Monte Carlo spreadsheet modeling of stable isotope biosynthesis

Computers in Biology and Medicine

Volumn 26, Issue 5, 1996, Pages 429-437

  Masterson, Thomas M ^a   Kelleher, Joanne K ^a  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

Ketone bodies; Mass spectrometry; Metabolism; Models; Monte Carlo; Spreadsheet; Stable isotopes; Theoretical

Indexed keywords

KETONE BODY; STABLE ISOTOPE;

ARTICLE; BIOSYNTHESIS; MASS SPECTROMETRY; MODEL; PRIORITY JOURNAL;

EID: 0030249440     PISSN: 00104825     EISSN: None     Source Type: Journal    
DOI: 10.1016/0010-4825(96)00020-0     Document Type: Article

References (6)

1. 1. J.K. Kelleher and T.M. Masterson, Model equations for condensation biosynthesis using stable isotopes and radioisotopes, Am. J. Physiol., 262, E118-E125 (1992).
2. 2. M.K. Hellerstein, M. Christiansen, S. Kaempfer, C. Kletke, K. Wu, J.S. Reid, K. Mulligan, N.S. Hellerstein and C.H.L. Shacklelon, Measurement of De Novo hepatic lipogenesis in humans using stable isotopes, J. Clin. Invest., 87, 1841-1852 (1991).
3. 3. A.K. Kharroubi, T.M. Masterson, T.A. Aldaghlas, K.A. Kennedy and J.K. Kelleher, Isotopomer spectral analysis estimates of triglyceride fatty acids synthesis in 3T3-L1 cells, Am. J. Physiol., 263, E667-E675 (1992).
4. 4. R. R. Wolfe, Tracers in Metabolic Research. Radioisotope and Stable Isotope/Mass Spectrometry Methods. Laboratory and Research Methods in Biology and Medicine, 9. Alan R. Liss, New York (1984).
5. 5. C. Des Rosiers, J.A. Montgomery, S. Desrochers, M. Garneau, F. David, O.A. Mamer and H. Brunengraber, Interference of 3-hydroxyisobutyrate with measurements of ketone body concentration and isotopic enrichment by gas chromatography-mass Spectrometry. Anal. Biochem., 173, 96-105 (1988).
6. 6. D.M. Cohen and R.N. Bergman, Prediction of positional isotopomers of the citric acid cycle: the syntactic approach, Am. J. Physiol., 266, E341-E350 (1994).