Sequence comparisons of the CDR3 hyper-variable loops of human T cell receptors specific for three major T cell epitopes of the birch pollen allergen Bet v 1

Molecular Immunology

Volumn 33, Issue 13, 1996, Pages 1039-1048

  Breiteneder, H ^a   Friedl Hajek, R ^a   Ebner, C ^a   Schenk, S ^a   Fischer, G ^a   Kraft, D ^a   Scheiner, O ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Allergenic peptides; Bet v 1; CDR3; T cell receptor ; Tree pollen allergy

Indexed keywords

CD3 ANTIGEN; EPITOPE; IMMUNOGLOBULIN E; POLLEN ANTIGEN; T LYMPHOCYTE RECEPTOR;

ALLERGY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; EPITOPE MAPPING; FEMALE; HUMAN; MALE; PRIORITY JOURNAL;

ALLERGENS; AMINO ACID SEQUENCE; BASE SEQUENCE; CLONE CELLS; CLONING, MOLECULAR; EPITOPE MAPPING; EPITOPES; FEMALE; HUMANS; HYPERSENSITIVITY; MALE; MOLECULAR SEQUENCE DATA; PLANT PROTEINS; POLLEN; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY; TREES;

EID: 0030236150     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(96)00064-8     Document Type: Article

References (53)

1. Boitel B., Ermonval M., Panina-Bordignon P., Mariuzza R. A., Lanzavecchia A. and Acuto O. (1992) Preferential Vb gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin-derived peptide: evidence for a dominant role of a germline-encoded V region in antigen/major histocompatibility complex recognition. J. exp. Med. 175, 765-777.
2. Breiteneder H., Pettenburger K., Bito A., Kraft D., Rumpold H., Scheiner O. and Breitenbach M. (1989) The gene coding for the major birch pollen allergen, BetvI, is highly homologous to a pea disease resistance response gene. EMBO J. 8, 1935-1938.
3. Breiteneder H., Scheiner O., Hajek R., Hulla W., Hüttinger R., Fischer G., Kraft D. and Ebner C. (1995) Diversity of TCRAV and TCRBV sequences used by human T-cell clones specific for a minimal epitope of Bet v 1, the major birch pollen allergen. Immunogenetics 42, 53-58.
4. Carballido J. M., Carballido-Perrig N., Kägi M. K., Meloen R. H., Wüthrich B., Heusser C. H. and Blaser K. (1993) T cell epitope specificity in human allergic and non-allergic subjects to bee venom phospholipase A2. J. Immun. 150, 3582-3591.
5. Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156159.
6. Chrétien I., Pène J., Brière F., De Waal Maljefit R., Rousset F. and De Vries J. E. (1990) Regulation of IgE synthesis. I. Human IgE synthesis in vitro is determined by the reciprocal antagonistic effects of interleukin 4 and interferon-γ. Eur. J. Immun. 20, 243-251.
7. Chua K. Y., Stewart G. A., Thomas W. R., Simpson R. J., Dilworth R. J., Plozza T. M. and Turner K. J. (1988) Sequence analysis of cDNA coding for house dust mite allergen Der p I. J. exp. Med. 167, 175-182.
8. Claverie J.-M., Prochnicka-Chalufour A. and Bougueleret L. (1989) Implications of Fab-like structure for the T cell receptor. Immun. Today 10, 10-14.
9. Clothia C., Boswell D. R. and Lesk A. M. (1988) The outline structure of the of the T-cell αβ receptor. EMBO J. 7, 3745-3755.
10. Coffman R. L. and Carty J. A. (1986) T cell activity that enhances polyclonal IgE-production and its inhibition by IFN γ. J. Immun. 136, 949-954.
11. Davis M. M. and Bjorkman P. J. (1988) T-cell antigen receptor genes and T-cell recognition. Nature 334, 395-402.
12. Davodeau F., Peyrat M. -A., Romagné F., Necker A., Hallet M.-M., Vié H. and Bonneville M. (1995) Dual T cell receptor β chain expression on human T lymphocytes. J. exp. Med. 181, 1391-1398.
13. Dhillon M., Roberts C., Nunn T. and Kuo M. (1992) Mapping human T cell epitopes on phospholipase A2: the major bee-venom allergen. J. Allergy Clin. Immun. 90, 42-51.
14. Ebner C., Ferreira F., Hoffmann-Sommergruber K., Hirschwehr R., Schenk S., Szépfalusi Z., Breiteneder H., Parronchi P., Romagnani S., Scheiner O. and Kraft D. (1993a) T-cell clones specific for Bet v I, the major birch pollen allergen, cross-react with the major allergens of hazel, Cor a I and alder Aln g I. Molec. Immun. 30, 1323-1329.
15. Ebner C., Szépfalusi Z., Ferreira F., Jilek A., Valenta R., Parronchi P., Maggi E., Romagnani S., Scheiner O. and Kraft D. (1993b) Identification of multiple T cell epitopes on Bet v I, the major birch pollen allergen, using specific T cell clones and overlapping peptides. J. Immun. 150, 1047-1054.
16. Ebner C., Schenk S., Szépfalusi Z., Hoffmann K., Ferreira F., Willheim M., Scheiner O. and Kraft D. (1993c) Multiple T cell specificities for Bet v I, the major birch pollen allergen, within single individuals. Studies using specific T cell clones and overlapping peptides. Eur. J. Immun. 23, 1523-1527.
17. β subfamilies. Eur. J. Immun. 21, 935-942.
18. Ferreira F., Hoffman-Sommergruber K., Breiteneder H., Pettenburger K., Ebner C., Szépfalusi Z., Steiner R., Bohle B., Rumpold H., Kraft D. and Scheiner O. (1993) Purification and characterization of recombinant Bet v I, the major birch pollen allergen. J. Biol. Chem. 268, 19574-19580.
19. Fischer G. F., Faé I. and Pickl W. F. (1992) Distribution of polymorphic HLA-DR and -DQ alleles as determined by restriction fragment length polymorphism analysis in an Austrian population. Vox Sang 62, 236-241.
20. β1-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction. Eur. J. Immun. 22, 1261-1269.
21. Giegerich G., Pette M., Meinl E., Epplen J. T., Wekerle H. and Hinkkanen A. (1992) Diversity of T cell receptor α and β chain genes expressed by human T cells specific for similar myelin basic protein peptide/major histocompatibility complexes. Eur. J. Immun. 22, 753-758.
22. Hawes G. E., Struyk L., Godthelp B. C. and Elsen P. van den (1995) Limited restriction in the TCR-αβ V region usage of antigen-specific clones. Recognition of myelin basic protein (amino acids 84-102) and Mycobacterium bovis 65 kDa heat shock protein (amino acids 3-13) by T cell clones established from peripheral blood mononuclear cells of monozygotic twins and HLA-identical individuals. J. Immun. 154, 555-566.
23. Henwood J., Loveridge J., Bell J. I. and Gaston J. S. H. (1993) Restricted T cell receptor expression by human T cell clones specific for mycobacterial 65 kDa heat-shock protein: selective in vivo expansion of T cells bearing defined receptors. Eur. J. Immun. 23, 1256-1265.
24. Higgins J. A., Thorpe C. J., Hayball J. D., O'Hehir R. E. and Lamb J. (1994) Overlapping T-cell epitopes in the group I allergen of Dermatophagoides species restricted by HLA-DP and HLA-DR class II molecules. J. Allergy Clin. Immun. 93, 891-899.
25. Jones C. M., Lake R. A., Lamb J. R. and Faith A. (1994) Degeneracy of T cell receptor recognition of an influenza virus hemagglutinin epitope restricted by HLA-DQ and -DR class II molecules. Eur. J. Immun. 24, 1137-1142.
26. Kimura N., Toyonaga B., Yoshikai Y., Du R. -P. and Mak T. W. (1987) Sequences and repertoire of the human T cell receptor α and β chain variable region genes in thymocytes. Eur. J. Immun. 17, 375-383.
27. Kimura N., Toyonaga B., Yoshikai Y., Triebel F., Debre P., Minden M. D. and Mak T. W. (1986) Sequences and diversity of human T cell receptor β chain variable region genes. J. exp. Med. 164, 739-750.
28. Klein M. H., Concannon P., Everett M., Kim L. D. H., Hunkapiller T. and Hood L. (1987) Diversity and structure of human T-cell receptor α-chain variable region genes. Proc. natn. Acad. Sci. U.S.A. 84, 6884-6888.
29. Koop B. F., Rowen L., Wan K., Kuo C. L., Seto D., Lenstra J. A., Howard S., Shan W., Deshpande P. and Hood L. (1994) The human T-cell receptor TCRAC/TCRDC (Cα/C δ) region: organization, sequence, and evolution of 97.6 kb of DNA. Genomics 19, 478-493.
30. Kronenberg M., Siu G., Hood L. E. and Shastri N. (1986) The molecular genetics of the T-cell receptor and T-cell antigen recognition. Annu. Rev. Immun. 4, 529-591.
31. Larsen J. N., Stroman P. and Ipsen H. (1992) PCR based cloning and sequencing of isogenes encoding the tree pollen major allergen Car b 1 from Carpinus betulus, hornbeam. Molec. Immun. 29, 703-711.
32. Matis L. A. (1990) The molecular basis of T-cell specificity. Annu. Rev. Immun. 8, 65-82.
33. Moss P. A. H. and Bell J. I. (1995) Sequence analysis of the human αβ T-cell receptor CDR3 region. Immunogenetics 42, 10-18.
34. Moss P. A. H., Moots R. J., Rosenberg W. M. C., Rowland-Jones S. J., Bodmer H. C., McMichael A. and Bell J. I. (1991) Extensive conservation of α and β chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide. Proc. natn. Acad. Sci. U.S.A. 88, 8987-8990.
35. Moss P. A. H., Rosenberg W. M. C., Zintzaras E. and Bell J. I. (1993) Characterization of the human T cell receptor α-chain repertoire and demonstration of a genetic influence on V α usage. Eur. J. Immun. 23, 1153-1159.
36. O'Hehir R. E., Eckels D. D., Frew A. J., Kay A. B. and Lamb J. R. (1988) MHC class II restriction specificity of cloned human T lymphocytes reactive with Dermatophagoides farinae (housedust mite). Immunology 64, 627-631.
37. Padovan E., Casorati G., Dellabona P., Meyer S., Brokhaus M. and Lanzavecchia A. (1993) Expression of two T cell receptor a chains: dual receptor T cells. Science 262, 422-424.
38. Panzara M. A., Gussoni E., Steinmann L. and Oksenberg J. R. (1992) Analysis of the T cell repertoire using the PCR and specific oligonucleotide primers. BioTechniques 12, 728-735.
39. Perez M., Ishioka G. Y., Walker L. E. and Chesnut R. W. (1990) cDNA cloning and immunological characterization of the rye grass allergen Lol p I. J. Biol. Chem. 265, 16210-16215.
40. Prochnicka-Chalufour A., Casanova J.-L., Avrameas S., Claverie J.-M. and Kourilsky P. (1991) Biased amino acid distributions in regions of the T cell receptors and MHC molecules potentially involved in their association. Int. Immun. 3, 853-864.
41. Robinson M. A. (1992) Usage of human T-cell receptor Vβ, Jβ, C β and Vα gene segments is not proportional to gene number. Hum. Immun. 35, 60-67.
42. α gene segments. Eur. J. Immun. 21, 927-933.
43. Rosenberg W. M. C., Moss P. A. H. and Bell J. I. (1992) Variation in human T cell receptor Vβ and J β repertoire: analysis using anchor polymerase chain reaction. Eur. J. Immun. 22, 541-549.
44. Sanger S., Nicklen S. and Coulsen A. R. (1977) DNA sequencing with chain-terminating inhibitors. Proc. natn. Acad. Sci. U.S.A. 74, 5463-5467.
45. Schenk S., Breiteneder H., Susani M., Najafian N., Laffer S., Duchêne M., Valenta R., Fischer G., Scheiner O., Kraft D. and Ebner C. (1995) T cell epitopes of Phl p 1, the major allergen of timothy grass (Phleum pratense). Evidence for cross-reacting and non-cross-reacting T cell epitopes within grass group I allergens. J. Allergy Clin. Immun. 96, 986-996.
46. Spiegelberg H. L., Beck L., Stevenson D. and Ishioka G. Y. (1994) Recognition of T cell epitopes and lymphokine secretion by rye-grass allergen Lolium perenne-specific human T cell clones. J. Immun. 152, 4706-4711.
47. Toyonaga B., Yoshikai Y., Vadasz V., Chin B. and Mak T. W. (1985) Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor β chain. Proc. natn. Acad. Sci. U.S.A. 82, 8624-8628.
48. Van Neerven R. J. J., Van't Hof W., Ringrose J. H., Jansen H. M., Aalberse R. C., Wierenga E. A. and Kapsenberg M. (1993) T cell epitopes of house dust mite major allergen Der p II. J. Immun. 151, 2326-2335.
49. Van Neerven R. J. J., Van de Pol M. M., Van Milligen F. J., Janse H. M., Aalberse R. G. and Kapsenberg M. (1994) Characterization of cat dander-specific T lymphocytes from atopic patients. J. Immun. 152, 4203-4210.
50. + T-cell recognition of house dust mite allergens. Proc. natn. Acad. Sci. U.S.A. 90, 8214-8218.
51. Wilson R. K., Lai E., Concannon P., Barth R. K. and Hood L. E. (1988) Structure, organization and polymorphism of murine and human T-cell receptor α and β chain gene families. Immun. Rev. 101, 149-172.
52. Yoshikai Y., Kimura N., Toyonaga B. and Mak T. W. (1986) Sequences and repertoire of human T cell receptor α chain variable region genes in mature T lymphocytes. J. exp. Med. 164, 90-103.
53. Yssel H., Johnson K. E., Schneider P. V., Wideman J., Terr A., Kastelein R. and De Vries J. E. (1992) T cell activation-inducing epitopes of the house dust mite allergen Der p I. J. Immun. 148, 738-745.