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Volumn 32, Issue 2, 1996, Pages 81-89

In vitro protein-binding characteristics of delavirdine and its N-dealkylated metabolite

Author keywords

Bisheteroarylpiperazine; Delavirdine; HIV; Pharmacokinetics; Protein binding; Reverse transcriptase inhibitor

Indexed keywords

ALBUMIN; DELAVIRDINE; DRUG METABOLITE; IMMUNOGLOBULIN; OROSOMUCOID; RNA DIRECTED DNA POLYMERASE INHIBITOR;

EID: 0030270023     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-3542(95)00984-1     Document Type: Article
Times cited : (14)

References (21)
  • 1
    • 0021276141 scopus 로고
    • Fluid shifts and other factors affecting plasma protein binding of prednisolone by equilibrium dialysis
    • Boudinot, F.D. and Jusko, W.J. (1984) Fluid shifts and other factors affecting plasma protein binding of prednisolone by equilibrium dialysis. J. Pharm. Sci. 73, 774-780.
    • (1984) J. Pharm. Sci. , vol.73 , pp. 774-780
    • Boudinot, F.D.1    Jusko, W.J.2
  • 2
    • 0023801617 scopus 로고
    • The clinical spectrum of renal disease associated with human immunodeficiency virus
    • Bourgoignie, J.J., Meneses, R., Ortiz, C. et al. (1988) The clinical spectrum of renal disease associated with human immunodeficiency virus. Am. J. Kidney Dis. 12, 131-137.
    • (1988) Am. J. Kidney Dis. , vol.12 , pp. 131-137
    • Bourgoignie, J.J.1    Meneses, R.2    Ortiz, C.3
  • 3
    • 0023712855 scopus 로고
    • Isolated thrombocytopenia in patients infected with HIV: Treatment with intravenous gamma globulin
    • Bussel, J.B. and Haimi, J.S. (1988) Isolated thrombocytopenia in patients infected with HIV: treatment with intravenous gamma globulin. Am. J. Hematol. 28, 79-84.
    • (1988) Am. J. Hematol. , vol.28 , pp. 79-84
    • Bussel, J.B.1    Haimi, J.S.2
  • 4
    • 0024412953 scopus 로고
    • Nutritional status, gastrointestinal disfunction, and survival in patients with AIDS
    • Chlebowski, R.T., Grosvenor, M.B., Bernhard, N.H. et al. (1989) Nutritional status, gastrointestinal disfunction, and survival in patients with AIDS. Am. J. Gastroenterol. 84, 1288-1293.
    • (1989) Am. J. Gastroenterol. , vol.84 , pp. 1288-1293
    • Chlebowski, R.T.1    Grosvenor, M.B.2    Bernhard, N.H.3
  • 5
    • 0027178052 scopus 로고
    • U-90152, a potent inhibitor of human immunodeficiency virus type-1 replication
    • Dueweke, T.J., Poppe, S.M., Romero, D.L. et al. (1993) U-90152, a potent inhibitor of human immunodeficiency virus type-1 replication. Antimicrob. Agents Chemother. 37, 1127-1131.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 1127-1131
    • Dueweke, T.J.1    Poppe, S.M.2    Romero, D.L.3
  • 6
    • 0011726686 scopus 로고
    • Phase II clinical trials of delavirdine mesylate combination therapy
    • Tokyo, Japan, Aug. 1994, (abstract No. 512B)
    • Freimuth, W., Davey, R., Batts, D., Lane, C., Cox, S., Wathen, L., Peel, B., Daenzer, G., Morse, G., Chaitt, D. et al. (1994) Phase II clinical trials of delavirdine mesylate combination therapy. Int. Conf. AIDS, Tokyo, Japan, Aug. 1994, 10(2):59 (abstract No. 512B).
    • (1994) Int. Conf. AIDS , vol.10 , Issue.2 , pp. 59
    • Freimuth, W.1    Davey, R.2    Batts, D.3    Lane, C.4    Cox, S.5    Wathen, L.6    Peel, B.7    Daenzer, G.8    Morse, G.9    Chaitt, D.10
  • 7
    • 0011783826 scopus 로고    scopus 로고
    • Delavirdine in combination with zidovudine causes sustained antiviral and immunological effects in HIV-1 infected individuals
    • Washington, DC, USA, Jan. 28-Feb. 1, 1996, p. abstract no. LB8a
    • Freimuth, W.W., Wathen, L.K., Cox, S.R., Chuang-Stein, C.J., Greenwald, C.A., Daenzer, C.L., Wang, Y. and Delavirdine Team, Pharmacia and Upjohn (1996) Delavirdine in combination with zidovudine causes sustained antiviral and immunological effects in HIV-1 infected individuals. 3rd Conf. Retroviruses and Opportunistic Infections, Washington, DC, USA, Jan. 28-Feb. 1, 1996, p. abstract no. LB8a.
    • (1996) 3rd Conf. Retroviruses and Opportunistic Infections
    • Freimuth, W.W.1    Wathen, L.K.2    Cox, S.R.3    Chuang-Stein, C.J.4    Greenwald, C.A.5    Daenzer, C.L.6    Wang, Y.7
  • 8
    • 85030278882 scopus 로고
    • Delavirdine dosage requirements during a concentration-targeted study
    • San Francisco, USA, Sept. 17-20, 1995, abstract no. 128
    • Morse, G., Para, M., Fischl, M., Freimuth, W. and the ACTG 260 Study Team (1995) Delavirdine dosage requirements during a concentration-targeted study. 35th ICAAC, San Francisco, USA, Sept. 17-20, 1995, abstract no. 128.
    • (1995) 35th ICAAC
    • Morse, G.1    Para, M.2    Fischl, M.3    Freimuth, W.4
  • 9
    • 0011753699 scopus 로고
    • The development of HPLC-based analytical methods for delavirdine
    • in press
    • Howard, G.M. and Schwende, F.J. (1995) The development of HPLC-based analytical methods for delavirdine. J. Chromatogr. (in press).
    • (1995) J. Chromatogr.
    • Howard, G.M.1    Schwende, F.J.2
  • 10
    • 0025954701 scopus 로고
    • Nephrotic syndrome associated with acquired immunodeficiency syndrome in children
    • Ingulli, E., Tejani, A., Fikrig, S. et al. (1991) Nephrotic syndrome associated with acquired immunodeficiency syndrome in children. J. Pediatr. 119, 710-716.
    • (1991) J. Pediatr. , vol.119 , pp. 710-716
    • Ingulli, E.1    Tejani, A.2    Fikrig, S.3
  • 11
    • 0023201266 scopus 로고
    • Urologic manifestations of AIDS
    • Kaplan, M.S., Wechsler, M. and Benson, M.C. (1987) Urologic manifestations of AIDS. Urology 30, 441-443.
    • (1987) Urology , vol.30 , pp. 441-443
    • Kaplan, M.S.1    Wechsler, M.2    Benson, M.C.3
  • 12
    • 0026704031 scopus 로고
    • Human immunodeficiency virus infection and nephrotic syndrome
    • Korbet, S.M. and Schwartz, M.M. (1992) Human immunodeficiency virus infection and nephrotic syndrome. Am. J. Kidney Dis. 20, 97-103.
    • (1992) Am. J. Kidney Dis. , vol.20 , pp. 97-103
    • Korbet, S.M.1    Schwartz, M.M.2
  • 13
    • 0023690101 scopus 로고
    • Drug binding to human alpha-1-acid glycoprotein in health and disease
    • Kremer, J.M.H., Wilting, J. and Janssen, L.H.M. (1988) Drug binding to human alpha-1-acid glycoprotein in health and disease. Pharmacol. Rev. 40, 1-41.
    • (1988) Pharmacol. Rev. , vol.40 , pp. 1-41
    • Kremer, J.M.H.1    Wilting, J.2    Janssen, L.H.M.3
  • 14
    • 0020516865 scopus 로고
    • Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome
    • Lane, H.C., Masur, H., Edgar, L.C. et al. (1983) Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med. 309, 453-458.
    • (1983) N. Engl. J. Med. , vol.309 , pp. 453-458
    • Lane, H.C.1    Masur, H.2    Edgar, L.C.3
  • 15
    • 0026673957 scopus 로고
    • Incidence of microalbuminuria in ambulatory patients with acquired immunodeficiency syndrome
    • Luke, D.R., Sarnoski, T.P. and Dennis, S. (1992) Incidence of microalbuminuria in ambulatory patients with acquired immunodeficiency syndrome. Clin. Nephrol. 38, 69-74.
    • (1992) Clin. Nephrol. , vol.38 , pp. 69-74
    • Luke, D.R.1    Sarnoski, T.P.2    Dennis, S.3
  • 16
    • 0000062283 scopus 로고
    • Influence of protein binding and use of unbound (free) drug concentrations
    • W.E. Evans, J.J. Schentag and W.J. Jusko (Eds). Applied Therapeutics Inc., Vancouver, WA
    • MacKichan, J.J. (1992) Influence of protein binding and use of unbound (free) drug concentrations. In: W.E. Evans, J.J. Schentag and W.J. Jusko (Eds), Applied Pharmacokinetics: Principles of Therapeutic Drug Monitoring, pp. 5-1-5-48. Applied Therapeutics Inc., Vancouver, WA.
    • (1992) Applied Pharmacokinetics: Principles of Therapeutic Drug Monitoring , pp. 5-11
    • MacKichan, J.J.1
  • 17
    • 0025740950 scopus 로고
    • Intravenous immune globulin for the prevention of bacterial infections in children with symptomatic human immunodeficiency virus infection
    • National Institute of Child Health and Human Development Intravenous Immunoglobulin Study Group (1991) Intravenous immune globulin for the prevention of bacterial infections in children with symptomatic human immunodeficiency virus infection. N. Engl. J. Med. 325, 73-80.
    • (1991) N. Engl. J. Med. , vol.325 , pp. 73-80
  • 19
    • 0028024426 scopus 로고
    • In vitro protein-binding characteristics of atevirdine and its N-dealkylated metabolite
    • Rosser, L.M., O'Donnell, A.M., Lee, K.M. et al. (1994) In vitro protein-binding characteristics of atevirdine and its N-dealkylated metabolite. Antiviral Res. 25, 193-200.
    • (1994) Antiviral Res. , vol.25 , pp. 193-200
    • Rosser, L.M.1    O'Donnell, A.M.2    Lee, K.M.3
  • 20
    • 0026599230 scopus 로고
    • Nutritional aspects of the acquired immunodeficiency syndrome
    • Singer, P., Katz, D.P., Dillon, L. et al. (1992) Nutritional aspects of the acquired immunodeficiency syndrome. Am. J. Gastroenterol. 87, 265-273.
    • (1992) Am. J. Gastroenterol. , vol.87 , pp. 265-273
    • Singer, P.1    Katz, D.P.2    Dillon, L.3
  • 21
    • 0023607989 scopus 로고
    • Intravenous gamma globulin treatment for thrombocytopenia purpura in patients with human immunodeficiency virus (HIV) infection
    • Tertian, G., Risler, N., LeBras, P et al. (1987) Intravenous gamma globulin treatment for thrombocytopenia purpura in patients with human immunodeficiency virus (HIV) infection. Eur. J. Hematol. 39, 180-181.
    • (1987) Eur. J. Hematol. , vol.39 , pp. 180-181
    • Tertian, G.1    Risler, N.2    LeBras, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.