Modulation of tryptophan hydroxylase activity in vitro by ethanol depends on biopterin cofactor concentration

Alcohol

Volumn 13, Issue 5, 1996, Pages 455-459

  Matsubara, K ^a   Kobayashi, Y ^a   Tanabe, Y ^a   Maruyama, W ^a   Ishinaga, Y ^b   Idzu, T ^a   Kimura, K ^a   Naoi, M ^c  

^a SHIMANE UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NAGOYA INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Alcohol; Ethanol; Rat brain; Tetrahydrobiopterin; Tryptophan; Tryptophan hydroxylase

Indexed keywords

TETRAHYDROBIOPTERIN; TRYPTOPHAN HYDROXYLASE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRINKING BEHAVIOR; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME SYNTHESIS; IN VITRO STUDY; NONHUMAN; RAT; SEROTONINERGIC SYSTEM;

EID: 0030249756     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/0741-8329(96)00033-X     Document Type: Article

References (25)

1. 1. Ballard, W. P.; Guthrie, P. B.; Russio, P. V.; Mandell, A. J. Regional and subcellular distribution and some factors in regulation of reduced pterins in rat brain. J. Phartnacol. Exp. Ther. 206:4-20: 1978.
2. 2. Ballenger, J. C.; Goodwin, F. K.; Major, L. F.; Brown, G. L. Alcohol and central serotonin metabolism in man. Arch. Gen. Psychiatry 36:224-227: 1979.
3. 3. Banki, C. M. Factors influencing monoamine metabolites and tryptophan in patients with alcohol dependence. J. Neural Transm. 50:89-101: 1981.
4. 4. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein dye binding. Anal. Biochem. 72:248-254: 1976.
5. 5. Buckholz, N. S.; Zhou, D.; Tabakoff, B. Ethanol does not affect serotonin receptor binding in rodent brain. Alcohol 6:277-280: 1989.
6. 6. French, T. A.; Weiner, N. Serotoninergic involvement in ethanol-induced alterations of thermoregulation in long-sleep and short-sleep mice. J. Pharmacol. Exp. Ther. 259:833-840: 1991.
7. 7. Gothoni, P.; Ahtee, L. Chronic ethanol administration decreases 5-HT and increases 5-HIAA concentration in rat brain. Acta Pharmacol. Toxicol. 46:113-120: 1980.
8. 8. Hellevuo, K.; Kiianmaa, K. Effects of ethanol, barbital, and lorazepam on brain monoamines in rat lines selectively outbred for differential sensitivity to ethanol. Pharmacol. Biochem. Behav. 29:183-188: 1988.
9. 2+-calmodulin and cyclic AMP in the regulation of the tyrosine hydroxylase system in rat striatal tissue slices. Biochem. Pharmacol. 34:2637-2643; 1985.
10. 10. Kuriyama, K.; Rauscher, G. E.; Sze, P. Y. Effect of acute and chronic administration of ethanol on the 5-hydroxytryptamine turnover and tryptophan hydroxylase activity of the mouse brain. Brain Res. 26:450-454: 1971.
11. 11. Lyon, R. C.; McComb, J. A.; Schreurs, J.; Goldstein, D. B. A relationship between alcohol intoxication and the disordering of brain membranes by a series of short-chain alcohol. J. Pharmacol. Exp. Ther. 218:669-675: 1981.
12. 12. Martin, P. R.; Adinoff, B. B.; Eckardt, M. J.; Stapleton, J. M.; Bone, G. A.; Rubinow, D. R.; Lane, E. A.; Linnoila, M. Effective pharmacotherapy of alcoholic amnestic disorder with fluvoxamine. Arch. Gen. Psychiatry 46:617-621: 1989.
13. 13. Matsubara, K.; Ota, M.; Takahashi, T.; Maruyama, W.; Naoi, M. Structural studies of condensation products of biogenic amines as inhibitors of tryptophan hydroxylase. Brain Res. 655:121-127: 1994.
14. 14. Myers, R. D. Isoquinolines, beta-carbolines and alcohol drinking: Involvement of opioid and dopaminergic mechanisms. Experientia 45:436-443: 1989.
15. 15. Myers, R. D. New drugs for the treatment of experimental alcoholism. Alcohol 11:439-451: 1994.
16. 16. Naoi, M.; Maruyama, W.; Takahashi, T.; Ota, M.; Parvez, H. Inhibition of tryptophan hydroxylase by dopamine and the precursor amino acids. Biochem. Pharmacol. 48:207-212: 1994.
17. 17. Nasrin, S.; Ichinose, H.; Hidaka, H.; Nagatsu, T. Recombinant human tyrosine hydroxylase types 1-4 show regulatory kinetic properties for the natural (6R)-tetrahydrobiopterin cofactor. J. Biochem. 116:393-398: 1994.
18. 18. Oka, K.; Kato, T.; Sugimoto, T.; Matsuura, S.; Nagatsu, T. Kinetic properties of tyrosine hydroxylase with natural tetrahydrobiopterin as cofactor. Biochim. Biophys. Acta 661:45-53: 1981.
19. 19. Ollat, H.; Parvez, H.; Parvez, S. Alcohol and central neurotransmitters. Neurochem. Int. 13:275-300: 1988.
20. 20. Ota, M.; Dostert, P.; Hamanaka, T.; Nagatsu, T.; Naoi, M. Inhibition of tryptophan hydroxylase by (R)- and (S)-1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines (salsolinols). Neuropharmacology 31:337-341: 1992.
21. 21. Pohorecky, L. A.; Newman, B.; Sun, J.; Bailey, W. H. Acute and chronic ethanol ingestion and serotonin metabolism in rat brain. J. Pharmacol. Exp. Ther. 204:424-432: 1978.
22. 22. Wang, Y.-L.; Wei, J.-W. Ethanol alters monoamine content in different brain regions of spontaneously hypertensive rats. In: Sun, G. Y.; Rudeen, P. K.; Wood, W. G.; Wei, Y. H.; Sun, A. Y., eds. Molecular mechanisms of alcohol. Clifton, NJ: Humana Press; 1989:97-105.
23. 23. Wozniak, K. M.; Pert, A.; Mele, A.; Linnolia, M. Focal application of alcohols elevates extracellular dopamine in rat brain: a microdialysis study. Brain Res. 540:31-40: 1991.
24. 24. Yoshimoto, K.; McBride, W. J.; Lumeng, L.; Li, T.-K. Alcohol stimulates the release of dopamine and serotonin in nucleus accumbens. Alcohol 9:17-22: 1991.
25. 25. Zhou, F. C.; Pu, C. F.; Murphy, J.; Lumeng, L.; Li, T.-K. Serotonergic Neurons in the alcohol preferring rats. Alcohol 11:397-403: 1994.