Physiological and Hormonal Responses of Lambs Repeatedly Implanted with Zeranol and Provided Two Levels of Feed Intake

Journal of Animal Science

Volumn 74, Issue 10, 1996, Pages 2376-2384

  Hufstedler, G D ^a   Gillman, P L ^a,b   Carstens, G E ^a   Greene, L W ^a   Turner, N D ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Bones; Carcass; Growth; Hormones; Lambs; Zeranol

Indexed keywords

ESTROGEN; GROWTH HORMONE; SOMATOMEDIN C; ZERANOL;

ANIMAL; ARTICLE; BLOOD; BODY COMPOSITION; BONE; DOSE RESPONSE; DRUG IMPLANT; EATING; GLUCOSE BLOOD LEVEL; GROWTH, DEVELOPMENT AND AGING; HISTOLOGY; HYPOPHYSIS; MALE; MEAT; ORGAN SIZE; PHYSIOLOGY; SHEEP; STANDARD; UREA NITROGEN BLOOD LEVEL; WEIGHT GAIN;

ANIMALS; BLOOD GLUCOSE; BLOOD UREA NITROGEN; BODY COMPOSITION; BONE AND BONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG IMPLANTS; EATING; ESTROGENS, NON-STEROIDAL; GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR I; MALE; MEAT; ORGAN SIZE; PITUITARY GLAND; SHEEP; WEIGHT GAIN; ZERANOL;

EID: 0030254272     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/1996.74102376x     Document Type: Article

References (34)

1. AOAC. 1990. Official Methods of Analysis (15th Ed.). Association of Official Analytical Chemists, Arlington, VA.
2. Breier, B. H., P. D. Gluckman, and J. J. Bass. 1988. Influence of nutritional status and oestradiol-17β on plasma growth hormone, insulin-like growth factors I and II and the response to exogenous growth hormone in young steers. J. Endocrinol. 118:243.
3. Elsasser, T. H., T. S. Rumsey, and A. C. Hammond. 1989. Influence of diet on basal and growth hormone-stimulated plasma concentrations of IGF-I in beef cattle. J. Anim. Sci. 67:128.
4. Enright, W. J., J. F. Quirke, P. D. Gluckman, B. H. Breier, L. G. Kennedy, I. C. Hart, J. F. Roche, A. Coert, and P. Allen. 1990. Effects of long-term administration of pituitary-derived bovine growth hormone and estradiol on growth in steers. J. Anim. Sci. 68:2345.
5. Fassel, V. A. 1978. Quantitative elemental analysis by plasma emission spectroscopy. Science (Wash., DC) 202:183.
6. Field, R. A., G. Maiorano, F. C. Hinds, W. J. Murdoch, and M. L. Riley. 1990. Bone ossification and carcass characteristics of wethers given silastic implants containing estradiol. J. Anim. Sci. 68:3663.
7. French, J. T. 1991. Regulation of growth hormone (GH): Effect of zeranol and synovex on secretion of GH and accumulation of GH mRNA in the bovine pituitary gland. Ph.D. Dissertation. Texas A&M University, College Station.
8. Gopinath, R., and W. D. Kitts. 1984. Growth hormone secretion and clearance rates in growing beef steers implanted with estrogenic anabolic compounds. Growth 48:499.
9. Griffiths, T. W. 1982. Effects of trenbolone acetate and resorcyclic acid lactone on protein metabolism and growth in steers. Anim. Prod. 34:309.
10. Houseknecht, K. L., D. L. Boggs, D. R. Campion, J. L. Sartin, T. E. Riser, G. B. Rampacek, and H. E. Amos. 1988. Effect of dietary energy source and level on serum growth hormone, insulin-like growth factor 1, growth and body composition in beef heifers. J. Anim. Sci. 66:2916.
11. Hutcheson, J. P., L. W. Greene, G. E. Carstens, and F. M. Byers. 1992. Effects of zeranol and two dietary levels of calcium and phosphorus on performance, carcass and bone characteristics, and calcium status in growing lambs. J. Anim. Sci. 70:1346.
12. Johnsson, I. D., I. C. Hart, A. D. Simmonds, and S. V. Morant. 1985. Prepubertal mammogenesis in the sheep: 2. The effects of level of nutrition on the plasma concentrations of growth hormone, insulin and prolactin at various ages in female lambs and their relationship with mammary development. Anim. Prod. 38:57.
13. Lemieux, P. G., F. M. Byers, and G. T. Schelling. 1988. Anabolic effects on rate, composition and energetic efficiency of growth in cattle fed forage and grain diets. J. Anim. Sci. 66:1824.
14. Loy, D. D., H. W. Harpster, and E. H. Cash. 1988. Rate, composition and efficiency of growth in feedlot steers reimplanted with growth stimulants. J. Anim. Sci. 66:2668.
15. Mader, T. L. 1994. Effect of implant sequence and dose on feedlot cattle performance. J. Anim. Sci. 72:277.
16. Marriam, G. R., and K. W. Wachter. 1982. Algorithms for the study of episodic hormone secretion. Am. J. Physiol. 243:310.
17. McCaughey, W. J. 1988. Detection of zeranol in the blood of ram lambs by a radioimmunoassay technique. Vet. Rec. 123:511.
18. Nold, R. A., J. A. Unruh, C. W. Spaeth, and J. E. Minton. 1992. Effects of zeranol implants in ram and wether lambs on performance traits, carcass characteristics, and subprimal cut yields and distribution. J. Anim. Sci. 70:1699.
19. NRC. 1985. Nutrition Requirements of Sheep (6th Ed.). National Academy Press, Washington D.C.
20. NRC. 1994. Metabolic Modifiers: Effects on the Nutrient Requirements of Food-Producing Animals. National Academy Press, Washington, DC.
21. Olivares, V. H., D. M. Hallford, R. A. Spoon, D. W. Holcombe, T. C. Pope, R. H. Oyler, and J. D. Thomas. 1988. Growth and carcass characteristics of fine-wool lambs treated with ovine growth hormone and(or) zeranol. Proc. West. Sect. ASAS 39:138.
22. Olsen, R. F., P. J. Wangsness, R. J. Martin, and J. H. Gahagan. 1977. Effects of zeranol on blood metabolites and hormones in wether lambs. J. Anim. Sci. 45:1392.
23. Phelps, C. J., J. P. Wiggins, and P. J. Wangsness. 1988. Effects of zeranol on in vitro growth hormone release by lamb and rat pituitary cells. J. Anim. Sci. 66:2614.
24. Rompala, R. E., T. A. Hoagland, and L. A. Malkus. 1988. Effect of dietary history and zeranol on feedlot performance, carcass characteristics and chemical body composition of growing lambs. SID Res. J 4:38.
25. Rothenbacher, H., J. P. Wiggins, and L. L. Wilson. 1975. Pathologic changes in endocrine glands and certain other tissues of lambs implanted with the synthetic growth promotant zeranol. Am. J. Vet. Res. 36:1313.
26. SAS. 1985. SAS User's Guide: Statistics (Version 5 Ed.). SAS Inst. Inc., Cary, NC.
27. Sinnett-Smith, P. A., N. W. Dumelow, and P. J. Buttery. 1983. Effects of trenbolone acetate and zeranol on protein metabolism in male castrate and female lambs. Br. J. Nutr. 50:225.
28. Solís, J. C., F. M. Byers, G. T. Schelling, and L. W. Greene. 1989. Anabolic implant and frame size effects on growth regulation, nutrient repartitioning and energetic efficiency of feedlot steers. J. Anim. Sci. 67:2792.
29. Southgate, J. R., A. R. Peters, and S. N. Dixon. 1988. Effects of oestradiol-17β or zeranol with or without trenbolone acetate on live weight gain, carcass composition and zeranol residues in steers on an 18-month beef system. Anim. Prod. 47:209.
30. Thomas, G. B., T. C. Cummins, H. Francis, A. W. Sudbury, P. I. McCloud, and I. J. Clarke. 1991. Effect of restricted feeding on the relationship between hypophysial portal concentrations of growth hormone (GH)-releasing factor and somatostatin, and jugular concentrations of GH in ovariectomized ewes. Endocrinology 128:1151.
31. Turner, N. D., L. W. Greene, F. M. Byers, and D. C. Kenison. 1995. Influence of incremental zeranol implant doses on the chemical and physical characteristics of third metacarpal bone and chemical composition of liver and soft tissue from feedlot steers. J. Anim. Sci. 73:1.
32. Wester, T. J., R. A. Britton, T. J. Klopfenstein, G. A. Ham, D. T. Hickok, and C. R. Krehbiel. 1995. Differential effects of plane of protein or energy nutrition on visceral organs and hormones in lambs. J. Anim. Sci. 73:1674.
33. Wiggins, J. P., L. L. Wilson, H. Rothenbacher, and S. L. Davis. 1976. Effects of diethylstilbestrol, zeranol and sex on live, blood metabolite, carcass and endocrine characteristics of lambs. J. Anim. Sci. 43:518.
34. Williams, J. E., S. J. Ireland, T. A. Mollett, D. L. Hancock, E. E. Beaver, and S. Hannah. 1991. Influence of zeranol and breed on growth, composition of gain, and plasma hormone concentrations. J. Anim. Sci. 69:1688.