Effect of acute tryptophan depletion on behavioral, cardiovascular, and hormonal sensitivity to cholecystokinin-tetrapeptide challenge in healthy volunteers

Biological Psychiatry

Volumn 40, Issue 7, 1996, Pages 648-655

  Koszycki, Diana ^a   Zacharko, Robert M ^b   Le Melledo, Jean Michel ^a   Young, Simon N ^c   Bradwejn, Jacques ^a  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b CARLETON UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

cholecystokinin; panic attacks; serotonin; tryptophan depletion

Indexed keywords

CHOLECYSTOKININ; HYDROCORTISONE; PROLACTIN; SEROTONIN; TETRAPEPTIDE; TRYPTOPHAN;

ADULT; ARTICLE; BEHAVIOR; HUMAN; HUMAN EXPERIMENT; MALE; NEUROENDOCRINOLOGY; NORMAL HUMAN; PANIC; PRIORITY JOURNAL;

EID: 0030272964     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-3223(95)00479-3     Document Type: Article

References (19)

1. Abbott FV, Etienne P, Franklin KBJ, Morgan MJ, Sewitch MJ, Young SN (1992): Acute tryptophan depletion blocks morphine analgesia in the cold-pressor test in humans. Psychopharmacology 108:60-66.
2. 3H]spiperone binding sites linked to dopamine and 5-hydroxytryptamine receptors in the brain of the rat. Neurosci Lett 35:179-183.
3. American Psychiatric Association (1987): Diagnostic and Statistical Manual of Mental Disorders, 3rd ed rev. Washington DC: American Psychiatric Association.
4. Benkelfat C, Ellenbogen MA, Dean P, Palmour RM, Young SN (1994): Mood-lowering effect of tryptophan depletion: Enhanced susceptibility in young men at risk for major affective disorders. Arch Gen Psychiatry 51:687-697.
5. Bradwejn J, Koszycki D (1994a): The cholecystokinin hypothesis of anxiety and panic disorders. Annals NY Academy of Sciences 173:273-282.
6. Bradwejn J, Koszycki D (1994b): Imipramine antagonism of the panicogenic effects of cholecystokinin-tetrapeptide in panic disorder patients. Am J Psychiatry 151:261-263.
7. Charney D, Heninger G (1985): Noradrenergic function and the mechanism of action of antianxiety treatment II: The effect of long-term treatment. Arch Gen Psychiatry 42:473-481.
8. Danjou P, Hamon M, Lacomblez L, Warot D, Kecskemeti S, Puech AJ (1990): Psychomotor, subjective and neuroendocrine effects of acute tryptophan depletion in the healthy volunteer. Psychiatr Psychobiol 5:31-38.
9. Delgado PL, Charney DS, Price LH, Aghajanian GK, Landis H, Heninger GR (1990): Serotonin function and the mechanism of antidepressant action: reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry 47:411-418.
10. Ellenbogen M, Palmour RM, Young SN, Dean P, Benkelfat C (1994): Affective response to tryptophan depletion in humans. Sex differences and stability over time. Proceedings from the 17th annual meeting of the Canadian College of Neuropsychopharmacology. June, Quebec City, Quebec, p 82.
11. Goddard WW, Charney DS, Germine M, Woods SW, Heninger GR, Krystal JH, Goodman WK, Price LH (1995): Effects of tryptophan depletion on responses to yohimbine in healthy human subjects. Biol Psychiatry 38:74-85.
12. Harro J, Vasar E, Bradwejn J (1993): CCK in animal and humans research in anxiety. TIPS 141:244-249.
13. Maes M, Melzer HY (1995). The serotonin hypothesis of major depression. In Bloom FE, Kupfer DJ (eds), Psychopharmacology: The Fourth Generation of Progress. Raven Press: New York, pp 933-944.
14. Rex A, Fink H, Marsden CA (1994): Effects of BOC-CCK-4 and L365.260 on cortical 5-HT release in guinea-pigs on exposure to the elevated plus maze. Neuropharmacology 33:559-565.
15. Smith SE, Pihl RO, Young SN, Ervin FR (1987): A test of possible cognitive and environmental influences on the mood lowering effect of tryptophan depletion in normal males. Psychopharmacology 91:451-457.
16. Van Megen H, Westenberg H, den Boer J (1994): Effect of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine on CCK-4 induced panic attacks (Abstract). Neuropsychopharmacology 10:270S.
17. 2 receptors in regulation of aggressive behaviour. Zh Vyss Nerv Deyat 34:283-289.
18. Vasar E, Peuranen E, Ööpik T, Harro J, Männistö PT (1993): Ondansetron, an antagonist of 5-HT3-receptors, antagonizes the antiexploratory effects of caerulein, an agonists of CCK-receptors, in the elevated plus maze. Psychopharmacology 110:213-218.
19. Young SN, Smith SE, Pihl RO, Ervin FR (1985): Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology 87:173-177.