Chromosome translocations measured by fluorescence in-situ hybridization: A promising biomarker

ASTM Special Technical Publication

Volumn 1306, Issue , 1996, Pages 109-116

  Lucas, Joe N ^a   Straume, Tore ^a  

^a LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

Chromosome; FISH; Persistence; Radiation; Translocation

Indexed keywords

BIOMARKERS; DOSIMETRY; FLUORESCENCE; HEALTH RISKS; RADIATION EFFECTS; RISK ASSESSMENT;

CHROMOSOME TRANSLOCATIONS; FLUORESCENCE IN SITU HYBRIDIZATION (FISH);

CHROMOSOMES;

EID: 0030265061     PISSN: 00660558     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1520/stp11702s     Document Type: Article

References (18)

1. Bauchinger, M., Schmid, E., Zitzelsberger, H., Braselmann, H., and Nahrstedt, U., 1993, "Radiation-induced chromosome aberrations analysed by two-color fluorescence in situ hybridization with composite whole chromosome-specific DNA probes and a pancentromeric DNA probe", International Journal of Radiation Biology, 64, pp. 179-184
2. Bender, M. A., Awa, A. A., Brooks, A. L., Evans, H. J., Groer, P. G., Littlefield, L. G., Pereira, C., Preston, R. J., and Wackholtz, B. W., 1988, "Current status of cytogenetic procedures to detect and quantify previous exposures to radiation", Mutation Research, 196, pp. 103-159
3. Brewen, J. G., and Gengozian, N., 1971, "Radiation-induced human chromosome aberrations. II. Human in vitro irradiation compared to in vitro and in vivo irradiation of marmoset leukocytes", Mutation Research, 13, pp. 383-391
4. Evans, H. C., Buckton, K. E., Hamilton, G. E., Carothers, A., 1979, "Radiation-induced chromosome aberrations in nuclear-dockyard workers", Nature, 277, pp. 531-534
5. Hardy, K. A., 1991, "Dosimetry methods used in the studies of the effects of protons on primates: a review", Radiation Research, 126, pp. 120-126
6. Littlefield, L.G., Sayer, A. M., Colyer, S., Joiner, E.E., Outlaw, J., and Dry, L., 1984, "Persistent radiation-induced chromosome lesions in lymphocytes of the Y-12 accident survivors: Evaluation 25 years post-exposure", Mamilian Chromosome Newsletter, 25, p. 18
7. Lucas, J. N., Awa, A., Straume, T., Poggensee, M., Kodama, Y., Nakano, M., Ohtaki, K., Weier, U., Pinkel, D., Gray, J., and Littlefield, G., 1992a, "Rapid translocation frequency analysis in humans decades after exposure to ionizing radiation", International Journal of Radiation Biology, 62, pp. 53-63
8. 60Co gamma rays", Health Physics, 63, pp. 761-765
9. Lucas, J. N., Poggensee, M., Straume, T., 1992b, "The persistence of chromosome translocations in a radiation worker accidentally exposed to tritium", Cytogenetics and Cell Genetics, 60, pp. 255-256
10. Lucas, J. N., Swansbury, G., Clutterbuck, R., Hill, F., Burk, C., and Straume, T., 1994, "Discrimination between leukemia- and non-lekemia-induced chromosomal abnormalities in the patient's lymphocytes", International Journal of Radiation Biology, 66, pp. 135-189
11. Lucas, J. N., Hill, F. S., Burk, C. E., Cox, A. B., Straume, T., 1996, "Stability of translocation frequency following whole-body irradiation measured in rhesus monkeys", International Journal of Radiation Biology, (in press)
12. Nakano, M., Nakashima, E., Pawel, D.J., Kodama, Y., and Awa, A., 1993, "Frequency of reciprocal translocations and dicentrics induced in human blood lymphocytes by X-irradiation and determined by fluorescence in situ hybridization", International Journal of Radiation Biology, 64, pp. 565-569
13. National Research Council, 1995, Radiation Dose Reconstruction for Epidemiologic Uses. US National Academy of Sciences Press, Washington, DC., pp. 52-54
14. Pinkel, D., Straume, T., and Gray, J. W., 1986, "Cytogenetic analysis using quantitative, high sensitivity, fluorescence hybridization", Proceedings of the National Academy of Sciences (USA), 33, pp. 2934-2938
15. Salassidis, K., Georgiadou-Schumacher, G., Braselmann, H., Muller, P., Peter, R.U., Bauchinger, M., 1995, "Chromosome painting in highly irradiated Chernobyl victims: a follow-up study to evaluate the stability of symmetrical translocations and the influence of clonal aberrations for retrospective dose estimation", International Journal of Radiation Biology, 68, pp. 257-262
16. Straume, T. and Lucas, J. N., 1993, "A comparison of the yields of translocations and dicentrics measured using fluorescence in situ hybridization", International Journal of Radiation Biology, 64, pp.185-187
17. Straume, T. and Lucas, J. N., 1995, "Validation studies for monitoring of workers using molecular cytogenetics", Biomarkers in Occupational Health: Progress and Perspectives (M. L. Mendelsohn, J.P. Peeters, and M.J. Normandt, Eds.), Joseph Henry Press, Washington DC, pp. 174-193
18. Straume, T., Lucas, J. N., Tucker, J. D., Bigbee, W. L., and Langlois, R. G., 1992, "Biodosimetry for a radiation worker using multiple assays", Health Physics, 62, pp. 122-130