Identification of a pKM101 region which confers a slow growth rate and interferes with susceptibility to quinolone in Escherichia coli AB1157

Journal of Bacteriology

Volumn 178, Issue 19, 1996, Pages 5568-5572

  Clerch, Berta ^a   Rivera, Eusebi ^a   Llagostera, Montserrat ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); GYRASE INHIBITOR; QUINOLONE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; ESCHERICHIA COLI PROTEIN; KORA PROTEIN, BACTERIA; KORB PROTEIN, PLASMID RK2; MEMBRANE PROTEIN; MUCA PROTEIN, BACTERIA; MUCB PROTEIN, BACTERIA; REPRESSOR PROTEIN; TRAL PROTEIN, E COLI;

ARTICLE; BACTERIAL GROWTH; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE EXPRESSION; GENE MUTATION; GROWTH RATE; PHENOTYPE; PLASMID; PRIORITY JOURNAL; PROTEIN MALNUTRITION; SURVIVAL RATE; ANTIBIOTIC RESISTANCE; CELL CYCLE; DOSE RESPONSE; DRUG EFFECT; GENE REPRESSION; GENETICS; GROWTH, DEVELOPMENT AND AGING; MICROBIOLOGICAL EXAMINATION;

ANTI-INFECTIVE AGENTS; BACTERIAL PROTEINS; CELL CYCLE; CIPROFLOXACIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MEMBRANE PROTEINS; MICROBIAL SENSITIVITY TESTS; PLASMIDS; REPRESSOR PROTEINS; SUPPRESSION, GENETIC;

EID: 0030266974     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.178.19.5568-5572.1996     Document Type: Article

References (27)

1. Blanco, M., G. Herrtra, and V. Alelxandre. 1986. Different efficiency of UmuDC und MuoAB proteins in UV light induced mutagenesis in Escherichia coli. Mol. Gen. Genet. 205:234-239.
2. Brown, A. M. C., and N. S. Wllletts. 1981. A physical and genetic map of the IncN plasmid R46. Plasmid 5:188-201.
3. Clark, D. J., and O. Maaløe. 1967. DNA replication and the division cycle of Escherichia coli. J. Mol. Biol. 23:99-112.
4. Clerch, B., J. Barbé, and M. Liagostera. 1992. The rule of the excision and emir-prone repair systems in mutagenesis by fluorinated quinolones in Salnumellu ryphimiirium. Mutation Res. 281:207-213.
5. Crumplin, G. C., M. Kenwright, and T. Hirst. 1984. Investigations into the mechanism of action of the antibacterial agent norfloxacin. J. Antimicrob. Chemother. 13(Suppl. 8):9-23.
6. Davey, P., M. Barza, and M. Stuart. 1988. Tolerunce of Pseudomonas aeruginosa to killing by ciprofloxacin, gentamicin, and imipenem in vitro and in vivo. J. Antimicroh. Chemother. 21:395-404.
7. Evans, D. J., D. G. Alliscn, M. R. W. Brown, and P. Gilbert. 1991. Susceptibility of Pseudomonus aeruginosa and Eschrichia cali biofilms towards ciprofloxacin: effect of specific growth rate, J. Antimicrob. Chemother. 27:177-184.
8. Hull, K. M. 1985. Identification and mapping of regions of the plasmid pKMIOl which influence the growth rate and resistance to phleomycin F. of Encherichia coli WP2. J. Bacteriol. 163:1142-1146.
9. Hooper, D. C., and J. S. Wolfson. 1993. Mechanisms of quinolone action and bacterial killing, p. 53-75. In D. C Hooper and J. S. Wolfson (ed.), Quinolone untimicrobial agents. American Society for Microbiology, Washington, D.C.
10. Hooper, D. C., and J. S. Wolfson. 1993. Mechanisms of bacterial resistance to quinolones, p. 97-118. In D. C. Hooper and J. S. Wolfson (ed.), Ouinolone antimicrobial agents. American Society fur Microbiology, Washington, D.C.
11. Langer, P. J., W. G. Shanabruch, and G. C. Walker. 1981. Functional organization of plasmid pKM101. J. Bacteriol. 145:1310-1316.
12. Langer, P. J., and G. C. Walker. 1981. Restriction endonuclease cleavage map of pKM101: relationship to parental plasmid R46. Mol. Gen. Genet. 182:268-272.
13. Lewin, C. S., I. Morrissey, and J. T. Smith. 1991. The fluoroquinolones exert a reduced rate of kill against Entemcoccus faecalis. J. Pharm. Pharmacol. 43:492-494.
14. Lewin, C. S., and J. T. Smith. 1988. Bactericidal mechanisms of ofloxacin. J. Antimicrob, Chcmother. 22(Suppl. C):1-8.
15. Maxwell, A. 1992. The molecular basis of quinolone action. J. Antimicrob. Chemother. 30:409-416.
16. McCann, J., N. E. Spingarn, J. Koborl, and B. N. Ames. 1975. Detection of carcinogens us mutagens: bacterial tester strains with R factor plasmids. Proc. Natl. Acad, Sci. USA 72:979-983.
17. Mortelmans, K. E., and B. A. D. Stocker. 1979. Segregation of the mutator property of plasmid R46 from its ultraviolet-protecting property. Mol. Gen. Genet. 167:317-328.
18. Perry, K. L., S. J. Elledge, B. B. Mitchell, L. Marsh, and G. C. Walker. 1985. umuDC and mucAB operons whose products are required for UV light- and chemical-induced mulagenesis: UmuD. MucA. and LexA proteins share homology. Proc. Natl. Acud. Sci. USA 82:4131-4135.
19. Pohlman, R. F., H. D. Genettl, and S. C. Winans. 1994. Common ancestry between IncN conjugal transfer genes and macromulecular export systems of plant and animal pathogens. Mol. Microbiol. 14:655-668.
20. Ratcilffe, N. T., and J. T. Smith. 1985. Norfloxacin has a novel bactericidal mechanism unrelated to that of other 4-quinolones. J. Pharm Pharmacol. 37(Suppl.):92P.
21. Sumbraok, J., E. F. Fritsch, and T. Maniutls. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory. Cold Spring Harbor. N.Y.
22. Waleh, N. S., and B. A. D. Stocker. 1981. Some group N plusmids make Escluirichiu call K-12 strain AB1157 dependent on exogenous purine. Curr. Microbiol, 6:337-341.
23. Winans, S. C. and G. C. Walker. 1985. Conjugal transfer system of the IncN plasmid pKM101. J. Bacteriol. 161:402-410.
24. Winans, S. C., and G. C. Walker. 1985. Identification of pKM101-encoded loci specifying potentially lethal gene products. J. Bacteriol. 161:417-424.
25. Ysern, P., B. Clerch, M. Castaflo, I. Glbert, J. Barbé, and M. Llagostera. 1991). Induction of SOS genes in Esclicrichin coli and mutagenesis in Salmonella typhimurium by rluoroquinolones. Mutagenesis 5:63-66.
26. Zeiler, H. J. 1985. Evaluation of the In vitro bactericidal action of ciprofloxacin on cells of Escherichia coli in the logarithmic and stationary phases of growth. Antimicroh, Agents Chemolher. 28:524-527.
27. Zeiler, H. J., and K. Grohe. 1984. The in vitro and in vivo activity of ciprofloxacin. Eur. J. Gin. Microbiol. 3:339-343.