Short Term Treatment with Soluble Neuroantigen and Anti-CD11a (LFA-1) Protects Rats Against Autoimmune Encephalomyelitis: Treatment Abrogates Autoimmune Disease but Not Autoimmunity

Journal of Immunology

Volumn 157, Issue 5, 1996, Pages 1973-1980

  Willenborg, David O ^a   Staykova, Maria A ^a   Miyasaka, Masayuki ^b  

^a WODEN VALLEY HOSPITAL   (Australia)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CYCLOPHOSPHAMIDE; FREUND ADJUVANT; GAMMA INTERFERON; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCLONAL ANTIBODY; MYELIN BASIC PROTEIN;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL; ARTICLE; AUTOIMMUNITY; BIOSYNTHESIS; DRUG ADMINISTRATION; DRUG EFFECT; FEMALE; IMMUNOLOGY; LEWIS RAT; LYMPHOCYTE ACTIVATION; MOUSE; NUDE MOUSE; PATHOLOGY; RAT; SOLUBILITY; TH2 CELL;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; AUTOIMMUNITY; CYCLOPHOSPHAMIDE; DRUG ADMINISTRATION SCHEDULE; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FREUND'S ADJUVANT; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MICE; MICE, NUDE; MYELIN BASIC PROTEINS; RATS; RATS, INBRED LEW; SOLUBILITY; TH2 CELLS;

EID: 0030240384     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Jenkins, M. K., and R. H. Schwartz. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165:302.
2. Jenkins, M. K., D. M. Pardoll, J. Mizuguchi, T. M. Chused, and R. H. Schwartz. 1987. Molecular events in the induction of a non-responsive state in IL-2 producing helper T lymphocyte clones. Proc. Natl. Acad. Sci USA 54:5409.
3. Jenkins, M. K., and J. G. Johnson. 1993. Molecules involved in T cell costimulation. Curr. Opin. Immunol. 5:361.
4. Schwartz, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248:1349.
5. Norton, S. D., L. Zuckerman, K. B. Urdahl, R. Shefner, J. Miller, and M. K. Jenkins. 1992. The CD28 ligand B7, enhances IL-2 production by providing a costimulatory signal to T cells. J. Immunol. 149:1556.
6. Thompson, C. B. 1995. Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation? Cell 81:979.
7. Van Seventer, G. A., Y. Shimizu, K. J. Horgan, and S. Shaw. 1990. The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells. J. Immunol. 144:4579.
8. + T lymphocytes. J. Immunol. 148:1985.
9. Hollenbaugh, D., L. S. Grosmarie, C. D. Kullus, N. J. Chalupny, S. Braesch-Andersen, R. J. Noelle, I. Stamenkovic, J. A. Ledbetter, and A. Aruffo. 1992. The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell costimulatory activity. EMBO J. 11:4313.
10. + T cell growth. J. Exp. Med. 175:437.
11. Isobe, M., H. Yagita, K. Okumura, and A. Ihara. 1992. Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. Science 255:1125.
12. Talento, A., M. Nguyen, T. Blake, A. Sirotima, C. Fioravanti, D. Burkholder, R. Gibson, N. H. Sigal, M. S. Springer, and G. Koo. 1993. A single administration of LFA-1 antibody confers prolonged allograft survival. Transplantation 55:418.
13. Dijken, P. J., T. Ghayur, P. Mauch, J. Down, S. J. Burakoff, and J. L. M. Farrara. 1990. Evidence that anti-LFA-1 in vivo improves engraftment and survival afgter allogeneic bone marrow transplantation. Transplantation 49:882.
14. Willenborg, D. O., R. D. Simmons, T. Tamatani, and M. Miyasaka. 1993. ICAM-1-dependent pathway is not critically involved in the inflammatory process of autoimmune encephalomyelitis or in cytokine-induced inflammation of the central nervous system. J. Neuroimmunol. 45:147.
15. Tamatani, T., and M. Miyasaka. 1990. Identification of monoclonal antibodies reactive with the rat homolog of ICAM-1, and evidence of differential involvement of ICAM-1 in the adherence of resting versus activated lymphocytes to high endothelial cells. Int. Immunol. 2:165.
16. Tamatani, T., M. Kotani, and M. Miyasaka. 1991. Characterization of the rat leukocyte integrin, CD11a/CD18, by use of the LFA-1 subunit-specific monoclonal antibodies. Eur. J. Immunol. 21:627.
17. Rothlein, R., and T. A. Springer. 1986. The requirement for lymphocyte function-associated antigen in homotypic leukocyte adhesion stimulated by phorbol ester. J. Exp. Med. 163:1132
18. Eylar, E. H., P. J. Kniskern, and J. J. Jackson. 1974. Myelin Basic Proteins. In Methods in Enzymology, Vol 32. S. Fleischer and L. Packer, eds. Academic Press, New York, pp. 323-341.
19. Boudet, F., J. Theze, and M. Zouali. 1991. UV-treated polystyrene microtiter plates use in an ELISA to measure antibodies against synthetic peptides. J. Immunol. Meth. 142:73.
20. MacPhee, I. A. M., M. J. Day, and D. W. Mason. 1990. The role of serum factors in the suppression of experimental allergic encephalomyelitis: evidence for immunoregulation by antibody to the encephalitogenic peptide. Immunology 70: 527.
21. Bretscher, P., and M. Cohn. 1970. A model of self-nonself discrimination. Science 169:1042.
22. Mueller, D. L., M. K. Jenkins, and R. H. Schwartz. 1989. Clonal expansion versus functional inactivation: a costimulatory signalling pathway determines the outcome of T cell receptor occupancy. Ann. Rev. Immunol. 7:445.
23. Durum, S. K., J. A. Schmidt, and J. J. Oppenheim. 1985. Interleukin 1: an immunologic perspective. Ann. Rev. Immunol. 3:263.
24. Wakasugi, H., Y. Mahe, S. Huet, L. Boumsell, A. Bernard, and T. Tursz. 1988. Comparison of signals delivered through CD3 and CD2 for T-cell activation: the role of calcium influx and interleukin-1. Human Immunol. 23:163.
25. Kawakami, K., Y. Yamamoto, K. Kakimoto, and K. Onoue. 1989. Requirement for delivery of signals by physical interaction and soluble factors from accessory cells in the induction of receptor-mediated T cell proliferation: effectiveness of IFNγ modulation of accessory cells for physical interaction with T cells. J. Immunol. 142:1818.
26. Springer, T. A., M. L. Dustin, T. K. Kishimoto, and S. D. Marlin. 1987. The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system. Ann. Rev. Immunol. 5:223.
27. van Noesel, F. Miedema, M. Brouwer, M. A. de Rie, L. A. Aarden, and R. A. W. van Lier. 1988. Regulatory properties of LFA-1α and β chains in human T-lymphocyte activation. Nature 333:850.
28. Pircher, H., P. Groscruth, S. Baumhutter, M. Aguet, R. M. Zinkernagel, and H. Hengartner. 1986. A monoclonal antibody against altered LFA-1 induces proliferation and lymphokine release of cloned T cells. Eur. J. Immunol. 16:172.
29. Talento, A., M. Nguyen, T. Blake, A. Siorotina, C. Fioravanti, D. Burkholder, R. Gibson, N. H. Sigal, M. Springer, and G. Koo. 1993. A single administration of LFA-1 antibody confers prolonged allograft survival. Transplantation 55:418.
30. van Dijken, P. J., T. Ghayur, P. Mauch, J. Down, S. J. Burakoff, and J. Ferrara. 1990. Evidence that anti-LFA-1 in vivo improves engraftment and survival after allogenic bone marrow transplantation. Transplantation 49:882.
31. Kawasaki, K., E. Yaoita, T. Yamamoto, T. Tamatani, M. Miyasaka, and I. Kihara. 1993. Antibodies against intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 prevent glomerular injury in the rat experimental crescent lomerulonephritis. J. Immunol. 150:1074.
32. Schurmans, S., A. Gonzalez, C. Revilla, A. Ramos, P. H. Lambert, and J. Merino. 1994. Anti-LFA-1 (CD11a) monoclonal antibody interferes with neonatal induction of tolerance to alloantigens. Eur J. Immunol. 24:985.
33. Movat, McI. A., S. Strobel, H. E. Drumond, and A. Ferguson. 1982. Immunological responses to fed protein antigens in mice. I. Reversal of oral tolerance to ovalbumin by cyclophosphamide. Immunology 45:105.
34. Polak, L., H. Geleick, and J. L. Turk. 1975. Reversal by cyclophosphamide of tolerance in contact sensitisation tolerance induced by prior feeding with DNCB. Immunology 28:939.
35. + T lymphocytes. J. Immunol. 142:748.
36. Friedman, A., and H. Weiner. 1994. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc. Natl. Acad. Sci. USA 91:6688.
37. + T cell lines with antigen and mitogen. Cell. Immunol. 159:220.
38. McKnignt, A. J., and C. J. Classon. 1992. Biochemical and immunological properties of rat recombinant IL-2 and IL-4. Immunology 75:286.
39. Benjamin, R. J., S. Qin, M. P. Wise, S. P. Cobbold, and H. Waldman. 1988. Mechanisms of monoclonal antibody-facilitated tolerance induction: a possible role for the CD4 (L3T4) and CD11a (LFA-1) molecules in self-non-self discrimination. Eur. J. Immunol. 18:1079.
40. Mishra, G. C., M. T. Berton, K. G. Oliver, P. H. Kramer, J. W. Uhr, and E. S. Vitetta. 1986. A monoclonal anti-mouse LFA-1α antibody mimics the biological effects of B cell stimulatory factor-1 (BSF-1). J. Immunol. 137:1590.
41. Schmitz, J., M. Assenmacher, and A. Radbruch. 1993. Regulation of T helper cell cytokine expression: functional dichotomy of antigen-presenting cells. Eur. J. Immunol. 23:191.
42. Day, M. J., A. G. D. Tse, M. Puklavec, S. J. Simmonds, and D. W. Mason. 1992. Tergeting autoantigen to B cells prevents the induction of a cell-mediated autoimmune disease in rats. J. Exp. Med. 175:655.
43. Shehadeh, N. N., and K. J. Lafferty. 1993. The role of T cells in the development of autoimmune diabetes. Diabetes Rev. 1:141.
44. Lub, M., Y. van Kooyk, and C. G. Figdor. 1995. Ins and outs of LFA-1. Immunol. Today 16:479.
45. Picker, L. J., and E. C. Butcher. 1992. Physiological and molecular mechanisms of lymphocyte homing. Ann. Rev. Immunol. 10:561.