Blockade of (±)12-chloroscoulerine on feed-back regulation of dopamine D2 autoreceptors

Acta Pharmacologica Sinica

Volumn 17, Issue 5, 1996, Pages 477-480

  Chen, Li Juan ^a   Zhang, Xue Xiang ^a   Guo, Xin ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

( )12 chloroscoulerine; autoreceptors; berbines; corpus striatum; dopamine; levodopa; subst antia nigra

Indexed keywords

12 CHLOROSCOULERINE; APOMORPHINE; BENSERAZIDE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE AUTORECEPTOR; GAMMA BUTYROLACTONE; HALOPERIDOL; LEVODOPA; UNCLASSIFIED DRUG; 12-CHLOROSCOULERINE; AUTORECEPTOR; BERBERINE DERIVATIVE; DOPAMINE RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DRUG ANTAGONISM; DRUG MECHANISM; ELECTROCHEMICAL DETECTION; ELECTROPHYSIOLOGY; FEEDBACK SYSTEM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; REGULATORY MECHANISM; SUBSTANTIA NIGRA; TISSUE LEVEL; ANIMAL; DRUG EFFECT; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; AUTORECEPTORS; BERBERINE ALKALOIDS; CORPUS STRIATUM; DOPAMINE ANTAGONISTS; LEVODOPA; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; SUBSTANTIA NIGRA;

EID: 0030222993     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Chen LJ, Xi Y, Pang DW, Zhou QT, Jin GZ. Effect of (±)12-chloroscoulerine on brain dopamine receptors. Acta Pharmacol Sin 1996; 17: 185-9.
2. Jin GZ. (-)Tetrahydropalmatine and its analogues as new dopamine receptor antagonists. Trends Pharmacol Sci 1987; 8: 81-2.
3. Xu SX, Yu LP, Han YR, Chen Y, Jin GZ. Effect of tetrahydroprotoberberines on dopamine receptor subtypes in brain. Acta Pharmacol Sin 1989; 10: 104-10.
4. Shi WX, Chen Y, Jin GZ. Effect of l-stepholidine on rotational behavior in rats. Acta Pharmacol Sin 1984; 5: 222-5.
5. Jin GZ, Wang XL, Shi WX. Tetrahydroprotoberberine - A new chemical type of antagonist of dopamine receptors. Sci Sin (B) 1986; 29: 527-34.
6. Huang KX, Sun BC, Jun GZ. (-)Stepholidine: a dopamine receptor antagonist shows agonistic effect on rotational behavior in 6-hydroxydopamine-lesioned rats. Acta Pharmacol Sin 1992; 13: 17-22.
7. 2 receptors blockaded by l-stepholidine and l-tetrahydropalmatine. Acta Pharmacol Sin 1992; 13: 442-5.
8. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Sydney: Academic Press, 1982: Plate 24-6.
9. Skirboll LR, Grace AA, Bunney BS. Dopamine auto- and postsynaptic receptors: electrophysiological evidence for differential sensitivity to dopamine agonists. Science 1979; 206: 80-2.
10. Guo X, Chen LJ, Buda M, Jin GZ. Effects of l-stepholidine on tyrosine hydroxylase activity in rat corpus striatum. Acta Pharmacol Sin 1992; 13: 289-92.
11. Bunney BS, Walters JR, Roth RH, Aghajanian GK. Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity. J Pharmacol Exp Ther 1973; 185: 560-71.
12. Huang KX, Jin GZ. The antagonistic effects of tetrahydroprotoberberines on dopamine receptors: electrophysiological studies. Sci China (B) 1992; 35: 688-96.