DNA interaction and topoisomerase II inhibition by the antitumor agent 3'-(9-acridinylamino)-5'-hydroxymethylaniline and derivatives

Bioorganic Chemistry

Volumn 24, Issue 3, 1996, Pages 229-241

  Scarborough, Alex ^a   Su, Tsann Long ^a   Leteutre, F F ^c   Pommier, Yves ^c   Chou, Ting Chao ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (9 ACRIDINYLAMINO) 5 HYDROXYMETHYLANILINE; AMSACRINE; ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING); UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DNA BINDING; DNA CLEAVAGE; IN VITRO STUDY; PRIORITY JOURNAL;

EID: 0030249494     PISSN: 00452068     EISSN: None     Source Type: Journal    
DOI: 10.1006/bioo.1996.0021     Document Type: Article

References (28)

1. 1. ARLIN, Z. (1983) Cancer Treat. Rep. 67, 967-970.
2. 2. NELSON, E. M., TEWEY, K. M., AND LIU, L. F. (1984) Proc. Natl. Acad. Sci. USA 81, 1361-1364.
3. 3. LIU, L. F. (1989) Annu. Rev. Biochem. 58, 351-375.
4. 4. WARING, M. J. (1976) Eur. J. Cancer 12, 995-1001.
5. 5. DENNY, AND WAKELIN, L. P. G. (1986) Cancer Res. 46, 1717-1721.
6. 6. WADKINS, R. M., AND GRAVES, D. E. (1989) Nucleic Acids. Res. 16, 9933-9946.
7. 7. BAILLY, C., DENNY, W. A., MELLOR, M. E., WAKELIN, L. P. G., AND WARING, M. J. (1992) Biochemistry 31, 3514-3524.
8. 8. KARLE, J. M., CYSYK, R. L., AND KARLE, I. L. (1980) Acta Crystallogr. B. 36, 3012-3016.
9. 9. SAKORE, T. D., REDDY, B. S., AND SOBELL, D. M. (1979) J. Mol. Biol. 135, 763-785.
10. 10. CHEN, K.-X., GRESH, N., AND PULLMAN, B. (1988) FEBS Lett. 224, 361-364.
11. 11. WADKINS, R. M., AND GRAVES, D. E. (1991) Biochemistry 30, 4277-4283.
12. 12. Su, T.-L., CHOU, T.-C., KIM, J. Y., HUANG, J.-T., CISZEWSKA, G., REN, W.-Y., OTTER, G. M., SIROTNAK, F. M., AND WATANABE, K. A. (1995) J. Med. Chem., 38, 3226-3235.
13. 13. CHOU, T. C., LETEURE F., SU, T. L., WATANABE, K. A., KONG, K. B., BECK, W. T., AND POMMIER, Y. (1994) Proc. Am. Assoc. Cancer Res. 35, 368.
14. 14. SCHMECHEL, D. E. V., AND CROTHERS, D. M. (1971) Biopolymers 10, 465-480.
15. 15. MULLER, W., AND CROTHERS, D. M. (1971) Biopolymers 10, 465-480.
16. 16. SCATCHARD, G. (1949) Ann. N. Y. Acad. Sci. 51, 660-672.
17. 17. BLAKE, A., AND PEACOCKE, A. R. (1955) Biopolymers 79, 1240-1253.
18. 18. MCGHEE, J. D., AND VON HIPPLE, P. H. (1974) J. Mol. Biol. 86, 469-489.
19. 19. FISHER, L. M., KURODA, R., AND SAKAI, T. T. (1985) Biochemistry 3199-3207.
20. 20. SAMBROOK, J., FRITSCH, E. F., AND MANIATIS, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd ed, Appendix B4, Cold Spring Harbor Press, Plainview, NY.
21. 21. KONG, X. B., RUBIN, L., CHEN, L. I., CISZEWSKA, G., WATANABE, K. Y., TONG, W. P., SIROTNAK, F. M., AND CHOU, T. C. (1992) Mol. Pharm. 41, 237-244.
22. 22. MINFORD, J., POMMIER, Y., FILIPSKI, J., KOHN, K. W., KERRIGAN, D., MATTERN, M., MICHAELS, S., SCHWARTZ, R., AND ZWELLING, L. A. (1986) Biochemistry 25, 9-16.
23. 23. LETEUTRE, F., FESEN, M., KOHLHAGEN, G., KOHN, K. W., AND POMMIER, Y. (1993) Biochemistry 32, 8955-8962.
24. 24. LETEUTRE, F., KOHLHAGEN, G., FESSEN, M., TANIZAWA, A., KOHN, K. AND POMMIER, Y., (1994) J. Biol. Chem., 269, 7893-7900.
25. 25. LETEUTRE, F., MADALENGOITIA, J., ORR, A., GUZI, T. J., LEHNERT, E., MACDONALD, T., AND POMMIER, Y. (1992) Cancer Res. 52, 4478-4483.
26. 26. LYNG, R., RODGER, A., AND NORDEN, B. (1991) Biopolymers 31, 1709-1720.
27. 27. SCUDIERO, D. A., (1988) Cancer Res. 48, 4827-4833.
28. 28. CHOU, J., AND CHOU, T. C. (1989) Dose-Effect Analysis with Microcomputers, Biosoft, Cambridge, England.