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Volumn 7, Issue 5, 1996, Pages 560-562

Metabolic engineering of polyketide biosynthesis

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; POLYKETIDE;

EID: 0030272727     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(96)80062-0     Document Type: Article
Times cited : (16)

References (17)
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    • Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage
    • of special interest. The 6-deoxyerythronolide B synthase of Saccharopolyspora erythraea, which synthesizes the aglycone core of the antibiotic erythromycin A, has been modified by the repositioning of a chain-terminating cyclase domain to the carboxyl terminus of 6-deoxyerythronolide B synthase. The resulting mutant markedly accelerates the formation of the predicted triketide lactone, compared to a control in which the repositioned domains is inactive. The repositioning the the cyclase should be generally useful for redirecting polyketide synthesis to obtain polyketide of specified chain lengths.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.