Bispecific antibody mediated targeting of nido-carboranes to human colon carcinoma cells

Bioconjugate Chemistry

Volumn 7, Issue 5, 1996, Pages 532-535

  Primus, F James ^a   Pak, Roger H ^b   Rickard Dickson, Karen J ^a   Szalai, György ^a   Bolen Jr , James L ^a   Kane, Robert R ^b,c   Hawthorne, M Frederick ^b  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BAYLOR UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; TUMORS;

BORON NEUTRON CAPTURE THERAPY; BORON NEUTRONCAPTURE THERAPY; CARBORANES; CARCINOEMBRYONIC ANTIGEN; COLLATERAL DAMAGE; COLON CARCINOMA CELLS; CYTOTOXIC; HUMAN COLON; NORMAL TISSUE; TUMOUR CELLS;

MONOCLONAL ANTIBODIES;

EID: 0030250409     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc960050m     Document Type: Article

References (23)

1. Hawthorne, M. F. (1993) The role of chemistry in the development of boron neutron capture therapy of cancer. Angew. Chem., Int. Ed. Engl. 32, 950.
2. Varadarajan, A., Sharkey, R. M., Goldenberg, D. M., and Hawthorne, M. F. (1991) Conjugation of phenyl isothiocyanate derivatives of carborane to antitumor antibody and in vivo localization of conjugates in nude mice. Bioconjugate Chem. 2, 102.
3. Paxton, R. J., Beatty, B. G., Varadarajan, A., and Hawthorne, M. F. (1992) Carboranyl peptide-antibody conjugates for neutron-capture therapy: preparation, characterization, and in vivo evaluation. Bioconjugate Chem. 3, 241.
4. Chen, C.-J., Kane, R. R., Primus, F. J., Szalai, G., Hawthorne, M. F., and Shively, J. E. (1994) Synthesis and characterization of oligomeric nido-carboranyl phosphate diester conjugates to antibody and antibody fragments for potential use in boron neutron capture therapy of solid tumors. Bioconjugate Chem. 5, 557.
5. Ferro, V. A., Morris, J. H., and Stimson, W. H. (1995) A novel method for boronating antibodies without loss of immunoreactivity, for use in neutron capture therapy. Drug Des. Discovery 13, 13.
6. Barth, R. F., Adams, D. M., Soloway, A. H., Alam, F., and Darby, M. V. (1994) Boronated starburst dendrimer monoclonal antibody immunoconjugates - evaluation as a potential delivery system for neutron capture therapy. Bioconjugate Chem. 5, 58.
7. Hawthorne, M. F. (1991) Biochemical applications of boron cluster chemistry. Pure Appl. Chem. 63, 327.
8. Nolan, O., and O'Kennedy, R. (1990) Bifunctional antibodies: concept, production, and applications. Biochim. Biophys. Acta 1040, 1.
9. Yuan, F., Baxter, L. T., and Jain, R. K. (1991) Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies. Cancer Res. 51, 3119.
10. Varadarajan, A., and Hawthorne, M. F. (1991) Novel carboranyl amino acids and peptides: reagents for antibody modification and subsequent neutron-capture studies. Bioconjugate Chem. 2, 102.
11. Kane, R. R., Pak, R. H., and Hawthorne, M. F. (1993) Solution-phase segment synthesis of boron-rich peptides. J. Org. Chem. 58, 991.
12. Kane, R. R., Lee, C. S., Drechsel, K., and Hawthorne, M. F. (1993) Solution-phase synthesis of boron-rich oligophosphates. J. Org. Chem. 58, 3227.
13. Kane, R. R., Drechsel, K., and Hawthorne, M. F. (1993) Automated syntheses of carborane-derived homogeneous oligophosphates. J. Am. Chem. Soc. 115, 8853.
14. Pak, R. H., Primus, F. J., Rickard-Dickson, K. J., Ng, L. L., Kane, R. R., and Hawthorne, M. F. (1995) Preparation and properties of nido-carborane-specific monoclonal antibodies for potential use in boron neutron capture therapy (BNCT) of cancer. Proc. Natl. Acad. Sci. U.S.A. 92, 6986.
15. Liu, L., Barth, R. F., Adams, D. M., Soloway, A. H., and Reisfeld, R. A. (1995) Bispecific antibodies as targeting agents for boron neutron capture therapy of brain tumors. J. Hematother. 4, 477.
16. Sikorska, H., Shuster, J., and Gold, P. (1988) Clinical applications of carcinombryonic antigen. Cancer Detect. Prev. 12, 321.
17. Goldenberg, D. M. (1991) Imaging and therapy of gastrointestinal cancers with radiolabeled antibodies. Am. J. Gastroenterol. 86, 1392.
18. Phelps, J. L., Beilder, D. E., Jue, R. A., Unger, B. W., and Johnson, M. J. (1990) Expression and characterization of a chimeric bifunctional antibody with therapeutic applications. J. Immunol. 145 (4), 1200.
19. Stickney, D. R., Anderson, L. D., Slater, J. B., Ahem, C. N., Kirk, G. A., Schweighardt, S. A., and Frincke, J. M. (1991) Bifunctional antibody: a binary radiopharmaceutical delivery system for imaging colorectal carcinoma. Cancer Res. 51, 6650.
20. Corvalan, J. R. F., Smith, W., and Gore, V. A. (1988) Tumour therapy with vinca alkaloids targeted by a hybrid-hybrid monoclonal antibody recognising both CEA and vinca alkaloids. Int. J. Cancer, Suppl. 2, 22.
21. Beatty, J. D., Williams, L. E., Yamauchi, D., Morton, B. A., Hill, L. R., Beatty, B. G., Paxton, R. J., Merchant, B., and Shively, J. E. (1990) Presurgical imaging with indium-labeled anti-carcinoembryonic antigen antibody for colon cancer staging. Cancer Res. 50, 922s.
22. Karawajew, L., Micheel, B., Behrsing, O., and Gaestel, M. (1987) Bispecific antibody-producing hybrid hybridomas selected by a fluorescence activated cell sorter. J. Immunol. Methods 96, 265.
23. Kane, R. R., Guan, L., Kim, Y. S., Rickard-Dickson, K. J., Primus, F. J., and Hawthorne, M. F. Unpublished results.