Identification of human antigenic epitopes in an alanine-rich repeating region using sera from hu-PBL-SCID mice immunized with a surface protein antigen of Streptococcus mutans

Oral Microbiology and Immunology

Volumn 11, Issue 5, 1996, Pages 343-349

  Senpuku, H ^a   Iizima, T ^a   Koga, T ^b   Nisizawa, T ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Antigenic epitope; Dental vaccine; Hu PBL SCID mice; Human peripheral blood mononuclear cell; Streptococcus mutans; Surface protein antigen

Indexed keywords

EID: 0030260752     PISSN: 09020055     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-302X.1996.tb00192.x     Document Type: Article

References (38)

1. Ackermans SF, Klein JP, Ogier JA, Bazin H, Cormont F, Franck RM. Purification and characterization of a saliva interacting cell wall protein from Streptococcus mutans serotype f by using monoclonal antibody immunoaffinity chromatography. Biochem J 1985: 228: 211-217.
2. Bosma GC, Custer RP, Bosma MJ A severe combined immunodeficiency mutation in the mouse. Nature 1983: 301: 527-530.
3. Bosma MJ, Caroll AM The SCID mouse mutant: definition, characterization and potential uses. Annu Rev Immunol 1991: 9: 323-328.
4. Brady LJ, Piacentini DA, Crowley PJ, Oyston PCF, Bleiweis AS. Differentiation of salivary agglutinin-mediated adherence and aggregation of mutans streptococci by use of monoclonal antibodies against the major surface adhesin P1. Infect Immun 1992: 60: 1008-1017.
5. Carlsson R, Martensson C, Kalliomaki S, Ohlin M, Borrebaeck CAK. Human peripheral blood lymphocytes transplanted into SCID mice constitute an in vivo culture system exhibiting several parameters found in a normal humoral immune response and are a source of immunocytes for the production of human monoclonal antibodies. J Immunol 1992: 148: 1065-1071.
6. Crowley PJ, Brady LJ, Piacentini DA, Beiweis AS. Identification of a salivary agglutinin-binding domain within cell surface adhesin P1 of Streptococcus mutons. Infect Immun 1993: 61: 1547-1552.
7. Demuth DR, Lammey MS, Huck M, Lally ET, Malamud D. Comparison of Streptococcus mutans and Streptococcus sanguis receptors for human salivary agglutinin. Microb Pathog 1990: 9: 199-211.
8. Duchosal MA, Eming SA, Fischer P et al. Immunization of hu-PBL-SCID mice and the rescue of human monoclonal Fab fragments through combinatorial libraries. Nature 1992: 355: 258-262.
9. Forester H, Hunter H, Knox KW. Characteristics of a high molecular weight extracellular protein of Streptococcus mutans. J Gen Microbiol 1983: 129: 2779-2788.
10. Fulop GM, Phillips RA. The SCID mutation in mice causes a general defect in DNA repair. Nature 1990: 347: 479-482.
11. Hajishengallis G, Koga T, Russell MW. Affinity and specificity of the interactions between Streptococcus mutans antison I/II and salivary component. J Dent Res 1994: 73: 1493-1502.
12. Hamada S, Slade HD. Biology, immunology, and canogenicity of Streptococcus mutans. Microbiol Rev 1980: 44: 331-384.
13. Ingvar C, Carlsson R, Borrebacck CAK. Induction of primary antigen-specific immune responses in SCID-Hu-PBL by coupled T-B epitopes. Immunology 1995: 84: 111-116.
14. Kelly CG, Todryk S, Kendal HL, Munro GH, Lehner T. T-cell. adhesion, and B-cell epitopes of the cell surface Streptococcus mutans protein antigen I/II. Infect Immun 1995: 63: 3649-3658.
15. Koga T, Okahashi N, Takahashi I, Kanamoto T, Asakawa H, Iwaki M. Surface hydrophobicity, adherence, and aggregation of cell surface protein antigen mutants of Streptococcus mutans serotype c. Infect Immun 1990: 58: 289-296.
16. Lee SE, Progulske-Fox A, Erdos GW et al. Construction and characterization of isogenic mutants of Streptococcus mutants deficient in major surface protein antigen Pl (II/I). Infect Immun 1989: 57: 3306-3313.
17. Lehner T, Russell MW, Caldwell J. Immunisation with a purified protein from Streptococcus mutans against dental caries in rhesus monkeys. Lancet 1980: i: 995-996.
18. Lehner T, Russell MW, Caldwell J, Smith R. Immunization with purified protein antigens from Streptococcus mutans against dental caries in rhesus monkeys. Infect Immun 1981: 34: 407-415.
19. Lehner T, Caldwell I, Smith R. Local passive immunization by monoclonal antibodies against streptococcal antigen I/II in the prevention of dental caries. Infect Immun 1985: 50: 796-799.
20. Ma JK-C, Smith R, Lehner T. Use of monoclonal antibodies in local passive immunization to prevent colonization of human teeth by Streptococcus mutans. Infect Immun 1987: 55: 1274-1278.
21. Markham PB, Donnenberg AD. Effect of donor and recipient immunization protocols on primary and secondary human antibody response in SCID mice reconstituted with human peripheral blood monoclonal cells. Infect Immun 1992: 60: 2305-2308.
22. Matsushita K, Nisizawa T, Nagaoka S, Kawagoe M, Koga T. Identification of antigenic epitopes in a surface protein antigen of Streptococcus mutans in humans. Infect Immun 1994: 62: 4034-4042.
23. Merrifield RB. Solid phase peptide synthesis. I. The synthesis of a tetrapeptide. J Am Chem Soc 1963: 85: 2149-2154.
24. Moisset A, Schatz N, Lepoivre Y et al. Conservation of salivary glycoprotein-interacting and human immunoglobulin G-cross-reactive domains of antigen I/II in oral streptococci. Infect Immun 1994: 62: 184-193.
25. Mosier DE, Gulizia RJ, Bairb SM. Wilson DB. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 1993: 333: 256-259.
26. Munro GH, Evans P, Todryk S, Budcett P, Kelly CG. Lehner T. A protein fragment of streptococcal cell surface antigen I/II which prevents adhesion of Streptococcus mutans. Infect Immun 1993: 62: 184-193.
27. Nakai M, Okahashi N, Ohta H, Koga T. Saliva-binding region of Streptococcus mutans surface protein antigen. Infect Immun 1993: 61: 4344-4349.
28. Nonoyama S, Smith FO, Ochs HD. Specific antibody production to a recall or a neoantigen by SCID mice reconstitute with human peripheral blood lymphocytes. J Immunol 1993: 151: 3894-3901.
29. Okahashi N, Sasakawa C, Yoshikawa M, Hamada S, Koga T. Molecular characterization of a surface protein antigen gene from serotype c Streptococcus mutans, implicated in dental caries. Mol Microbiol 1989: 3: 673-678.
30. Okahashi N, Takahashi I, Nakai M, Senpuku H, Nisizawa T, Koga T. Identification of antigenic epitopes in an alanine-rich repeating region of a surface protein antigen of Streptococcus mutans. Infect Immun 1993: 61: 1301-1306.
31. Russell MW, Lehner T. Characterization of antigens extracted from cells and culture fluids of Streptococcus mutans serotype c. Arch Oral Biol 1978: 23: 7-15.
32. Russell RRB. Wall-associated protein antigens of Streptococcus mutans. J Gen Microbiol. 1979: 114: 109-115.
33. Russell RRB, Beighton D, Cohen B. Immunization of monkeys (Macaco fascicularis) with antigens purified from Streptococcus mutans. Br Dent J 1982: 152: 81-84.
34. Sandhu J, Shpitz B, Gallinger S, Hozumi N. Primary immune response in SCID mice engrafted with human peripheral blood lymphocytes. Infect Immun 1994: 152: 3806-3813.
35. Senpuku H, Nakai M, Koga T, Hanada N, Nisizawa T. Identification of a repeated epitope recognized by human serum antibodies in a surface protein antigen of Streptococcus mutans. Oral Microbiol Immunol 1995: 11: 121-128.
36. Senpuku H, Miyauchi T, Hanada N, Nisizawa T. An antigenic peptide inducing the cross-inhibiting antibodies against the interaction of Streptococcus mutans PAc with human salivary components. Infect Immun 1995: 63: 4695-4703.
37. Torbett BE, Picchio G, Mosier DE. Hu-PBL-SCID mice: a model for human immune function, AIDS, and lymphomagenesis. Immunol Rev 1991: 124: 139-164.
38. Turck CW. Identification of phosphotylosine residues in peptide by high performance liquid chromatography on-line derivative spectroscopy. Peptides 1992: 5: 156-160.