Two novel pyrrolopyrimidine lipid peroxidation inhibitors U-101033E and U-104067F protect facial motor neurons following neonatal axotomy

Experimental Neurology

Volumn 141, Issue 2, 1996, Pages 304-309

  Smith, Sarah L ^a   Oostveen, Jo A ^a   Hall, Edward D ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6,7,8,9 TETRAHYDRO 9 (2 MORPHOLINOETHYL) 2,4 BIS(1 PYRROLIDINYL) 5H PYRIMIDO[4,5 B]INDOLE; CHOLINE ACETYLTRANSFERASE; NEUROPROTECTIVE AGENT; U 104067F; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; FACIAL NERVE; IMMUNOCYTOCHEMISTRY; LIPID PEROXIDATION; MALE; MOTONEURON; NERVE INJURY; NEWBORN; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0030271453     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1996.0165     Document Type: Article

References (16)

1. 1. ANSARI, K. S., P. H. YU, T. P. KRUCK, AND W. G. TATTON. 1993. Rescue of axotomized immature rat facial motoneurons by R(-)-deprenyl: Stereospecificity and independence from monoamine oxidase inhibition. J. Neurosci. 13: 4042-4053.
2. 2. CHIUEH, C. C., S. J. HUANG, AND D. L. MURPHY. 1992. Enhanced hydroxyl radical generation by 2′-methyl analog of MPTP: Suppression by clorgyline and deprenyl. Synapse 11: 346-348.
3. 3. DUBOIS-DAUPHIN, M., H. FRANKOWSKI, Y. TSUJIMOTO, ET AL. 1994. Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death. Neurobiology 91: 3309-3313.
4. 4. HALL, E. D. 1987. Intensive antioxidant pretreatment retards motor nerve degeneration. Brain Res. 413:175-178.
5. 5. HALL, E. D. 1992. The neuroprotective pharmacology of methylprednisolone. J. Neurosurg. 76: 13-22.
6. 6. HALL, E. D., P. K. ANDRUS, S. L. SMITH, ET AL. 1995. Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants. Acta Neurochir., 66 (Suppl): 107-113, 1995.
7. 7. HALL, E. D., S. L. SMITH, AND J. A. OOSTVEEN. 1996. Inhibition of lipid peroxidation attenuates axotomy-induced apoptotic degeneration of facial motor neurons in neonatal rats. J. Neurosci. Res. 44: 293-299.
8. 8. HALL, E. D., AND D. L. WOLF. 1984. methylprednisolone preservation of motor nerve function during early degeneration. Exp. Neurol. 84: 715-720.
9. 9. HALL, E. D., AND P. A. YONKERS. 1990. Preservation of motor nerve function during early degeneration by the 21-aminosteroid anti-oxidant U74006F. Brain Res. 513: 244-247.
10. 10. HOCKENBERY, D. M., Z. N. OLTVAI, X.-M. YIN, ET AL. 1993. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241-251.
11. 11. JU, W. Y., D. P. HOLLAND, AND W. G. TATTON. 1994. (-)-Deprenyl alters the time course of death of axotomized facial motoneurons and the hypertrophy of neighboring astrocytes in immature rats. Exp. Neurol. 126: 233-246.
12. 12. KANE, D. J., T. A. SARAFIAN, R. ANTON, ET AL. 1993. Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species. Science 262: 1274-1277.
13. 13. SALO, P. T., AND W. G. TATTON. 1992. Deprenyl reduces the death of motoneurons caused by axotomy. J. Neurosci. Res. 31: 394-400.
14. 14. SMITH, S. L., J. A. OOSTVEEN, AND E. D. HALL. 1995. Tirilazad mesylate (U-74006F) protects motor neurons in the facial nucleus following transection of the facial nerve in neonatal rats. J. Cell. Biochem. Suppl. 21B: 100.
15. 15. UMEMIYA, M., I. ARAKI, AND M. KUNO. 1993. Electrophysiological properties of axotomized facial motoneurons that are destined to die in neonatal rats. J. Physiol. 462: 661-678.
16. + toxicity by deprenyl (selegiline). Ann. N.Y. Acad. Sci. 738: 214-221.