Detection of tumor response to radiation therapy by in vivo proton MR spectroscopy

International Journal of Radiation Oncology Biology Physics

Volumn 36, Issue 3, 1996, Pages 635-639

  Bhujwalla, Zaver M ^a   Glickson, Jerry D ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Irradiation; Lactate; Proton spectroscopic imaging; Tumors

Indexed keywords

ANIMAL MODEL; ARTICLE; CANCER RADIOTHERAPY; CONTROLLED STUDY; GAMMA IRRADIATION; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RADIOBIOLOGY; RADIOSENSITIVITY; TUMOR RESISTANCE;

HYDROGEN; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; NEOPLASMS; RADIATION DOSAGE; TIME FACTORS;

EID: 0030272850     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(96)00371-9     Document Type: Article

References (20)

1. 1. Bristow, R. G.; Hill, R. P. Comparison between in vitro radiosensitivity and in vivo radioresponse in murine tumor cell lines II: In vivo radioresponse following fractionated treatment and in vitro/in vivo correlations. Int. J. Radiat. Oncol. Biol. Phys. 18:331-345; 1990.
2. 2. Falk, P. The vascular pattern of the spontaneous C3H mouse mammary carcinoma and its significance in radiation response and in hyperthermia. Eur. J. Cancer. 16:203-217; 1980.
3. 31P Nuclear magnetic resonance evidence for the regulation of intracellular pH by Ehrlich ascites tumor cells. J. Cell Biol. 95:24-28; 1982.
4. 4. Griffiths, J. R. Are cancer cells acidic? Br. J. Cancer 64:425-427; 1991.
5. 5. He, Q.; Shungu, D. C.; van Zijl, P. C. M.; Bhujwalla, Z. M.; Glickson, J. D. Single scan in vivo lactate editing with complete lipid and water suppression by selective multiple quantum coherance transfer (Sel-MQC) with application to tumors. J. Magn. Reson. B. 106:203-211; 1995.
6. 6. Jain, R. K. Determinants of tumor blood flow: A review. Cancer Res. 48:2641-2658; 1988.
7. 31P NMR Spectroscopy. Int. J. Radiat. Oncol. Biol. Phys. 13:1851-1855; 1987.
8. 8. Negendank, W. Studies of human tumors by MRS: A review. NMR Biomed. 5:303-324; 1992.
9. 9. Pedersen, P. L. Tumor mitochondria and the bioenergetics of cancer cells. Prog. Exp. Tumor Res. 22:190-274; 1978.
10. 31P NMR studies of radiation-induced changes in metabolism of RIF-1 cells using a monolayer perfusion system. Proc. 4th Scientific Meeting of International Society for Magnetic Resonace in Medicine; 1996:1144.
11. 11. Rajan, S. S.; Wehrle, J. P.; Li, S.-J.; Steen, R. G.; Glickson, J. D. Phosphorus-31 NMR spectroscopic study of bioenergetic changes in RIF-1 after radiation therapy. NMR Biomed. 2:165-171; 1989.
12. 1H NMR spectroscopy of subcutaneous tumors in mice: Preliminary studies of effects of growth, chemotherapy and blood flow reduction. NMR Biomed. 5:296-302; 1992.
13. 1H NMR spectroscopy. Magn. Reson. Med. 32:277-284; 1994.
14. 31P MRS as a method of measuring pH in rat tumours. NMR Biomed. 5:351-359; 1992.
15. 15. Tozer, G. M.; Bhujwalla, Z. M.; Griffiths, J. R.; Maxwell, R. J. Phosphorus-31 magnetic resonance spectroscopy of the RIF-1 tumor following x-irradiation. Int. J. Radiat. Oncol. Biol. Phys. 16:155-164; 1989.
16. 16. Tozer, G. M.; Lewis, S.; Michalowski, A.; Aber, V. The relationship between regional variations in blood flow and histology in a transplanted rat fibrosarcoma. Br. J. Cancer 61:250-257; 1990.
17. 17. Tozer, G.; Suit, H. D.; Barlai-Kovach, M.; Brunengraber, H.; Biaglow, J. Energy metabolism and blood perfusion in a mouse mammary adenocarcinoma during growth and following X-irradiation. Radiat. Res. 109:275-293; 1987.
18. 18. Twentyman, P. R.; Brown, J. M.; Gray, J. W.; Franko, A. J.; Scoles, M. A.; Kallman, R. F. A new mouse tumor system (RIF-1) for comparison of endpoint studies. J. Natl. Cancer Inst. 49:735-749; 1980.
19. 19. Vaupel, P.; Okunieff, P.; Neuringer, L. J. Blood flow, tissue oxygenation, pH distribution, and energy metabolism of murine mammary adenocarcinoma during growth. Adv. Exp. Med. Biol. 248:835-845; 1989.
20. 20. Walden, T. L.; Farzaneh, N. K. Biochemistry of ionizing radiation. New York: Raven Press; 1990.