Effect of 17α-ethinylestradiol, levonorgestrel, 3-keto-desogestrel, and gestodene on calcium influx via voltage-gated calcium channels in human aortic smooth muscles

Contraception

Volumn 54, Issue 4, 1996, Pages 265-268

  Seeger, H ^a   Muck A O ^a   Lorkowski, G ^a   Teichmann, A T ^b   Lippert, T H ^a,c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Dept Obstetrics/Gynecology ^*  (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

17 ethinylestradiol; calcium influx; human vascular smooth muscle cells; progestogens

Indexed keywords

CALCIUM CHANNEL; ETHINYLESTRADIOL; ETONOGESTREL; GESTODENE; LEVONORGESTREL;

ARTICLE; BLOOD VESSEL TONE; CALCIUM TRANSPORT; CONTRACEPTION; DRUG EFFECT; HUMAN; HUMAN TISSUE; VASCULAR SMOOTH MUSCLE;

EID: 0030273139     PISSN: 00107824     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0010-7824(96)00188-6     Document Type: Article

References (14)

1. 1. Thorogood M, Vessey MP. An epidemiologic survey of cardiovascular disease in women taking oral contraceptives. Am J Obstet Gynecol 1990;163:274-81.
2. 2. DeWood M, Apores AJ, Notske R, et al. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. New Engl J Med 1980;303: 897-902.
3. 3. Kuhl H. Oral contraception and replacement therapy: the significance of the progestogen for cardiovascular diseases, Geburtsh u Frauenheilk 1992;52:653-62.
4. 4. Weir RJ, Davies DL, Fraser R, Morton JJ, Tree M, Wilson A. Contraceptive steroids and hypertension. J Steroid Biochem 1975;6:961-4.
5. 5. Dzau VJ. Circulating versus local renin-angiotensin system in cardiovascular homeostasis. Circulation 1988;77(suppl.I):14-113.
6. 6. Taubert HD, Kuhl H. Kontrazeption mit Hormonen. Stuttgart, New York: Georg Thieme Verlag, 1995.
7. 7. Winkler UH. Hemostasis in oral contraception: the role of progestogens. Gynecol Endocrinol 1993;7(suppl):59-64.
8. 8. Gisclard V, Miller VM, Vanhoutte PM. Effect of 17β-estradiol on endothelium-dependent responses in the rabbit. J Pharmacol Exp Ther 1988;244:19-22.
9. 9. Hamlet MA, Rorie DK, Tyce GM. Effects of estradiol on release and disposition of norepinephrine from nerve endings. Am J Physiol 1980;239:H450-H456.
10. 2+ in guinea-pig isolated cardiac myocytes. Br J Pharmacol 1992;106:739-45.
11. 11. Lippert TH, Seeger H, Mück AO, Hanke H, Haasis R. Effect of estradiol, progesterone and progestogens on calcium influx in cell cultures of human vessels. J Menopause; in press.
12. 12. Seeger H, Mück AO, Lippert TH. Effect of estradiol, and of the progestogens chlormadinone acetate, dienogest and norethisterone on calcium influx in human aortic smooth muscle cells: Comparison between resting and activated cells. J Menopause 1996;1:32-34.
13. 13. Byrne KB, Stanton BJ, Coupar IM, Burcher E. Effect of levonorgestrel and ethinyloestradiol on vasoconstriction in rat isolated vasculature. J Pharm Pharmacol 1988;40:562-6.
14. 2+ currents on aortic smooth muscle cells. Eur J Pharmacol 1995;294:625-35.