The importance of 2,3-dimercaptopropinol (British anti-lewisite, BAL) in the trypanocidal activity of topical melarsoprol

Acta Tropica

Volumn 62, Issue 2, 1996, Pages 83-89

  Jennings, F W ^a   Atouguia, J M ^a,b   Murray, M ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

Author keywords

Cymelarsan; dimercaptopropinol (bal); melarsen oxide; melarsoprol; topical gel

Indexed keywords

DIMERCAPROL; HYDROXYPROPYLCELLULOSE; MELARSAMINE; MELARSENOXIDE; MELARSOPROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GEL; MOUSE; NONHUMAN; RELAPSE; TOPICAL DRUG ADMINISTRATION; TRYPANOSOMA BRUCEI; TRYPANOSOMIASIS;

ADMINISTRATION, TOPICAL; ANIMALS; ARSENICALS; DIMERCAPROL; DRUG COMBINATIONS; FEMALE; GELS; MELARSOPROL; MICE; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

ANIMALIA; TRYPANOSOMA; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0030267944     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0001-706X(96)00036-8     Document Type: Article

References (5)

1. Atouguia, J.M., Jennings, F.W. and Murray, M. (1995) Successful treatment of experimental murine Trypanosoma brucei infection with topical melarsoprol gel. Trans. Roy. Soc. Trop. Med. Hyg. 89, 531-533.
2. Berger, B.J. and Fairlamb, A.H. (1994) Properties of melarsamine hydrochloride (Cymelarsan) in aqueous solution. Antimicrob. Ag. Chemother. 38, 1298-1302.
3. Jennings, F.W. (1993) Combination chemotherapy of CNS-trypanosomiasis. Acta Trop., 54, 205-213.
4. Jennings, F.W. and Gray, G.D. (1983) Relapsed parasitaemias following chemotherapy of chronic T. brucei infections in mice and its relation to cerebral trypanosomiasis. Contr. Microbiol. Immunol. 7, 147-154.
5. Pépin, J., Milord, F., Khonde, A.N., Niyonsenga, T., Loko, L., Mpia, B. and De Wals, P. (1995) Risk factors for encephalopathy and mortality during melarsoprol treatment of Trypanosoma brucei gambiense sleeping sickness. Trans. Roy. Soc. Trop. Med. Hyg. 89, 92-97.