharmac. Toxicol. 32, 449-470.
36. Passonneau J. V., Lowry O. H., Schulz D. W. and Brown J. G. (1969) Glucose 1,6-diphosphate formation by phosphoglucomutase in mammalian tissues. J. Biol. Chem. 244, 902-909.
37. Pfleiderer G. (1965) Glycogen. In Methods of Enzymatic Analysis (Edited by Bergmeyer H. U.), pp. 59-62. Academic Press, New York.
38. Rajs J., Sundberg M., Härm T., Grandinsson M. and Söndelund U. (1980) Interrelationships between ATP levels, enzyme leakage, gluconate uptake, trypan blue exclusion and length/width ratio of isolated rat cardiac myocytes subjected to anoxia and reoxygenation. J. Molec. Cell Cardiol. 12, 1227-1238.
39. Ray C. A., Blin J., Chase T. N. and Piercey M. F. (1992) Effects of cholinergic agonists on regional brain energy metabolism in the scopolamine-treated rat. Neuropharmacology 31, 1193-1199.
40. Sugiyama S., Kato T., Ozawa T. and Yagi K. (1991) Deterioration of mitochondrial function in heart muscles of rats with hypothyroidism. J. Clin. Biochem. Nutr. 11, 199-204.
41. Thompson W. H. S., Sweetin J. C. and Hamilton I. J. D. (1975) ATP and muscle enzyme efflux after physical exertion. Clin. Chim. Acta 59, 241-245.
42. Tsuboi H., Ohno O., Ogavva K., Ito T., Hashimoto H., Okumura K. and Satake T. (1987) Acetylcholine and norepinephrine concentrations in the heart of spontaneously hypertensive rats; a parasympathetic role in hypertension. J. Hypertens. 5, 323-330.
43. Van Schattingen E. and Hers H. G. (1983) Fructose 2,6-bisphosphate in relation with the resumption of metabolic activity in slices of Jerusalem artichokes tubers. FEBS Lett. 164, 195-200.
44. Van Schaftingen E., Lederer B., Battrons R. and Hers H. G. (1982) A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tuber. Application to a microassay of fructose 2,6-bisphosphate. Eur. J. Biochem. 129, 191-195.
45. Viitanen P. V., Geiger P. J., Erickson-Viitanen S. and Bessman S. P. (1984) Evidence for functional hexokinase compartmentation in rat skeletal muscle mitochondria. J. Biol. Chem. 259, 9679-9686.
46. Weed R. I., Lacelle P. L. and Merrill E. W. (1969) Metabolic dependence of red cell deformability. J. Clin. Invest. 48, 795-809.
47. Wilkinson J. H. and Robinson J. M. (1974) Effect of ATP on release of intracellular enzymes from damaged cells. Nature (Lond.) 249, 662-663.