Results of a phase i trial of a recombinant vaccinia virus that expresses carcinoembryonic antigen in patients with advanced colorectal cancer

Annals of Surgical Oncology

Volumn 3, Issue 5, 1996, Pages 495-500

  McAneny, David ^a  

^a NONE   (United States)

Author keywords

CEA; Colorectal cancer; I trial of recombinant vaccinia CEA; Phase; Phase I; Recombinant vaccinia

Indexed keywords

CANCER VACCINE; CARCINOEMBRYONIC ANTIGEN; RECOMBINANT VACCINE;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CLINICAL TRIAL; COLORECTAL TUMOR; DOSE RESPONSE; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; PATHOLOGY; PHASE 1 CLINICAL TRIAL; PROGNOSIS; SAFETY; VACCINIA VIRUS;

ADENOCARCINOMA; ADULT; AGED; CANCER VACCINES; CARCINOEMBRYONIC ANTIGEN; COLORECTAL NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; SAFETY; VACCINES, SYNTHETIC; VACCINIA VIRUS;

EID: 0030228469     PISSN: 10689265     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02305769     Document Type: Article

References (5)

1. Wingo PA, Tong T, Bolden S. Cancer statistics, 1995. CA Cancer J Clin 1995;45:8-30.
2. Kaufman H, Schlom J, Kantor J. A recombinant vaccinia virus expressing human carcinoembryonic antigen (CEA). Int J Cancer 1991;48:900-7.
3. Oikawa S, Nakazato H, Kosaki G. Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence. Biochem Biophys Res Commun 1987;142:511-18.
4. Kantor J, Irvine K, Abrams S, Kaufman H, DiPietro J, Schlom J. Antitumor activity and immune responses induced by a recombinant carcinoembryonic antigen-vaccinia virus vaccine. J Natl Cancer Inst 1992;84:1084-91.
5. Kantor J, Irvine K, Abrams S, et al. Immunogenicity and safety of a vaccinia virus vaccine expressing the carcinoembryonic antigen gene in a nonhuman primate. Cancer Res 1992:52:6917-25.