The novel inotropic agent CGP 48506 alters force primarily by Ca2+-independent mechanisms in porcine skinned trabeculae

Cardiovascular Research

Volumn 32, Issue 2, 1996, Pages 411-421

  Palmer, Sue ^a,b   Di Bello, Sandrine ^a   Davenport, Sarah L ^b   Herzig, Joachim W ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b G   (United Kingdom)

Author keywords

BA 41899; Calcium sensitivity; CGP 48506; Contractile force; Pig, ventricle; Rat, ventricle

Indexed keywords

1,3,5,6 TETRAHYDRO 5 METHYL 6 PHENYL 3,6 METHANO 1,5 BENZODIAZOCINE 2,4 DIONE; BA 41899; CALCIUM; INOTROPIC AGENT; TROPONIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENANTIOMER; HEART VENTRICLE CONTRACTILITY; MUSCLE FORCE; NONHUMAN; PRIORITY JOURNAL; RAT; SWINE;

ADENOSINE TRIPHOSPHATE; ANIMALS; AZOCINES; CALCIUM; CARDIOTONIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MICROFILAMENTS; MYOCARDIAL CONTRACTION; MYOCARDIUM; RATS; SWINE; TROPONIN;

EID: 0030222379     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/0008-6363(96)00098-3     Document Type: Article

References (32)

1. [1] Lee JA, Allen DG. Altering the strength of the heart. In: Lee JA, Allen DG. eds. Modulation of Cardiac Calcium Sensitivity. A New Approach to Increasing the Strength of the Heart. Oxford: Oxford University Press, 1993:1-36.
2. [2] Wetzel B, Hauel N. New cardiotonic agents - a promising approach for treatment of heart failure. Trends Pharmacol Sci 1988;9:166-170.
3. [3] Lues I, Beier N, Jonas R, Klockow M, Haeusler G. The two mechanisms of action of racemic cardiotonic EMD 53998, calcium sensitisation and phosphodiesterase inhibition, reside in different enantiomers. J Cardiovasc Pharmacol 1993;21:883-892.
4. 2+ sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea-pig heart. Circ Res 1995;77:107-113.
5. [5] Reuter H. The dependence of the slow inward current on external calcium concentration in Purkinje fibres. J Physiol 1967;192:479-492.
6. 2+-regulatory site of bovine cardiac troponin. J Biol Chem 1982;257:260-263.
7. [7] Tada M, Kirchberger MA, Repke DI, Katz AM. The stimulation of calcium transport in cardiac sarcoplasmic reticulum by adenosine 3′:5′-monophosphate-dependent protein kinase. J Biol Chem 1974;249:6174-6180.
8. [8] Herold P, Herzig JW, Wenk P, et al. 5-Methyl-6-phenyl-1,3,5,6-tetrahydro-3,6-methano-1,5-benzodiazocine-2,4- dione (BA41899): representative of a novel class of purely calcium-sensitizing agents. J Med Chem 1995;38:2946-2954.
9. 2+ on cross-bridge turnover kinetics in skinned single rabbit psoas fibers: implications for regulation of muscle contraction. Proc Natl Acad Sci USA 1988;85:3265-3269.
10. [10] Güth K, Wojciechowski R. Perfusion cuvette for the simultaneous measurement of mechanical, optical and energetic parameters of skinned muscle fibres. Pflügers Arch 1986;407:552-557.
11. [11] Palmer S, Di Bello S, Herzig JW. The effects of EMD 57033 on rigor tension in porcine skinned cardiac trabecula. Eur J Pharmacol 1995:294:83-90.
12. [12] Strauss JD, Zeugner C, Van Eyk JE, Bletz C, Troschka M, Rüegg JC. Troponin replacement in permeahilized cardiac muscle. Reversible extraction of troponin I by incubation with vanadate. FEBS Lett 1992;310:229-234.
13. [13] Kentish JC. The inhibitory effects of monovalent ions on force development in detergent-skinned ventricular muscle from guinea-pig. J Physiol 1984:352:353-374.
14. 2+ sensitivity of myofibrillar ATPase activity in skinned fibres from pig ventricles. Pflügers Arch 1990:415:741-746.
15. 2+-sensitizing agent. Pflügers Arch 1992;421:388-390.
16. [16] Best PM. Cardiac muscle function: results from skinned fiber preparations. Am J Physiol 1983;244:H167-H177.
17. 2+ sensitivity in intact versus skinned rat ventricular muscle. Circ Res 1994;74:408-415.
18. max) in isolated contractile structures from mammalian heart muscle. Arzneim Forsch/Drug Res 1981;31:188-191.
19. 2+ in skinned cardiac muscle. Jpn J Pharmacol 1989;50:411-419.
20. [20] Miller DJ, Steele DS. The "calcium sensitising" effects of ORG 30029 in saponin-or Triton-skinned rat cardiac muscle. Br J Pharmacol 1990;100:843-849.
21. [21] Wendt IR, Stephenson DG. Effects of caffeine on Ca-activated force production in skinned cardiac and skeletal muscle fibres of the rat. Pflügers Arch 1983;398:210-216.
22. 2+ sensitivity of mammalian skinned cardiac and skeletal muscle fibres. J Physiol 1994;480:45-60.
23. -+ sensitization by the cardiotonic agent APP 201-533. Basic Res Cardiol 1989;84(suppl 1): 117-124.
24. [24] Gambassi G, Capogrossi MC, Klockow M, Lakatta EG. Enantiomeric dissection of the effects of the inotropic agent, EMD 53998, in single cardiac myocytes. Am J Physiol 1993;264:H728-H738.
25. [25] El-Saleh SC, Solaro RJ. Calmidazolium, a calmodulin antagonist, stimulates calcium-troponin C and calcium-calmodulin-dependent activation of striated muscle myofilament. J Biol Chem 1987;262:17240-17246.
26. ++ binding by bepridil. J Pharmacol Exp Ther 1986;238:502-507.
27. 2+ sensitizer, Levosimendan, to recombinant human cardiac troponin C. J Biol Chem 1994;269:28584-28590.
28. 2+ sensitivity. J Gen Physiol 1982;79:997-1016.
29. 2+ on rigor tension in triton-treated rat ventricular trabeculae. Pflügers Arch 1992;421:343-349.
30. [30] Solaro RJ, Gambassi G, Warshaw DM, Keller MR, Spurgeon HA, Beier N, Lakatta EG. Stereoselective actions of thiadiazinones on canine cardiac myocytes and myofilaments. Circ Res 1993;73:981-990.
31. 2+ sensitivity of skinned striated muscle. Am J Physiol 1988;254:C491-C497.
32. 2+ binding to troponin C. Am J Physiol 1995;268:C1348-C1353.