Structure and polymorphism of the upstream region of the pfg27/25 gene, transcriptionally regulated in gametocytogenesis of Plasmodium falciparum

Molecular and Biochemical Parasitology

Volumn 79, Issue 2, 1996, Pages 207-217

  Alano, Pietro ^a   Silvestrini, Francesco ^a   Roca, Lucia ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Gametocyte specific transcription; Genomic polymorphism; Plasmodium falciparum; Sexual differentiation

Indexed keywords

MESSENGER RNA; POLY(DEOXYADENYLATE DEOXYTHYMIDYLATE); POLYTHYMIDYLIC ACID; PROTOZOAL DNA;

ARTICLE; GAMETOGENESIS; GENE STRUCTURE; GENETIC POLYMORPHISM; MALARIA; MOLECULAR CLONING; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SEX DIFFERENTIATION DISORDER; TRANSCRIPTION REGULATION;

PLASMODIUM FALCIPARUM;

EID: 0030222091     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-6851(96)02663-1     Document Type: Article

References (24)

1. [1] Inselburg, J. (1983) Gametocyte formation by the progeny of single Plasmodium falciparum schizonts. J. Parasitol. 69, 584-591.
2. [2] Bruce, M.C., Alano, P., Duthie, S. and Carter, R. (1990) Commitment of the malaria parasite Plasmodium falciparum to asexual and sexual development. Parasitology 100, 191-200.
3. [3] Carter, R., Graves, P.M., Creasey, A., Byrne, K., Read, D. Alano, P. and Fenton, B. (1989) Plasmodium falciparum: an abundant stage specific protein expressed during early gametocyte development. Exp. Parasitol. 69, 140-149.
4. [4] Lobo, C., Konings, R.N.H. and Kumar, N. (1994) Expression of early gametocyte-stage antigens Pfg27 and Pfs16 in synchronised gametocytes and non-gametocyte producing clones of Plasmodium falciparum. Mol. Biochem. Parasitol. 68, 151-154.
5. [5] Alano, P., Premawansa, S., Bruce, M.C. and Carter, R. (1991) A stage specific gene expressed at the onset of gametocytogenesis in Plasmodium falciparum. Mol. Biochem. Parasitol. 46, 81-88.
6. [6] Pologe, L.G. (1994) Aberrant transcription and the failure of Plasmodium falciparum to differentiate into gametocytes. Mol. Biochem. Parasitol. 68, 35-43.
7. [7] Alano, P., Roca, L., Smith, D., Read, D., Carter, R. and Day, K. (1995) Plasmodium falciparum: parasites defective in early stages of gametocytogenesis. Exp. Parasitol. 81, 227-235.
8. [8] Walliker, D., Quakyi, I.A., Wellems, T.E., McCutchan, T.F., Szarfman, A., London, W.T., Corcoran, L.M., Burkot, T.R. and Carter, R. (1987) Genetic analysis of the human malaria parasite Plasmodium falciparum. Science 236, 1661-1666.
9. [9] Shirley, M.V., Biggs, B.A., Forsyth, K.P., Brown, H.J., Thompson, J.K., Brown, G.V. and Kemp, D.J. (1990) Chromosome 9 from independent clones and isolates of Plasmodium falciparum undergoes subtelomeric deletions with similar breakpoints in vitro. Mol. Biochem. Parasitol. 40, 137-146.
10. [10] Day, K.P., Karamalis, F., Thompson, J., Barnes, D.A., Peterson, C., Brown, H., Brown, G.V. and Kemp, D.J. (1993) Genes necessary for expression of a virulence determinant and for trasmission of Plasmodium falciparum are located on a 0.3-megabase region of chromosome 9. Proc. Natl. Acad. Sci. USA 90, 8292-8296.
11. [11] Suresh, K.G., Shulman, S. and Vanderberg, J.P. (1985) Stage dependent toxicity of N-acetyl-glucosamine to Plasmodium falciparum. J. Protozool. 15, 1-8.
12. [12] Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
13. [13] Delves, C.J., Alano, P., Ridley, R.G., Goman, M, Holloway S.P., Hyde, J.E. and Scaife J.G. (1990) Expression of alpha and beta tubulin genes during the asexual and sexual blood stages of Plasmodium falciparum. Mol. Biochem. Parasitol. 43, 271-278.
14. [14] Lanzer, M., de Bruin, D. and Ravetch, J.V. (1992) Transcription mapping of a 100 kb locus of Plasmodium falciparum identifies an intergenic region in which transcription terminates and reinitiates. EMBO J. 11, 1949-1955.
15. [15] Chomzyinski, P. and Sacchi, N. (1987) Single step method of RNA isolation by acid guanidinium-thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
16. [16] Tanabe, K., Mackay, M., Goman, M. and Scaife, J.G. (1987) Allelic dimorphism in a surface antigen gene of the malaria parasite Plasmodium falciparum. J. Mol. Biol. 195, 273-287.
17. [17] Moelans, J.M.D., Kocken, C.H.N., Meis, J., Konings, R.N.H. and Schoenmakers, J.G.G. (1991) A novel protein antigen of the malaria parasite Plasmodium falciparum located on the surface of gametes and sporozoites. Mol. Biochem. Parasitol. 45, 193-204.
18. [18] Pace, T., Ponzi, M., Scotti, R. and Frontali, C. (1995) Structure and superstructure of Plasmodium falciparum subtelomeric regions. Mol. Biochem. Parasitol. 69, 257-268.
19. [19] Hawking, F., Wilson, M.E. and Gammage, K. (1971) Evidence for cyclic development and short lived maturity in the gametocytes of Plasmodium falciparum. Trans. R. Soc. Trop. Med. Hyg. 65, 549-559.
20. [20] Chodosh, L. A., Baldwin, A.S., Carthew, R.W. and Sharp, P.A. (1988) Human CCAAT binding proteins have heterologous subunits. Cell 53, 11-24.
21. [21] Vishwanat, I. and Strhul, K. (1995) Poly(dA:dT), a ubiquitous promoter element that stimulates transcription via its intrinsic DNA structure. EMBO J. 14, 2570-79
22. [22] Kunkel, G.R. and Martinson, H.G. (1981) Nucleosomes will not form on double stranded RNA or over poly(dA):poly(dT) tracts in recombinant DNA. Nucleic Acids Res. 9, 6869-6888.
23. [23] Boffelli, D., De Santis, P., Palleschi., Scipioni, A. and Savino, M. (1992) Theoretical prediction of sequence-dependent DNA superstructures and their implications in recognition mechanisms with proteins. Int. J. Quantum Chem. 42, 1409-1426.
24. [24] Soldati, D. and Boothroyd, J.C. (1995). A selector of transcription initiation in the protozoan parasite Toxoplasma gondii. Mol. Cell. Biol. 15, 87-93.