The effect of aflatoxin B1 on cytokine mRNA and corresponding protein levels in peritoneal macrophages and splenic lymphocytes

International Journal of Immunopharmacology

Volumn 18, Issue 10, 1996, Pages 599-608

  Dugyala, Raviprakash R ^a   Sharma, Raghubir P ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Aflatoxin B1; Cytokine expression; Cytokines; Immunotoxicity; Interleukins; Macrophages; Mice; Splenocytes

Indexed keywords

AFLATOXIN B1; CONCANAVALIN A; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOTOXICITY; MACROPHAGE FUNCTION; MALE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; SPLEEN CELL; ANIMAL; BIOSYNTHESIS; BODY WEIGHT; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; LYMPHOCYTE; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE STRAIN; SPLEEN;

AFLATOXIN B1; ANIMALS; BODY WEIGHT; CELLS, CULTURED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED STRAINS; RNA, MESSENGER; SPLEEN;

EID: 0030250969     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(96)00066-5     Document Type: Article

References (38)

1. Akira, S., Hirano, T., Taga, T. & Kishimato, T. (1990) Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J., 4, 2860-2867.
2. 1 with guanines in different DNA sequences. Biochemistry, 27, 472-481.
3. 1 on phytohemagglutinin-stimulated lymphoblastogenesis of bovine lymphocytes. J. Dairy Sci., 67, 110-114.
4. Carruth, L. M., Demczuk, S. & Mizel, S. B.. (1991) J. Biol. Chem., 266, 12162-12167.
5. Chang, C. F. & Hamilton, P. B. (1979) Impaired phagocytosis by heterophils from chickens during aflatoxicosis. Toxicol. Appl. Pharmacol., 48, 459-466.
6. Coulombe, R. A. (1993) Symposium: biological action of mycotoxins. J. Dairy Sci., 76, 880-891.
7. 1. Cancer Res., 41, 197-203.
8. Croy, R. G. & Wogan, G. N. (1981) Quantitative comparison of covalent aflatoxin-DNA adducts formed in rat and mouse livers and kidneys. J. natn. Cancer Inst., 66, 761-768.
9. 1-DNA adduct formed in vitro in rat liver. Proc. natn. Acad. Sci. U.S.A., 75, 1745-1749.
10. 1 and its metabolites. FEMS Immun. Med. Microbiol., 10, 151-156.
11. Dinarello, C. A. (1992) The biology of interleukin-1. In Interleukins: Molecular Biology and Immunology (ed. Kishimato, T.), pp. 1-32, Karger Press, New York..
12. 1 and T-2 toxin on the granulocyte-macrophage progenitor cells in mouse bone marrow culture. Immunopharmacology, 27, 57-65.
13. 1 and sterigmatocystin. Cancer Res., 40, 4085-4091.
14. Fiers, W. (1991) Tumor necrosis factor: characterization at the molecular, cellular and in vivo level. FEBS Lett., 285, 199-212.
15. Giri, J. G., Lomedico, P. T. & Mizel, S. B. (1985) Studies on the synthesis and secretion of interleukin 1. L A 33 000 molecular weight precursor for interleukin 1. J. Immun., 134, 343-349.
16. Hanke, J. H., Nichols, L. N. & Coon, M. E. (1992) FK506 and rapamycin selectively enhanced degradation of 1L-2 and GM-CSF mRNA. Lymph. Cyt. Res., 11, 221-231.
17. 1 and relationship with neuroendocrine mechanisms. Immunopharmacology, 22, 127-136.
18. Hazuda, D. J., Strickler, J., Simon, P. & Young, P. R. (1991) Structure-function mapping of interleukin 1 precursors. Cleavage leads to a conformational change in the mature protein. J. Biol. Chem., 266, 7081-7086.
19. Hsieh, D. P. H. (1987) Mode of action of mycotoxins. In Mycotoxins in Food (ed. Krogh, P.), pp. 149-176, Academic Press, Cambridge, U.K..
20. Jakab, G. J., Hmieleski, R. R., Zabra, A., Hemenway, D. R. & Groopman, J. D. (1994) Respiratory aflatoxicosis: suppression of pulmonary and systemic host defenses in rat and mice. Toxicol. Appl. Pharmacol., 125, 198-205.
21. 1 on in vitro production of interleukin-1 by bovine mononuclear phagocytes. Vet. Immun. Immunopathol., 34, 149-158.
22. Mollenhauer, H. H., Correir, D. E., Huff, W. E., Kubena, L. F., Harvey, R. B. & Droleskey, R. E. (1989) Ultra structure of hepatic and renal lesions in chicken fed aflatoxin. Am. J. Vet. Res., 50, 771-777.
23. 1, exposure and its effects on turkey peritoneal macrophages. Toxicol. Appl. Pharmacol., 109, 432-442.
24. Newberne, P. M. & Butler, W. H. (1969) Acute and chronic effects of aflatoxin on the liver of domestic and laboratory animals. A review. Cancer. Res., 29, 236-250.
25. Paul, W. E. & Sedar, R. A. (1994) Lymphocyte responses and cytokines. Cell, 76, 241-251.
26. 1 on murine lymphocyte functions. Toxicology, 54, 31-44.
27. 1. Toxicology, 43, 23-132.
28. Robens, J. F. & Richard, J. L. (1992) Aflatoxins in animal and human health. Rev. Environ. Contam. Toxicol., 127, 69-94.
29. Rosenthal, G. J., Corsini, E., Craig, W. A., Comment, C. E. & Luster, M. I. (1991) Pentamidine: an inhibitor of interleukin-1 that acts via a post-translational event. Toxicol. Appl. Pharmacol., 107, 555-561.
30. Savel, H., Forsyth, B., Schaeffer, W. & Cardella, T. (1970) Effect of aflatoxin B1 upon phytohemagglutinin-transformed human lymphocytes. Proc. Soc. Exp. Biol. Med., 134, 1112-1115.
31. Sharma, R. P. (1993) Immunotoxicity of mycotoxins. J. Dairy Sci., 76, 892-897.
32. Siders, W. M., Kilmovitz, J. C. & Mizel, S. B. (1993) Characterization of the structural requirements and cell type specificity of IL-1 and IL-1 secretion. J. Biol. Chem., 268, 22170-22174.
33. Skamene, E. & Gros, P. (1983) Role of macrophages in resistance against infectious diseases. Clin. Immun. Allerg., 3, 539-560.
34. Terao, K. & Ueno, Y. (1978) Morphological and functional damage to cells and tissues. In Toxicology, Biochemistry and Pathology of Mycotoxins (eds Uraguchi, K. & Yamazaki, M.), pp. 189-238, Kodansha Press, Tokyo..
35. Unanue, E. R. (1984) Antigen presenting functions of the macrophages. Annu. Rev. Immun., 2, 395-401.
36. 1 alters protein phosphorylation in rat livers. Biochem. Biophys. Res. Commun., 129, 85-89.
37. 1 inhibition of rat hepatic nuclear RNA synthesis. J. Biol. Chem., 256, 3245-3251.
38. 1 inhibition of rat liver nucleolar RNA synthesis. J. Biol. Chem., 256, 3292-3297.