Soluble CD46 (membrane cofactor protein, MCP) in human reproductive tract fluids

Journal of Reproductive Immunology

Volumn 31, Issue 3, 1996, Pages 209-219

  McLaughlin, P J ^a   Holland, S J ^a   Taylor, C T ^b   Olah, K S ^b   Lewis Jones, D I ^b   Hara, T ^c   Seya, T ^c   Johnson, P M ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b LIVERPOOL WOMEN S HOSPITAL   (United Kingdom)

^c CENTER FOR ADULT DISEASES   (Japan)

Author keywords

Breast milk; CD46 (membrane cofactor protein MCP); Endometriosis; Infertility; Pregnancy; Seminal plasma

Indexed keywords

MEMBRANE COFACTOR PROTEIN; MONOCLONAL ANTIBODY; REGULATOR PROTEIN;

AMNION FLUID; ARTICLE; BODY FLUID; BREAST MILK; COLOSTRUM; CONTROLLED STUDY; ENDOMETRIOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENITAL SYSTEM; HUMAN; MAJOR CLINICAL STUDY; MALE; MALE FERTILITY; MALE INFERTILITY; OVARY FOLLICLE FLUID; PERITONEAL FLUID; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; SEMINAL PLASMA; SPERMATOZOON PENETRATION; UMBILICAL CORD BLOOD; VAS DEFERENS; VASECTOMY;

EID: 0030272768     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-0378(96)00967-9     Document Type: Article

References (28)

1. Anderson, D.J., Michaelson, J.S. and Johnson, P.M. (1989) Trophoblast/leucocyte common-antigen is expressed by human testicular germ cells and appears on the surface of acrosome-reacted sperm. Biol. Reprod. 41, 285-293.
2. Bjorge, L., Jensen, T.S., Vedeler, C.A., Ulvestad, E., Kristoffersen, E.K. and Matre, R. (1993) Soluble CD59 in pregnancy and infancy. Immunol. Lett. 36, 233.
3. Cervoni, F., Oglesby, T.J., Adams, E.M., Milesi-Fluet C., Nickells M., Fenichel P., Atkinson, J.P. and Hsi, B.L. (1992) Identification and characterisation of membrane cofactor protein of human spermatozoa. J. Immunol. 148, 1431-1743.
4. Davitz, M.A., Low, M.G. and Nussenzweig, V. (1986) Release of decay-accelerating factor (DAF) from the cell membrane by phosphatidylinositol-specific phospholipase C (PI-PLC). J. Exp. Med. 163, 1150-1158.
5. Hara, T., Kuriyama, S., Kiyohara, H., Nagase, Y., Matsumoto, M. and Seya T. (1992) Soluble forms of membrane cofactor protein (CD46, MCP) are present in plasma, tears and seminal fluid in normal subjects. Clin. Exp. Immunol. 89, 490-494.
6. Holmes, C.H., Simpson, K.L., Okada, N., Wainwright, S.D., Purcell, D.F.J. and Houlihan, J.M. (1992) Complement regulatory proteins at the feto-maternal interface during human placental development: comparison of CD59 by comparison with membrane cofactor protein (CD46) and decay accelerating factor (DAF). Eur. J. Immunol. 22, 1579-1585.
7. Hourcade, D., Holers, V.M. and Atkinson, J.P. (1989) The regulators of complement activation (RCA) gene cluster. Adv. Immunol. 45, 381-416.
8. Jensen, T.S., Bjorge, L., Wollen, A-L. and Ulstein, M. (1995) Identification of the complement regulatory proteins CD46, CD55 and CD59 in human fallopian tube, endometrium and cervical mucosa and secretion. Am. J. Reprod. Immunol. 34, 1-9.
9. Johnstone, R.W., Russell, S.M., Loveland, B.E. and McKenzie, I.F.C. (1993) Polymorphic expression of CD46 protein isoforms due to tissue-specific RNA splicing. Mol. Immunol. 30, 1231-1241.
10. Johnson, P.M. and Bulmer, J.N. (1984) Uterine gland epithelium in human pregnancy lacks maternal MHC antigens but does express fetal trophoblast antigens. J. Immunol. 132, 1608-1611.
11. Kitamura, M., Namiki, M., Matsumiya, K., Tanaka, K., Matsumoto, M., Hara, T., Kiyohara, H., Okabe, M., Okuyama, A. and Seya, T. (1995) Membrane cofactor protein (CD46) in seminal plasma is a prostasome-bound form with complement regulatory activity and measles virus neutralizing activity. Immunology 84, 626-632.
12. Matsumoto, M., Seya, T. and Nagasawa, S. (1992) Polymorphism and proteolytic fragments of granulocyte membrane cofactor protein (MCP, CD46) of complement. Biochem. J. 281, 493-499.
13. Medof, M.E., Walter, E.I., Rutgers, J.L., Knowles, D.M. and Nussenzweig, V. (1987) Identification of the complement decay-accelerating factor (DAF) on epithelium and glandular cells and in body fluids. J. Exp. Med. 165, 848-864.
14. Perricone, R., Pasetto, N., De Carolis, C., Vaquero, E., Piccione, E., Baschieri, L. and Fontana, L. (1992) Functionally active complement is present in human ovarian follicular fluid and can be activated by seminal plasma. Clin. Exp. Immunol. 89, 154-157.
15. Ripoche, J. and Sim, R.B. (1986) Loss of complement receptor type 1 (CR1) on ageing erythrocytes. Biochem. J. 235, 815-821.
16. Roberts, J.M., Taylor, C.T., Melling, G.C., Kingsland, C.R. and Johnson, P.M. (1992) Expression of the CD46 antigen and absence of class I MHC antigen on the human oocyte and preimplantation blastocyst. Immunology 75, 202-205.
17. Rooney, I.A. and Atkinson, J.P. (1993) Carriage of complement regulatory proteins by vesicles (prostasomes) in seminal plasma. Mol. Immunol. 30 (suppl. 1), 47.
18. Rooney, I.A., Atkinson, J.P., Krul, G.S., Polakoski, K., Saffitz, J.E. and Morgan, B.P. (1993) Physiologic relevance of the membrane attack complement inhibitory protein in human seminal plasma: CD59 is present on extracellular organelles (prostasomes), binds cell membranes and inhibits complement-mediated lysis. J. Exp. Med. 177, 1409-1420.
19. Seya, T., Hara, T., Iwata, K., Kuriyama, S., Hasegawa, T., Nagase, Y., Miyagawa, S., Matsumato, M., Hatanaka, M., Atkinson, J.P. and Shigeharu, N. (1995) Purification and functional properties of soluble forms of membrane cofactor protein (CD46) of complement: identification of forms increased in cancer patients' sera. Int. Immunol. 7, 727-736.
20. Seya, T., Hara, T., Matsumoto, M., Kiyohara, H., Nakanishi, I., Kinouchi, T., Okabe, M., Shimizu, A. and Akedo, H. (1993) Membrane cofactor protein (MCP, CD46) in seminal plasma and on spermatozoa in normal and 'sterile' subjects. Eur. J. Immunol. 23, 1322-1327.
21. Seya, T., Inoue, H., Okada, M., Matsumoto, M., Kitamura, H., Kinoshita, T. and Akedo, H. (1990) Proteolytic elimination of decay-accelerating factor (DAF): lytic abnormality coincides with removal of DAF in papain-treated human erythrocytes. Mol. Immunol. 27, 69-78.
22. Simpson, K.L. and Holmes, C.H. (1994a) Differential expression of complement regulatory proteins, decay-accelerating factor (CD55), membrane cofactor protein (CD46) and CD59 during human spermatogenesis. Immunology 81, 452-461.
23. Simpson, K.L. and Holmes, C.H. (1994b) Presence of the complement regulatory protein, membrane cofactor protein (MCP, CD46), as a membrane-associated product in seminal plasma. J. Reprod. Fertil. 102, 419-424.
24. Skibinski, G., Kelly, R.W. and James, K. (1994) Expression of common secretory granule-specific protein as a marker for the extracellular organelles (prostasomes) in human semen. Fertil. Steril. 61, 755-759.
25. Taguchi, R., Funahashi, Y., Ikezawa, H. and Nakashima, I. (1990) Analysis of PI (phosphatidylinositol)-anchoring antigens in a patient of paroxysmal nocturnal hemoglobulinuria (PNH) reveals deficiency of IF5 antigen (CD59), a new complement-regulatory factor. FEBS Lett. 261, 142-146.
26. Taylor, C.T., Biljan, M.M., Kingsland, C.R. and Johnson, P.M. (1994) Inhibition of human sperm-oocyte interaction in vitro by monoclonal antibodies to CD46 (membrane cofactor protein). Hum. Reprod. 9, 907-911.
27. Taylor, C.T. and Johnson, P.M. (1996) Complement-binding proteins are strongly expressed by human pre-implantation blastocysts and cumulus cells as well as gametes. Mol. Hum. Reprod. 2, 52-59.
28. Yoon, S.H. and Fearon, D.T. (1985) Characterisation of a soluble form of the C3b/C4b receptor (CR1) in human plasma. J. Immunol. 134, 3332-3338.