Liquid-liquid equilibrium of the acetonitrile-water system for protein purification

Separations Technology

Volumn 6, Issue 4, 1996, Pages 261-264

  Pence, David N ^a   Gu, Tingyue ^a  

^a Ohio University   (United States)

Author keywords

Acetonitrile; Equilibrium; Protein; Purification; Water

Indexed keywords

ACETONITRILE; ATMOSPHERIC PRESSURE; BINARY MIXTURES; GAS CHROMATOGRAPHY; PHASE COMPOSITION; PROTEINS; PURIFICATION; TEMPERATURE; WATER;

CLOUD POINT METHOD; LEVER RULE; LIQUID LIQUID EQUILIBRIUM; PHASE ENVELOPE; PHASE VOLUMES; ULTRAFILTRATION CARTRIDGE SYSTEM;

PHASE EQUILIBRIA;

EID: 0030263277     PISSN: 09569618     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0956-9618(96)00161-0     Document Type: Article

References (6)

1. Ou, T., Gu, Y., Zheng, Y., Wielh, P.E. and Kopchick, J.J. (1994) Phase separation of acetonitrile-water mixture in protein purification. Sep. Technol. 4, 258.
2. Francis, A.W. (1963) Liquid-Liquid Equilibria. New York: Interscience Publishers, pp. 44-45.
3. Hurth, M. and Woerman, D. (1987) Deuterium isotope effects in binary critical mixtures study of the systems methanol/isooctane and acetonitrile/water. Ber Busenges Phys. Chem. 91, 614.
4. Walas, S. (1985) Phase Equilibria in Chemical Engineering. Stoneham, MA: Butterworth Publishers, pp. 201-205.
5. DiCave, S. and Mazzarotta, B. (1991) Liquid-Liquid equilibria for ternary systems formed by acetonitrile, water, and aromatic hydrocarbons. J. Chem. Eng. Data 36, 298.
6. Riggs, J.B. (1988) An Introduction to Numerical Methods for Chemical Engineers. Lubbock, TX: Texas Tech. University Press, pp. 334-338