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Volumn 34, Issue 1, 1996, Pages 13-22

Effect of a novel hypoglycemic agent, KAD-1229 on glucose metabolism and fructose-2,6-bisphosphate content in isolated hepatocytes of normal rats

Author keywords

6 phosphofructo 2 kinase; fructose 2,6 bisphosphatase; gluconeogenesis; glycolysis; sulfonylurea

Indexed keywords

ANTIDIABETIC AGENT; FRUCTOSE 2,6 BISPHOSPHATE; MITIGLINIDE; SUCCINIC ACID DERIVATIVE; TOLBUTAMIDE;

EID: 0030249555     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(96)01331-9     Document Type: Article
Times cited : (9)

References (42)
  • 1
    • 0025318574 scopus 로고
    • Ion channels and insulin secretion
    • [1] Rajan, A.S., Aguilar, B.L., Nelson, D.A., et al. (1990) Ion channels and insulin secretion. Diabetes Care 13, 340-363.
    • (1990) Diabetes Care , vol.13 , pp. 340-363
    • Rajan, A.S.1    Aguilar, B.L.2    Nelson, D.A.3
  • 2
    • 0016391308 scopus 로고
    • Effect of short and long term chlorpropamide treatment on insulin release and blood glucose
    • [2] Barnes, A.J., Crowley, M., Garbien, K. and Bloom, A. (1974) Effect of short and long term chlorpropamide treatment on insulin release and blood glucose. Lancet 2, 69-72.
    • (1974) Lancet , vol.2 , pp. 69-72
    • Barnes, A.J.1    Crowley, M.2    Garbien, K.3    Bloom, A.4
  • 3
    • 0000211190 scopus 로고
    • Endocrine and metabolic effects of glibenclamide: Evidence for an extra-pancreatic mechanism of action
    • [3] Feldman, J.M. and Levobitz, H.E. (1971) Endocrine and metabolic effects of glibenclamide: evidence for an extra-pancreatic mechanism of action. Diabetes 20, 745-755.
    • (1971) Diabetes , vol.20 , pp. 745-755
    • Feldman, J.M.1    Levobitz, H.E.2
  • 4
    • 0021244843 scopus 로고
    • Oral sulfonylurea agents suppress hepatic glucose production in non-insulin-dependent diabetic individuals
    • [4] DeFronzo, R.A. and Simonson, D.C. (1984) Oral sulfonylurea agents suppress hepatic glucose production in non-insulin-dependent diabetic individuals. Diabetes Care 1, 72-80.
    • (1984) Diabetes Care , vol.1 , pp. 72-80
    • DeFronzo, R.A.1    Simonson, D.C.2
  • 5
    • 0021361298 scopus 로고
    • The acute and chronic effects of sulfonylurea therapy in type II diabetic subjects
    • [5] Kolterman, O.G., Gray, R.S., Shapiro, G., Scarlett, J.A., Griffin, J. and Olefsky, J.M. (1984) The acute and chronic effects of sulfonylurea therapy in type II diabetic subjects. Diabetes 33, 346-354.
    • (1984) Diabetes , vol.33 , pp. 346-354
    • Kolterman, O.G.1    Gray, R.S.2    Shapiro, G.3    Scarlett, J.A.4    Griffin, J.5    Olefsky, J.M.6
  • 6
    • 0023873229 scopus 로고
    • Increased rate of Cori cycle in obese subjects with NIDDM and effects of weight reduction
    • [6] Zawadski, J., Wolfe, R., Mott, D., Lillioja, B., Howard, B. and Bogardus, C. (1988) Increased rate of Cori cycle in obese subjects with NIDDM and effects of weight reduction. Diabetes 37, 154-159.
    • (1988) Diabetes , vol.37 , pp. 154-159
    • Zawadski, J.1    Wolfe, R.2    Mott, D.3    Lillioja, B.4    Howard, B.5    Bogardus, C.6
  • 7
    • 0025630056 scopus 로고
    • Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism
    • [7] Consoli, A., Nurjhan, N., Reilly, J.J., Bier, D.M. and Gerich, J.E. (1990) Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism. J. Clin. Invest. 86, 2038-2045.
    • (1990) J. Clin. Invest. , vol.86 , pp. 2038-2045
    • Consoli, A.1    Nurjhan, N.2    Reilly, J.J.3    Bier, D.M.4    Gerich, J.E.5
  • 8
    • 0023548405 scopus 로고
    • Glyburide sensitizes perfused rat liver to insulin-induced suppression of glucose output
    • [8] McGuinness, O.P., Green, D.R. and Cherrington, A.D. (1987) Glyburide sensitizes perfused rat liver to insulin-induced suppression of glucose output. Diabetes 36, 472-476.
    • (1987) Diabetes , vol.36 , pp. 472-476
    • McGuinness, O.P.1    Green, D.R.2    Cherrington, A.D.3
  • 9
    • 0021331317 scopus 로고
    • Modulation by a sulfonylurea of insulin-dependent glycogenesis, but not of insulin binding, in cultured rat hepatocytes. Evidence for a postreceptor mechanism of action
    • [9] Fleig, W.E., Noether, F.G., Fussgaenger, R. and Ditschuneit, H. (1984) Modulation by a sulfonylurea of insulin-dependent glycogenesis, but not of insulin binding, in cultured rat hepatocytes. Evidence for a postreceptor mechanism of action. Diabetes 33, 285-290.
    • (1984) Diabetes , vol.33 , pp. 285-290
    • Fleig, W.E.1    Noether, F.G.2    Fussgaenger, R.3    Ditschuneit, H.4
  • 10
    • 0025370482 scopus 로고
    • Fructose-2,6-bisphosphate in control of hepatic gluconeogenesis. From metabolites to molecular genetics
    • [10] Pilkis, S.J., El-Maghrabi, M.R. and Claus, T.H. (1990) Fructose-2,6-bisphosphate in control of hepatic gluconeogenesis. From metabolites to molecular genetics. Diabetes Care 13, 582-99.
    • (1990) Diabetes Care , vol.13 , pp. 582-599
    • Pilkis, S.J.1    El-Maghrabi, M.R.2    Claus, T.H.3
  • 11
    • 0027157760 scopus 로고
    • Glycolysis revisited
    • [11] Van Schaftingen, E. (1993) Glycolysis revisited. Diabetologia 36, 581-588.
    • (1993) Diabetologia , vol.36 , pp. 581-588
    • Van Schaftingen, E.1
  • 12
    • 0022599621 scopus 로고
    • Chlorpropamide raises fructose-2,6-bisphosphate concentration and inhibits gluconeogenesis in isolated rat hepatocytes
    • [12] Monge, L., Mojena, M., Ortega, J.L., Samper, B., Cabello, M.A. and Feliu, J.E. (1986) Chlorpropamide raises fructose-2,6-bisphosphate concentration and inhibits gluconeogenesis in isolated rat hepatocytes. Diabetes 35, 89-96.
    • (1986) Diabetes , vol.35 , pp. 89-96
    • Monge, L.1    Mojena, M.2    Ortega, J.L.3    Samper, B.4    Cabello, M.A.5    Feliu, J.E.6
  • 13
    • 0021276963 scopus 로고
    • Tolbutamide stimulates fructose-2, 6-bisphosphate formation in perfused rat liver
    • [13] Matsutani, A., Kaku, K. and Kaneko, T. (1984) Tolbutamide stimulates fructose-2, 6-bisphosphate formation in perfused rat liver. Diabetes 33, 495-498.
    • (1984) Diabetes , vol.33 , pp. 495-498
    • Matsutani, A.1    Kaku, K.2    Kaneko, T.3
  • 14
    • 0028284740 scopus 로고
    • Novel rapid-and short-acting hypoglycemic agent, a calcium(2s)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) that acts on the sulfonylurea receptor: Comparison of effects between KAD-1229 and gliclazide
    • [14] Ohnota, H., Koizumi, T., Tsutsumi, N., Kobayashi, M., Inoue, S. and Sato, F. (1994) Novel rapid-and short-acting hypoglycemic agent, a calcium(2s)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) that acts on the sulfonylurea receptor: comparison of effects between KAD-1229 and gliclazide. J. Pharmacol. Exp. Ther. 269, 489-495.
    • (1994) J. Pharmacol. Exp. Ther. , vol.269 , pp. 489-495
    • Ohnota, H.1    Koizumi, T.2    Tsutsumi, N.3    Kobayashi, M.4    Inoue, S.5    Sato, F.6
  • 15
    • 0028900472 scopus 로고
    • Normalization of impaired glucose tolerance by the short-acting hypoglycemic agent calcium (2s)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) in non-insulin-dependent diabetes mellitus rats
    • [15] Ohnota, H., Koizumi, T., Kobayashi, M., Momose, Y. and Sato, F. (1995) Normalization of impaired glucose tolerance by the short-acting hypoglycemic agent calcium (2s)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) in non-insulin-dependent diabetes mellitus rats. Can. J. Physiol. Pharmacol. 73, 1-6.
    • (1995) Can. J. Physiol. Pharmacol. , vol.73 , pp. 1-6
    • Ohnota, H.1    Koizumi, T.2    Kobayashi, M.3    Momose, Y.4    Sato, F.5
  • 16
    • 0014645531 scopus 로고
    • High-yield preparation of isolated rat liver parenchymal cells
    • [16] Berry, M.N. and Friend, D.S. (1969) High-yield preparation of isolated rat liver parenchymal cells. J. Cell. Biol. 43, 506-520.
    • (1969) J. Cell. Biol. , vol.43 , pp. 506-520
    • Berry, M.N.1    Friend, D.S.2
  • 17
    • 0027461867 scopus 로고
    • The inhibitory action of buformin, a biguanide on gluconeogenesis from alanine and its transport system in rat livers
    • [17] Hotta, N., Komori, T., Kobayashi, M., Sakakibara, F., Koh, N. and Sakamoto, N. (1993) The inhibitory action of buformin, a biguanide on gluconeogenesis from alanine and its transport system in rat livers. Diabetes Res. Clin. Pract. 19, 49-58.
    • (1993) Diabetes Res. Clin. Pract. , vol.19 , pp. 49-58
    • Hotta, N.1    Komori, T.2    Kobayashi, M.3    Sakakibara, F.4    Koh, N.5    Sakamoto, N.6
  • 18
    • 0020288433 scopus 로고
    • Lack of effect of bovine pancreatic polypeptide on glucose production by isolated rat hepatocytes
    • [18] Felíu, J.E., Mojena, M., Correas, I. and Marco, J. (1982) Lack of effect of bovine pancreatic polypeptide on glucose production by isolated rat hepatocytes. Diabete. Metab. 2, 141-145.
    • (1982) Diabete. Metab. , vol.2 , pp. 141-145
    • Felíu, J.E.1    Mojena, M.2    Correas, I.3    Marco, J.4
  • 19
    • 0016743960 scopus 로고
    • Stimulation by glucagon of the incorporation of U-14C-labeled substrates into glucose by isolated rat hepatocytes
    • [19] Claus, T.H., Plikis, S.J. and Park, C.R. (1975) Stimulation by glucagon of the incorporation of U-14C-labeled substrates into glucose by isolated rat hepatocytes. Biochim. Biophys. Acta 404, 110-123.
    • (1975) Biochim. Biophys. Acta , vol.404 , pp. 110-123
    • Claus, T.H.1    Plikis, S.J.2    Park, C.R.3
  • 20
    • 2442733778 scopus 로고
    • Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated rat hepatocytes
    • [20] Felíu, J.E., Hue, L. and Hers, H.C. (1976) Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated rat hepatocytes. Proc. Natl. Acad. Sci, USA 73, 829-837.
    • (1976) Proc. Natl. Acad. Sci, USA , vol.73 , pp. 829-837
    • Felíu, J.E.1    Hue, L.2    Hers, H.C.3
  • 21
    • 0002104059 scopus 로고
    • L-(+)-Lactate determination with lactic dehydrogenase and DPN
    • H. Bergmeyer (Ed.), Academic Press, New York
    • [21] Hohorst, H.J. (1965) L-(+)-Lactate determination with lactic dehydrogenase and DPN. In: H. Bergmeyer (Ed.), Methods of Enzymatic Analysis, Academic Press, New York, pp. 266-270.
    • (1965) Methods of Enzymatic Analysis , pp. 266-270
    • Hohorst, H.J.1
  • 22
    • 0001839476 scopus 로고
    • D-glucose 6-phosphate and D-fructose 6-phosphate. Determination with glucose 6-phosphate dehydrogenase and phosphoglucose isomerase
    • H. Bergmeyer (Ed.). Academic Press, Orlando, FL
    • [22] Hohorst, H.J. (1965) D-glucose 6-phosphate and D-fructose 6-phosphate. Determination with glucose 6-phosphate dehydrogenase and phosphoglucose isomerase. In: H. Bergmeyer (Ed.). Methods of Enzymatic Analysis, Academic Press, Orlando, FL, pp. 134-138.
    • (1965) Methods of Enzymatic Analysis , pp. 134-138
    • Hohorst, H.J.1
  • 23
    • 0020438908 scopus 로고
    • A kinetic study of pyrophosphate: Fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate
    • [23] Van Schaftingen, E., Lederer, B., Bartrons, R. and Hers, H.G. (1982) A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate. Eur. J. Biochem. 129, 191-195.
    • (1982) Eur. J. Biochem. , vol.129 , pp. 191-195
    • Van Schaftingen, E.1    Lederer, B.2    Bartrons, R.3    Hers, H.G.4
  • 24
    • 0001337932 scopus 로고
    • Insulin-like activity of dilute human serum assayed by an isolated adipose cell method
    • [24] Gliemann, J. (1965) Insulin-like activity of dilute human serum assayed by an isolated adipose cell method. Diabetes 14, 643-649.
    • (1965) Diabetes , vol.14 , pp. 643-649
    • Gliemann, J.1
  • 25
    • 0020524566 scopus 로고
    • Hormonal control of fructose-2,6-bisphosphate concentration in isolated rat hepatocytes
    • [25] Bartrons, R., Hue, L., Van Schaftingen, E. and Hers, H.G. (1983) Hormonal control of fructose-2,6-bisphosphate concentration in isolated rat hepatocytes. Biochem. J. 214, 829-837.
    • (1983) Biochem. J. , vol.214 , pp. 829-837
    • Bartrons, R.1    Hue, L.2    Van Schaftingen, E.3    Hers, H.G.4
  • 27
    • 0029125726 scopus 로고
    • Modulation of glycogen phosphorylase activity and fructose 2,6-bisphosphate levels by glibenclamide and meglitinide in isolated rat hepatocytes: A comparative study
    • [27] López-Alarcón, L., Muñoz-Alonso, M.J., Guijarro, C. and Feliu, J.E. (1995) Modulation of glycogen phosphorylase activity and fructose 2,6-bisphosphate levels by glibenclamide and meglitinide in isolated rat hepatocytes: a comparative study. Metabolism 44, 1000-1007.
    • (1995) Metabolism , vol.44 , pp. 1000-1007
    • López-Alarcón, L.1    Muñoz-Alonso, M.J.2    Guijarro, C.3    Feliu, J.E.4
  • 28
    • 0024205709 scopus 로고
    • Tolbutamide enhances insulin action on gluconeogenesis and on fructose 2,6-bisphosphate levels in isolated rat hepatocytes
    • [28] Monge, L., Cabello, M.A., Samper, B., Mojena, M. and Feliu, J.E. (1988) Tolbutamide enhances insulin action on gluconeogenesis and on fructose 2,6-bisphosphate levels in isolated rat hepatocytes. Diabete. Metab. 14, 712-716.
    • (1988) Diabete. Metab. , vol.14 , pp. 712-716
    • Monge, L.1    Cabello, M.A.2    Samper, B.3    Mojena, M.4    Feliu, J.E.5
  • 29
    • 0023258469 scopus 로고
    • Effect of glipizide on hepatic fructose 2,6-bisphosphate concentration and glucose metabolism
    • [29] Cabello, M.A., Monge, L., Ortega, J.L., Samper, B. and Feliu, J.E. (1987) Effect of glipizide on hepatic fructose 2,6-bisphosphate concentration and glucose metabolism. Metabolism 36, 738-742.
    • (1987) Metabolism , vol.36 , pp. 738-742
    • Cabello, M.A.1    Monge, L.2    Ortega, J.L.3    Samper, B.4    Feliu, J.E.5
  • 30
    • 0025870945 scopus 로고
    • Inhibition of gluconeogenesis by tolbutamide in isolated rat hepatocytes: Modulation of glucose-6-phosphate substrate cycle
    • [30] Cabello, M.A., Rodriguez, T.G., Ortega, J.L., Samper, B. and Felíu, J.E. (1991) Inhibition of gluconeogenesis by tolbutamide in isolated rat hepatocytes: modulation of glucose-6-phosphate substrate cycle. Metabolism 40, 934-940.
    • (1991) Metabolism , vol.40 , pp. 934-940
    • Cabello, M.A.1    Rodriguez, T.G.2    Ortega, J.L.3    Samper, B.4    Felíu, J.E.5
  • 31
    • 0020483680 scopus 로고
    • Fructose 2,6-bisphosphate 2 years after its discovery
    • [31] Hers, H.G. and Van, S.E. (1982) Fructose 2,6-bisphosphate 2 years after its discovery. Biochem. J. 206, 1-12.
    • (1982) Biochem. J. , vol.206 , pp. 1-12
    • Hers, H.G.1    Van, S.E.2
  • 32
    • 0020972416 scopus 로고
    • Gluconeogenesis and related aspects of glycolysis
    • [32] Hers, H.G. and Hue, L. (1983) Gluconeogenesis and related aspects of glycolysis. Annu. Rev. Biochem. 52, 617-653.
    • (1983) Annu. Rev. Biochem. , vol.52 , pp. 617-653
    • Hers, H.G.1    Hue, L.2
  • 33
    • 0019755633 scopus 로고
    • Effect of diabetes, insulin, starvation, and refeeding on the level of rat hepatic fructose 2,6-bisphosphate
    • [33] Neely, P., El, M.M., Pilkis, S.J. and Claus, T.H. (1981) Effect of diabetes, insulin, starvation, and refeeding on the level of rat hepatic fructose 2,6-bisphosphate. Diabetes 30, 1062-1064.
    • (1981) Diabetes , vol.30 , pp. 1062-1064
    • Neely, P.1    El, M.M.2    Pilkis, S.J.3    Claus, T.H.4
  • 34
    • 0020011160 scopus 로고
    • Regulation of 6-phosphofructo-2-kinase activity by cyclic AMP-dependent phosphorylation
    • [34] El, M.M., Claus, T.H., Pilkis, J. and Pilkis, S.J. (1982) Regulation of 6-phosphofructo-2-kinase activity by cyclic AMP-dependent phosphorylation. Proc. Natl. Acad. Sci. USA 79, 315-319.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 315-319
    • El, M.M.1    Claus, T.H.2    Pilkis, J.3    Pilkis, S.J.4
  • 35
    • 0021759150 scopus 로고
    • Differences in kinetic properties of phospho and dephospho forms of fructose-6-phosphate, 2-kinase and fructose 2,6-bisphosphatase
    • [35] Sakakibara, R., Kitajima, S. and Uyeda, K. (1983) Differences in kinetic properties of phospho and dephospho forms of fructose-6-phosphate, 2-kinase and fructose 2,6-bisphosphatase. J. Biol. Chem. 259, 41-46.
    • (1983) J. Biol. Chem. , vol.259 , pp. 41-46
    • Sakakibara, R.1    Kitajima, S.2    Uyeda, K.3
  • 36
    • 0028904351 scopus 로고
    • Tolbutamide inhibits glucagon-induced phosphorylation of 6PF-2-K/Fru-2,6-P2ase in rat hepatocytes
    • [36] Ayame, H., Matsutani, A., Inoue, H., Kaneko, T. and Kaku, K. (1995) Tolbutamide inhibits glucagon-induced phosphorylation of 6PF-2-K/Fru-2,6-P2ase in rat hepatocytes. Am. J. Physiol. 268, E391-E396.
    • (1995) Am. J. Physiol. , vol.268
    • Ayame, H.1    Matsutani, A.2    Inoue, H.3    Kaneko, T.4    Kaku, K.5
  • 39
    • 0020052895 scopus 로고
    • Fructose 2,6-bisphosphate: A mediator of hormone action at the fructose 6-phosphate/ fructose 1,6-bisphosphate substrate cycle
    • [39] Pilkis, S.J., El, M.M., McGrane, M., Pilkis, J., Fox, E. and Claus, T.H. (1982) Fructose 2,6-bisphosphate: a mediator of hormone action at the fructose 6-phosphate/ fructose 1,6-bisphosphate substrate cycle. Mol. Cell. Endocrinol. 25, 245-266.
    • (1982) Mol. Cell. Endocrinol. , vol.25 , pp. 245-266
    • Pilkis, S.J.1    El, M.M.2    McGrane, M.3    Pilkis, J.4    Fox, E.5    Claus, T.H.6
  • 40
    • 0019821335 scopus 로고
    • Fructose 2,6-bisphosphate. Hormonal regulation and mechanism of its formation in liver
    • [40] Hue, E., Blackmore, P.F. and Exton, J.H. (1981) Fructose 2,6-bisphosphate. Hormonal regulation and mechanism of its formation in liver. J. Biol. Chem. 256, 8900-8903.
    • (1981) J. Biol. Chem. , vol.256 , pp. 8900-8903
    • Hue, E.1    Blackmore, P.F.2    Exton, J.H.3
  • 41
    • 0015950989 scopus 로고
    • Metabolic effects of hypoglycemic sulfonylureas-III, effect of chlorpropamide on energy metabolism and ketogenesis in the isolated perfused rat liver
    • [41] Mannaerts, G., Debeer, L. and DeSchepper, P.J. (1974) Metabolic effects of hypoglycemic sulfonylureas-III, Effect of chlorpropamide on energy metabolism and ketogenesis in the isolated perfused rat liver. Biochem. Pharmacol. 23, 75-87.
    • (1974) Biochem. Pharmacol. , vol.23 , pp. 75-87
    • Mannaerts, G.1    Debeer, L.2    DeSchepper, P.J.3
  • 42
    • 0022648679 scopus 로고
    • Effects of tolbutamide on gluconeogenesis and glycolysis in isolated perfused rat liver
    • [42] Patel, T.B. (1986) Effects of tolbutamide on gluconeogenesis and glycolysis in isolated perfused rat liver. Am. J. Physiol. 250, E82-E86.
    • (1986) Am. J. Physiol. , vol.250
    • Patel, T.B.1


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