Effects of lead on growth plate chondrocyte phenotype

Toxicology and Applied Pharmacology

Volumn 140, Issue 1, 1996, Pages 164-172

  Hicks, David G ^a   O'Keefe, Regis J ^a   Reynolds, Kiley J ^a   Cory Slechta, Deborah A ^a   Puzas, J Edward ^a   Judkins, Alexander ^a   Rosier, Randy N ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN TYPE 10; COLLAGEN TYPE 2; LEAD; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CALCIFICATION; CARTILAGE CELL; CELL CULTURE; CHICKEN; CONTROLLED STUDY; CYTOCHEMISTRY; DOSE RESPONSE; GROWTH PLATE; LEAD POISONING; NONHUMAN; PHENOTYPE; PROTEOGLYCAN SYNTHESIS;

ANIMALIA; AVES; GALLUS GALLUS;

EID: 0030248153     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0209     Document Type: Article

References (46)

1. Anderson, C., and Danylchuk, K. D. (1977). The effect of chronic low level lead intoxication on the haversian remodeling system in dogs. Lab. Invest. 37, 466-469.
2. 3 and IGF-I. Toxicol. Appl. Pharmacol. 103, 281-287.
3. Barry, P. (1975). A comparison of concentrations of lead in human tissues. Br. J. Intern. Med. 32, 119-139.
4. Bashey, R. I., Leach, R. M., Gay, C. V., and Jimenez, S. A. (1989). Type X collagen in avian tibial dyschondroplasia. Lab Invest. 60, 106-112.
5. Binderman, I., Greene, R. M., and Pennypacker, J. P. (1979). Calcification of differentiating skeletal mesenchyme in vitro. Science 206, 222-225.
6. Camoratto, A. M., White, L. M., Lau, Y. S., Ware, G. O., Berry, W. D., and Moriarty, C. M. (1993). Effect of exposure to low level lead on growth and growth hormone release in rats. Toxicology 83, 101-114.
7. Crabb, I. D., Hughes, S. S., Hicks, D. G., Puzas, J. E., and Rosier, R. N. (1992a). Nonradioactive in-situ hybridization using digoxigenin labeled oligonucleotides: Applications to musculoskeletal tissues. Am. J. Pathol. 141, 579-589.
8. Crabb, I. D., O'Keefe, R. J., Puzas, J. E., and Rosier, R. N. (1992b). Differential effects of parathyroid hormone on chick growth plate and articular chondrocytes. Calcif. Tissue. Int. 50, 61-66.
9. Crabb, I. D., O'Keefe, R. J., Puzas, J. E., and Rosier, R. N. (1990). Synergistic effect of transforming growth factor-beta and fibroblast growth factor on DNA synthesis in chick growth plate chondrocytes. J. Bone Miner. Res. 5, 1105-1113.
10. Eisenstein, R., and Kawanoue, S. (1975). The lead line in bone-A lesion apparently due to chondroclastic indigestion. Am. J. Pathol. 80, 309-316.
11. Gelb, D., Rosier, R. N., and Puzas, J. E. (1990). Transforming growth factor production by chick growth plate chondrocytes. Endocrinology 127, 1941-1947.
12. Hamilton, J. D., and O'Flaherty, E. J. (1994). Effects of lead exposure on skeletal development in rats. Fundam. Appl. Toxicol. 22, 594-604.
13. Hamilton, J. D., and O'Flaherty, E. J. (1995). Influence of lead on mineralization during bone growth. Fundam. Appl. Toxicol. 26, 265-271.
14. Hammond, P. B., Chernausek, S. D., Succop, P. A., Shukla, R., and Bornschein, R. L. (1989). Mechanisms by which lead depresses linear and ponderal growth in weanling rats. Toxicol. Appl. Pharmacol. 99, 474-86.
15. Hammond, P. B., Minnema, D. J., and Shukla, R. (1990). Lead exposure lowers the set point for food consumption and growth in weanling rats. Toxicol. Appl. Pharmacol. 106, 80-87.
16. Hass, G. M., Landerholm, W., and Annehemmens, A. (1967). Inhibition of intercellular matrix synthesis during ingestion of inorganic lead. Am. J. Pathol. 50, 815-847.
17. Iannotti, J. P. (1990). Growth plate physiology and pathology. Orthop. Clin. N. Am. 21, 1-17.
18. Jacenko, O., LuValle, P. A., and Olsen, B. R. (1993). Spondylometaphyseal dysplasia in mice carrying a dominant negative mutation in a matrix protein specific for cartilage-to-bone transition. Nature. 365, 56-61.
19. Klein, G. L. (1993). Nutritional rickets and osteomalacia. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (M. J. Favus, Ed.), 2nd ed., pp. 264-268. Raven Press New York.
20. Klein, R. F., and Wiren, K. M. (1993). Regulation of osteoblastic gene expression by lead. Endocrinology 132, 2531-2537.
21. Lauwers, M. C., Hauspie, R. C., Susanne, C., and Verheyden, J. (1986). Comparison of biometric data of children with high and low levels of lead in the blood. Am. J. Phys. Anthrop. 69, 107-116.
22. Lewinson, D., Toister, Z., and Silbermann, M. (1982). Quantitative and distributional changes in the activity of alkaline phosphatase during the maturation of cartilage. J. Histochem. Cytochem. 30, 261-269.
23. Long, G. J., Rosen, J. F., and Pounds, J. G. (1990). Cellular lead toxicity and metabolism in primary and clonal osteoblastic bone cells. Toxicol. Appl. Pharmacol. 102, 346-361.
24. Loveys, L. S., Crabb, I. D., O'Keefe, R. J., Reynolds, P. R., Hicks, D. G., Puzas, J. E., and Rosier, R. N. (1995). Differential regulation of type II and type X collagen synthesis by parathyroid hormone related peptide in chick growth plate chondrocytes. Submitted for publication.
25. Milgram, J. W. (1990). Chemical toxic agents affecting bone growth and structure, Lead. In Radiologic and Histologic Pathology of Non-tumorous Diseases of Bones and Joints, pp. 859-860 Northbrook Publishing Co., Northbrook, IL.
26. Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63.
27. O'Keefe, R. J., Crabb, I. D., Puzas, J. E., and Rosier, R. N. (1988a). Effect of transforming growth factor-β on DNA synthesis by growth plate chondrocytes: Modulation by factors present in serum. Calcif. Tissue Int. 43(6), 352-358.
28. O'Keefe, R. J., Puzas, J. E., Brand, J. S., and Rosier, R. N. (1988b). Effects of transforming growth factor beta on matrix synthesis by chick growth plate chondrocytes. Endocrinology 122, 2953-2961.
29. O'Keefe, R. J., Crabb, I. D., Puzas, J. E., and Rosier, R. N. (1989). Counter current centrifugal elutriation-high resolution method for the separation of growth plate chondrocytes. J. Bone Joint Surg. 71A, 607-620.
30. O'Keefe, R. J., Rosier, R. N., and Puzas, J. E. (1990). Differential expression of biological effects in maturationally distinct subpopulations of growth plate chondrocytes. Conn. Tiss. Res. 24, 53-66.
31. O'Keefe, R. J., Crabb, I. D., Puzas, J. E., and Rosier, R. N. (1992). The influence of prostaglandins on DNA and matrix synthesis by growth plate chondrocytes. J. Bone Miner. Res. 7(4), 397-404.
32. O'Keefe, R. J., Puzas, J. E., Loveys, L. S., Hicks, D. G., and Rosier, R. N. (1994). Analysis of type II and type X collagen synthesis in cultured growth plate chondrocytes by in situ hybridization: Rapid induction of type X collagen in culture. J. Bone Miner. Res. 9, 1713-1722.
33. Park, E. A. (1933). Xray shadows in growing bones produced by lead, their characteristics, causes, anatomical counterpart in the bone and differentiation. J. Pediatr. 3, 265-298.
34. Pearl, M., and Boxt, L. M. (1980). Radiographic findings in congenital lead poisoning. Radiology 136, 83-84.
35. Pounds, J. G., Long, G. J., and Rosen, J. F. (1991). Cellular and molecular toxicity of lead in bone. Environ. Health Perspect. 91, 17-32.
36. Puzas, J. E., and Brand, J. S. (1986). The effect of bone cell stimulatory factors can be measured with thymidine incorporation only under specific conditions. Calc. Tissue Intl. 39, 104-108.
37. Puzas, J. E., and Goodman, D. B. P. (1978). A rapid assay for cellular deoxyribonucleic acid. Anal. Biochem. 86, 50-55.
38. Puzas, J. E., Sickel, M. J., and Felter, M. E. (1992). Osteoblasts and chondrocytes are important target cells for the toxic effects of lead. Neurotoxicology 13, 783-788.
39. Schwartz, J., Angle, C., and Pitcher, H. (1986). Relationship between childhood blood lead levels and stature. Pediatrics 77, 281-288.
40. Shukla, R., Bornschein, R. L., et al. (1989). Effects of fetal and infant lead exposure on growth in stature. Pediatrics 84, 604-612.
41. Shukla, R., Dietrich, K. N., Bornschein, R. L., Berger, O., and Hammond, P. B. (1991). Lead exposure and growth in the early preschool child: A follow-up report from the Cincinnati Lead Study. Pediatrics 88, 886.
42. Spranger, J., Winterpacht, A., and Zabel, B. (1994). The type II collagenopathies: A spectrum of chondrodysplasias. Eur. J. Pediatr. 153, 56-65.
43. Suzuki, F., Takase, T., Takigawa, M., and Uchida, A. (1981). Simulation of the initial stage of endochondral ossification: In vitro sequential culture of growth cartilage cells and bone marrow cells. Proc. Natl. Acad. Sci. USA 78, 2368-2372.
44. Teitelbaum, S. L. (1993). Molecular defects of bone development. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (M. J. Favus, Ed.) 2nd ed., pp. 10-21. Raven Press, New York.
45. Wallis, G. A., Sweetman, W. A., Thomas, J. T., Super, M., Evans, G., Grant, M. E., and Boot-Handford, R. P. (1994). Amino acid substitutions of conserved residues in the carboxyl-terminal domain of the α1(X) chain of type X collagen occur in two unrelated families with metaphyseal chondrodysplasia type Schmid. Am. J. Hum. Genet. 54, 169-178.
46. Whyte, M. P. (1993). Molecular defects of bone development. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (M. J. Favus, Ed.) 2nd ed., pp. 288-290. Raven Press, New York.