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Volumn 14, Issue 14, 1996, Pages 1366-1374

Safety, efficacy, and immunogenicity of a recombinant Osp subunit canine Lyme disease vaccine

Author keywords

Borrelia burgdorferi; Osp canine Lyme disease vaccine efficacy; Tick challenge

Indexed keywords

LYME DISEASE VACCINE; RECOMBINANT VACCINE; UNCLASSIFIED DRUG;

EID: 0030266962     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(96)00045-X     Document Type: Article
Times cited : (18)

References (61)
  • 1
    • 0024362494 scopus 로고
    • Lyme disease
    • Steere, A.C. Lyme disease. N. Engl. J. Med. 1989, 321, 586-596
    • (1989) N. Engl. J. Med. , vol.321 , pp. 586-596
    • Steere, A.C.1
  • 2
    • 0026722008 scopus 로고
    • Delineation of Borrelia burgdorferi sensu stricto, Borrelia garinii sp. nov., and group VS461 associated with Lyme borreliosis
    • Baranton, G., Postic, D., Saint Girons, I. et al. Delineation of Borrelia burgdorferi sensu stricto, Borrelia garinii sp. nov., and group VS461 associated with Lyme borreliosis. Int. J. Sys. Bacteriol. 1992, 42, 378-383
    • (1992) Int. J. Sys. Bacteriol. , vol.42 , pp. 378-383
    • Baranton, G.1    Postic, D.2    Saint Girons, I.3
  • 4
    • 0027170535 scopus 로고
    • Monoclonal antibodies for identification of Borrelia afzellii sp. nov. associated with cutaneous manifestations of Lyme borreliosis
    • Canica, MM, Nato, F., du Merle, L., Mazie, J.C., Baranton, G. and Postic, D. Monoclonal antibodies for identification of Borrelia afzellii sp. nov. associated with cutaneous manifestations of Lyme borreliosis. Scand. J. Infect. Dis. 1993, 25, 441-448
    • (1993) Scand. J. Infect. Dis. , vol.25 , pp. 441-448
    • Canica, M.M.1    Nato, F.2    Du Merle, L.3    Mazie, J.C.4    Baranton, G.5    Postic, D.6
  • 5
    • 0023134510 scopus 로고
    • Reservoir competence of white-footed mice for Lyme disease spirochetes
    • Donahue, J.G., Piesman, J. and Spielman, A. Reservoir competence of white-footed mice for Lyme disease spirochetes. Am. J. Trop. Med. Hyg. 1987, 36, 92-96
    • (1987) Am. J. Trop. Med. Hyg. , vol.36 , pp. 92-96
    • Donahue, J.G.1    Piesman, J.2    Spielman, A.3
  • 6
    • 0024320231 scopus 로고
    • Comparing the relative potential of rodents as reservoir of the Lyme disease spirochete (Borrelia burgdorferi)
    • Mather, T.N., Wilson, M.L., Moore, S.I., Ribeiro, J.M. and Spielman, A. Comparing the relative potential of rodents as reservoir of the Lyme disease spirochete (Borrelia burgdorferi). Am. J. Epidemiol. 1989, 130, 143-150
    • (1989) Am. J. Epidemiol. , vol.130 , pp. 143-150
    • Mather, T.N.1    Wilson, M.L.2    Moore, S.I.3    Ribeiro, J.M.4    Spielman, A.5
  • 7
    • 0025169767 scopus 로고
    • Borrelia burgdorferi and Babesia microtr. efficiency of transmission from reservoirs to vector ticks (Ixodes dammini)
    • Mather, T.N., Telford, S.R.III, Moore, S.I. and Spielman, A. Borrelia burgdorferi and Babesia microtr. efficiency of transmission from reservoirs to vector ticks (Ixodes dammini). Exp. Parasitol. 1990, 70, 55-61
    • (1990) Exp. Parasitol. , vol.70 , pp. 55-61
    • Mather, T.N.1    Telford III, S.R.2    Moore, S.I.3    Spielman, A.4
  • 9
    • 0022727129 scopus 로고
    • Natural exposure of Wisconsin dogs to the Lyme disease spirochete (Borrelia burgdorferi)
    • Burgess, E.C. Natural exposure of Wisconsin dogs to the Lyme disease spirochete (Borrelia burgdorferi). Lab. Anim. Sci. 1986, 36, 288-290
    • (1986) Lab. Anim. Sci. , vol.36 , pp. 288-290
    • Burgess, E.C.1
  • 11
    • 0024676564 scopus 로고
    • Lyme borreliosis in domestic animals
    • Levy, S.A. Lyme borreliosis in domestic animals. Conn. Med. 1989, 53, 352-353
    • (1989) Conn. Med. , vol.53 , pp. 352-353
    • Levy, S.A.1
  • 13
    • 0024743490 scopus 로고
    • Rheumatoid arthritis subsequent to Borrelia burgdorferi infection in two dogs
    • Roush, J.K., Manley, D.A. and Dueland, R.T. Rheumatoid arthritis subsequent to Borrelia burgdorferi infection in two dogs. J. Am. Vet. Med. Assoc. 1989, 195, 951-953
    • (1989) J. Am. Vet. Med. Assoc. , vol.195 , pp. 951-953
    • Roush, J.K.1    Manley, D.A.2    Dueland, R.T.3
  • 14
    • 0027270765 scopus 로고
    • The distribution of canine exposure to Borrelia burgdorferi in a Lyme-disease endemic area
    • Falco, R.C., Smith, H.A., Fish, D. et al. The distribution of canine exposure to Borrelia burgdorferi in a Lyme-disease endemic area. Am. J. Publ. Hlth 1993, 83, 1305-1310
    • (1993) Am. J. Publ. Hlth , vol.83 , pp. 1305-1310
    • Falco, R.C.1    Smith, H.A.2    Fish, D.3
  • 16
    • 0025242171 scopus 로고
    • Amoxicillin plus probenecid versus deoxycycline for the treatment of erythema migrans borreliosis
    • Dattwyler, R.J., Volkman, D.J., Conaty, S.M., Platkin, S.P. and Luft, B.J. Amoxicillin plus probenecid versus deoxycycline for the treatment of erythema migrans borreliosis. Lancet 1990, 336, 1404-1406
    • (1990) Lancet , vol.336 , pp. 1404-1406
    • Dattwyler, R.J.1    Volkman, D.J.2    Conaty, S.M.3    Platkin, S.P.4    Luft, B.J.5
  • 17
    • 0022443553 scopus 로고
    • Treating erythema chronicum migrans of Lyme disease. J
    • Berger, B.W. Treating erythema chronicum migrans of Lyme disease. J. Am. Acad. Dermat. 1986, 15, 459-463
    • (1986) Am. Acad. Dermat. , vol.15 , pp. 459-463
    • Berger, B.W.1
  • 18
    • 0023731994 scopus 로고
    • Cultivation of Borrelia burgdorferi from joint fluid three months after treatment of facial palsy due to Lyme borreliosis
    • Schmidli, J., Hunziker, T, Moesli, P. and Schaad, U.B. Cultivation of Borrelia burgdorferi from joint fluid three months after treatment of facial palsy due to Lyme borreliosis. J. Infect. Dis. 1988, 158, 905-906
    • (1988) J. Infect. Dis. , vol.158 , pp. 905-906
    • Schmidli, J.1    Hunziker, T.2    Moesli, P.3    Schaad, U.B.4
  • 19
    • 0022479177 scopus 로고
    • Passive immunization of hamsters against experimental infection with Borrelia burgdorferi
    • Johnson, R.C., Kodner, C. and Russell, M. Passive immunization of hamsters against experimental infection with Borrelia burgdorferi. Infect. Immun. 1986, 53, 713-714
    • (1986) Infect. Immun. , vol.53 , pp. 713-714
    • Johnson, R.C.1    Kodner, C.2    Russell, M.3
  • 20
    • 0023025241 scopus 로고
    • Active immunization of hamsters against experimental infection with Borrelia burgdorferi
    • Johnson, R.C., Kodner, C. and Russell, M. Active immunization of hamsters against experimental infection with Borrelia burgdorferi. Infect. Immun. 1986, 54, 897-898
    • (1986) Infect. Immun. , vol.54 , pp. 897-898
    • Johnson, R.C.1    Kodner, C.2    Russell, M.3
  • 21
    • 0026017527 scopus 로고
    • A mouse model for Borrelia burgdorferi infection: Approach to a vaccine against Lyme disease
    • Simon, M.M., Schaible, U.E., Wallich, R. and Kramer, M.D. A mouse model for Borrelia burgdorferi infection: approach to a vaccine against Lyme disease. Immun. Today 1991, 12, 11-16
    • (1991) Immun. Today , vol.12 , pp. 11-16
    • Simon, M.M.1    Schaible, U.E.2    Wallich, R.3    Kramer, M.D.4
  • 22
    • 0026073406 scopus 로고
    • Lyme borreliosis: Host responses to Borrelia burgdorferi
    • Szczepanski, A. and Benach, J.L. Lyme borreliosis: host responses to Borrelia burgdorferi. Microbiol. Rev. 1991, 55, 21-34
    • (1991) Microbiol. Rev. , vol.55 , pp. 21-34
    • Szczepanski, A.1    Benach, J.L.2
  • 23
    • 0024421344 scopus 로고
    • Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochete Borrelia burgdorferi
    • Bergström, S., Bundoc, V.G. and Barbour, A.G. Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochete Borrelia burgdorferi. Mol. Microbiol. 1989, 3, 479-486
    • (1989) Mol. Microbiol. , vol.3 , pp. 479-486
    • Bergström, S.1    Bundoc, V.G.2    Barbour, A.G.3
  • 24
    • 0025202254 scopus 로고
    • Protection of mice against the Lyme disease agent by immunizing with recombinant OspA
    • Fikrig, E., Barthoid, S.W., Kantor, F.S. and Flavell, R.A. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science 1990, 250, 553-556
    • (1990) Science , vol.250 , pp. 553-556
    • Fikrig, E.1    Barthoid, S.W.2    Kantor, F.S.3    Flavell, R.A.4
  • 25
    • 0026321549 scopus 로고
    • Role of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice
    • Fikrig, E., Barthoid, S.W., Marcantonio, N., Deponie, K., Kantor, F.S. and Flavell, R.A. Role of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice. Infect. Immun. 1992, 60, 657-661
    • (1992) Infect. Immun. , vol.60 , pp. 657-661
    • Fikrig, E.1    Barthoid, S.W.2    Marcantonio, N.3    Deponie, K.4    Kantor, F.S.5    Flavell, R.A.6
  • 26
    • 0027535821 scopus 로고
    • Experimental Lyme disease in dogs produces arthritis and persistent infection
    • Appel, M.J., Allan, S., Jacobson, R.H. et al. Experimental Lyme disease in dogs produces arthritis and persistent infection. J. Infect. Dis. 1993, 167, 651-664
    • (1993) J. Infect. Dis. , vol.167 , pp. 651-664
    • Appel, M.J.1    Allan, S.2    Jacobson, R.H.3
  • 28
    • 0027200214 scopus 로고
    • Early and early disseminated phases of Lyme disease in the rhesus monkey: A model for infection in humans
    • Philipp, M.T., Aydintug, M.K., Bohm, R.P.Jr et al. Early and early disseminated phases of Lyme disease in the rhesus monkey: a model for infection in humans. Infect. Immun. 1993, 61, 3047-3059
    • (1993) Infect. Immun. , vol.61 , pp. 3047-3059
    • Philipp, M.T.1    Aydintug, M.K.2    Bohm Jr., R.P.3
  • 29
    • 0027102378 scopus 로고
    • Active immunization with pC protein of Borrelia burgdorferi protects gerbils against B. burgdorferi infection
    • Preac-Mursic, V., Wilske, B., Patsouris, E. et al. Active immunization with pC protein of Borrelia burgdorferi protects gerbils against B. burgdorferi infection. Infection 1992, 20, 342-349
    • (1992) Infection , vol.20 , pp. 342-349
    • Preac-Mursic, V.1    Wilske, B.2    Patsouris, E.3
  • 30
    • 0025333897 scopus 로고
    • Monoclonal antibodies specific for the outer surface protein a (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice
    • Schaible, U.E., Kramer, M.D., Eichman, K., Modolell, M., Museteanu, C. and Simon, M.M. Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proc. Natl. Acad. Sci. USA 1990, 8, 3768-3772
    • (1990) Proc. Natl. Acad. Sci. USA , vol.8 , pp. 3768-3772
    • Schaible, U.E.1    Kramer, M.D.2    Eichman, K.3    Modolell, M.4    Museteanu, C.5    Simon, M.M.6
  • 31
    • 0025856907 scopus 로고
    • Borreliacidal activity of sera from hamsters infected with the Lyme disease spirochete
    • Lovrich, S.D., Callister, S.M., Schmitz, J.L., Alder, D.J. and Schell, R.F. Borreliacidal activity of sera from hamsters infected with the Lyme disease spirochete. Infect. Immun. 1991, 59, 2522-2528
    • (1991) Infect. Immun. , vol.59 , pp. 2522-2528
    • Lovrich, S.D.1    Callister, S.M.2    Schmitz, J.L.3    Alder, D.J.4    Schell, R.F.5
  • 32
    • 0027447095 scopus 로고
    • A simple, colorimetric microtiter assay for borreliacidal activity of antisera
    • Ma, J. and Coughlin, R.T. A simple, colorimetric microtiter assay for borreliacidal activity of antisera. J. Microbiol. Meth. 1992, 17, 145-153
    • (1992) J. Microbiol. Meth. , vol.17 , pp. 145-153
    • Ma, J.1    Coughlin, R.T.2
  • 33
    • 0025976063 scopus 로고
    • Antiborrelial activity of serum from rats injected with the Lyme disease spirochete
    • Pavia, C.S., Kissel, V., Bittker, S., Cabello, F. and Levine, S. Antiborrelial activity of serum from rats injected with the Lyme disease spirochete. J. Infect. Dis. 1991, 163, 656-659
    • (1991) J. Infect. Dis. , vol.163 , pp. 656-659
    • Pavia, C.S.1    Kissel, V.2    Bittker, S.3    Cabello, F.4    Levine, S.5
  • 34
    • 0027509237 scopus 로고
    • In vitro inhibition of Borrelia burgdorferi growth by antibodies
    • Šadziene, A., Thompson, P.A. and Barbour, A.G. In vitro inhibition of Borrelia burgdorferi growth by antibodies. J. Infect. Dis. 1992, 167, 165-172
    • (1992) J. Infect. Dis. , vol.167 , pp. 165-172
    • Šadziene, A.1    Thompson, P.A.2    Barbour, A.G.3
  • 35
    • 0028144436 scopus 로고
    • Ability of canine Lyme disease vaccine to protect hamsters against infection with several isolates of Borrelia burgdorferi
    • Jobe, D.A., Callister, S.M., Lim, L.C.L., Lovrich, S.D. and Schell, R.F. Ability of canine Lyme disease vaccine to protect hamsters against infection with several isolates of Borrelia burgdorferi. J. Clin. Microbiol. 1994, 32, 618-622
    • (1994) J. Clin. Microbiol. , vol.32 , pp. 618-622
    • Jobe, D.A.1    Callister, S.M.2    Lim, L.C.L.3    Lovrich, S.D.4    Schell, R.F.5
  • 37
    • 0028943532 scopus 로고
    • Characterization of canine humoral immune responses to outer surface protein subunit vaccines and to natural infection by Lyme disease spirochetes
    • Ma, J., Bulger, P.A., Dante, S., Davis, D.v.R., Perilli-Palmer, B. and Coughlin, R.T. Characterization of canine humoral immune responses to outer surface protein subunit vaccines and to natural infection by Lyme disease spirochetes. J. Infect. Dis. 1995, 171, 909-915
    • (1995) J. Infect. Dis. , vol.171 , pp. 909-915
    • Ma, J.1    Bulger, P.A.2    Dante, S.3    Davis, D.V.R.4    Perilli-Palmer, B.5    Coughlin, R.T.6
  • 38
    • 0026033441 scopus 로고
    • Separation and characterization of saponins with adjuvant activity from Quillaja saponaria molina cortex
    • Kensil, C.R., Patel, U., Lennick, M. and Marciani, D.J. Separation and characterization of saponins with adjuvant activity from Quillaja saponaria molina cortex. J. Immun. 1990, 146, 431-437
    • (1990) J. Immun. , vol.146 , pp. 431-437
    • Kensil, C.R.1    Patel, U.2    Lennick, M.3    Marciani, D.J.4
  • 39
    • 0028102556 scopus 로고
    • Impact of the saponin adjuvant QS-21 and aluminum hydroxide on the immunogenicity of recombinant OspA and OspB of Borrelia burgdorferi
    • Ma, J., Bulger, P.A., Davis, D.v.R. et al. Impact of the saponin adjuvant QS-21 and aluminum hydroxide on the immunogenicity of recombinant OspA and OspB of Borrelia burgdorferi. Vaccine 1994, 12, 925-932
    • (1994) Vaccine , vol.12 , pp. 925-932
    • Ma, J.1    Bulger, P.A.2    Davis, D.V.R.3
  • 40
    • 0027523763 scopus 로고
    • Role of attached lipid on immunogenicity of Borrelia burgdorferi OspA
    • Erdile, L.F., Brandt, M.-A., Warskomski, D.J. et al. Role of attached lipid on immunogenicity of Borrelia burgdorferi OspA. Infect. Immun. 1993, 61, 81-90
    • (1993) Infect. Immun. , vol.61 , pp. 81-90
    • Erdile, L.F.1    Brandt, M.-A.2    Warskomski, D.J.3
  • 41
    • 0027327158 scopus 로고
    • Borrelia burgdorferi outer surface lipoproteins OspA and OspB possess B cell mitogenic and cytokine-stimulatory properties
    • Ma, Y. and Weis, J.J. Borrelia burgdorferi outer surface lipoproteins OspA and OspB possess B cell mitogenic and cytokine-stimulatory properties. Infect. Immun. 1993, 61, 3843-3853
    • (1993) Infect. Immun. , vol.61 , pp. 3843-3853
    • Ma, Y.1    Weis, J.J.2
  • 42
    • 0027248955 scopus 로고
    • Approaches to augmenting the IgG antibody response to melanoma ganglioside vaccines
    • Livingston, P.O. Approaches to augmenting the IgG antibody response to melanoma ganglioside vaccines. Ann. NY Acad. Sci. 1993, 690, 204-213
    • (1993) Ann. NY Acad. Sci. , vol.690 , pp. 204-213
    • Livingston, P.O.1
  • 44
    • 0026021796 scopus 로고
    • Genetically engineered subunit vaccine against feline leukaemia virus: Protective immune response in cats
    • Marciani, D.J., Kensil, C.R., Beltz, G.A., Hung, C.-H., Cronier, J. and Aubert, A. Genetically engineered subunit vaccine against feline leukaemia virus: protective immune response in cats. Vaccine 1991, 9, 89-96
    • (1991) Vaccine , vol.9 , pp. 89-96
    • Marciani, D.J.1    Kensil, C.R.2    Beltz, G.A.3    Hung, C.-H.4    Cronier, J.5    Aubert, A.6
  • 45
    • 0028936053 scopus 로고
    • Protection of dogs from Lyme disease with a vaccine containing outer surface protein (Osp) A, OspB, and the saponin adjuvant QS21
    • Coughlin, R.T., Fish, D., Mather, T.N., Ma, J., Pavia, C. and Bulger, P. Protection of dogs from Lyme disease with a vaccine containing outer surface protein (Osp) A, OspB, and the saponin adjuvant QS21. J. Infect. Dis. 1995, 171, 1049-1052
    • (1995) J. Infect. Dis. , vol.171 , pp. 1049-1052
    • Coughlin, R.T.1    Fish, D.2    Mather, T.N.3    Ma, J.4    Pavia, C.5    Bulger, P.6
  • 46
    • 0029008138 scopus 로고
    • Molecular analysis of neutralizing epitopes on outer surface proteins A and B of Borrelia burgdorferi
    • Ma, J., Gingrich-Baker, C., Franchi, P.M., Bulger, P.A. and Coughlin, R.T. Molecular analysis of neutralizing epitopes on outer surface proteins A and B of Borrelia burgdorferi. Infect. Immun. 1995, 63, 2221-2227
    • (1995) Infect. Immun. , vol.63 , pp. 2221-2227
    • Ma, J.1    Gingrich-Baker, C.2    Franchi, P.M.3    Bulger, P.A.4    Coughlin, R.T.5
  • 47
    • 0025327547 scopus 로고
    • Indirect enzyme-linked immunosorbent assay for detection of antibody to a 110-kilodalton hemolysin of Actinobacillus pleuropneumoniae
    • Ma, J. and Inzana, T.J. Indirect enzyme-linked immunosorbent assay for detection of antibody to a 110-kilodalton hemolysin of Actinobacillus pleuropneumoniae. J. Clin. Microbiol. 1990, 28, 1356-1361
    • (1990) J. Clin. Microbiol. , vol.28 , pp. 1356-1361
    • Ma, J.1    Inzana, T.J.2
  • 48
    • 0025977648 scopus 로고
    • Antibody to a 39-kilodalton Borrelia burgdorferi antigen (p39) as a marker for infection in experimentally and naturally inoculated animals
    • Simpson, W.J., Burgdorferi, W., Schrumpf, M.E. et al. Antibody to a 39-kilodalton Borrelia burgdorferi antigen (p39) as a marker for infection in experimentally and naturally inoculated animals. J. Clin. Microbiol. 1991, 29, 236-243
    • (1991) J. Clin. Microbiol. , vol.29 , pp. 236-243
    • Simpson, W.J.1    Burgdorferi, W.2    Schrumpf, M.E.3
  • 49
    • 0028871270 scopus 로고
    • Serological responses of dogs naturally exposed to or vaccinated against Borrelia burgdorferi infection
    • Barthold, S.W., Levy, S.A., Fikrig, E., Bochenstedt, L.K. and Smith, A.L. Serological responses of dogs naturally exposed to or vaccinated against Borrelia burgdorferi infection. J. Am. Vet. Med. Assoc. 1995, 207, 1435-1440
    • (1995) J. Am. Vet. Med. Assoc. , vol.207 , pp. 1435-1440
    • Barthold, S.W.1    Levy, S.A.2    Fikrig, E.3    Bochenstedt, L.K.4    Smith, A.L.5
  • 50
    • 0027288183 scopus 로고
    • Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi
    • Kalish, R.A., Leong, J.M. and Steere, A.C. Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi. Infect. Immun. 1993, 61, 2774-2779
    • (1993) Infect. Immun. , vol.61 , pp. 2774-2779
    • Kalish, R.A.1    Leong, J.M.2    Steere, A.C.3
  • 51
    • 0029024957 scopus 로고
    • Early and late antibody responses to full-length and truncated constructs of outer surface proteins A of Borrelia burgdorferi in Lyme disease
    • Kalish, R.A., Leong, J.M. and Steere, A.C. Early and late antibody responses to full-length and truncated constructs of outer surface proteins A of Borrelia burgdorferi in Lyme disease. Infect. Immun. 1995, 63, 2228-2235
    • (1995) Infect. Immun. , vol.63 , pp. 2228-2235
    • Kalish, R.A.1    Leong, J.M.2    Steere, A.C.3
  • 52
    • 0028334621 scopus 로고
    • Development of destructive arthritis in vaccinated hamsters challenged with Borrelia burgdorferi
    • Lim, L.C.L., England, D.M., DuChateau, B.K. et al. Development of destructive arthritis in vaccinated hamsters challenged with Borrelia burgdorferi. Infect. Immun. 1994, 62, 2825-2833
    • (1994) Infect. Immun. , vol.62 , pp. 2825-2833
    • Lim, L.C.L.1    England, D.M.2    DuChateau, B.K.3
  • 53
    • 0028916091 scopus 로고
    • Borrelia burgdorferi-specific T lymphocytes induce severe destructive Lyme arthritis
    • Lim, L.C.L., England, D.M., DuChateau, B.K., Glowacki, N.J. and Schell, R.F. Borrelia burgdorferi-specific T lymphocytes induce severe destructive Lyme arthritis. Infect. Immun. 1995, 63, 1400-1408
    • (1995) Infect. Immun. , vol.63 , pp. 1400-1408
    • Lim, L.C.L.1    England, D.M.2    DuChateau, B.K.3    Glowacki, N.J.4    Schell, R.F.5
  • 55
    • 0023832955 scopus 로고
    • Immunoblot analysis of immunoglobulin G response to the Lyme disease agent (Borrelia burgdorferi) in experimentally and naturally exposed dogs
    • Greene, R.T., Walker, R.J., Nicholson, W.L. et al. Immunoblot analysis of immunoglobulin G response to the Lyme disease agent (Borrelia burgdorferi) in experimentally and naturally exposed dogs. J. Clin. Microbiol. 1988, 26, 648-653
    • (1988) J. Clin. Microbiol. , vol.26 , pp. 648-653
    • Greene, R.T.1    Walker, R.J.2    Nicholson, W.L.3
  • 56
    • 0028926240 scopus 로고
    • Induction of an outer surface protein on Borrelia burgdorferi during tick feeding
    • Schwan, T.G., Piesman, J., Golde, W.T., Dolan, M.C. and Rosa, P.A. Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc. Natl. Acad. Sci. USA 1995, 92, 2909-2913
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 2909-2913
    • Schwan, T.G.1    Piesman, J.2    Golde, W.T.3    Dolan, M.C.4    Rosa, P.A.5
  • 57
    • 0028906773 scopus 로고
    • Selection of variant Borrelia burgdorferi isolates from mice immunized with outer surface protein a or B
    • Unpublished observation-Fikrig, E., Tao, H., Barthold, S.W. and Flavell, R.A.
    • Ma, J., Herrig, B. and Salsbury, D.L. Unpublished observation-Fikrig, E., Tao, H., Barthold, S.W. and Flavell, R.A. Selection of variant Borrelia burgdorferi isolates from mice immunized with outer surface protein A or B. Infect. Immun. 1995, 63, 1658-1662
    • (1995) Infect. Immun. , vol.63 , pp. 1658-1662
    • Ma, J.1    Herrig, B.2    Salsbury, D.L.3
  • 58
    • 84920231262 scopus 로고
    • Cross immunity among types of Borrelia burgdorferi
    • Vienecke, R., Neubert, U. and Volkenardt, M. Cross immunity among types of Borrelia burgdorferi. Lancet 1993, 342, 435
    • (1993) Lancet , vol.342 , pp. 435
    • Vienecke, R.1    Neubert, U.2    Volkenardt, M.3
  • 59
    • 0026721358 scopus 로고
    • Selection of an escape variant of Borrelia burgdorferi by use of bacteriacidal antibodies to OspB
    • Coleman, J.L., Rogers, R.C. and Benach, J.L Selection of an escape variant of Borrelia burgdorferi by use of bacteriacidal antibodies to OspB. Infect. Immun. 1992, 60, 3098-3104
    • (1992) Infect. Immun. , vol.60 , pp. 3098-3104
    • Coleman, J.L.1    Rogers, R.C.2    Benach, J.L.3
  • 60
    • 0026761405 scopus 로고
    • Antibody resistant mutants of Borrelia burgdorferi: In vitro selection and characterization
    • Šadziene, A., Rosa, P., Hogan, D. and Barbour, A.G. Antibody resistant mutants of Borrelia burgdorferi: in vitro selection and characterization. J. Exp. Med. 1992, 176, 799-809
    • (1992) J. Exp. Med. , vol.176 , pp. 799-809
    • Šadziene, A.1    Rosa, P.2    Hogan, D.3    Barbour, A.G.4
  • 61
    • 0026722173 scopus 로고
    • Lyme disease in California: A novel enzootic transmission cycle of Borrelia burgdorferi
    • Brown, R.N. and Lane, R.S. Lyme disease in California: a novel enzootic transmission cycle of Borrelia burgdorferi. Science 1992, 256, 1439-1442
    • (1992) Science , vol.256 , pp. 1439-1442
    • Brown, R.N.1    Lane, R.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.