Flow cytometric analysis of lymphocytes from rats following chronic ethanol treatment

Alcohol

Volumn 13, Issue 5, 1996, Pages 467-471

  Helm, Ricki M ^a,b   Wheeler, Gary ^a   Burks, A Wesley ^a   Hakkak, Reza ^a   Badger, Thomas M ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b ARKANSAS CHILDREN S HOSPITAL   (United States)

Author keywords

Alcoholism; B cells; CD4 CD8 rat lymphocytes; Total enteral nutrition

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENTERIC FEEDING; FLOW CYTOMETRY; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; NONHUMAN; NUTRIENT; RAT;

EID: 0030248710     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/0741-8329(96)00036-5     Document Type: Article

References (36)

1. 1. Adams, H. G.; Jordon, C. Infections in the alcoholic. Med. Clin. North Am. 68:179-200; 1984.
2. 2. Ali, M. F.; Nolan, J. P. Alcohol induced depression of reticuloendothelial function in the rat. J. Lab. Clin. Med. 70:295-301; 1967.
3. 3. Badger, T. M. Effects of total parenteral nutrition on luteinizing hormone dynamics in the male rat. J. Nutr. 115:798-806; 1985.
4. 4. Badger, T. M.; Crouch, J.; Irby, D.; Hakkak, R.; Shahare, M. Episodic excretion of ethanol during chronic intragastric ethanol infusion in the male rat: Continuous vs. cyclic ethanol and nutrient infusions. J. Pharmacol. Exp. Ther. 264:938-943; 1993.
5. 5. Badger, T. M.; Ronis, M. J.; Ingelman-Sundberg, M.; Hakkak, R. Pulsatile blood alcohol and CYP2E1 induction during chronic alcohol infusion in rats. Alcohol 10:453-457; 1993.
6. 6. Badger, T. M.; Ronis, M. J .J.; Lumpkin, C. K.; Valentine, C. R.; Sharare, M.; Irby, D.; Huang, J.; Mercado, C.; Thomas, P. E.; Ingelman-Sundberg, M.; Crouch, J. Effects of chronic ethanol on growth hormone secretion and hepatic cytochrome P450 isozymes of the rat. J. Pharmacol. Exp. Ther. 264: 438-447; 1993.
7. 7. Bagasra, O.; Howeedy, A.; Dorio, R.; Kajdacsy-Balla, A. Functional analysis of T-cell subsets in chronic experimental alcoholism. Immunology 61:63-69; 1987.
8. 8. Bernstein, I. M.; Webster, K. H.; Williams, R. C., Jr.; Strickland, R. G. Reduction in circulation T lymphocytes in alcoholic liver disease. Lancet 2:488-490; 1974.
9. 9. Brayton, R. G.; Stokes, P. E.; Schwartz, M.S.; Louria, D. B. Effect of alcohol and various diseases on leukocyte mobilization, phagocytosis and intracellular bacterial killing. N. Engl. J. Med. 282:123-128; 1970.
10. 10. Chandra, R. K. Nutrition and immunology. New York: Alan R. Liss; 1988.
11. 11. Cooper, B.; Maderazo, E. G. Alcohol abuse and impaired immunity. Infect. Surg. March:94-101; 1989.
12. 12. French, S. W.; Miyamoto, K.; Tsukamoto, J. Ethanol-induced hepatic fibrosis in the rat: Role of the amount of dietary fat. Alcohol. Clin. Exp. Res. 10:13S-19S; 1986.
13. 13. Grossman, C. J.; Nienaber, M.; Mendenhall, C. L.; Huitubise, P.; Roselle, G. A.; Rouster, S.; Weber, N.; Schmitt, G.; Gartside, P. S. Sex differences and the effects of alcohol on immune response in male and female rats. Alcohol. Clin, Exp. Res. 17:832-840; 1993.
14. 14. Jerrells, T. R.; Marietta, C. A.; Bone, G.; Weight. F. F.; Eckhardt, M. J. Ethanol-associated immunosuppression. In: Bridge, T. P., ed. Psychological, neuropsychiatric and substance abuse aspects of AIDS. New York: Raven Press; 1988:173.
15. 15. Jerrells, T. R.; Marietta, C. A.; Eckhardt, M. J.; Majchrowicz, E.; Weight, F. F. Effects of ethanol on parameters of immunocompetency in rats. J. Leukocyte Biol. 39:499-510; 1986.
16. 16. Jerrells, T. R.; Smith, W.; Eckhardt, M. J. Murine model of ethanol-induced immunosuppression. Alcohol. Clin. Exp. Res. 14:546-550; 1990.
17. 17. Lieber, C. S.; DeCarli, L. M. Liquid diet technique of ethanol administration: 1989 update. Alcohol Alcohol. 24:197-211; 1989.
18. 18. Marietta, C. A.; Jerrells, T. R.; Meagher, R. C.; et al. Effects of long-term ethanol inhalation of the immune and hemopoietic systems of the rat. Alcohol. Clin. Exp. Res. 12:211-214; 1988.
19. 19. Meadows, G. G.; Blank, S. E.; Duncan, D. A. Modulation of natural killer cell activity by alcohol consumption and nutritional status. In: Seminara, D.; Watson, R. R.; Pawlowski, A., eds. Alcohol, immunomodulation, and AIDS. New York: Alan R. Liss, Inc.; 1990:181-190.
20. 20. Meadows, G. G.; Wallendal, M.; Kosugi.; Wunderlich, J.; Singer, D. S. Ethanol induces marked changes in lymphocyte populations and natural killer cell activity in mice. Alcohol. Clin. Exp. Res. 16:474-479; 1992.
21. 21. Mufti, S. I.; Prabhala, R.; Moriguchi, S.; Sipes, I. G.; Watson, R. R. Functional and numerical alterations induced by ethanol in the cellular immune response. Immunopharmacology 15:85-93; 1988.
22. 22. National Research Council. Nutrient requirements of the laboratory rat. In: Nutrient requirements of laboratory animals. No. 101, 3rd ed. Washington, DC: National Academy of Sciences; 178:7-37.
23. 23. Palmer, D. L. Infection and the compromised host: Clinical correlations and therapeutic approaches. Baltimore: Williams and Wilkins; 1981.
24. 24. Rao, G. A.; Larkin, E. C. Inadequate intake by growing rats of essential nutrients from liquid diets used for chronic alcohol consumption. Nutr. Res. 5:789-796; 1985.
25. 25. Rao, G. A.; Larkin, E. C.; Derr, R. F. Effects of chronic alcohol ingestion: Role of nutritional factors. Biochem. Arch. 5:289-296; 1989.
26. 26. Rao, G. A.; Larkin, E. C.; Porta, E. A. Two decades of chronic alcoholism research with the misconception that liver damage occurred despite adequate nutrition. Biochem. Arch. 2:223-227; 1986.
27. 27. Ronis, M. J.; Lumpkin, C. K.; Ingelman-Sundberg, M.; Badger, T. M. Effects of short term ethanol and nutrition on the hepatic microsomal monooxygenase system in a model utilizing total enteral nutrition in the rat. Alcohol. Clin. Exp. Res. 15:693-699; 1991.
28. 28. Saad, A. J.; Jerrells, T. R. Flow cytometric and immunohistochemical evaluation of ethanol-induced changes in splenic and thymic lymphoid cell populations. Alcohol. Clin. Exp. Res. 15:796-803; 1991.
29. 29. Stone, F. L.; Smith, W. I.; Van Thiel, D. H. The effects of alcohol and partial portal ligation on the immune system of the rat. Gastroenterology 72:1133; 1977.
30. 30. Tennebaum, J. I.; Ruppert, R. D.; St. Pierre, R. L.; Greenberger, N. J. The effect of chronic alcohol concentration on the immune responsiveness of rats. J. Allergy 44:272-280; 1969.
31. 31. Tsukamoto, H.; French, S. W.; Benson, N.; Delgado, G.; Rao, G. A.; Larkin, E. C.; Largman, C. Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet. Hepatology 5:224-232; 1985.
32. 32. Tsukamoto, H.; Gaal, K.; French, S. W. Insights in the pathogenesis of alcoholic liver necrosis and fibrosis: Status report. Hepatology 12:599-608; 1990.
33. 33. Tsukamoto, H.; Towner, S. J.; Ciofalo, L. M.; French, S. W. Ethanol-induced liver fibrosis in rats fed a high fat diet. Hepatology 6(5):814-822; 1986.
34. 34. Watson, R. R. Nutrition, disease resistance, and immune function. New York: Marcel Dekker; 1984.
35. 35. Watson, R. R.; Prabhala, R. N.; Abril, E.; Smith, T. L. Changes in lymphocyte subsets and macrophage function from high, short-term dietary ethanol in C57/BL6 mice. Life Sci. 43:865-870; 1988.
36. 36. Young, G. P.; Van der Weyden, M. B.; Rose, I. S.; Dudley, F. J. Lymphopenia and lymphocyte transformation in alcoholics. Experimentia 35:268-269; 1977.