Monitoring thrombin generation with prothrombin fragment 1.2 assay during cardiopulmonary bypass surgery

Thrombosis Research

Volumn 84, Issue 1, 1996, Pages 45-54

  Knudsen, Lars ^a   Hasenkam, J Michael ^b   Kure, Hans Henrik ^b   Hughes, Pia ^b   Bellaiche, Louise ^b   Ahlburg, Peter ^b   Djurhuus, Christian ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b NONE

Author keywords

cardiopulmonary bypass surgery; extracorporeal circulation; fibrinopeptide A; prothrombin fragment 1.2; thrombin

Indexed keywords

FIBRINOPEPTIDE A; HEPARIN; PROTHROMBIN;

ADULT; AGED; ARTICLE; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CONTROLLED STUDY; EXTRACORPOREAL CIRCULATION; FEMALE; HUMAN; MALE; MONITORING; PRIORITY JOURNAL; THROMBOSIS;

EID: 0030272571     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/0049-3848(96)00160-0     Document Type: Article

References (22)

1. 1. BULL, B.S., HUSE, W.M., BRAUER, F.S. AND KORPMAN, R.S. Heparin therapy during extracorporeal circulation. II. The use of a dose reponse curve to individualize heparin and protamin dosage. J. Thorac. Cardiovasc. Surg. 69, 685-689, 1975.
2. 2. YOUNG, J.A., KISKER, C.T. AND DOTY, D.B. Adequate anticoagulation during cardiopulmonary bypass determined by activated clotting time and the apperance of fibrin monomer. Ann. Thorac. Surg. 26, 231-240, 1978.
3. 3. IRELAND H., RYLANCE P.B. & KESTEVEN P.J. Heparin as an anticoagulant during extracorporeal circulation. In Heparin. Chemical and biological properties, clinical applications. D.A. Lane & U. Lindahl (eds.) pp.549-574, Edward Arnold, London. (1989)
4. 4. BOISCLAIR, M.D., LANE, D.A., PHILIPPOU, H., SHEIKH, S. AND HUNT, B. Thrombin production, inactivation and expression during open heart surgery measured by assays for activation fragments including a new ELISA for prothrombin fragment F1+2. Thromb. Haemost. 70, 253-258, 1993.
5. 5. BRISTER, S.J., OFOSU, F.A. AND BUCHANAN, M.R. Thrombin generation during cardiac surgery: is heparin the ideal anticoagulant? Thromb. Haemost. 70, 259-262, 1993.
6. 6. SLAUGHTER, T.F., LEBLEU, T.H., DOUGLAS, J.M.J., LESLIE, J.B., PARKER, J.K. AND GREENBERG, C.S. Characterization of prothrombin activation during cardiac surgery by hemostatic molecular markers. Anesthesiology 80, 520-526, 1994.
7. 7. TANAKA, K., TAKAO, M., YADA, I., YUASA, H., KUSAGAWA, M. AND DEGUCHI, K. Alterations in coagulation and fibrinolysis associated with cardiopulmunary bypass during open heart surgery. J Cardiothorac Anesth 36, 181-188, 1989.
8. 8. GU, Y.J., VAN OEVEREN, W., VAN DER KAMP, K.W.H.J., AKKERMAN, C., BOONSTRA, P.W. AND WILDEVUUR, C.R.H. Heparin-coating of extracorporeal circuits reduces thrombin formation in patients undergoing cardiopulmonary bypass. Perfusion 6, 221-225, 1991.
9. 9. MATTHEWS, J.N., ALTMAN, D.G., CAMPBELL, M.J. AND ROYSTON, P. Analysis of serial measurements in medical research, BMJ. 300, 230-235, 1990.
10. 10. SMITH, R.C., LEUNG, J.M., MANGANO, D.T. AND SPI RESEARCH GROUP Postoperative myocardial ischemia in patients undergoing artery bypass graft surgery. Anesthesiology 74, 464-473, 1991.
11. 11. SPANNAGL, M., DIETRICH, W., BECK, A. AND SCHRAMM, W. High dose aprotenin reduces prothrombin and fibrinogen conversion in patients undergoing extracorporeal circulation for myocardial revascularization. Thromb. Haemost. 72, 159-165, 1994.
12. 12. VON SEGESSER, L.K., SCHILLING, J., LESKOSEK, B., MARQUARDT, K. AND TURINA, M. Surface treatment for perfusion devices. Perfusion 9, 197-205, 1994.
13. 13. TEITEL, J.M., BAUER, K.A., LAU, H.K. AND ROSENBERG, R.D. Studies of the prothrombin activation pathway utilizing radioimmunoassays for the F2/F1+2 fragment and thrombin-antithrombin complex. Blood 59, 1086-1097, 1982.
14. 14. PELZER, H., SCHWARZ, A. AND STUBER, W. Determination of human prothrombin activation fragment 1 + 2 in plasma with an antibody against a synthetic peptide. Thromb. Haemost. 65, 153-159, 1991.
15. 15. BRUHN, H.D., CONARD, J., MANNUCCI, M., MONTEAGUDO, J., PELZER, H., REVERTER, J.C., SAMAMA, M., TRIPODI, A. AND WAGNER, C. Multicentric evaluation of a new assay for prothrombin fragment F1+2 determination. Thromb. Haemost. 68, 413-417, 1992.
16. 16. HERREN, T., STRAUB, P.W. AND HAEBERLI, A. Prothrombin fragment 1+2, Thrombin-antithrombin III-complxes and fibrinopeptide A in spontaneously clotting whole blood in vitro. Effects of heparin addition and antithrombin III deficiency. Thromb. Haemost. 71, 49-53, 1994.
17. 17. ALTMAN D.G. Practical statistics for medical research. Chapman & Hall, London (1994).
18. 18. KESTEVEN, P.J., PASAOGLU, I., WILLIAMS, B.T. AND SAVIDGE, G.F. Significance of the whole blood activated clotting time in cardiopulmonary bypass. J. Cardiovasc. Surg. Torino. 27, 85-89, 1986.
19. 19. GRANT, P.J., TATE, G.M., DAVIES, J.A., WILLIAMS, N.S. AND PRENTICE, C.R.M. Intra-operative activation of coagulation - a stimulus to thrombosis mediated by vasopressin ? Thromb. Haemost. 55, 104-107, 1986.
20. 20. HARKER, L.A., MALPASS, T.W., BRANSON, H.E., HESSEL II, E.A. AND SLICHTER, S.J. Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: Acquired transient platelet dysfunction associated with selective alfa-granule release. Blood 56, 824-835, 1980.
21. 21. MAMMEN, E.F., KOETS, M.H., WASHINGTON, B.C., WOLK, L.W., BROWN, J.M., BURDICK, M., SELIK, N.R. AND WILSON, R.F. Hemostasis changes during cardiopulmonary bypass surgery. Semin. Thromb. Hemost. 11, 281-92IS, 1985.
22. 22. GRAM, J., JANETZKO, T., JESPERSEN, J. AND BRUHN, H.D. Enhanced effective fibrinolysis following the neutralization of heparin in open heart surgery increases the risk of post-surgical bleeding. Thromb. Haemost. 63, 241-245, 1990.