Vitamin E supplementation normalizes immune dysfunction in murine AIDS induced by LP-BM5 retrovirus infection

Nutrition Research

Volumn 16, Issue 10, 1996, Pages 1709-1720

  Okishima, Naoko ^a   Hirata, Kanako ^a   Moriguchi, Satoru ^a   Kishino, Yasuo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

IFN ; Immune Dysfunction; Murine AIDS; Reactive Oxygens; Splenomegaly; TNF ; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; LIPID PEROXIDE; PHYTOHEMAGGLUTININ; TUMOR NECROSIS FACTOR ALPHA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG MEGADOSE; FEMALE; IMMUNOPATHOLOGY; LYMPHOCYTE PROLIFERATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RETROVIRUS; SPLEEN CELL; SPLEEN WEIGHT; SPLENOMEGALY; T LYMPHOCYTE SUBPOPULATION; VIRUS INFECTION;

ALPHAVIRUS; ANIMALIA; MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 0030271897     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/0271-5317(96)00190-X     Document Type: Article

References (31)

1. 1. Watson RR. Murine models for acquired immune deficiency syndrome. Life Sci.1989; 44: iii-xv.
2. 2. Morse III HC, Chattopadhyay SK, Makino M, Fredrickson TN, Hügin W, and Hartley JW. Retrovirus-induced immunodeficiency in the mouse: MAIDS as a model for AIDS. AIDS 1992; 6: 607-621.
3. 3. Portnoi D, Stall AM, Schwartz D, Merigan TC and Herzenberg LA, Basham T. Zidovudine (azido dideoxythymidine) inhibits characteristic early alterations of lymphoid cell populations in retrovirus-induced murine AIDS. J Immunol 1990; 144: 1705-1710.
4. 4. Yasunaga T, Kato H, Ohgaki K, Inamoto T and Hikasa Y. Effect of vitamin E as an immunopotentiation agent for mice at optimal dosage and its toxicity at high doses. J Nutr 1982; 112: 1075-1084.
5. 5. Tanaka T, Fujimura H and Torisu M. Enhancement of helper T-cell activity by dietary supplementation of vitamin E in mice. Immunology 1979; 38: 724-734.
6. 6. Lim TS, Putt N, Satranki D, Chung C and Watson RR. Effect of vitamin E on cell mediated immune response and serum corticosterone in young and maturing mice. Immunology 1981; 44: 289-295.
7. 7. Meydani SN, Barklund MP, Liu S, Meydani M, Miller RA, Cannon JG, Morrow FD, Rocklin R and Blumberg JB. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am J Clin Nutr 1990; 52: 557-63.
8. 2 synthesis and enhances the immune response of aged mice. Mech Ageing Dev 1986; 34: 191-201.
9. 9. Moriguchi S, Maekawa K, Miwa H, Kishino Y. Effect of vitamin E supplementation on cellular immune functions decreased with aging spontaneously hypertensive rats. Nutr Res 1993; 13: 1039-1051.
10. 10. Bogden JD, Baker H, Frank O, Perez G, Kemp F, Bruening K and Louria D. Micronutrient status and human immunodeficiency virus (HIV) infection. Ann NY Acad Sci 1990; 587: 189-195.
11. 11. Wang Y, Liang B, Watson RR. Suppression of tissue levels of vitamin A, E, zinc and copper in murine AIDS. Nutr Res 1994; 14: 1031-1041.
12. 12. Wang Y, Huang DS, Liang B, Watson RR. Nutritional status and immune responses in mice with murine AIDS are normalized by vitamin E supplementation. J Nutr 1994; 124: 2024-2032.
13. 13. Schreck R, Rieber P and Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HTV-1. EMBO J 1991; 10: 2247-2258.
14. 14. Harakeh S, Jariwalla RJ and Pauling L. Suppression of human immunodeficiency virus replication by ascorbate chronically and acutely infected cells. Proc Natl Acad Sci USA 1990; 87: 7245-7249.
15. 15. Staal FJ, Roederer M, Herzenberg LA and Herzenberg LA. Intracellular thiols regulate activation of nuclear factor KB and transcription of human immunodeficiency virus. Proc Natl Acad Sci USA 1990; 87: 9943-9947.
16. 16. Dröge W, Eck HP, Gmünder H and Mihm S. Requirement for prooxidant and antioxidant status in T cell mediated immune responses.-Relevance for the pathogenetic mechanism of AIDS? Klin Wochenshr 1991; 69: 1118-1122.
17. + T cells in resistance to murine AIDS in A/J mice. J Immunol 1992; 149: 1702-1706.
18. 18. Kato H, Tanimura H, Hisaka Y Determination of serum tocopherol by high-performance liquid chromatography. Arch Jpn Chri 1981; 50: 740-746
19. 19. Yagi K. A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 1976; 15: 212-216.
20. 20. Yang X and Hay Glass KT. IFN-γ, but not IL-4, synthesis by antigen-primed murine T cells is IL-2 dependent. Differential requirement in de novo and established responses. J Immunol 1993; 150: 4354-4363.
21. 21. Meager A, Leuny H and Woolley J. Assays for tumor necrosis factor and related cytokines. J Immunol Meth 1989; 116: 1-17.
22. 22. Moriguchi S, Kim JK and Kishino Y. Alcohol, liver diseases and immunodeficiency. Adv Biosci 1993; 86: 219-226.
23. 23. Favier A, Sappey C, Leclerc P, Faure P and Micoud M. Antioxidant status and lipid peroxidation in patients infected with HIV. Chem Biol Intrac 1994; 91: 165-180.
24. 24. Flores SC, Marecki JC, Harper KP, Bose SK and Nelson SK. Tat protein of human immunodeficiency virus type 1 represses expression of manganese superoxide dismutase in Hela cells. Proc Natl Acad Sci USA 1993; 90: 7632-7636.
25. 25. Levin M. Acute hypersplenism and thrombocytopenia: a new presentation of disseminated mycobacterial infection in patients with acquired immunodeficiency syndrome. Acta Haematol 1994; 91: 28-31.
26. 26. Wang Y, Huang DS, Eskelson CD and Watson RR. Long-term dietary vitamin E retards development of retrovirus-induced disregulation in cytokine production. Clin Immunol Immunopathol 1994; 72: 70-75
27. 27. Eugui EM, DeLustro B, Rouhafza S, Ilnicka M, Lee SW, Wilhelm R and Allison AC. Some antioxidants inhibit, in a co-ordinate fashion, the production of tumor necrosis factor-a, IL-1beta and IL-6 by human peripheral blood mononuclear cells. Int-Immunol 1994; 6: 409-422.
28. 28. Gerstoft J, Petersen CS, Kroon S, Uliman S, Lindhardt BO, Hofmann B, Gaub J and Dickmeiss E. The immunological and clinical outcome of HIV infection: 31 month of follow-up in a cohort of homosexual men. Scand J Infect Dis 1987; 19: 503-509.
29. 29. Chau F, Levacher-Clergeot M, Desforges B, Ricatte L and Sinet M. Prognostic value of phenotypic alterations in blood lymphocyte subsets in a murine retrovirus-induced immunodeficiency syndrome (MAIDS). Clin Exp Immunol 1993; 91: 467-472.
30. 30. Lenardo MJ and Baltimore D. NF-κB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 1989; 58: 227-229.
31. 31. Meydani SN, Meydani M, Rall LC, Morrow F and Blumberg JB. Assessment of the safety of high-dose, short-term supplementation with vitamin E in healthy older adults. Am J Clin Nutr 1994; 60: 704-709.