Effects of cytochrome P450 antibodies on the oxidative demethylation of methoxychlor catalyzed by rat liver microsomal cytochrome P450 isozymes: Isozyme specificity and alteration of enantiotopic selectivity

Pesticide Biochemistry and Physiology

Volumn 56, Issue 1, 1996, Pages 44-52

  Kishimoto, Daisuke ^a,c   Kurihara, Norio ^b  

^a Department of Agricultural Chemistry ^*  (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c ISHIHARA SANGYO KAISHA LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0030235940     PISSN: 00483575     EISSN: None     Source Type: Journal    
DOI: 10.1006/pest.1996.0057     Document Type: Article

References (9)

1. 1. N. Kurihara and A. Oku, Effects of added protein (bovine serum albumin) on the rate and enantiotopic selectivity of oxidative O-demethylation of methoxychlor in rat liver microsomes, Pestic. Biochem. Physiol. 40, 227 (1991).
2. 2. D. Kishimoto, A. Oku, and N. Kurihara, Enantiotopic selectivity of cytochrome P450-catalyzed oxidative demethylation of methoxychlor: Alteration of selectivity depending on isozymes and substrate concentrations, Pestic. Biochem. Physiol. 51, 12 (1995).
3. 3. D. E. Ryan, P. E. Thomas, and W. Levin, Purification and characterization of a minor form of hepatic microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, Arch. Biochem. Biophys. 216, 272 (1982).
4. 4. D. W. Nebert, D. R. Nelson, M. J. Coon, R. W. Estabrook, R. Feyereisen, Y. Fujii-Kuriyama, F. J. Gonzalez, F. P. Guengerich, I. C. Gunsalus, E. F. Johnson, J. C. Loper, R. Sato, M. R. Waterman, and D. J. Waxman, The P450 superfamily: Update on new sequences, gene mapping, and recommended nomenclature, DNA Cell Biol. 10, 1 (1991).
5. 5. T. Omura and R. Sato, The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification and properties, J. Biol. Chem. 239, 2379 (1964).
6. 3]-methoxychlor and related deuterium-labeled compounds, Agric. Biol. Chem. 50, 1331 (1986).
7. 7. M. Schweizer, M. A. Peter, D. Filipovic, R. Tinner, H. R. Bosshard, and M. Oertle, Mechanism of monoclonal antibody inhibition/stimulation of reactions catalyzed by cytochrome P450IIB1, Arch. Biochem. Biophys. 288, 64 (1991).
8. 8. Z. Amelizad, K. E. Appel, F. Oesch, and A. G. Hildebrandt, Effect of antibodies against cytochrome P-450 on demethylation and denitrosation of N-nitrosodimethylamine and N-nitrosomethylaniline, J. Cancer Res. Clin. Oncol. 114, 380 (1988).
9. LM4, Mol. Pharmacol. 21, 248 (1982).