Human CD4-reactive antibodies from SLE patients induce reversible inhibition of polyclonal T lymphocyte proliferation

Human Immunology

Volumn 49, Issue 2, 1996, Pages 113-121

  Lenert, Gordana ^a   Lenert, Petar ^a  

^a NOTRE DAME HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 2; STAPHYLOCOCCUS ENTEROTOXIN A; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN;

ANTIBODY DETECTION; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION;

EID: 0030249163     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/0198-8859(96)00054-7     Document Type: Article

References (39)

1. 1. Maddon PJ, Littman DR, Godfrey M, Maddon DE, Chess L, Axel R: The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. Cell 42:93, 1985.
2. 2. Gay D, Maddon P, Sékaly R, Talle MA, Godfrey M, Long E, Goldstein G, Chess L, Axel R, Kappler J, Marrack P: Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen. Nature 328:626, 1987.
3. 3. Janeway CA Jr, Haque S, Smith LA, Saizawa K: The role of the murine L3T4 molecule in T cell activation: differential effects of anti-L3T4 on activation by monoclonal anti-receptor antibodies. J Mol Cell Immunol 3:121, 1987.
4. 4. Doyle C, Strominger JL: Interaction between CD4 and class II MHC molecules mediates cell adhesion. Nature 330:256, 1987.
5. 5. Lamarre D, Ashkenazi A, Fleury S, Smith DH, Sekaly R-P, Capon DJ: The MHC-binding and gp120-binding functions of CD4 are separable. Science 245:743, 1989.
6. 6. Clayton LK, Sieh M, Pious DA, Reinherz EL: Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding. Nature 339:549, 1989.
7. 7. Lamarre D, Capon DJ, Karp DR, Gregory T, Long EO, Sékaly R-P: Class II MHC molecules and the HIV gp120 envelope protein interact with functionally distinct regions of the CD4 molecule. EMBO J 8:3271, 1989.
8. 8. Cammarota G, Scheirie A, Takacs B, Doran DM, Knorr R, Bannwarth W, Guardiola J, Sinigaglia F: Identification of a CD4 binding site on the β2 domain of HLA-DR molecules. Nature 356:799, 1992.
9. 9. Weber S, Karjalainen K: Mouse CD4 binds MHC class II with extremely low affinity. Int Immunol 5:695, 1993.
10. 10. Lenert P, Kroon D, Spiegelberg H, Golub ES, Zanetti M: Human CD4 binds immunoglobulins. Science 248:1639, 1990.
11. 11. Lenert P, Zanetti M: CD4/immunoglobulin interaction: implications for immune physiology and autoimmunity. Int Rev Immunol 7:237, 1991.
12. 12. Dianzani U, Bragardo M, Buonfiglio D, Redoglia V, Funaro A, Portoles P, Rojo J, Malavasi F, Pileri A: Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120. Eur J Immunol 25: 1306, 1995.
13. 13. Janeway CA Jr: The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu Rev Immunol 10:645, 1992.
14. 14. Anderson P, Blue ML, Morimoto C, Schlossman SF: Cross-linking of T3 (CD3) with T4 (CD4) enhances the proliferation of resting T lymphocytes. J Immunol 139: 678, 1987.
15. 15. Emmrich F, Kanz L, Eichmann K: Cross-linking of the T cell receptor complex with the subset-specific differentiation antigen stimulates interleukin 2 receptor expression in human CD4 and CD8 T cells. Eur J Immunol 17:529, 1987.
16. 16. Anderson P, Blue ML, Schlossman SF: Comodulation of CD3 and CD4. Evidence for a specific association between CD4 and approximately 5% of the CD3:T cell receptor complexes on helper T lymphocytes. J Immunol 140: 1732, 1988.
17. 17. Dianzani U, Shaw A, al-Ramadi BK, Kubo RT, Janeway CA Jr: Physical association of CD4 with the T cell receptor. J Immunol 148:678, 1992.
18. 18. Bank I, Chess L: Perturbation of the T4 molecule transmits negative signal to T cells. J Exp Med 162:1294, 1985.
19. 19. Wassmer PP, Chan C, Logdberg L, Shevach EM: Role of the L3T4-antigen in T cell activation. II. Inhibition of T cell activation by monoclonal anti-L3T4 antibodies in the absence of accessory cells. J Immunol 135:2237, 1985.
20. 20. Owens T, Fazekas de St. Groth B: Participation of L3T4 in T cell activation in the absence of class II major histocompatibility complex antigens: inhibition by anti-L3T4 antibodies is a function both of epitope density and mode of presentation of anti-receptor antibody. J Immunol 138:2402, 1987.
21. 21. Mann DL, Lasane F, Popovic M, Arthur LO, Robey WG, Blattner WA, Newman MJ: HTLV-III large envelope protein (gp120) suppresses PHA-induced lymphocyte blastogenesis. J Immunol 138:2640, 1987.
22. 22. Diamond DC, Sleckman BP, Gregory T, Lasky LA, Greenstein JL, Burakoff SJ: Inhibition of CD4+ T cell function by the HIV envelope protein gp120. J Immunol 141:3715, 1988.
23. 23. Mittler RS, Hoffmann MK: Synergism between HIV gp120 and gp120-specific antibody in blocking human T cell activation. Science 245:1380, 1989.
24. 24. Carrel S, Moretta A, Pantaleo G, Tambussi G, Isler P, Perussia B, Cerottini JC: Stimulation and proliferation of CD4+ peripheral blood T lymphocytes induced by an anti-CD4 monoclonal antibody. Eur J Immunol 18:333, 1988.
25. 25. Robey E, Allison JP: T cell activation: integration of signals from the antigen receptor and costimulatory molecules: Immunol Today 16:306, 1995.
26. 26. Newell MK, Haughn LJ, Maroun CR, Julius MH: Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen. Nature 347:286, 1990.
27. 27. Banda NK, Bernier J, Kurahara DK, Kurrle R, Haigwood N, Sekaly R-P, Finkel TH: Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J Exp Med 176:1099, 1992.
28. 28. Oyaizu N, McCloskey TW, Than S, Hu R, Kalyanaraman VS, Pahwa S: Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-γ and tumor necrosis factor-α secretion. Blood 84: 2622, 1994.
29. 29. Di Somma MM, Nuti S, Telford JL, Baldari CT: p56lck plays a key role in transducing apoptotic signals in T cells. FEBS Lett 363:101, 1995.
30. 30. Wang Z-q, Dudhane A, Orlikowsky T, Clarke K, Li X, Darzynkiewicz Z, Hoffmann MK: CD4 engagement induces Fas antigen-dependent apoptosis of T cells in vivo. Eur J Immunol 24:1549, 1994.
31. 31. Jabs DA, Kuppers RC, Saboori AM, Burek CL, Enger C, Lee B, Prendergast RA: Effects of early and late treatment with anti-CD4 monoclonal antibody on autoimmune disease in MRL/MP-lpr/lpr mice. Cell Immunol 154:66, 1994.
32. 32. O'Sullivan FX, Vogelweid CM, Besch-Williford CL, Walker SE: Differential effects of CD4 + T cell depletion on inflammatory central nervous system disease, arthritis and sialadenitis in MRL/lpr mice. J Autoimmun 8:163, 1995.
33. 33. Zerbib AC, Reske-Kunz AB, Lock P, Sekaly R-P: CD4-mediated enhancement or inhibition of T cell activation does not require the CD4:p56lck association. J Exp Med 179:1973, 1994.
34. 34. Wang J, Yan T, Simmer B, Emmrich F: The effect of anti-CD4 on helper function of CD4, 45RA+ versus CD4, 45RO+ T cells. Clin Exp Immunol 95:128, 1994.
35. 35. Howie SE, Sommerfield AJ, Gray E, Harrison DJ: Peripheral T lymphocyte depletion by apoptosis after CD4 ligation in vivo: selective loss of CD44- and 'activating' memory T cells. Clin Exp Immunol 95:195, 1994.
36. 36. Stumbles P, Mason D: Activation of CD4+ T cells in the presence of nondepleting monoclonal antibody to CD4 induces a Th2-type response in vitro. J Exp Med 182:5, 1995.
37. 37. Mottram PL, Han WR, Purcell LJ, McKenzie IF, Hancock WW: Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-gamma in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy. Transplantation 59:559, 1995.
38. 38. Winfield JB, Mimura T: Pathogenetic significance of anti-lymphocyte autoantibodies in systemic lupus erythematosus. Clin Immunol Immunopathol 63:13, 1992.
39. 39. Denburg SD, Behmann SA, Carbotte RM, Denburg JA: Lymphocyte antigens in neuropsychiatric systemic lupus erythematosus. Arthritis Rheum 37:369, 1994.