Protective effect of 21-aminosteroid pretreatment in peripheral nerve low-load crush injury in mature and immature rats

Journal of Orthopaedic Research

Volumn 14, Issue 5, 1996, Pages 823-829

  Nasser, R M ^a   Chen, L E ^a   Seaber, A V ^a   Urbaniak, J R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPOSITION EFFECTS; DRUG PRODUCTS; DRUG THERAPY; FUNCTIONAL ASSESSMENT; LIVING SYSTEMS STUDIES; NEUROLOGY; NEUROPHYSIOLOGY; PHYSIOLOGICAL MODELS;

AMINOSTEROID ANTIOXIDANTS; PERIPHERAL NERVES; SCIATIC FUNCTIONAL INDEX;

ORTHOPEDICS;

TIRILAZAD;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; NERVE CRUSH; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; SCIATIC NERVE;

EID: 0030250318     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.1100140521     Document Type: Article

References (46)

1. 1 Almquist E, Eeg‐Olofsson O: Sensory nerve conduction velocity and two point discrimination in sutured nerves. J Bone Joint Surg [Am] 52: 791–796, 1970
2. 2 Ames BN: Endogenous oxidative DNA damage, aging and cancer. Free Rad Res Commun 7: 121–128, 1989
3. 3 Anderson DK, Hall ED, Braughler JM, McCall JM, Means ED: Effect of delayed administration of U74006F (tirilazad mesylate) on recovery of locomotor function after experimental spinal cord injury. J Neurotrauma 8: 187–192, 1991
4. 4 Audus KL: Contributions of the physical properties of neuroprotective agents to their efficacy as inhibitors of lipid peroxidation. In: Oxygen Free Radicals in Tissue Damage, pp 196–210. Ed by M Tarr and F Samson. Boston, Birkhauser, 1993
5. 5 Bain JR, Mackinnon SE, Hunter DA: Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the rat. Plast Reconstr Surg 83: 129–138, 1989
6. 6 Black MM, Lasek RJ: Slowing of the rate of axonal regeneration during growth and maturation. Exp Neurol 63: 108–119, 1979
7. 7 Braughler JM, Pregenzer JF, Chase RL, Duncan LA, McCall JM, Jacobsen EJ: Novel 21‐amino steroids as potent inhibitors of iron‐dependent lipid peroxidation. J Biol Chem 262: 10438–10440, 1987
8. 8 Bulkley GB: Free radicals and other reactive oxygen metabolites: clinical relevance and the therapeutic efficacy of antioxidant therapy. Surgery 113: 479–483, 1993
9. 9 Cheeseman KH, Slater TF: An introduction to free radical biochemistry. Br Med Bull 49: 481–493, 1993
10. 10 Chen LE, Seaber AV, Glisson RR, Davies H, Murrell GAC, Anthony DC, Urbaniak JR: The functional recovery of peripheral nerve following defined acute crush injuries. J Orthop Res 10: 657–664, 1992
11. 11 Chen LE, Seaber AV, Urbaniak JR: The influence of magnitude and duration of crush load on functional recovery of the peripheral nerve. J Reconstr Microsurg 9: 299–306, 1993
12. 12 Chen LE, Seaber AV, Urbaniak JR, Murrell GAC: Denatured muscle as a nerve conduit: a functional, morphological and electrophysiological evaluation. J Reconstr Microsurg 10: 137–144, 1994
13. 13 Chen ZW, Yang DY, Chang DS: Microsurgery, p 349. New York, Springer‐Verlag, 1982
14. 14 Committee on the Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources Commission on Life Sciences, National Research Council: Guide for the Care and Use of Laboratory Animals. National Institutes of Health Publication 86–23. Washington, D.C., United States Public Health Service, 1985
15. 15 Dahlin LB: Aspects on pathophysiology of nerve entrapments and nerve compression injuries. Neurosurg Clin North Am 2: 21–29, 1991
16. 16 Dellon AL, Mackinnon SE: Sciatic nerve regeneration in the rat: validity of walking track assessment in the presence of chronic contractures. Microsurgery 10: 220–225, 1989
17. 17 de Medinaceli L, Freed WJ, Wyatt RJ: An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks. Exp Neurol 77: 634–643, 1982
18. 18 de Medinaceli L: Seaber AV: Experimental nerve reconnection: importance of initial repair. Microsurgery 10: 56–70, 1989
19. 19 de Medinaceli L: Cell Surgery to Repair Divided Nerve, p 46. New York, C.A.S.I.S.‐C.I.D., 1994
20. 20 Divakaran P, Wiggins RC: Tocopherol in brain metabolism and disease: a review. Metab Brain Dis 2: 1–16, 1987
21. 21 Drahota Z, Gutmann E: The influences of age on the course of reinnervation of muscle. Gerontologia 5: 88–109, 1961
22. 22 Ernster L, Nordenbrand K, Orreniuis S: Microsomal lipid peroxidation: mechanisms and some biomedical implications. In: Lipid Peroxidation in Biology and Medicine, pp 55–79. Ed by K Yagi. New York, Academic Press, 1982
23. 23 Farooque M, Olsson Y, Holtz A: Effect of the 21‐aminosteroid U74006F and methylprednisolone on motor function recovery and oedema after spinal cord compression in rats. Acta Neurol Scand 89: 36–41, 1994
24. 24 Hall ED: Effects of the 21‐aminosteroid U74006F on posttraumatic spinal cord ischemia in cats. J Nuerosurg 68: 462–465, 1988
25. 25 Hall ED, Yonkers PA: Preservation of motor nerve function during early degeneration by the 21‐aminosteroid anti‐oxidant U74006F. Brain Res 513: 244–247, 1990
26. 26 Hall ED, McCall JM: Antioxidant actions of lazaroids. Methods Enzymol 234: 548–555, 1994
27. 27 Hall ED, McCall JM, Means ED: Therapeutic potential of the lazaroids (21‐aminosteroids) in acute central nervous system trauma, ischemia, and subarachnoid hemorrhage. Adv Pharmacol 28: 221–268, 1994
28. 28 Holtz A, Gerdin B: Efficacy of the 21‐aminosteroid U74006F in improving neurological recovery after spinal cord injury in rats. Neurol Res 14: 49–52, 1992
29. 29 Komiya Y: Axonal regeneration in bifurcating axons of rat dorsal root ganglion cells. Exp Neurol 73: 824–826, 1981
30. 30 Liu P, Vonderfecht SL, McGuire M, Fisher MA, Farhood A, Jaeschke H: The 21‐aminosteroid tirilazad mesylate protects against endotoxin shock and acute liver failure in rats. J Pharmacol Exp Ther 271: 438–445, 1994
31. 31 Lowdon IMR, Seaber AV, Urbaniak JR: An improved method of recording rat tracks for measurement of the sciatic functional index of de Medinaceli. J Neurosci Methods 24: 279–281, 1988
32. 32 Lundborg G, Dahlin LB: The pathophysiology of nerve compression. Hand Clin 8: 215–227, 1992
33. 33 Miller RG: Acute vs chronic compressive neuropathy. Muscle Nerve 7: 427–430, 1984
34. 34 Murrell GAC, Davies H, Seaber AV, Goldner RD, Chen LE: The effects of Allopurinol on the functional recovery of rats subjected to sciatic nerve contusion. Neuro‐Orthopedics 14: 13–24, 1993
35. 35 Nohl H: Involvement of free radicals in aging: a consequence or cause of senescence. Br Med Bull 49: 653–667, 1993
36. 36 Onne L: Recovery of sensibility and sudomotor activity in the hand after nerve suture. Acta Chir Scand Suppl 300: 1–69, 1962
37. 37 Pestronk A, Drachman DB, Griffin JW: Effect of aging on nerve sprouting and regeneration. Exp Neurol 70: 65–82, 1980
38. 38 Rydevik B, Lundborg G: Permeability of intraneural microvessels and perineurium following acute, graded experimental nerve compression. Scand J Plast Reconstr Surg 11: 179–187, 1977
39. 39 Sagai M, Ichinose T: Age‐related changes in lipid peroxidation as measured by ethane, ethylene, butane and pentane in respired gases of rats. Life Sci 27: 731–738. 1980
40. 40 Spiegel DA, Seaber AV, Chen LE, Urbaniak JR: Recovery following stretch injury to the sciatic nerve of the rat: an in vivo study. J Reconstr Microsurg 9: 69–74, 1993
41. 41 Sunderland S: Nerve Injuries and Their Repair: A Critical Appraisal, pp 7–10. Edinburgh, Churchill Livingstone, 1991
42. 42 Vaughan DW: Effects of advancing age on the central response of rat facial neurons to axotomy: light microscope morphometry. Anat Rec 228: 211–219, 1990
43. 43 Vollmer DG, Kassell NF, Hongo K, Ogawa H, Tsukahara T: Effect of the nonglucocorticoid 21‐aminosteroid U74006F on experimental cerebral vasospasm. Surg Neurol 31: 190–194, 1989
44. 44 Weiss SJ: Oxygen, ischemia, and inflammation. Acta Physiol Scand Suppl 548: 9–37, 1986
45. 45 Zimmerman BJ, Granger DN: Mechanisms of reperfusion injury. Am J Med Sci 307: 284–292, 1994
46. 46 Zuccarello M, Marsch JT, Schmitt G, Woodward J, Anderson DK: Effect of the 21‐aminosteroid U‐74006F on cerebral vasospasm following subarachnoid hemorrhage. J Neurosurg 71: 98–104, 1989