Severe hyperphosphatemia and hypocalcemia: A dilemma in patient management

Journal of the American Society of Nephrology

Volumn 7, Issue 10, 1996, Pages 2055-2061

  Sutters, Michael ^a,b   Gaboury, Cynthia L ^a   Bennett, William M ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Hyperphosphatemia; Hypocalcemia; Man; Phosphate enema; Tetany

Indexed keywords

CALCIUM; DOPAMINE; PHOSPHATE;

ARTICLE; CALCIUM BLOOD LEVEL; CLINICAL FEATURE; ELECTROLYTE BALANCE; HUMAN; HYPERPHOSPHATEMIA; HYPOCALCEMIA; KIDNEY FUNCTION; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; REGULATORY MECHANISM; TETANUS; TREATMENT PLANNING; URINARY EXCRETION; AGED; BLOOD; CASE REPORT; CHEMICALLY INDUCED DISORDER; HOSPITALIZATION; KIDNEY; MALE; METABOLISM; REVIEW;

AGED; HOSPITALIZATION; HUMANS; HYPOCALCEMIA; KIDNEY; MALE; PHOSPHATES;

EID: 0030256121     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Walton J, Gray TK: Absorption of inorganic phosphate in the human small intestine. Clin Sci 1979;56:407-412.
2. Davis GR, Zerwekh JE, Parker TF, et al.: Absorption of phosphate in the jejunum of patients with chronic renal failure before and after correction of vitamin D deficiency. Gastroenterology 1983;85:908-916.
3. Ghishan FK: Phosphate transport by plasma membranes of enterocytes during development: Role of 1,25-dihydroxycholecalciferol. Am J Clin Nutr 1992;55:873-877.
4. Quamme GA, Shapiro RJ: Membrane controls of epithelial phosphate transport. Can J Physiol Pharmacol 1986; 65:275-286.
5. Karr WG, Abbott WO: Intubation studies of the human small intestine. IV. Chemical characteristics of the intestinal contents in the fasting state and as influenced by the administration of acids, of alkalies and of water. J Clin Invest 1935;14:893-900.
6. i cotransport mediated by a transporter cloned from the rat kidney and expressed in Xenopus oocytes. Proc Natl Acad Sci USA 1994;91:8205-8208.
7. Murer H, Markovich D, Biber J: Renal and small intestinal sodium-dependent symporters of phosphate and sulphate. J Exp Biol 1994;196:167-181.
8. i reabsorption: Some answers and more questions. J Am Soc Nephrol 1992;2:1649-1665.
9. Murer H, Werner A, Reshkin S, Wuarin F, Biber J: Cellular mechanisms in proximal tubular reabsorption of inorganic phosphate. Am J Physiol 1991;260:C885-C899.
10. Kurnik BRC, Hruska KA: Effects of 1,25-dihydroxycholecalciferol on phosphate transport in vitamin D-deprived rats. Am J Physiol 1984;247:F177-F182.
11. Berndt T, Knox FG: The renal handling of phosphate. In: Massry SG, Glassvock RJ, Eds. Textbook of Nephrology. 3rd Ed. Baltimore: Williams & Wilkins; 1995:388-398.
12. Levi M, Lotscher M, Sorribas E, et al.: Cellular mechanisms of acute and chronic adaptation of rat renal P(i) transporter to alterations in dietary P(i). Am J Physiol 1994;267:F900-F908.
13. Taylor DJ, Coppack SW, Cadoux-Hudson TAD, et al.: Effect of insulin on intracellular pH and phosphate metabolism in human skeletal muscle in vivo. Clin Sci 1991;81:123-128.
14. Butterworth PJ, Younus MJ: Uptake of phosphate by rat hepatocytes in primary culture: A sodium-dependent system that is stimulated by insulin. Biochim Biophys Acta 1993;1148:117-122.
15. Polgreen KE, Leighton B, Kemp GJ, Radda GK: Insulin-like growth factor stimulation of inorganic phosphate transport into skeletal muscle [Abstract]. Biochem Soc Trans 1993;21:4398.
16. Usala A-L, Madigan T, Burguera B, et al.: Treatment of insulin resistant diabetic ketoacidosis with insulin-like frowth factor I in an adolescent with insulin dependent diabetes. N Engl J Med 1992;327:853-857.
17. Massry SG: Hypophosphatemia and hyperphosphatemia. In: Massry SG, Glassrock RJ, Eds. Textbook of Nephrology. 3rd Ed. Baltimore: Williams & Wilkins; 1995:398-412.
18. Sotos JF, Cutler EA, Finkel MA, Doody D: Hypocalcemic coma following two pediatric phosphate enemas. Pediatrics 1977;60:305-307.
19. Biberstein M, Parker BA: Enema-induced hyperphosphatemia. Am J Med 1985;79:645-646.
20. Grosskopf I, Graff E, Charach G, Binyamin G, Spinrad S, Blum I: Hyperphosphatemia and hypocalcaemia induced by hypertonic phosphate enema - An experimental study and review of the literature. Hum Exp Toxicol 1991;10:351-355.
21. Reedy JC, Zwiren GT: Enema induced hypocalcemia and hyperphosphatemia leading to cardiac arrest during induction of anaesthesia in an outpatient surgery center. Anesthesiology 1983;59:578-579.
22. Larson LE, Swigart SA, Angle CR: Laxative poisoning: Pharmacokinetics of serum phosphorus. Hum Toxicol 1986;5:45-49.
23. Goldsmith RS, Ingbar SH: Inorganic phosphate treatment of hypercalcemia of diverse etiologies. N Engl J Med 1966;274:1-7.
24. Hebert LA, Lemann J, Peterson JR, Lennon EJ: Studies of the mechanism by which phosphate infusion lowers serum calcium concentration. J Clin Invest 1966;45: 1886-1894.
25. Adler AJ, Ferran N, Berlyne GN: Effect of phosphate on serum ionized calcium concentration in vitro: A reassessment of the "trade-off hypothesis." Kidney Int 1985; 28:932-935.
26. Valentzas C, Meindock H, Oreopoulos DG, et al.: Visceral calcification and the calcium phosphate product. Homeostasis of phosphate and other minerals. Adv Exp Med Biol 1978;103:195-201.
27. Ibels LS: The pathogenesis of metastatic calcification in uraemia. Prog Biochem Pharmacol 1980;17:242-250.
28. Bevington A, Brough D, Baker FE, Hattersley J, Walls J: Metabolic acidosis is a potent stimulus for cellular inorganic phosphate generation in uraemia. Clin Sci 1995; 88:405-412.
29. Cuche J-L, Marchand GR, Rainer FG, Lang FC, Knox FG: Phosphaturic effect of dopamine in dogs. J Clin Invest 1976;58:71-76.
30. Rasmussen H, Feinblatt J, Nagata N, Pechet M: Effects of ions upon bone cell function. Fed Proc 1970;29:1190-1197.
31. Raisz GL: Physiologic and pharmacologic regulation of bone resorption. N Engl J Med 1970;282:909-916.