Bistable characteristics of motoneurone activity during DOPA induced fictive locomotion in spinal cats

Neuroscience Research

Volumn 26, Issue 1, 1996, Pages 47-56

  Schomburg, Eike Dieter ^a   Steffens, Heinz ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

DOPA; Fictive locomotion; Membrane bistability; Plateau potentials; Spinal cat

Indexed keywords

DOPA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CAT; CONTROLLED STUDY; DECAPITATION; DEPOLARIZATION; LOCOMOTION; MOTONEURON; NERVE CELL MEMBRANE POTENTIAL; NERVE CONDUCTION; NERVE STIMULATION; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; SYNAPSE; VENTRAL ROOT;

EID: 0030245593     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(96)01073-5     Document Type: Article

References (38)

1. Benecke, R., Conrad, B., Meinck, H.-M. and Höhne, J. (1983) Electromyographic analysis of bicycling on an ergometer for evaluation of spasticity of lower limbs. In: E. Desmedt (Ed.). Motor Control Mechanisms in Health and Disease. Advances in Neurology, Vol. 39, Raven Press, New York, pp. 1035-1046.
2. Berger, W., Quintern, J. and Dietz, V. (1983) Pathophysiology of gait in children with cerebral palsy. EEG Clin. Neurophysiol., 53: 538-548.
3. Brownstone, R.M., Jordan, L.M., Kriellaars, D.J., Noga, B.R. and Shefchyk, S.J. (1992) On the regulation of repetitive firing in lumbar motoneurones during fictive locomotion in the cat. Exp. Brain Res., 90: 441-455.
4. Burke, R.E. (1981) Motor units: anatomy, physiology, and functional organization. In: V.B. Brooks (Ed.). Handbook of Physiology, Section 1, Vol. II. Part 1, Motor Control, American Physiological Society, Bethesda. pp. 345-423.
5. Carp, J.S. and Rymer, W.Z. (1986) Enhancement by serotonin of tonic vibration and stretch reflexes in the decerebrate cat. Exp. Brain Res.. 62: 111-122.
6. Conrad, B., Benecke, R. and Meinck, H.-M. (1985) Gait disturbances in paraspastic patients. In: P.J. Delwaide and R.R. Young (Eds.), Clinical Neurophysiology in Spasticity. Elsevier, Amsterdam, pp. 155-174.
7. Conway, B.A., Hultborn, H. and Kiehn. O. (1987) Proprioceptive input resets central locomotor rhythm in the spinal cat. Exp. Brain Res., 68: 643-656.
8. Conway, B.A., Hultborn, H., Kiehn, O. and Mintz, I. (1988) Plateau potentials in α-motoneurones induced by intravenous injection of L-DOPA and clonidine in the spinal cat. J. Physiol. (Lond.), 405: 369-384.
9. Creed, R.S., Denny-Brown. D., Eccles. J.C., Liddell. E.G.T. and Sherrington, C.S. (1932) Reflex Activity of the Spinal Cord, Oxford University Press. London.
10. Crone, C., Hultborn. H., Kiehn. O., Mazieres, L. and Wigström, H. (1988) Maintained changes in motoneuronal excitability by short-lasting synaptic inputs in the decerebrate cat. J. Physiol. (London), 405: 321-343.
11. Delwaide, P.J. and Young, R.R. (1985) Clinical Neurophysiology in Spasticity, Elsevier. Amsterdam.
12. Dimitrijevic, M.R. and Nathan, P.W. (1967) Studies of spasticity in man, 1. Some features of spasticity. Brain. 90: 1-30.
13. Edgerton, V.R., Grillner, S., Sjöström, A. and Zangger, P. (1976) Central generation of locomotion in vertebrates. In: R.M. Herman, S. Grillner, P.S.G. Stein and D.G. Stuart (Eds.), Neural Control of Locomotion. Plenum Press. New York, pp. 439-464.
14. Eken, T., Hultborn, H. and Kiehn, O. (1989) Possible functions of transmitter-controlled plateau potentials in α-motoneurones. In: J.H.J. Allum and M. Hulliger (Eds.), Progress in Brain Research, Vol. 80, Elsevier. Amsterdam, pp. 257-267.
15. Eken, T. and Kiehn. O. (1989) Bistable tiring properties of soleus motor units in freely moving rats. Acta Physiol. Scand., 136: 383-394.
16. Granit. R., Kernell, D. and Shortess. G.K. (1963) Quantitative aspects of repetitive tiring of mammalian motoneurones, caused by injected currents. J. Physiol. (London), 168: 911-931.
17. Grimm, R.J. (1983) Program disorders of movement. In: J.E. Desmedt (Ed.). Motor Control Mechanisms in Health and Disease, Advances in Neurology. Vol. 39. Raven Press. Newr York, pp. 1-11.
18. Hoffer, J.A., Sugano, N., Loeb. G.E., Marks, W.B.. O'Donovan, M.J. and Pratt. C.A. (1987) Cat hindlimb motoneurones during locomotion. II. Normal activity patterns. J. Neurophysiol., 57: 530-553.
19. Hounsgaard, J., Hultborn, H., Jespersen, B. and Kiehn, O. (1984) Intrinsic membrane properties causing a bistable behaviour of α-motoneurones. Exp. Brain Res., 55: 391-394.
20. Hounsgaard, J., Hultborn, H., Jespersen, B. and Kiehn, O. (1988) Bistability of α-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxy-tryptophan. J. Physiol. (London), 405: 345-367.
21. 2+ dependent bistability induced by serotonin in spinal motoneurones. Exp. Brain Res., 57: 422-425.
22. Hounsgaard, J. and Kiehn, O. (1989) Serotonin-induced bistability of turtle motoneurones caused by a nifedipine-sensitive calcium plateau potential. J. Physiol. (London), 414: 265-282.
23. Hultborn, H. and Wigström, H. (1980) Motor response with long latency and maintained duration evoked by activity in Ia afferents. In: J.E. Desmedt (Ed.), Spinal and Supraspinal Mechanisms of Voluntary Motor Control and Locomotion, Progress in Clinical Neurophysiology, Vol. 8, Karger, Basel, pp. 99-115.
24. Hultborn, H., Wigström, H. and Wängberg, B. (1975) Prolonged activation of soleus motoneurones following a conditioning train in soleus Ia afferents - a case for a reverberating loop? Neurosci. Lett., 1: 147-152.
25. Jordan, L.M. (1983) Factors determining motoneuron rhythmicity during fictive locomotion. In: A. Roberts and B.L. Roberts (Eds.), Neural Origin of Rhythmic Movements, Society of Experimental Biology, University of Cambridge, pp. 423-444.
26. Kernell, D. (1965) The adaptation and the relation between discharge frequency and current strength of cat lumbosacral motoneurones stimulated by long-lasting injected currents. Acta Physiol. Scand., 65: 65-73.
27. Kniffki, K.D., Schomburg, E.D. and Steffens, H. (1981) Effects from fine muscle and cutaneous afferents on spinal locomotion in cats. J. Physiol. (London). 319: 543-554.
28. Matthews, P.B.C. (1966) The reflex excitation of the soleus muscle of the decerebrate cat caused by vibration applied to its tendon. J. Physiol.(London), 184: 450-472.
29. Pearson, K.G., Jiang, W. and Ramirez, J.M. (1992) The use of naloxone to facilitate the generation of the locomotor rhythm in spinal cats. J. Neurophysiol. Meth., 42: 75-81.
30. Sahrmann, S.A. and Norton, B.J. (1977) The relationship of voluntary movement to spasticity in the upper motor neuron syndrome. Ann. Neurol., 2: 460-465.
31. Schomburg, E.D., Petersen, N., Barajon, I. and Hultborn, H. (1993) Flexor reflex afferents reset the step cycle during fictive locomotion in the cat. Acta Physiol. Scand., 149 (Suppl.): 22A.
32. Schomburg, E.D. and Steffens, H. (1995a) Bistable firing characteristics of motoneurones during DOPA induced fictive locomotion in cats. Acta Physiol. Scand., 153: 30A.
33. Schomburg, E.D. and Steffens, H. (1995b) Influence of opioids and naloxone on rhythmic motor activity in spinal cats. Exp. Brain Res., 103: 333-343.
34. Schwindt, P. and Crill, W. (1980a) Role of persistent inward current in motoneuron bursting during spinal seizures. J. Neurophysiol., 43: 1296-1318.
35. Schwindt, P.C. and Crill, W.E. (1980b), Properties of a persistent inward current in normal and TEA-injected motoneurons. J. Neurophysiol., 43: 1700-1724.
36. Severin, F.V., Shik, M.L. and Orlowskii, G.N. (1967) Work of the muscles and single motor neurones during controlled locomotion. Biophysics. 12: 762-772.
37. Sherrington, C.S. (1906) The Integrative Action of the Nervous System. Constable, London.
38. Zajac, F.E. and Young, J.L. (1980) Discharge properties of hindlimb motoneurones in decerebrate cats during locomotion induced by mesencephalic stimulation. J. Neurophysiol., 43: 1221-1235.