Response to interferon treatment decreases with epidermal dedifferentiation in condylomas

Antiviral Research

Volumn 32, Issue 1, 1996, Pages 19-26

  Arany, Istvan ^a   Brysk, Miriam M ^a   Brysk, Henry ^a   Tyring, Stephen K ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Condyloma; Epidermal differentiation; Gene expression; Human papillomavirus; Interferon treatment

Indexed keywords

INTERFERON; MESSENGER RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONDYLOMA ACUMINATUM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MALE; PAPILLOMA VIRUS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

HUMAN PAPILLOMAVIRUS; PAPILLOMAVIRUS;

EID: 0030222126     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-3542(95)00970-1     Document Type: Article

References (28)

1. Arany, I., Rady, P. and Tyring, S.K. (1993) Alterations in cytokine/antioncogene expression in skin lesions caused by 'low risk' types of human papillomaviruses. Viral Immunol. 6, 255-265.
2. Arany, I., Rady, P. and Tyring, S.K. (1994) Interferon treatment enhances the expression of underphosphorylated (biologically active) retinoblastoma protein in human papillomavirus infected cells through the inhibitory TGFβ1/IFNβ cytokine pathway. Antiviral Res. 23, 131-141.
3. Arany, I., Goel, A. and Tyring, S.K. (1995a) Response to interferon treatment depends on levels of different viral genes in 'low risk' human papillomavirus-containing lesions. Anticancer Res. 15, 2865-2870.
4. Arany, I., Nagamani, K. and Tyring, S.K. (1995) Interferon resistance is independent from copy numbers in benign HPV-induced lesions. Anticancer Res. 15, 1003-1006.
5. Barbosa, M.S., Edmonds, C., Fisher, C., Schiller, J.T., Lowy, D.R. and Vousden, K.H. (1990) The region of the HPV E7 oncoprotein homologous to adenovirus Ela and SV40 large T antigen contains separate domains for Rb binding and casein kinase II phosphorylation. EMBO J. 9, 153-160.
6. Bernard, H.-U. and Apt. D. (1994) Trancriptional control and cell type specificity of HPV gene expression. Arch. Dermatol. 130, 210-215.
7. Brysk, M.M., Arany, I., Brysk, H., Chen, S.-H., Calhoun, K.H. and Tyring, S.K. (1995a) Epithelial cell responsiveness to interferon gamma: epidermis vs. buccal mucosa. Mol. Cell. Differ. 3, 213-223.
8. Brysk, M.M., Arany. I., Brysk, H., Chen, S.-H., Calhoun, K.H. and Tyring, S.K. (1995b) Gene expression of markers associated with proliferation and differentiation in keratinocytes cultured from skin and from oral mucosa. Arch. Oral Biol. 40, 855-862.
9. Ciccolini, F., Di Pasquale, G., Carlotti, F., Crawford, L. and Tommasino, M. (1994) Functional studies of E7 proteins from different HPV types. Oncogene 9, 2633-2638.
10. Cirelli, R. and Tyring, S.K. (1994) Interferons in human papillomavirus infection. Antiviral Res. 24, 191-204.
11. Dalton, S. (1992) Cell cycle regulation of the human cdc2 gene. EMBO J. 11, 1797-1804.
12. Demeter, L.M., Stoler, M.H., Broker, T.R. and Chow, L.T. (1994) Induction of proliferating cell nuclear antigen in differentiated keratinocytes of human papillomavirus-infected lesions. Hum. Pathol. 25, 343-348.
13. Dürst, M., Bosch, F.X., Glitz, D., Schneider, A. and zur Hausen, H. (1991) Inverse relationship between human papillomavirus (HPV) type 16 early gene expression and cell differentiation in nude mouse epithelial cysts and tumors induced by HPV-positive human cell lines. J. Virol. 65, 796-804.
14. Iftner, T., Oft, M., Bohm, S., Wilczynski, S.P. and Pfister, H. (1992) Transcription of the E6 and E7 genes of human papillomavirus type 6 in anogenital condylomata is restricted to undifferentiated cell layers of the epithelium. J. Virol. 66, 4639-4646.
15. Manos, M.M., Ting, Y., Wright, D.K., Lewis. A.J., Broker, T.R. and Wolinsky, S.M. (1989) The use of polymerase chain reaction amplification for the detection of genital human papillomaviruses. Cancer Cells 7, 209-214.
16. Mistchenko, A.S., Diez, R.A., Romquin, N., Sanceau, J. and Wieterbin, J. (1993) Interferon-γ modulates retinoblastoma gene mRNA in monocytoid cells. Int. J. Cancer 53, 87-90.
17. Moll, R., Moll, I. and Franke, W.W. (1984) Differences of expression of cytokeratin polypeptides in various epithelial skin tumors. Arch. Dermatol. Res. 276, 349-363.
18. Mullink, H., Jiwa, N.M., Walboomers. J.M.M., Horstman, A., Vos, W. and Meijer, C.J.L.M. (1991) Demonstration of changes in cytokeratin expression in condylomata acuminata in relation to the presence of human papilloma virus as shown by a combination of immunohistochemistry and in situ hybridization. Am. J. Dermatopathol. 13, 530-537.
19. Münger, K. and Phelps, W.C. (1993) The human papillomavirus E7 protein as a transforming and transactivating factor. Biochim. Biophys. Acta 1155, 111-123.
20. O'Guin, W.M., Schermer, A., Lynch, M. and Sun, T.-T. (1990) Differentiation-specific expression of keratin pairs. In: R.D. Goldman and P.M. Steinert (Eds.), Cellular and Molecular Biology of Intermediate Filaments, pp. 301-334. Plenum. New York.
21. Oliver, A.M. (1990) The cytokeratin expression of cultured human foetal keratinocytes. Br. J. Dermatol. 123, 707-716.
22. Phelps, W.C. and Alexander, K.A. (1995) Antiviral therapy for human papillomaviruses: rationale and prospects. Ann. Intern. Med. 123, 368-382.
23. Rady, P., Arany, I., Hughes, T.K. and Tyring, S.K. (1995) Type-specific primer-mediated direct sequencing of consensus primer-generated PCR amplicons of human papilloma viruses: a new approach for the simultaneous detection of multiple viral type infections. J. Virol. Methods 53, 245-254.
24. Stoler, M.H., Wolinsky, S.M., Whitbeck, A., Broker, T.R. and Chow, L.T. (1989) Differentiation-linked human papillomavirus types 6 and 11 transcription in genital condylomata revealed by in situ hybridization with message-specific RNA probes. Virology 172, 331-340.
25. Vowels, B.R., Lessin, S.R., Cassin, M., Jaworsky, C., Benoit, B., Wolfe, J.T. and Rook, A.H. (1994) Th2 cytokine mRNA expression in skin in cutaneous T-cell lymphoma. J. Invest. Dermatol. 103, 669-673.
26. Werness, B.A., Levine, A.J. and Howley, P.M. (1990) Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248, 76-79.
27. Yuspa, S.H. (1994) The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis. Thirty-third G.H.A. Clowes memorial award lecture. Cancer Res. 54, 1178-1189.
28. zur Hausen, H. (1991) Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 184, 9-13.