Replication and pathogenicity after intranasal and intracranial inoculation of swine with a recombinant pseudorabies virus containing a deletion at the UL/IR junction

Virology

Volumn 223, Issue 1, 1996, Pages 19-28

  Dean, H J ^a,c   Miller, J M ^a   Ackermann, M R ^a   Gao, X Y ^e   Anderson, L L ^b   Jacobson, C D ^b   Cheung, A K ^a,d  

^a NATIONAL ANIMAL DISEASE CENTER   (United States)

^b IOWA STATE UNIVERSITY   (United States)

^c MALLINCKRODT PHARMACEUTICALS   (United States)

^d AGRICULTURAL RESEARCH SERVICE   (United States)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DELETION MUTANT; INOCULATION; NONHUMAN; NOSE; PRIORITY JOURNAL; PSEUDORABIES HERPETOVIRUS; SWINE; VIRUS PATHOGENESIS; VIRUS REPLICATION;

EID: 0030248092     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1996.0451     Document Type: Article

References (22)

1. Babic, N., Mettenleiter, T. C., Flamand, A., and Ugolini, G. (1993). Role of essential glycoproteins gII and gp50 in transneuronal transfer of pseudorabies virus from the hypoglossal nerves of mice. J. Virol. 67, 4421-4426.
2. Babic, N., Mettenleiter, T. C., Ugolini, G., Flamand, A., and Coulon, P. (1994). Propagation of pseudorabies virus in the nervous system of the mouse after intranasal inoculation. Virology 204, 616-625.
3. Bloom, D., and Stevens, J. G. (1994). Neuron-specific restriction of a herpes simplex virus recombinant maps to the UL5 gene. J. Virol. 68, 3761-3772.
4. Bolovan, C. A., Sawtell, N. M., and Thompson, R. L. (1994). ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures. J. Virol. 68, 48-55.
5. Card, J. P., and Enquist, L. W. (1994). Use of pseudorabies virus for definition of synaptically linked populations of neurons. In "Methods in Molecular Genetics, Vol. 4: Molecular Virology Techniques, Part A" (W. Adolph, Ed.), pp. 363-382. Academic Press, New York.
6. Card, J. P., Rinaman, L., Schwaber, J. S., Miselis, R. R., Whealy, M. E., Robbins, A. K., and Enquist, L. W. (1990). Neurotropic properties of pseudorabies virus: Uptake and transneuronal passage in the rat central nervous system. J. Neurosci. 10(66), 1974-1994.
7. Card, J. P., Whealy, M. E., Robbins, A. K., and Enquist, L. W. (1992). Pseudorabies virus envelope glycoprotein gI influences both neurotropism and virulence during infection of the rat visual system. J. Virol. 66, 3032-3041.
8. Cheung, A. K. (1990). The BamHI Jfragment (0.706 to 0.737 map units) of pseudorabies virus is transcriptionally active during viral replication. J. Virol. 64, 977-983.
9. Cheung, A. K., Fang, J., and Wesley, R. D. (1994). Characterization of a pseudorabies virus defective in the early protein 0 and latency genes. Am. J. Vet. Res. 55, 1710-1716.
10. Chou, J., Kern, E. R., Whitley, R. J., and Roizman, B. (1990). Mapping of herpes simplex virus-1 neurovirulence to gamma 34.5, a gene nonessential for growth in culture. Science 250, 1262-1266.
11. Dean, H. J., and Cheung, A. K. (1995). A deletion at the UL/IR junction reduces pseudorabies virus neurovirulence. J. Virol. 69, 1334-1338.
12. Izumi, K. M., and Stevens, J. G. (1990). Molecular and biological characterization of a herpes simplex virus type 1 (HSV-1) neuroinvasiveness gene. J. Exp. Med. 172, 487-496.
13. Javier, R. T., Izumi, K. M., and Stevens, J. G. (1988). Localization of a herpes simplex virus neurovirulence gene dissociated from high-titer virus replication in the brain. J. Virol. 62, 1381-1387.12.
14. Kimman, T. G., DeWind, N., Oei-Lie, N., Pol, J. M. A., Berns, A. J. M., and Gielkens, A. L. J. (1992). Contribution of single genes within the unique short region of Aujeszky's disease virus (suid herpesvirus type 1) to virulence, pathogenesis and immunogenicity. J. Gen. Virol. 73, 243-251.
15. Martin, X., and Dolivo, M. (1983). Neuronal and transneuronal tracing in the trigeminal system of the rat using the herpesvirus suis. Brain Res. 273, 253-276.
16. McFerran, J. B., and Dow, C. (1965). The distribution of the virus of Aujeszky's disease (pseudorabies virus) in experimentally infected swine. Am. J. Vet. Res. 26, 631-635.
17. Miller, J. M., Jenny, A. L., Taylor, W. D., Marsh, R. F., Rubenstein, R., and Race, R. E. (1993). Immunohistochemical detection of prion protein in sheep with scrapie. J. Vet. Diagn. Invest. 5, 309-316.
18. Miller, J. M., Jenny, A. L., Taylor, W. D., Race, R. E., Ernst, D. R., Katz, J. B., and Rubenstein, R. (1994). Detection of prion protein in formalin-fixed brain by hydrated autoclaving immunohistochemistry for the diagnosis of scrapie in sheep. J. Vet. Diagn. Invest. 6, 366-368.
19. Mulder, W. A. M., Jacobs, L., Priem, J., Kok, G. L., Wagenaar, F., Kimman, T. G., and Pol, J. M. A. (1994). Glycoprotein gE-negative pseudorabies virus has a reduced capability to infect second-and third-order neurons of the olfactory and trigeminal routes in the porcine central nervous system. J. Gen. Virol. 75, 3095-3106.
20. Rinaman, L., Card, J. P., and Enquist, L. W. (1993). Spatiotemporal responses of astrocytes, ramified microglia, and brain macrophages to central neuronal infection with pseudorabies virus. J. Neurosci. 13(2), 685-702.
21. Stevens, J. G. (1991). Herpes simplex virus: neuroinvasiveness, neurovirulence and latency. Semin. Neurosci. 3, 141-147.
22. Wittman, G., and Rziha, H.-J. (1989). Aujeszky's Disease (pseudorabies) in pigs. In "Herpesvirus Diseases of Cattle, Horses and Pigs" (G. ittman, Ed.), pp. 230-325. Kluwer, Boston.