Visceral perception in functional gastro-intestinal disorders: Disease marker or epiphenomenon?

Digestive Diseases

Volumn 14, Issue 5, 1996, Pages 276-288

  Hu, Wayne H C ^a   Talley, Nicholas J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Balloon distension; Barostat; Functional dyspepsia; Functional gastro intestinal disorders; Irritable bowel syndrome; Non cardiac chest pain; Visceral perception

Indexed keywords

DYSPEPSIA; GASTROINTESTINAL DISEASE; HUMAN; IRRITABLE COLON; PAIN THRESHOLD; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; SENSORY NERVE; THORAX PAIN;

CHEST PAIN; COLONIC DISEASES, FUNCTIONAL; DYSPEPSIA; GASTROINTESTINAL DISEASES; HUMANS; PAIN THRESHOLD; VISCERAL AFFERENTS;

EID: 0030225864     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000171559     Document Type: Article

References (110)

1. Drossman DA, Thompson WG, Talley NJ, Funch-Jensen P, Janssens J, Whiiehead WE: Identification of subgroups of functional gastrointestinal disorders. Gastroenterol Int 1990;3:159-172.
2. Talley NJ, Zinsmeister AR, Van Dyke C, Melton LJ III: Epidemiology of colonic symptoms and the irritable bowel syndrome. Gastroenterology 1991;101:927-934.
3. Drossman DA, Li Z, Andruzzi E, Temple RD, Talley NJ, Thompson WG, Whitehead WE, Janssens J, Funch-Jensen P, Corazziari E, Richter JE, Koch GG: U.S. Householder Survey of Functional Gastrointestinal Disorders: Prevalence, sociodemography and health impact. Dig Dis Sei 1993:38:1569- 1580.
4. Thompson WG, Creed F, Drossman DA, Heaton KW, Mazzaca G: Functional bowel disorders and functional abdominal pain. Gastroenterol Int 1992:5:75-91.
5. Welch GW, Pomare EW: Functional gastrointestinal symptoms in a Wellington community sample. NZ Med J 1990;103:418-420.
6. Manning AP, Thompson WG, Heaton KW, Morris AF: Towards positive diagnosis of the irritable bowel. Br Med J 1978;ii:653-654.
7. Schmidt CD, Jones HD, Hunt JC, Code CF, Anderson MW, Andersen HA: The value of the esophageal motility test in the evaluat ion of thoracic pain problems. Dis Chest 1962:41:303-314.
8. Katz PO, Dalton CB, Richter JE, Wu WC, Castell DO: Esophageal testing in patients with non-cardiac chest pain and/or dysphagia. Ann Intern Med 1987:106:593-597.
9. Rees WD, Miller JJ, Malagclada JR: Dyspepsia, antral motor dysfunction and gastric stasis of solids. Gastroenterology 1980:78:360-365.
10. Camilleri M, Malagclada JR, Kao PC, Zinsmeister AR: Gastric autonomic responses to stress in functional dyspepsia. Dig Dis Sci 1986; 31:1169-1177.
11. Whorwell PJ, Cloutcr C, Smith CL: Oesophageal motility in the irritable bowel syndrome. Br Med J 1981: 283:1101-1102.
12. Kellow JE, Phillips SF, Miller JJ, Zinsmeister AR: Dysmotility of the small intestine in irritable bowel syndrome. Gut 1988:29:1236- 1243.
13. Kumar D, Wingate DL: Irritable bowel syndrome: A paroxysmal motor disorder. Lancet 1985;ii:973- 977.
14. Young SJ, Alpers DM, Norland CC, Woodruff RA Jr: Psychiatric illness and the irritable bowel syndrome: Practical implications for thcprima-ry care physician. Gastroenterology 1976;70:162-166.
15. Esler MD, Goulston KJ: Levels of anxiety in colonic disorders. N Engl J Med 1973:288:16-20.
16. Drossman DA, Leserman J, Nachman G, Li Z, Gluck H, Toomey TC, Mitchell M: Sexual and physical abuse in women with functional or organic gastrointestinal disorders. Ann Intern Med 1990:113:828-833.
17. Drossman DA, McKee DC, Snadler RS, Mitchell CM, Cramer EM, Low-man BC, Burger AL: Psychosocial factors in the irritable bowel syndrome: A multivariate study of patients and nonpaticnts with irritable bowel syndrome. Gastroenterology 1988;95:701-708.
18. Whitehead WE, Bosmajian L, Zon-derman AB, Costa PT Jr, Schuster MM: Symptoms of psychologic distress associated with irritable bowel syndrome: Comparison of community and medical clinic samples. Gastroenterology 1988;95:709-714.
19. Jacnig W, Koltzcnburg M: The function of spinal primary afferents supplying the colon and urinary bladder. J Auton Nerv Syst 1990,30: 589-596.
20. Jacnig W, Koltzenburg M: Receptive properties of sacral primary afferent neurons supplying the colon. J Neurophysiol 1991:65:1067-1077.
21. Hacbler J, Jaenig W, Koltzenburg M: Spinal cord integration of colon function: Afferent and efferent pathways; in Tache Y. Wingate D (eds): Brain-Gut Interactions. Boca Raton. CRC Press. 1991, pp 147-160.
22. Grundy D: Speculations on the structure/function relationship for vagal and splanchnic afferent endings supplying the gastrointestinal tract. J Auton Nerv Syst 1988,22: 175-180.
23. Gebhart GF, Randich A: Vagal modulation of nociception. Am Pain Soc J 1992:1:26-32.
24. Gabella G: Structures of muscles and nerves in the gastrointestinal tract: in Johnson LR (ed): Physiology of the Gastrointestinal Tract. New York. Raven Press, 1987. pp 335-382.
25. Mayer EA, Raybould HE: Role of visceral afferent mechanisms in functional bowel disorders. Gastroenterology 1990;99:1688-1704.
26. Morrison JFB: Splanchnic slowly adapting mechanoreceptors with punctate receptive fields in the mesentery and gastrointestinal tract of the cat. J Physiol (Lond) 1977:233: 349-362.
27. Leek BF: Abdominal and pelvic visceral receptors. Br Med Bull 1977: 33:163-168.
28. Lcmbo T, Munakata J, Mertz H, Niazi N, Kodner A, Nikas V, Mayer EA: Evidence for the hypersensitivity of lumbar splanchnic affcrents in the irritable bowel syndrome. Gastroenterology 1994; 107:1686-1696.
29. Sun WM, Read NW, Prior A, Daly J-A, Cheah SK, Grundy D: Sensory and motor response to rectal distension vary' according to rate and pattern of balloon inflation. Gastroenterology 1990;99:1008-1015.
30. Jaenig W, Morrison JFB: Functional properties of spinal visceral affer-ents supplying abdominal and pelvic organs, with special emphasis on visceral nociception. Prog Brain Res 1986:67:87-114.
31. Cohen RH, Perl ER: Contributions of arachidonic acid derivatives and substances P to the sensitization of cutaneous nociceptors. J Physiol 1990:64:457-464.
32. Schaible HG, Schmidt RF: Excitation and sensitization of fine articular affcrents from cat's knee joint by prostaglandin E;. J Physiol (Lond) 1988:403:91-104.
33. Mayer EA, Gebhart GF: Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 1994:107: 271-293.
34. Scarinci IC, McDonald-Haile J, Bradley L.A, Richter JE: Altered pain perception and psychosocial features among women with gastrointestinal disorders and history of abuse: A preliminary model. Am J Med 1994:97:108-118.
35. Bradley LA, Richter JE, Scarinci IC, Haile JM, Schan CA: Mechanisms of altered pain perception in noncardiac chest pain patients. Gastroenterology 1993; 104: A482.
36. Fielding JF: The diagnostic sensitivity of physical signs in the irritable bowel syndrome. Ir Med J 1981;74: 143-144.
37. Bloomfield AL, Pollard WS: Experimental referred pain from the gastrointestinal tract. 11. Stomach, duodenum and colon. J Clin Invest 1931:10:453-473.
38. Ritchie J: Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome. Gut 1973:14:125-132.
39. Kullman G, Fielding JF: Rectal dis-tensibility in the irritable bowel syndrome. Ir Med J 1981;74:140-142.
40. Whitehead WE, Engel BT, Schuster MM: Irritable bowel syndrome: Physiological and psychological differences between diarrhoea-predominant and constipation-predominant patients. Dig Dis Sci 1980;25:404-413.
41. Doran FSA: The sites to which pain is referred from the common bile duct in man and its implication for the theory of referred pain. Br J Surg 1967;54:599-606.
42. Kingham JGC, Dawson AM: Origin of chronic right upper quadrant pain. Gut 1985:26:783-788.
43. Swarbrick ET, Hcgarty JE, Bat L, Williams CB, Dawson AM: Site of pain from the irritable bowel. Lancet 1980;ii:443-446.
44. Plourde V, Lcmbo T, Shui Z, Parker J, Mertz H, Tache Y, Svtnik B, Mayer E: Effects of the somatostatin analogue octreotide on rectal afferent nerves in humans. Am J Physiol 1993;265:G742-G745.
45. Clark WC: Pain sensitivity and the report of pain: An introduction to sensory decision theory. Anesthesiology 1974:40:272-287.
46. Chapman CR, Casey KL, Dubner R, Foley KM, Gracclcy RH, Reading AE: Pain measurement: An overview. Pain 1985:22:1-31.
47. Azpiroz F, Malagelada J-R: Physiologic variations in canine gastric tone measured by an electronic ba-rostat. Am J Physiol 1985:248: G229-G237.
48. Bradette M, Delvaux M, Staumont G, Fioramonti J, Bueno L, Frexinos J: Evaluation of colonic sensory thresholds in IBS patients using a barostat: Definition of optimal conditions and comparison with healthy subjects. Dig Dis Sci 1994; 39:449-457.
49. Accarino AM, Azpiroz F, Malagelada J-R: Gut sensitivity testing: Factors that determine the response to transmucosal electrical nerve stimulation. Gastroenterology 1992; 102: A413.
50. Accarino AM, Azpiroz F, Malagelada J-R: Receptor vs suprareccptor level of gut sensory dysfunction in the irritable bowel syndrome. Gastroenterology 1992:102:A413.
51. White AM, Stevens WH, Upton AR, O’Bymc PM, Collins SM: Airway responsiveness to inhaled me-thacholine in patients with irritable bowel syndrome. Gastroenterology 1991;100:68-74.
52. Fielding JF, Regan R: Excessive cold pressor response in the irritable bowel syndrome. Ir J Med Sci 1984; 153:348-350.
53. Whorwell PJ, McCallum M, Creed FH, Roberts CT: Non-colonic features of irritable bowel syndrome. Gut 1986:27:37-40.
54. Whorwell PJ, Clouter C, Smith CL: Oesophageal motility in the irritable bowel syndrome. Br Med J 1981: 282:1101-1102.
55. Kellow JE, Eckerslcy GM, Jones MP: Enhanced perception of physiological intestinal motility in the irritable bowel syndrome. Gastroenterology 1991:101:1621-1627.
56. Kellow JE, Phillips SF: Altered small bowel motility in irritable bowel syndrome is correlated with symptoms. Gastroenterology 1987: 92:1885-1893.
57. Cook IJ, van Hcdcn A, Collins SM: Patients with irritable bowel syndrome have greater pain tolerance than normal subjects. Gastroenterology 1987;93:727-733.
58. Whitehead WE, Holtkotter B, Enck P, Hoclzl R, Holmes KD, Anthony J, Shabsin HS, Schuster MM: Tolerance for rectosigmoid distension in irritable bowel syndrome. Gastroenterology 1990:98:1187-1192.
59. Bradley LA, Richter JE, Scarinci IC', Haile JM, Schan CA: Psychosocial and psychophysical assessments of patients with unexplained chest pain. Am J Med 1992:92 (suppl 5A): 65-73.
60. Talley NJ, Fett S, Zinsmeister AR: Self-reported abuse and gastrointestinal disease in outpatients: Association with irritable bowel-type symptoms. Am J Gastroenterol 1995:90: 366-371.
61. Mertz H, Niazi N, Kodner A, Mayer EA: Are rectal sensory thresholds a biological marker of IBS disease activity? Gastroenterology 1994:106: A540.
62. Lcmbo T, Hirsh T, David D, Mertz H, Garrick T, Mayer EA: Is rectal hyperalgesia a state or trait in IBS patients? Gastroenterology 1993: I04:A540.
63. Talley NJ, Phillips SF: Non-ulcer dyspepsia: Potential causes and pathophysiology. Ann Intern Med 1988:108:865-879.
64. Waldron B, Cullen PT, Kumar R, Smith D, Jankowski J, Hopwood D, Sutton D, Kennedy N, Campbell FC: Evidence for hypomotility in non-ulcer dyspepsia: A prospective multifactorial study. Gut 1991:32: 246-251.
65. Kcrlin P: Postprandial antral hypomotility in patients with idiopathic nausea and vomiting. Gut 1989:30: 54-59.
66. Malagelada J-R, Stanghellini V: Manometric evaluation of functional upper gut symptoms. Gastroenterology 1985:88:1223-1231.
67. Leman M, Dederding JP, Flouric B, Franchisseur C, Rambaud JC, Jian R: Abnormal perception of visceral pain in response to gastric distension in chronic idiopathic dyspepsia: The irritable stomach syndrome. Dig Dis Sei 1991:36:1249-1254.
68. Mcarin F, Cucala M, Azpiroz F, Malagelada J-R: The origin of symptoms on the brain-gut axis in functional dyspepsia. Gastrocntcrologv 1991; 101:999- 1006.
69. Bradcttc M, Parc P, Douville P, Morin A: Visceral perception in health and functional dyspepsia: Crossover study of gastric distension with placebo and dompcridone. Dig Dis Sci 1991:36:52-58.
70. Coffin B, Azpiroz F, Guaner F, Malagelada J-R: Selective gastric hypersensitivity and reflex hyporeac-tivity in functional dyspepsia. Gastroenterology 1994; 107:1345-1351.
71. Holtmann G, Huber J, Fischer H, Flciter B, Goebcll H, Talley NJ: Functional dyspepsia: A sensory duodenal defect with impaired intestino-intestinal reflexes. Gastroenterology 1994; 106:A511.
72. Holtmann G, Goebell H, Talley NJ: Impaired small intestinal peristaltic reflexes and sensory thresholds are independent functional disturbances in patients with chronic unexplained dyspepsia. Am J Gastroenterol, in press.
73. Talley NJ, Phillips SF, Bruce B, Zinsmeister AR, Wittgcn C, Melton LJ III: Multisystem complaints in patients with the irritable bowel syndrome and functional dyspepsia. Eur J Gastroenterol Hepatol 1991:3: 71-77.
74. Holtmann G, Kolbcl CBM, Huber J, Bocker U, Talley NJ, Goebell H: Prevalence and severity of extra intestinal symptoms in patients with functional dyspepsia. Gastroenterology 1993:104:A521.
75. Jorgensen LS, Bach FW, Christiansen P, Raundahl U, Ostgaard S, Ek-man R: Decreased cerebrospinal fluid bcta-endorphin and increased pain sensitivity in patients with functional abdominal pain. Scand J Gastroenterol 1990:25:1235-1241.
76. Mertz H, Kodner A, Hirsh T, Sytnik B, Mavcr E: Gastric balloon distention as a diagnostic test for non-ulcer dyspepsia. Gastroenterology 1994: 106:A539.
77. DeMeester TR, O'Sullivan GC, Bermudez G, Midell AI, Cimochowski GE, O’Drobinak J: Esophageal function in patients with angina-type chest pain and normal coronary angiograms. Ann Surg 1982; 196:488- 498.
78. Katz PO, Dalton CB, Richter JE, Wu WC, Castell DO: Esophageal testing in patients with non-cardiac chest pain and/or dysphagia. Ann Intern Med 1987;106:593-597.
79. Eypasch EP, Stein II J, DeMeester TR, Johansson KE, Barlow AP, Schneider GT: A new technique to define and clarify esophageal motor disorders. Am J Surg 1990; 159:144-152.
80. Richter JE, Hackshaw BT, Wu WC, Castell DO: Edrophonium: A useful provocative test for esophageal chest pain. Ann Intern Med 1985; 103:14- 21.
81. Lipkin M, Sleiscnger MH: Studies of visceral pain: Measurements of stimulus intensity and duration associated with the onset of pain in oesophagus, ileum and colon. J Clin Invest 1958;37:28-34.
82. Richter JE, Barish CF, Castell DO: Abnormal sensory perception in patients with esophageal chest pain. Gastroenterology 1986:91:845-852.
83. Barish CF, Castell DO, Richter JE: Graded esophageal balloon distension: A new provocative test for noncardiac chest pain. Dig Dis Sci 1986;31:1292-1298.
84. Enzmann DR, Harrell GS, Zbo-ralske EF: Upper esophageal responses to intraluminal distension in man. Gastroenterology 1977;72: 1292-1298.
85. Mayrand S, Diamant NE: Measurement of human esophageal tone in vivo. Gastroenterology 1993:105: 1411-1420.
86. Rao SSC, Hayek B, Summers RW: Impedance planimetry: An integrated approach for assessing sensory, active and passive biomechanical properties of the human esophagus. Am J Gastroenterol 1995:90: 431-437.
87. Rao SSC, Hayek B, Summers RW: Esophageal impedance planimetry: A novel approach for assessing sensorimotor and viscoelastic properties. Gastroenterology 1994:106: A557.
88. Frieling T, Enck P, Wcinbcck M: Cerebral responses evoked by electrical stimulation of the esophagus in normal subjects. Gastroenterology 1989;97:475-478.
89. Smout AJPM, DeVore MS, Dalton CB, Castell DO: Cerebral potentials evoked by esophageal distention in patients with noncardiac chest pain. Gut 1992;33:298-302.
90. Pilot MA, Thompson HH, Zara GP: Effect of 5-hydroxytryptaminc on canine intestinal motility during fasting. J Physiol (Lond) 1967; 192: 823-846.
91. Pineiro-Carrero VM, Clerch MH, Davis RH, Andres JM, Franzini DA, Mathias JR: Intestinal motility changes in rats after enteric serotonergic neuron destruction. Am J Physiol 1991;260:G2 32-G239.
92. Itoh Z, Mizumoto A, Iwanaga Y, Yoshida N, Torii K, Wakabavashi K: Involvement of 5-hydroxytryp-tamin 3 receptors in regulation of interdigestive gastric contractions by motiiin in the dog. Gastroenterology 1991;100:901-908.
93. von dcrOhe MR, Hanson RB, Cam-illeri M: Serotonergic mediation of postprandial colonic tonic and phasic responses in humans. Gut 1994; 35:536-541.
94. 3 antagonist corrects the postprandial colonic hypertonic response in carcinoid diarrhea. Gastroenterology 1994;106:l184-1189.
95. Moss HE, Sanger GJ: The effects of granisetron. ICS 205-930 and ondansetron on the visceral pain reflex induced by duodenal distension. Br J Pharmacol 1990:100:497-501.
96. Prior A, Read NW: Reduction of rectal sensitivity and postprandial motility by granisetron, a 5-HT.i antagonist, in patients with irritable bowel syndrome. Gut 1990;31: All 74.
97. Steadman CJ, Talley NJ, Phillips SF, Zinsmeister AR: Selective 5-hydroxytryptaminetype 3 receptor antagonism with ondansetron as treatment for diarrhoea-predominant irritable bowel syndrome: A pilot study. Mavo Clin Proc 1992: 67:732-738.
98. Goldberg PA, Kamm MA, Setti-Carraro P, van der Sijp JRM, Roth C: 5-HTj antagonism does not modify visceral sensation or compliance in healthy subjects. Gastroenterology 1993:104:A512.
99. Champion MC: Domperidone. Gen Pharmacol 1988:19:499-505.
100. Davis RH, Clench MH, Matihas JR: Effects of domperidone in patients with chronic unexplained upper gastrointestinal symptoms: A double-blind, placebo-controlled study. Dig Dis Sei 1988:33:1505- 1511.
101. Nagler J, Miskovitz P: Clinical evaluation of domperidone in the treatment of chronic postprandial idiopathic upper gastrointestinal distress. Am J Gastroenterol 1981; 76:495-499.
102. Bradette M, Pare P, Douvillc P, Morin A: Visceral perception in health and functional dyspepsia: Crossover study of gastric distension with placebo and domperidone. Dig Dis Sei 1991:36:52-58.
103. Li Bassi S, Rovati LC, Giacovelli G, Bolondi L, Barbera L: Effects of loxiglumide, a cholecvstokinin antagonist, in non-ulcer dyspepsia. Gastroenterology 1990:98: A77.
104. Chua A, Bekkering M, Rovati LC, Keeling PWN: Clinical efficacy and prokinetic effect of the CCK-A antagonist loxiglumide in non-ulcer dyspepsia. Gastroenterology 1993:104: A491.
105. Anvari M, Malbert C, Taylor M, Sgro R, Horowitz M, Jamieson CG: Loxiglumide abolishes the effects of intraduodenal oleic acid on gastric motility and emptying. Gastroenterology 1992:102:A418.
106. Bradette M, Delvaux M, Staumont G, Fioramonti J, Bueno L, Frexi-nos J: Octreotide increases thresholds of colonic visceral perception in IBS patients without modifying muscle tone. Dig Dis Sci 1994:39; 1171-1178.
107. Guc M, Junien JL, Bueno L: The kappa agonist fedotozinc modulates colonic distention-induced inhibition of gastric motility and emptying in dogs. Gastroenterology 1994:107:1327-1334.
108. Delvaux M, Louvel D, Scherrer B, Fraitag B, Frexinos J: The K-ago-nist fedotozinc increases thresholds of first sensation and pain perception to colonic distension in patients with irritable bowel syndrome. Gastroenterology 1995; 108:A590.
109. Flesch S, Schumacher B, Enck P, Allescher HD, Crowell MD, Liibke HJ: Needles and pins: Acupuncture for visceral pain? Gastroenterology 1993; 104: A508.
110. Monnikes H, Mcissner-Kruse D, Sun P, Mayer EA, Koop H: Acupuncture affects perception of gastric distension by naloxone-sensitive pathways in healthy volunteers. Gastroenterology 1994:106: A542.