TGF-β1 pretreatment impairs the allostimulatory function of human bone marrow-derived antigen-presenting cells for both naive and primed T cells

Transplant Immunology

Volumn 4, Issue 3, 1996, Pages 186-191

  Bonham, C Andrew ^a   Lu, Lina ^a   Banas, Richard A ^a   Fontes, Paulo ^a   Rao, Abdul S ^a   Starzl, Thomas E ^a   Zeevi, Adriana ^a   Thomson, Angus W ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; MACROPHAGE; PRIORITY JOURNAL; T LYMPHOCYTE; VERTEBRA BODY;

EID: 0030249280     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0966-3274(96)80015-3     Document Type: Article

References (37)

1. 1 Derynck R. Transforming growth factor-beta. In: Thomson AW ed. The cytokine handbook, second edition. San Diego; Academic Press, 1994: 319-42.
2. 2 Roberts AB, Sporn MB. Physiological actions and clinical applications of transforming growth factor-β (TGF-β). Growth Factors 1993; 8: 1-9.
3. 3 Wahl SM, McCartney-Francis N, Mergenhagen SE. Inflammatory and immunomodulatory roles of TGF-beta. Immunol Today 1989; 10: 258-61.
4. 4 Ruscetti F, Varesio L, Ochoa A, Ortaldo J. Pleiotropic effects of transforming growth factor-beta on cells of the immune system. Ann NY Acad Sci 1993; 685: 488-500.
5. 5 Fontana A, Constam DB, Frei K, Malipiero U, Pfister HW. Modulation of the immune response by transforming growth factor beta. Int Arch Allergy Immunol 1992; 99: 1-7.
6. 6 Kehrl JH. Transforming growth factor-beta: an important mediator of immunoregulation. Int J Cell Cloning 1991; 9: 438-50.
7. 7 Rook AH, Kehrl JH, Wakefield LM et al. Effects of transforming growth factor beta on the functions of natural killer cells; depressed cytolytic activity and blunting of interferon responsiveness. J Immunol 1986; 136: 3916-20.
8. 8 Kehrl JH, Taylor A, Kim SJ, Fauci AS. Transforming growth factor-β is a potent negative regulator of human lymphocytes. Ann NY Acad Sci 1991; 628: 345-53.
9. + T lymphocytes. Inhibition by transforming growth factor-beta. J Immunol 1991; 146: 3289-97.
10. 10 Czarniecki CW, Chiu HH, Wong GH, McCabe SM, Palladino MA. Transforming growth factor-beta 1 modulates the expression of class II histocompatibility antigens on human cells. J Immunol 1988; 140: 4217-23.
11. 11 Espevik T, Figari IS, Shalaby MR et al. Inhibition of cytokine production by cyclosporin A and transforming growth factor beta. J Exp Med 1987; 166; 571-76.
12. 12 Tsunawaki S, Sporn M, Ding A, Nathan C. Deactivation of macrophages by transforming growth factor-beta. Nature 1988; 334: 260-62.
13. 13 McCluskey J, Blok R, Brooks A, Chen W, Kanost D, Kjer-Nielsen L. The biology of antigen processing and presentation. In: McCluskey J ed. Antigen processing and recognition. Boca Raton: CRC Press, 1991: 1-54.
14. 14 Unanue ER. Macrophages, antigen-presenting cells, and the phenomena of antigen handling and presentation. In: Paul WE ed. Fundamental immunology. New York: Raven Press, 1993: 111-44.
15. 15 Fontes P, Rao AS, Demetris AJ et al. Bone marrow augmentation of donor-cell chimerism in kidney, liver, heart, and pancreas islet transplantation. Lancet 1994; 344: 151-55.
16. 16 Starzl TE, Demetris AJ, Trucco M et al. Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance. Hepatology 1993; 17: 1127.
17. 17 Steinman RM, Inaba K, Austyn JM. Donor-derived chimerism in recipients of organ transplants. Hepatohgy 1993; 17: 1153-56.
18. 18 Thomson AW, Lu L, Murase N, Demetris AJ, Rao AS, Starzl TE. Microchimerism, dendritic cell progenitors and transplantation tolerance. Stem Cells 1995; 13: 622-39.
19. 19 Inaba K, Inaba M, Romani N et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992; 176: 1693-702.
20. 20 Caux C, Dezutter-Dambuyant D, Schmitt D, Banchereau J. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature 1992; 360; 258-61.
21. 21 Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J Exp Med 1994; 179: 1109-18.
22. 22 Lu L, Woo J, Rao AS et al. Propagation of dendritic cell progenitors from normal mouse liver using granulocyte/macrophage colony-stimulating factor and their maturational development in the presence of type-1 collagen. J Exp Med 1994; 179: 1823-34.
23. 23 Demidem A, Taylor JR, Grammer SF, Streilein JW. Comparison of effects of transforming growth factor-beta and cyclosporin A on antigen-presenting cells of blood and epidermis. J Invest Dermatol 1991; 96: 401-407.
24. 24 Wilbanks GA, Streilein JW. Fluids from immune privileged sites endow macrophages with the capacity to induce antigen-specific immune deviation via a mechanism involving transforming growth factor-β. Eur J Immunol 1992; 22: 1031-36.
25. 25 Grabbe S, Bruvers S, Granstein RD. Interleukin 1α but not transforming growth factor β inhibits tumor antigen presentation by epidermal antigen-presenting cells. J Invest Dermatol 1994; 102: 67-73.
26. 26 Steinman RM. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991; 9: 271-96.
27. 27 Thomas R, Davis LS, Lipsky PE. Comparative accessory cell function of human peripheral blood dendritic cells and monocytes. J Immunol 1993; 151: 6840-52.
28. 28 Hart DNJ, Calder VL. Human dendritic cells: function and cytokine production. In: Bruijnzeel-Koomen CA, Hoefsmit FC eds. Immunopharmacology of macrophages and other antigen-presenting cells. San Diego: Academic Press, 1994: 63-91.
29. 29 Fava R, Olsen N, Keski-Oja J, Moses H, Pincus T. Active and latent forms of TGF-beta activity in synovial effusions. J Exp Med 1989; 169: 291-96.
30. 30 Li B, Sehajpal PK, Khanna A et al. Differential regulation of transforming growth factor β and interleukin 2 genes in human T cells: demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction. J Exp Med 1991; 174: 1259-62.
31. 31 Raju GP, Belland SE, Eisen HJ. Prolongation of cardiac allograft survival with transforming growth factor-β1 in rats. Transplantation 1994; 58: 392-96.
32. 32 Carel JC, Sheehan KC, Schreiber RD, Lacy PE. Prevention of rejection of transforming growth factor beta-treated rat-to-mouse islet xenografts by monoclonal antibody to tumor necrosis factor. Transplantation 1993; 55: 456-58.
33. 33 Kuruvilla AP, Shah R, Hochwald GM, Liggitt HD, Palladino MA, Thorbecke GJ. Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice. Proc Natl Acad Sci USA 1991; 88: 2918-21.
34. 34 Brandes ME, Allen JB, Ogawa Y, Wahl SM. Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals. J Clin Invest 1991; 87: 1108-13.
35. 35 Verbanac KM, Carver FM, Haisch CE, Thomas JM. A role for transforming growth factor-beta in the veto mechanism in transplant tolerance. Transplantation 1994; 57: 893-900.
36. 36 Barber WH, Mankin JA, Laskow DA et al. Long term results of a controlled prospective study with transfusion of donor-specific bone marrow in 57 cadaveric renal allograft recipients. Transplantation 1991; 51: 70-75.
37. 37 Qin L, Chavin KD, Ding Y et al. Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Transplantation 1995; 59: 809-16.