An almitrine analog acts as hypoxia in isolated rat lungs

Respiration Physiology

Volumn 105, Issue 3, 1996, Pages 225-233

  Robineau, P ^a,b   Dhainaut, A ^a   Canet, E ^a  

^a INSTITUT DE RECHERCHES SERVIER   (France)

^b SANOFI   (France)

Author keywords

Circulation, pulmonary; Hypoxia, pulmonary vasoconstriction; Mammals, rat; Pharmacological agents, almitring, S 1867, DPI, U 46,619; Pulmonary artery, pressure, hypoxia

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ALMITRINE; DIPHENYLENEIODONIUM CHLORIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPOXIA; LUNG ARTERY; LUNG BLOOD FLOW; LUNG CIRCULATION; MALE; MAMMAL; NONHUMAN; PRIORITY JOURNAL; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

EID: 0030250519     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/0034-5687(96)00055-2     Document Type: Article

References (25)

1. Archer, S.L., J.P. Tolins, L. Raij and E.K. Weir (1989). Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor. Biochem. Biophys. Res. Commun. 164: 1198-1205.
2. Castaing, Y., G. Manier and H. Guenard (1986). Improvement in ventilation-perfusion relationship by almitrine in patients with chronic obstructive pulmonary disease during mechanical ventilation. Am. Rev. Respir. Dis. 134: 910-916.
3. Cross, A.R. and O.T.G. Jones (1986). The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Biochem. J. 237: 111-116.
4. 2 sensor protein in the rat carotid body. Biochem. J. 272: 743-747.
5. Gottschall, E.B., S. Fernyak, G. Wuertemberger and N.F. Voelkel (1992). Almitrine mimics hypoxic vasoconstriction in isolated rat lungs. Am. J. Physiol. 263: H383-H391.
6. Grimminger, F., N. Weissmann, R. Spriestersbach, E. Becker, S. Rosseau and W. Seeger (1995). Effects of NADPH oxidase inhibitors on hypoxic vasoconstriction in buffer-perfused rabbit lungs. Am. J. Physiol. 268: L747-L752.
7. He, L., S.-W. Chang and N.F. Voelkel (1991). Pulmonary vascular reactivity in Fisher rats. J. Appl. Physiol. 70: 1861-1866.
8. Laubie, M. and H, Schmitt (1980). Long-lasting hyperventilation induced by almitrine: evidence for a specific effect on carotid and thoracic chemoreceptors. Eur. J. Pharmacol, 61: 125-136.
9. Lopez-Barneo, J., A.R. Benot and J. Urena (1993). Oxygen sensing and the electrophysiology of arterial chemoreceptor cells. News Physiol. Sci. 8: 191-195.
10. 2 selectively inhibits K channel activity in chemoreceptor cells of the mammalian carotid body. J. Gen. Physiol. 93: 1001-1015.
11. + current in chemoreceptor cells of rabbit carotid body. J. Physiol. (London) 460: 15-32.
12. 2 in the cat. Respir. Physiol. 74: 275-284.
13. Mélot, C., P. Dechamps, R. Hallemans, P. Decroly and P. Mols (1989). Enhancement of hypoxic pulmonary vasoconstriction by low dose almitrine bismesylate in normal humans. Am. Rev. Respir. Dis. 139: 111-119.
14. Nakanishi, S., T. Hiramoto, N. Ahmed and Y. Nishimoto (1988). Almitrine enhances in low dose the reactivity of pulmonary vessels to hypoxia. Respir. Physiol. 74: 139-150.
15. Post, J.M., J.R. Hume, S.L. Archer and E.K. Weir (1992). Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am. J. Physiol. 262: C882-C890.
16. Stuehr, D.J., O.A. Fasehun, N.S. Kwon, S.S. Gross, J.A. Gonzalez, R. Levi and C.F. Nathan (1991). Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB J. 5: 98-103.
17. Thomas, H.M., R.C. Carson, E.D. Fried and R.S. Novitch (1991). Inhibition of hypoxic pulmonary vasoconstriction by diphenyleneiodonium. Biochem. Pharmacol. 42: R9-R12.
18. Voisin, C., B. Wallaert, C. Aerts and J.M. Grosbois (1985). Action of almitrine bismesylate on the generation of superoxide anion by human alveolar macrophages (in french). Rev. Med. Int. 6: 45-52.
19. Weir, E.K. and S.L. Archer (1995). The mechanism of acute pulmonary vasoconstriction: the tale of two channels. FASEB J. 9: 183-189.
20. Weir, E.K., J.W. Eaton and E. Chesler (1985). Redox status and pulmonary vascular reactivity. Chest 88: 249S-252S.
21. Weir, E.K., C.N. Wyatt, H.L. Reeve. J. Huang, S.L. Archer and C. Peers (1994). Diphenyleneiodonium inhibits both potassium and calcium currents in isolated artery smooth muscle cells. J. Appl. Physiol. 76: 2611-2615.
22. Youngson, C., C. Nurse, H. Yeger and E. Cutz (1993). Oxygen sensing in airway chemoreceptors. Nature 365: 153-155.
23. Yuan, X.-J., M.L. Tod, L.J. Rubin and M.P. Blaustein (1990). Contrasting effects of hypoxia in rat pulmonary and mesenteric arteries. Am. J. Physiol. 259: H281-H289.
24. Yuan, X.-J., W.F. Goldman, M.L. Tod, L.J. Rubin and M.P. Blaustein (1993). Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes. Am. J. Physiol. 264: L116-L123.
25. 2+ conductances in pulmonary artery cells. Am. J. Physiol. 267: L52-L63.